Journal
ONCOIMMUNOLOGY
Volume 1, Issue 3, Pages 384-386Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.18826
Keywords
ALDH1A1; CTL; adoptive therapy; cancer stem cells; xenograft
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ALDH(bright) cells in human tumor cells lines, xenografts and lesions have been shown to have characteristics of cancer stem cells (CSC). We have shown that these cells are recognized by ALDH1A1-specific CD8(+) T cells in vitro and in vivo. The results support the potential of ALDH1A1-based immunotherapy to target CSC.
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