Journal
ONCOIMMUNOLOGY
Volume 1, Issue 6, Pages 989-991Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.20238
Keywords
inflammation; innate immune cells; T cells; B cells; tumor endothelia; immunotherapy
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We aimed to determine if the tumor microenvironment could be turned into a self-vaccine site. We show that provoking a local inflammatory response modulates endothelia to permit the infiltration of innate and adaptive effector cells which collaborate to eradicate the inflamed tumor and other tumor deposits, and provide long-term protection.
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