Journal
ONCOIMMUNOLOGY
Volume 2, Issue 12, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.27440
Keywords
glycolipids; immunosurveillance; invariant natural killer T cells; perforin; tumor
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Funding
- NCI NIH HHS [K08 CA166184] Funding Source: Medline
- NHLBI NIH HHS [R01 HL089745] Funding Source: Medline
- NIAID NIH HHS [T32 AI007634] Funding Source: Medline
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Although invariant natural killer T (iNKT) cells influence antitumor responses indirectly by secreting cytokines and promoting the cytolytic functions of T and NK cells, we find that iNKT cells mediate direct tumoricidal activity in vitro and significantly inhibit tumor growth in vivo, even in the absence of other cytotoxic lymphocytes.
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