Article
Oncology
Jiacheng Bi, Chen Huang, Xiaomeng Jin, Chaoyue Zheng, Yingying Huang, Xiaohu Zheng, Zhigang Tian, Haoyu Sun
Summary: By analyzing single-cell transcriptomics and using gene reporter mice, this study found that TIPE2 expression correlated with NK cell exhaustion in the tumor microenvironment (TME) in both humans and mice. Deletion of TIPE2 improved the antitumor activity of adoptively transferred mouse NK cells and human NK cells, either derived from peripheral blood or induced pluripotent stem cells (iPSCs). Additionally, TIPE2 deletion synergized with CISH deletion to further enhance antitumor activity in vivo.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Sainiteesh Maddineni, John L. Silberstein, John B. Sunwoo
Summary: This article reviews multiple approaches for allogeneic NK cell therapy and discusses the advantages and disadvantages of each method. In recent years, NK cells have become increasingly important players in the immune response against cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Congcong Zhang, Jasmin Roeder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Anja Waldmann, Nina Mueller, Pranav Oberoi, Winfried S. Wels
Summary: The study developed a bispecific antibody NKAB-ErbB2 that redirects NKG2D-expressing effector cells to ErbB2-positive tumor cells, synergizing with NKG2D-CAR cells and natural NK cell-mediated cytotoxicity. In mouse model, NKAR-NK-92 cells combined with NKAB-ErbB2 effectively suppressed tumor outgrowth and induced antitumor immunity and cures in most animals.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Alvaro Haroun-Izquierdo, Marianna Vincenti, Herman Netskar, Hanna van Ooijen, Bin Zhang, Laura Bendzick, Minoru Kanaya, Pouria Momayyezi, Shuo Li, Merete Thune Wiiger, Hanna Julie Hoel, Silje Zandstra Krokeide, Veronika Kremer, Geir Tjonnfjord, Stephanie Berggren, Kristina Wikstroem, Pontus Blomberg, Evren Alici, Martin Felices, Bjoern oenfelt, Petter Hoeglund, Bahram Valamehr, Hans-Gustaf Ljunggren, Andreas Bjoerklund, Quirin Hammer, Lise Kveberg, Frank Cichocki, Jeffrey S. Miller, Karl-Johan Malmberg, Ebba Sohlberg
Summary: This study demonstrates the feasibility of off-the-shelf therapy with a non-engineered, yet highly specific, NK cell population for hematological malignancies. The expanded adaptive NK cells retained high cytotoxicity and efficiently killed leukemia cells from AML patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Ilias Christodoulou, Won Jin Ho, Andrew Marple, Jonas W. Ravich, Ada Tam, Ruyan Rahnama, Adam Fearnow, Cambrynne Rietberg, Sean Yanik, Elena E. Solomou, Ravi Varadhan, Michael A. Koldobskiy, Challice L. Bonifant
Summary: The study demonstrates that engineering NK cells to express CARs and IL-15 can enhance their anti-AML activity. However, this modification also comes with potential systemic toxicities.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Mireia Bachiller, Lorena Perez-Amill, Anthony Matthew Battram, Sebastian Ciro Carne, Amer Najjar, Els Verhoeyen, Manel Juan, Alvaro Urbano-Ispizua, Beatriz Martin-Antonio
Summary: This study demonstrates the important immunoregulatory role of CB-NK collaborating with CAR-T cells to enhance their antitumor activity. Combinatorial treatment based on CAR-T and CAR-NK cells or CB-NK and CAR-T cells showed that CB-NK required high doses for effectiveness, while a low number of CB-NK in the CAR-T product promoted early activation of CAR-T cells and enhanced anti-MM efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Farhoodeh Ghaedrahmati, Nafiseh Esmaeil, Maryam Abbaspour
Summary: Natural killer (NK) cells have potential for cancer immunotherapy, but the immunosuppressive tumor microenvironment (TME) hinders their efficacy. Immune checkpoints contribute to NK cell exhaustion and tumor immune escape. Blocking immune checkpoints can rescue exhausted NK cells and enhance their anti-tumor activity. This review focuses on immune checkpoint blockade strategies, particularly using chimeric antigen receptor (CAR)-NK cells, to redirect NK cells to solid tumors.
CANCER COMMUNICATIONS
(2023)
Article
Immunology
Samantha A. Barnes, Katherine M. Audsley, Hannah V. Newnes, Sonia Fernandez, Emma de Jong, Jason Waithman, Bree Foley
Summary: The study found that IFN alpha 14 and IFN beta are superior activators of NK cell effector function in vitro. It was also shown that NK cells pre-activated with IFN alpha 14 significantly prolonged survival in a preclinical model of leukaemia. These results suggest that further investigation into using IFN alpha 14 to modulate NK cells against leukaemia is promising.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lucas Henrique Rodrigues da Silva, Luana Correia Croda Catharino, Viviane Jennifer da Silva, Gabriela Coeli Menezes Evangelista, Jose Alexandre Marzagao Barbuto
Summary: Natural killer (NK) cells are innate lymphocytes that play a vital role in immune surveillance against tumors. Various NK-based therapies, including transfer of expanded and activated cells, genetic engineering, cytokine therapy, and tumor-specific antibody-guided cells, are being used in cancer treatment. This article also discusses the potential approaches to control glioblastoma.
Article
Biotechnology & Applied Microbiology
Peter J. J. Chockley, Jorge Ibanez-Vega, Giedre Krenciute, Lindsay J. J. Talbot, Stephen Gottschalk
Summary: In this study, researchers aimed to enhance the function of CAR immune cells by tuning the CAR immune synapses using an intracellular scaffolding protein binding site. The results showed that the synapse-tuned CAR immune cells exhibited increased effector cell functionality both in vitro and in vivo, leading to enhanced killing of tumor cells.
NATURE BIOTECHNOLOGY
(2023)
Review
Oncology
Changqing Pan, You Zhai, Guanzhang Li, Tao Jiang, Wei Zhang
Summary: NK cell-based immunotherapy shows promising potential for treating glioma due to its unique features, but faces challenges such as inadequate CAR design and lagging application compared to hematological malignancies. Further strategies are needed to enhance the efficacy of NK cell-based cancer immunotherapy in glioma treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yi-Chiu Kuo, Cheng-Fu Kuo, Kurt Jenkins, Alfur Fu-Hsin Hung, Wen-Chung Chang, Miso Park, Brenda Aguilar, Renate Starr, Jonathan Hibbard, Christine Brown, John C. Williams
Summary: The use of universal CAR T cells shows promise in improving the efficacy of cancer treatment and has broad potential applications.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Stefanie Renken, Takahiro Nakajima, Isabelle Magalhaes, Jonas Mattsson, Andreas Lundqvist, Elias S. J. Arner, Rolf Kiessling, Stina Linnea Wickstrom
Summary: Auranofin can significantly reduce intracellular ROS accumulation in human cytotoxic lymphocytes ex vivo, preserving their antitumoral activity and increasing resistance to oxidative stress.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Min Li, Di Xie, Xinfeng Tang, Chen Yang, Yanqiong Shen, Han Zhou, Wuxian Deng, Jiwei Liu, Shanbao Cai, Li Bai, Yucai Wang
Summary: The study demonstrates that the use of photothermal therapy can enhance the antitumor ability of adoptively transferred NKT cells, leading to excellent growth inhibition of local tumors and efficient rejection of distant tumors. It also triggers long-term immunological memory to prevent tumor recurrence, showing promising potential for cancer immunotherapy.
Article
Oncology
Sophia Stock, Mohamed-Reda Benmebarek, Anna-Kristina Kluever, Diana Darowski, Christian Jost, Kay-Gunnar Stubenrauch, Joerg Benz, Anne Freimoser-Grundschober, Ekkehard Moessner, Pablo Umana, Marion Subklewe, Stefan Endres, Christian Klein, Sebastian Kobold
Summary: This study developed a P329G-directed CAR T cell that can selectively bind with specific mutated antibodies, demonstrating significant in vitro and in vivo effector functions in different types of solid tumor models. This opens up possibilities for further clinical translation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cardiac & Cardiovascular Systems
Luis Angel, Zachary N. Kon, Stephanie H. Chang, Samaan Rafeq, Saketh Palasamudram Shekar, Brian Mitzman, Nancy Amoroso, Ronald Goldenberg, Kimberly Sureau, Deane E. Smith, Robert J. Cerfolio
ANNALS OF THORACIC SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Stephanie H. Chang, Luis Angel, Deane E. Smith, Julius Carillo, Darya Rudym, Melissa Lesko, Kimberly Sureau, Robert A. Montgomery, Nader Moazami, Zachary N. Kon
Summary: This study evaluates whether a modest change prioritizing high-LAS lung transplant candidates would lower wait list mortality. The results show that this simple prioritization change can decrease wait list mortality without significantly affecting posttransplant 1-year survival.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Zachary N. Kon, Deane E. Smith, Stephanie H. Chang, Ronald M. Goldenberg, Luis F. Angel, Julius A. Carillo, Travis C. Geraci, Robert J. Cerfolio, Robert A. Montgomery, Nader Moazami, Aubrey C. Galloway
Summary: This study reviewed the use of ECMO support in critically ill COVID-19 patients and found that the survival rate was high, with only 1 death reported during over 350 days of ECMO support.
ANNALS OF THORACIC SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Stephanie H. Chang, Deane E. Smith
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Stephanie H. Chang
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Travis C. Geraci, Navneet Narula, Deane E. Smith, Andre L. Moreira, Zachary N. Kon, Stephanie H. Chang
Summary: Patients with severe COVID-19 are prone to a strong inflammatory response and thrombotic complications. Pulmonary vein thrombosis, while rare, can lead to pulmonary congestion, infarction, and potentially mortality. This case report highlights the development of hemorrhagic infarction in a COVID-19 patient requiring ECMO, due to inferior vein thrombosis and subsequent lobectomy.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Neel K. Ranganath, Jad Malas, Stacey Chen, Deane E. Smith, Stephanie H. Chang, Melissa B. Lesko, Luis F. Angel, Bonnie E. Lonze, Zachary N. Kon
Summary: This study aimed to investigate the impact of pretransplant hospital admission status on posttransplant mortality, and found an association between admission status and posttransplant mortality. High-volume centers were independently associated with improved survival.
ANNALS OF THORACIC SURGERY
(2021)
Letter
Critical Care Medicine
Stephanie H. Chang, Jeffrey Jiang, Zachary N. Kon, David M. Williams, Travis C. Geraci, Deane E. Smith, Robert J. Cerfolio, Michael Zervos, Costas Bizekis
Article
Cardiac & Cardiovascular Systems
Stephanie H. Chang, Deane E. Smith, Nader Moazami, Zachary N. Kon
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Amie J. Kent, Kim A. Byrnes, Stephanie H. Chang
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Review
Surgery
Jeffrey Jiang, Stephanie H. Chang, Amie J. Kent, Travis C. Geraci, Robert J. Cerfolio
FRONTIERS IN SURGERY
(2020)
Review
Surgery
Dana Ferrari-Light, Travis C. Geraci, Stephanie H. Chang, Robert J. Cerfolio
FRONTIERS IN SURGERY
(2020)
Review
Surgery
Robert J. Cerfolio, Stephanie H. Chang
Summary: In the past decade, healthcare systems have shifted focus towards improving patient outcomes and quality, with the creation of the Efficiency Quality Index (EQI) to better assess quality and value. The unique aspect of the EQI is the involvement of physicians who perform procedures in determining metrics, ensuring an accurate and fair measurement of performance and outcomes.
FRONTIERS IN SURGERY
(2021)
Article
Pathology
Abdallah Flaifel, Benjamin Kwok, Jane Ko, Stephanie Chang, Deane Smith, Fang Zhou, Luis A. Chiriboga, Briana Zeck, Neil Theise, Darya Rudym, Melissa Lesko, Luis Angel, Andre Moreira, Navneet Narula
Summary: This study reports on the clinical course, pulmonary pathology, and outcomes after lung transplantation in three patients with chronic respiratory failure due to postacute sequelae of SARS-CoV-2 infection. The major pathological findings in the lung explants suggest ongoing fibrosis, prominent macrophage infiltration, neoangiogenesis, and microvascular thrombosis.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Stephanie H. Chang, Michael Zervos, Amie Kent, Abraham Chachoua, Costas Bizekis, Harvey Pass, Robert J. Cerfolio
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2020)
