Article
Immunology
Mostafa G. G. Aly, Eman H. H. Ibrahim, Hristos Karakizlis, Rolf Weimer, Gerhard Opelz, Christian Morath, Martin Zeier, Naruemol Ekpoom, Volker Daniel
Summary: In this study, the relationship between regulatory cells and immunosuppressive drugs in transplant recipients was investigated. The results showed a negative correlation between CD4+CD25+CD127-Foxp3+ Tregs and CD19+IL-10+ Bregs in early transplant recipients, with Tregs being affected by steroid dose and tacrolimus levels, while Bregs seemed less affected by potent immunosuppression. It was also found that CD4+CD25+CD127-Foxp3+ Tregs were lower in patients treated with certain antibodies compared to end-stage kidney disease patients. Early transplant recipients exhibited different patterns of Tregs and Bregs within the first 3 months post-transplant, indicating a complex relationship between these regulatory cells and immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jose M. Gonzalez-Navajas, Dengxia Denise Fan, Shuang Yang, Fengyuan Mandy Yang, Beatriz Lozano-Ruiz, Liya Shen, Jongdae Lee
Summary: Cancer arises from genetic mutations allowing cells to proliferate uncontrollably, but the failure of anticancer immunity, influenced by the tumor environment's impact on T cells, is essential for cancer survival. Immune checkpoint inhibitor therapy was developed to combat the immune paralysis induced by tumor environments, specifically by targeting molecules like PD-1. While effector T cells work to eliminate cancers, Tregs in the tumor environment suppress native anticancer immunity and reduce the efficacy of ICI therapies. Targeted efforts to deplete tumor-associated Tregs are underway to enhance ICI therapy effectiveness without causing systemic autoimmune responses. Understanding the roles of Tregs in anti-cancer immunity and ICI therapies can lead to more precise targeting of intratumoral Tregs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Article
Multidisciplinary Sciences
Brianna M. Lax, Joseph R. Palmeri, Emi A. Lutz, Allison Sheen, Jordan A. Stinson, Lauren Duhamel, Luciano Santollani, Alan Kennedy, Adrienne M. Rothschilds, Stefani Spranger, David M. Sansom, K. Dane Wittrup
Summary: Anti-CTLA-4 antibodies have limited long-term benefit in tumor regression. We engineered a nonantagonistic CTLA-4 binding domain and found that both CTLA-4 antagonism and intratumoral Treg depletion are needed for maximum efficacy in anti-CTLA-4 therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Zheng Zhang, Jihua Guo, Rong Jia
Summary: Treg plasticity is associated with inflammatory diseases and cancers. Regulating Treg plasticity is a promising direction for the treatment of inflammatory diseases and cancers.
INFLAMMATION RESEARCH
(2023)
Article
Immunology
Andres Paris-Munoz, Gonzalo Aizpurua, Domingo F. Barber
Summary: This study revealed the absence of CD8(+) regulatory T cells in two lupus-prone mouse models, MRL/MPJ and MRL/lpr, compared to a non-prone mouse strain, C57BL/6. The findings suggest that Helios plays a regulatory role in the pathogenesis of lupus and its expression profile is altered in other relevant T cell populations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Christine Weissenborn, Sophie von Lenthe, Nicole Hinz, Stefanie Langwisch, Mandy Busse, Anne Schumacher, Ana C. Zenclussen, Stefan Fest
Summary: This study found that transient ablation of Tregs hindered the growth of neuroblastoma (NB), while the absence of Bregs had no effect on NB growth, providing important evidence for targeting Tregs as a potential therapy for this aggressive childhood tumor.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Pearl A. Sutter, Antoine Menoret, Evan R. Jellison, Alexandra M. Nicaise, Allison M. Bradbury, Anthony T. Vella, Ernesto R. Bongarzone, Stephen J. Crocker
Summary: Globoid cell leukodystrophy (GLD), or Krabbe's disease, is a fatal genetic demyelinating disease caused by loss-of-function mutations in the galactosylceramidase (galc) gene. A study conducted on a mouse model of GLD has identified CD8(+) cytotoxic T lymphocytes as a key player in the development of the disease and its neuropathology. Blocking CD8 alpha effectively prevented disease onset, reduced morbidity and mortality, and prevented CNS demyelination in mice, suggesting potential novel therapeutic targets for GLD.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Emil Weiss, Gustavo Campos Ramos, Murilo Delgobo
Summary: The immune system plays a crucial role in maintaining tissue integrity and controlling inflammation during myocardial infarction (MI). This review discusses the central role of regulatory T-cells (Tregs) in tissue repair and inflammation control in the context of MI. It summarizes recent advances in this field, including the use of transgenic mouse models, whole-heart imaging techniques, clinical studies, and single-cell transcriptomics analysis. The review also explores the mechanisms and cell types targeted by Tregs in the infarcted heart and discusses the potential use of Treg manipulating drugs in clinical settings.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Feihong Zhu, Hehe Chen, Meifei Xu, Xiajun Zhang, Jing Yu, Yali Pan, Weixin Zhu
Summary: The study found that Cryptotanshinone (CT) can attenuate the infarct region in the MCAO model, increase the percentage of CD4(+)CD25(+)FOXP3(+) Treg cells in the peripheral blood, and recover the protein level of FOXP3 and the phosphorylation of STAT5 in CD4(+)CD25(+) Treg cells.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Lin Lin, Fei Dai, Jinjin Wei, Zheng Chen
Summary: CD8(+) Tregs have not been clearly elucidated in allergic rhinitis (AR), but this study found that CD8(+) Tregs may help alleviate inflammatory responses in AR condition. Percentages of CD4(+) or CD8(+) Tregs in PBMCs from AR patients were reduced compared to normal subjects, but IL-10 and TGF-beta were increased in CD4(+) and CD8(+) Tregs cultures from AR patients.
Review
Biotechnology & Applied Microbiology
Robert K. Bright
Summary: Overexpressed tumor-associated antigens (TAAs) include proteins found at increased levels in tumors. Tumor Protein D52 (TPD52) is an overexpressed TAA that plays a role in tumor transformation, proliferation, and metastasis. Preclinical studies have shown that vaccine-induced immunity against mD52 is effective against multiple cancers in murine models without inducing autoimmunity against healthy tissues and cells.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Immunology
Siawosh K. Eskandari, Hazim Allos, Basmah S. Al Dulaijan, Gandolina Melhem, Ina Sulkaj, Juliano B. Alhaddad, Anis J. Saad, Christa Deban, Philip Chu, John Y. Choi, Branislav Kollar, Bohdan Pomahac, Leonardo V. Riella, Stefan P. Berger, Jan S. F. Sanders, Judy Lieberman, Li Li, Jamil R. Azzi
Summary: Regulatory T cells (T-regs) have shown promise as cellular therapy for various immune diseases, but their clinical efficacy is limited by poor in vivo homeostasis. In this study, inhibiting mTORC1 effectively reduced intracytoplasmic expression and functionality of GrB in host T-regs, leading to decreased apoptosis and improved stability and homeostasis of T-regs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Rajeev K. Tyagi, Justin Jacobse, Jing Li, Margret M. Allaman, Kevin L. Otipoby, Erik R. Sampson, Keith T. Wilson, Jeremy A. Goettel
Summary: Regulatory T cells play a crucial role in maintaining immune homeostasis in the intestine, and dysfunction of T-reg cells is linked to various inflammatory and autoimmune disorders. Treatment with low-dose IL-2 may be a promising therapeutic strategy for inflammatory conditions, but its effectiveness in treating IBD is still uncertain.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Cyril Labbe, Natalie Grima, Thierry Gautier, Bertrand Favier, Jennifer A. Byrne
Article
Multidisciplinary Sciences
Yuyan Chen, Sarah Frost, Matloob Khushi, Laurence C. Cantrill, Hong Yu, Jonathan W. Arthur, Robert K. Bright, Guy E. Groblewski, Jennifer A. Byrne
SCIENTIFIC REPORTS
(2019)
Article
Biotechnology & Applied Microbiology
C. Riccay Elizondo, Jennifer D. Bright, Jennifer A. Byrne, Robert K. Bright
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2020)
Article
Computer Science, Interdisciplinary Applications
Cyril Labbe, Guillaume Cabanac, Rachael A. West, Thierry Gautier, Bertrand Favier, Jennifer A. Byrne
Letter
Biochemistry & Molecular Biology
Tracey Weissgerber, Nico Riedel, Halil Kilicoglu, Cyril Labbe, Peter Eckmann, Gerben ter Riet, Jennifer Byrne, Guillaume Cabanac, Amanda Capes-Davis, Bertrand Favier, Shyam Saladi, Peter Grabitz, Alexandra Bannach-Brown, Robert Schulz, Sarah McCann, Rene Bernard, Anita Bandrowski
Article
Computer Science, Interdisciplinary Applications
Jennifer A. Byrne, Yasunori Park, Rachael A. West, Amanda Capes-Davis, Bertrand Favier, Guillaume Cabanac, Cyril Labbe
Summary: This study compared journal responses to a specific reagent error in 31 human gene knockdown publications, revealing variations in responses between journals and suggesting a need for editorial staff to have more support in interpreting post-publication notifications of incorrect nucleotide sequences. A draft template was proposed to facilitate communication, interpretation, and investigation of published errors, including those affecting research reagents.
Article
Cell Biology
Amanda Rush, Daniel R. Catchpoole, Georget Reaiche-Miller, Thomas Gilbert, Wayne Ng, Peter Hamilton Watson, Jennifer A. Byrne
Summary: The survey revealed that most researchers were satisfied with the biobank application processes and the suitability of received biospecimens/data, but they still preferred creating their own collections due to gaps in sample availability and to increase efficiency. Researchers mostly accessed biobanks in close proximity to them, and they often had to limit the scope of their research due to difficulties in obtaining biospecimens/data.
BIOPRESERVATION AND BIOBANKING
(2022)
Article
Cell Biology
Sheila O'Donoghue, Simon Dee, Jennifer A. Byrne, Peter Hamilton Watson
Summary: It is important to know the number of biobanks that exist, but this information is often hard to find. The study analyzed four biobank locators and found that there are 11-30 health research biobanks per million population in regions with high research capacity. The establishment of biobank locators can help track the number of biobanks and prevent duplication of resources.
BIOPRESERVATION AND BIOBANKING
(2022)
Article
Ethics
Anna M. Scott, E. Ann Bryant, Jennifer A. Byrne, Natalie Taylor, Adrian G. Barnett
Summary: The analysis of the petition comments revealed that signatories were primarily concerned with changes to the research ethics and governance system, the drawbacks of the existing system, suggestions for improvements, anticipated impacts of changes, and miscellaneous issues.
JOURNAL OF EMPIRICAL RESEARCH ON HUMAN RESEARCH ETHICS
(2022)
Article
Biology
Yasunori Park, Rachael A. West, Pranujan Pathmendra, Bertrand Favier, Thomas Stoeger, Amanda Capes-Davis, Guillaume Cabanac, Cyril Labbe, Jennifer A. Byrne
Summary: Errors in identifying nucleotide sequence reagents in research publications may misinform the development of human therapies. The screening tool Seek & Blastn identified 712 problematic articles across 78 journals, and identified 1,535 wrongly identified sequences.
LIFE SCIENCE ALLIANCE
(2022)
Article
Cell Biology
Jennifer A. Byrne, Anastazia T. Banaszak, Jane E. Carpenter, Steven L. Carroll, Marta G. Castelhano, Paula S. Espinal, Marianne K. Henderson, Anusha Hettiaratchi, Mantombi Maseme, Wayne Ng, Kirtika Patel, Iuliana Popescu, Sergio Prada, William S. Schleif, Miranda Smith, Shirley Wee, Carol J. Weil, Katherine Woods
BIOPRESERVATION AND BIOBANKING
(2023)
Article
Biochemistry & Molecular Biology
Jennifer A. Byrne, Yasunori Park, Reese A. K. Richardson, Pranujan Pathmendra, Mengyi Sun, Thomas Stoeger
Summary: Human gene research is at risk from low-quality or fraudulent articles produced by paper mills. This review discusses the impact of paper mills on the human gene research literature and proposes methods for detecting and correcting these problematic publications.
NUCLEIC ACIDS RESEARCH
(2022)
Editorial Material
Genetics & Heredity
Amanda Rush, Peter Watson, Jennifer A. Byrne
Summary: Although biobanks can support research across boundaries, researchers prefer collaborating with local biobanks or establishing their own. This article summarizes the potential impacts of local biobank use and suggests improving descriptions of bio-specimen provenance in research publications.
TRENDS IN GENETICS
(2023)
Review
Medicine, Research & Experimental
Tamsin E. Tarling, Jennifer A. Byrne, Peter H. Watson
Summary: Preserved biospecimens in biobanks and clinical archives are important for biomarker research. However, recent advancements in technology have led to an excess supply of biospecimens, prompting a need to reassess inventory targets and allocate resources more effectively.
BIOMARKER INSIGHTS
(2022)
Article
Biochemical Research Methods
Yeu-Yao Cheng, Jack Nunn, John Skinner, Boe Rambaldini, Tiffany Boughtwood, Tom Calma, Alex Brown, Cliff Meldrum, Marcel E. Dinger, Jennifer A. Byrne, Debbie McCowen, Jayden Potter, Kerry Faires, Sandra Cooper, Kylie Gwynne
Summary: This study protocol is a crucial first step to ensure that genomic precision medicine (PM) research is relevant and acceptable to Aboriginal Australians. The use of co-design methods in developing the protocol aims to enhance the potential application of PM in Aboriginal communities.
METHODS AND PROTOCOLS
(2021)