Journal
ONCOIMMUNOLOGY
Volume 1, Issue 5, Pages 777-779Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.19730
Keywords
universal; T cell; biotin; chimeric; immune; receptor; avidin; adoptive; immunotherapy; platform
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Funding
- NCI NIH HHS [R01 CA168900, R21 CA152540] Funding Source: Medline
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Chimeric antigen receptors (CARs) possess fixed specificity for a single antigen and require empirical testing in T cells. To address this, we have developed a novel, adaptable immune receptor strategy that allows for the rapid generation and testing of T cells of nearly infinite antigen specificity.
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