Article
Oncology
Jieun Woo, Joo Weon Lim, Hyeyoung Kim
Summary: This study revealed that Helicobacter pylori increases the expression levels of integrin alpha 5 in gastric cancer cells and promotes cell adhesion and migration. Astaxanthin (ASX) effectively inhibits this process by decreasing ROS levels and suppressing JAK1/STAT3 activation, thereby reducing integrin alpha 5 expression and cell adhesion and migration.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Oncology
Sapna Oberoi, Amria Qumseya, Wei Xue, Douglas J. Harrison, Erin R. Rudzinski, Suzanne L. Wolden, Roshni Dasgupta, Rajkumar Venkatramani, Abha A. Gupta
Summary: This study aimed to determine the feasibility of incorporating temsirolimus into the standard COG chemotherapy regimen for intermediate-risk rhabdomyosarcoma. The results showed that weekly temsirolimus during VAC/VI chemotherapy was feasible and well tolerated. The efficacy of this regimen is currently being tested in a phase III randomized trial.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Eddy S. Yang, Amin H. Nassar, Elio Adib, Opeyemi A. Jegede, Sarah Abou Alaiwi, Deborah L. Della Manna, David A. Braun, Mahsa Zarei, Heng Du, Sumanta K. Pal, Gurudatta Naik, Guru P. Sonpavde
Summary: The study investigated the relationship between gene expression and treatment benefit of Everolimus in metastatic renal cell carcinoma patients. Specific gene signatures were identified that could potentially predict the response to Everolimus monotherapy or combination therapy with a vascular disrupting agent. Further validation of these gene signatures is needed to determine their clinical utility in patient selection.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Oncology
Sonia M. Abuzakhm, Vineeth Sukrithan, Briant Fruth, Rui Qin, Jonathan Strosberg, Timothy J. Hobday, Thomas Semrad, Diane Reidy-Lagunes, Hedy Lee Kindler, George P. Kim, Jennifer J. Knox, Andreas Kaubisch, Miguel Villalona-Calero, Helen Chen, Charles Erlichman, Manisha H. Shah
Summary: This study assessed the efficacy and safety of combining bevacizumab with temsirolimus for advanced extra-pancreatic neuroendocrine tumors. The results showed minimal efficacy and increased side effects with this combination therapy, and it is not recommended for use in these patients.
ENDOCRINE-RELATED CANCER
(2023)
Review
Developmental Biology
Naoya Yamaguchi, Holger Knaut
Summary: Cell-extracellular matrix interactions are essential for cell anchoring and migration, with focal adhesions (FAs) playing a key role. However, the role of FAs in vivo is still not well understood.
Article
Genetics & Heredity
Lawrence Liu, Carina Dehner, Nikhil Grandhi, Yang Lyu, Dana C. Borcherding, John S. A. Chrisinger, Xiao Zhang, Jingqin Luo, Yu Tao, Amanda Parkes, Nam Q. Bui, Elizabeth J. Davis, Mohammed M. Milhem, Varun Monga, Mia Weiss, Brian Van Tine, Angela C. Hirbe
Summary: This study investigated the impact of genetic mutations in PEComa patients on treatment response, and found no significant association between gene mutations and survival rate or progression-free survival after treatment. Further research should focus on identifying other TSC-1/-2 silencing driver genes to predict response to mTOR inhibition therapy.
Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ying-hua He, Guo Tian
Summary: Autophagy plays a crucial role in renal cell carcinoma, with many autophagy-related proteins serving as prognostic markers. Researchers are exploring synthetic and phytochemical drugs targeting autophagy for RCC therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Weili Xu, Tessa Bergsbaken, Karen L. Edelblum
Summary: Intestinal tissue-resident lymphocytes play a critical role in maintaining the mucosal barrier and preventing enteric infections. CD103, an integrin expressed on these lymphocytes, is involved in their activation and function, but the molecular signals it triggers are still not well understood. Research in this field can provide insights into the functional contribution of CD103 and its potential as a therapeutic target for tissue-resident lymphocyte-related diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cell Biology
Christoph J. Burckhardt, John D. Minna, Gaudenz Danuser
Summary: The research demonstrates that SH3BP4 regulates integrin surface expression in a signaling-dependent manner, impacting cell-matrix interactions. Decreased Akt kinase activity leads to SH3BP4 mediating endocytosis of neuropilin-1 and alpha 5/beta 1-integrins, inhibiting cell spreading.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Michele F. Caliandro, Felix Schmalbein, Luca Matteo Todesca, Matthias Moergelin, Maryam Rezaei, Juliane Meissner, Isabel Siepe, Julius Grosche, Albrecht Schwab, Johannes A. Eble
Summary: Integrin-mediated cell contacts with the extracellular matrix (ECM) play essential roles in cellular adhesion, force transmission, and migration. The binding activities of integrins and their cellular functions are regulated by various effectors, such as divalent cations and redox-active compounds. This study investigates the interplay between the Ca2+ binding site and redox-regulation within the hinge region of the integrin alpha 7 subunit, revealing their mutual dependence in adhesion strength and cell migration. Furthermore, protein-chemical analyses suggest that the activation of integrin via the alpha hinge is primed by the formation of cysteine pair-based crosslinkage, followed by Ca2+ complexation, resulting in altered cell functions mediated by integrin and ECM ligand binding.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Seo Yun Kim, Eun-Hui Jeong, Tae-Gul Lee, Hye-Ryoun Kim, Cheol Hyeon Kim
Summary: Combining trametinib and temsirolimus reduced clonogenic survival and promoted radiation-induced apoptosis in lung cancer cells. Inhibition of MEK and mTOR together led to prolonged expression of gamma H2AX after irradiation and prolonged G(2)/M cell cycle arrest in A549 cells. In vivo studies showed that co-administration of the drugs increased lung cancer xenograft sensitivity to radiotherapy.
ANTICANCER RESEARCH
(2021)
Review
Immunology
Michael J. Shannon, Emily M. Mace
Summary: Integrins are transmembrane receptors that play a crucial role in determining tissue residency and function of natural killer cell subsets by their differential expression. Understanding the expression of integrin subtypes on NK cells provides insight into how integrin selection influences cell properties and functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Liel Hamdi, Hanan Nabat, Yehuda Goldberg, Nina Fainstein, Shir Segal, Efrat Mediouni, Yarden Asis, Olga Touloumi, Nikolaos Grigoriadis, Abram Katz, Tamir Ben-Hur, Ofira Einstein
Summary: This study found that high-intensity continuous training (HICT) can attenuate the development of autoimmune neuroinflammation through immunomodulatory and neuroprotective effects. HICT inhibits the migratory potential of autoreactive cells and reduces blood-brain barrier permeability, leading to reduced inflammation.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Corinna L. Kleinholz, Monika Riek-Burchardt, Elena A. Seiss, Jonas Amore, Patricia Gintschel, Lars Philipsen, Philippe Bousso, Borna Relja, Burkhart Schraven, Juliane Handschuh, Juliane Mohr, Andreas J. Mueller
Summary: The study revealed that Ly6G deficiency reduces the initial infection rate of neutrophils at the site of infection, while the uptake of L. major by subsequently recruited monocytes remains unaffected. Ly6G-deficient neutrophils exhibit delayed initial recruitment kinetics into the site of infection.
SCIENTIFIC REPORTS
(2021)
Review
Urology & Nephrology
Charles Laine, Giorgio Gandaglia, Massimo Valerio, Isabel Heidegger, Igor Tsaur, Jonathan Olivier, Francesco Ceci, Roderick C. N. van den Bergh, Alexander Kretschmer, Constance Thibault, Peter K. Chiu, Derya Tilki, Veeru Kasivisvanathan, Felix Preisser, Fabio Zattoni, Christian Fankhauser, Claudia Kesch, Ignacio Puche-Sanz, Marco Moschini, Benjamin Pradere, Guillaume Ploussard, Giancarlo Marra
Summary: This review aims to investigate the features and optimal management of pN+ cM0 prostate cancer based on registry-based studies. The findings suggest that up to 15% of prostate cancer patients have lymph node invasion. However, the optimal management strategy in this setting is not well characterized. The study results show that adjuvant androgen deprivation therapy and adjuvant radiotherapy have survival benefits compared to observation in certain intermediate-risk categories. Factors such as age, Gleason score, Charlson score, etc. are relevant prognostic factors. The results of this study will contribute to future research in defining the optimal management strategy based on different risk categories.
CURRENT OPINION IN UROLOGY
(2022)
Article
Surgery
Peter Sparwasser, Maximilian Haack, Stefan Epple, Lisa Frey, Steffen Zeymer, Robert Dotzauer, Florian Jungmann, Katharina Boehm, Thomas Hoefner, Igor Tsaur, Axel Haferkamp, Hendrik Borgmann
Summary: This study investigated the usage of augmented reality smart glasses for prostate biopsy. The results showed that the smart glasses-assisted targeted biopsy had a higher detection rate for prostate cancer compared to systematic biopsy. The feasibility scores were high for practicality, multitasking, execution speed, comfort, and device weight, but low for handling, battery, and image quality.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2022)
Article
Oncology
Sascha D. Markowitsch, Olesya Vakhrusheva, Patricia Schupp, Yasminn Akele, Jovana Kitanovic, Kimberly S. Slade, Thomas Efferth, Anita Thomas, Igor Tsaur, Rene Mager, Axel Haferkamp, Eva Juengel
Summary: This study evaluated the impact of shikonin (SHI) from traditional Chinese medicine on therapy-sensitive and therapy-resistant renal cell carcinoma (RCC) cells. The results showed that SHI could inhibit the growth of RCC cells and block cell division. SHI also induced cell death and inhibited a key pathway for cell survival and growth. Therefore, SHI may be a potential option for treating RCC.
Article
Urology & Nephrology
Igor Tsaur, Roderick C. N. van den Bergh, Timo Soeterik, Anita Thomas, Maximilian P. Brandt, Fabio Zattoni, Fabrizio Dal Moro, Alessandro Morlacco, Jeanlou Collavino, Guillaume Ploussard, Christian Surcel, Christian Mirvald, Orel Carmona, Barak Rosenzweig, Christian Ruckes, Tatjana Heisinger, Isabel Heidegger, Giorgio Gandaglia, Robert Dotzauer
Summary: This study aimed to predict the risk of unfavorable pathology in prostate cancer discovered during surgery for benign prostatic obstruction. The study found that serum prostate-specific antigen (PSA) levels, International Society of Urological Pathology (ISUP) grade group (GG), and age were independent factors for predicting unfavorable histopathology. Based on these factors, the research team developed a calculator to assist in assessing the risk of adverse pathology in patients with prostate cancer.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Oncology
Igor Tsaur, Anita Thomas, Michelle Monecke, Marion Zugelder, Jochen Rutz, Timothy Grein, Sebastian Maxeiner, Hui Xie, Felix K. -H. Chun, Florian Rothweiler, Jindrich Cinatl, Martin Michaelis, Axel Haferkamp, Roman A. Blaheta
Summary: The natural compound amygdalin has been shown to inhibit the growth and disseminative properties of taxane-resistant prostate cancer cells. This finding is important for identifying effective treatment options for metastatic prostate cancer.
Review
Medicine, General & Internal
Cristian Surcel, Cristian Mirvald, Robert Stoica, Vasile Cerempei, Isabel Heidegger, Apostolos Labanaris, Igor Tsaur, Catalin Baston, Ioanel Sinescu
Summary: Uretero-arterial fistula (UAF) is a rare but life-threatening complication that requires collaboration between multiple specialties. Angiography is the best diagnostic modality, but there is no definitive imaging technique. Surgical exploration remains the most appropriate treatment option for patients with acute massive bleeding.
Article
Oncology
Aurelius Omlin, Richard Cathomas, Gunhild von Amsberg, Christoph Reuter, Susan Feyerabend, Wolfgang Loidl, Martin Boegemann, Anja Lorch, Axel Heidenreich, Igor Tsaur, Julian Larcher-Senn, Stefan A. J. Buck, Ron H. J. Mathijssen, Ulrich Jaehde, Silke Gillessen, Markus Joerger
Summary: This study compares the efficacy of cabazitaxel at different doses in patients with metastatic castration-resistant prostate cancer (mCRPC) and finds that individual dose adjustments of cabazitaxel can improve clinical feasibility and survival outcome in patients.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Eva Juengel, Jochen Rutz, Moritz Meiborg, Sascha D. Markowitsch, Sebastian Maxeiner, Timothy Grein, Anita Thomas, Felix K. -H. Chun, Axel Haferkamp, Igor Tsaur, Olesya Vakhrusheva, Roman A. Blaheta
Summary: This study investigates the effects of mistletoe extracts from four host trees on the growth and proliferation of bladder cancer cells and finds that these extracts significantly inhibit bladder cancer growth.
Article
Biochemistry & Molecular Biology
Gregor Duwe, Lukas Mueller, Christian Ruckes, Nikita Dhruva Fischer, Lisa Johanna Frey, Jan Hendrik Boerner, Niklas Roelz, Maximilian Haack, Peter Sparwasser, Tobias Jorg, Christopher C. M. Neumann, Igor Tsaur, Thomas Hoefner, Axel Haferkamp, Felix Hahn, Rene Mager, Maximilian Peter Brandt
Summary: This study is the first to investigate the correlation between splenic volume and immunotherapy in advanced urothelial carcinoma and renal cell carcinoma. The findings suggest that lower splenic volume after three months of treatment is significantly associated with improved overall survival in patients with renal cell carcinoma.
Article
Biochemistry & Molecular Biology
Dimitri Barski, Igor Tsaur, Mihaly Boros, Jan Brune, Thomas Otto
Summary: This study combines amniotic tissues and methylene blue to explore the neuroprotective effect on early functional outcomes in patients undergoing radical prostatectomy. The findings show early recovery of continence after three months, but no effect on potency. This tissue-engineering strategy is feasible and further prospective comparative studies are warranted.
Article
Urology & Nephrology
Gregor Duwe, Katharina Boehm, Maximilian Haack, Peter Sparwasser, Maximilian Peter Brandt, Rene Mager, Igor Tsaur, Axel Haferkamp, Thomas Hoefner
Summary: Focal therapy (FT) for localized prostate cancer (PCa) is only recommended within the context of clinical trials, and this study aimed to investigate the oncological follow-up and safety data of focal high-intensity focused ultrasound (HIFU) treatment. The results showed that HIFU treatment was feasible in carefully selected patients, but the tumor progression rate was 37.93% with a risk of metastasis, leading to the discontinuation of HIFU usage.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Igor Tsaur, Roman A. Blaheta, Robert Dotzauer, Maximilian P. Brandt, Giorgio Gandaglia, Ioanel Sinescu, Cristian Mirvald, Jonathan Olivier, Cristian Surcel
Summary: This study aims to summarize the evidence of focal therapy (FT) in oligometastatic prostate cancer (OMPC). The study found that OMPC has distinct differences in biological behavior and molecular signaling processes compared to polymetastatic disease (PMPC), and there are currently no established biomarkers to accurately identify OMPC. Although data comparing FT to standard care in OMPC are scarce, longer progression-free survival and time to castration resistance have been demonstrated for bone metastatic prostate cancer treated with cryosurgery followed by androgen deprivation therapy (ADT) compared to ADT alone.
WORLD JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
I Tsaur, A. Thomas, R. Dotzauer, A. Haferkamp, P. Sparwasser
Article
Urology & Nephrology
Robert Dotzauer, Arash Salamat, Nikita D. Nabar, Anita Thomas, Katharina Boehm, Maximilian P. Brandt, Rene Mager, Hendrik Borgmann, Martin Kurosch, Thomas Hoefner, Igor Tsaur, Andreas M. Hotker, Axel Haferkamp, Wolfgang Jaeger
Summary: This study aimed to investigate the association between the timing of initial staging and occurrence of unspecific lymph node enlargement and adjuvant therapies after inguinal orchiectomy for testicular cancer. The results showed that the postoperative imaging cohort had significantly more unspecific lymph node enlargement in the inguinal, pelvic, and retroperitoneal areas compared to the preoperative imaging cohort. Simultaneous occurrence of inguinal or pelvic lymph node enlargement together with retroperitoneal enlargements was only found in the postoperative imaging cohort. There was no significant difference in adjuvant therapies between the two cohorts.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Review
Oncology
Isabel Heidegger, Claudia Kesch, Alexander Kretschmer, Igor Tsaur, Francesco Ceci, Massimo Valerio, Derya Tilki, Giancarlo Marra, Felix Preisser, Christian D. Fankhauser, Fabio Zattoni, Peter Chiu, Ignacio Puche-Sanz, Jonathan Olivier, Roderik C. N. van den Bergh, Veeru Kasivisvanathan, Andreas Pircher, Irene Virgolini, Giorgio Gandaglia
Summary: This narrative review article summarizes recent studies investigating predictive and prognostic clinical, imaging-based, and molecular biomarkers to select the most suitable prostate cancer patients for 177Lu-PSMA-617 radioligand therapy.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)