Article
Engineering, Biomedical
Soyoung Son, Jung Min Shin, Sol Shin, Chan Ho Kim, Jae Ah Lee, Hyewon Ko, Eun Sook Lee, Jae Min Jung, Jeongyun Kim, Jae Hyung Park
Summary: The study demonstrates that macitentan can modulate the desmoplastic tumor microenvironment by regulating the function of cancer-associated fibroblasts, attenuating the biogenesis of cancer cell-derived exosomes, and modulating T cell subsets and distribution in the TME. These results indicate that macitentan effectively reorganizes the immunosuppressive TME and exhibits synergistic antitumor effects in combination with ICT.
Article
Pharmacology & Pharmacy
Yusi Chen, Jun Luo, Jingyuan Chen, Eugene Kotlyar, Zilu Li, Wenjie Chen, Jiang Li
Summary: The study on transitioning PAH patients from ambrisentan to macitentan showed successful and well-tolerated results, with improvements in exercise capacity, cardiac function, and hemodynamics. The transition was associated with greater efficacy and satisfaction.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Roberta Bartolucci, Anne-Gaelle Dosne, Denes Csonka, Juan Jose Perez-Ruixo, Paolo Magni, Italo Poggesi
Summary: This study developed a comprehensive population pharmacokinetic model to describe the pharmacokinetics of macitentan and aprocitentan in healthy adults and adult subjects with pulmonary arterial hypertension. Covariates such as body weight, sex, race, renal impairment, and health status significantly influenced the pharmacokinetics of these drugs.
CLINICAL PHARMACOKINETICS
(2021)
Article
Medicine, Research & Experimental
Jiezhu Feng, Zihan Peng, Lvfen Gao, Xiurou Yang, Zele Sun, Xiuying Hou, Enze Li, Linyan Zhu, Haifeng Yang
Summary: Over-expression of ClC-3 protein in PTX-resistant ovarian cancer cells promotes the combination of ClC-3 and beta-tubulin, reducing sensitivity to PTX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Anna Kleczka, Radoslaw Dzik, Agata Kabala-Dzik
Summary: This study investigated the effects of the combined use of caffeic acid phenethyl ester (CAPE) and paclitaxel (PTX) on ovarian cancer cells. The results showed that low doses of PTX exerted cytotoxic effects against all tested cell lines, and the combined use of CAPE and PTX enhanced the cytotoxicity and anti-migration activity.
Article
Cardiac & Cardiovascular Systems
Sulaima Albinni, Imre Pavo, Erwin Kitzmueller, Ina Michel-Behnke
Summary: Macitentan was introduced to pediatric patients with pulmonary arterial hypertension in a single-center prospective study. The results showed that macitentan was feasible and well tolerated in pediatric patients, with special attention needed for edema during drug introduction. This study provided valuable information on the applicability of macitentan in infants and children, but larger prospective trials are needed for verification.
PULMONARY CIRCULATION
(2021)
Article
Medicine, Research & Experimental
Raimund Dietze, Mohamad K. Hammoud, Maria Gomez-Serrano, Annika Unger, Tim Bieringer, Florian Finkernagel, Anna M. Sokol, Andrea Nist, Thorsten Stiewe, Silke Reinartz, Viviane Ponath, Christian Preusser, Elke Pogge von Strandmann, Sabine Mueller-Bruesselbach, Johannes Graumann, Rolf Mueller
Summary: The study reveals a potential link between arachidonic acid (AA) and macrophage functions in the ovarian cancer microenvironment. The signaling pathways triggered by non-metabolized AA involve the ASK1 - p38 delta/alpha axis, leading to impaired actin filament organization, inhibition of macropinocytosis, and enhanced release of exosome-like vesicles. The enzyme PLA2G2A is identified as a potential prognostic tool and therapeutic target in interfering with OC progression.
Article
Biochemistry & Molecular Biology
Yuxin Zhou, Minru Liao, Zixiang Li, Jing Ye, Lifeng Wu, Yi Mou, Leilei Fu, Yongqi Zhen
Summary: Paclitaxel and flubendazole combination therapy has synergistic effects on breast cancer, enhancing the efficacy of paclitaxel and reversing drug resistance. The mechanism may involve the HIF1 alpha/PI3K/AKT signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Dan Zi, Qing Li, Cheng-xiong Xu, Zhi-Wei Zhou, Guan-Bin Song, Cheng-Bin Hu, Fang Wen, Han-Lin Yang, Lei Nie, Xing Zhao, Jun Tan, Shu-Feng Zhou, Zhi-Xu He
Summary: This study investigates the effects of reducing CXCR4 expression on cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer (EOC). The results show that CXCR4 knockdown reduces CSCs and EMT formation, while enhancing chemotherapy sensitivity in EOC tumor cells. The study suggests that targeting CXCR4, in combination with paclitaxel treatment, may have potential clinical application value for suppressing EOC progression.
Article
Chemistry, Medicinal
Min Hee Yang, Seung Ho Baek, In Jin Ha, Jae-Young Um, Kwang Seok Ahn
Summary: BSN, extracted from Chinese cabbage, has shown promising anti-neoplastic effects on colon cancer cells by modulating oncogenic signaling pathways and inducing apoptosis. Furthermore, the combination of BSN and paclitaxel synergistically increased cytotoxicity and apoptosis, suggesting BSN as a novel candidate for targeted therapy in colon cancer.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Brijesh Lohchania, Abisha Crystal Christopher, Porkizhi Arjunan, Gokulnath Mahalingam, Durga Kathirvelu, Aishwarya Prasannan, Vigneshwaran Venkatesan, Pankaj Taneja, K. M. Mohan Kumar, Saravanabhavan Thangavel, Srujan Marepally
Summary: The CRISPR/Cas9 system is promising for treating genetic diseases, but faces challenges in controlling the expression of editing factors and achieving high fidelity. Non-viral vectors have been found as a potential solution. In this study, liposomes with diosgenin were shown to effectively deliver Cas9 pDNA and mRNA for genome editing at multiple loci, surpassing the efficacy of liposomes with cholesterol. Mechanistically, diosgenin facilitated the cholesterol-independent and clathrin-mediated endocytosis of lipoplexes, leading to enhanced intracellular delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yui Kuroda, Miki Nonaka, Yuji Kamikubo, Haruo Ogawa, Takashi Murayama, Nagomi Kurebayashi, Hakushun Sakairi, Kanako Miyano, Akane Komatsu, Tetsushi Dodo, Kyoko Nakano-Ito, Keisuke Yamaguchi, Takashi Sakurai, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono
Summary: The research found that the endothelin A receptor may affect pain mechanisms by heterodimerization with the mu opioid receptor, and the ETAR antagonist Compound-E can enhance the analgesic effects of morphine. These findings provide a new approach to reducing opioid use.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Taiwei Wang, Jian Liu, Xuemiao Huang, Chuanqi Zhang, Mengyuan Shangguan, Junyu Chen, Shan Wu, Mengmeng Chen, Zhaoyun Yang, Shuhua Zhao
Summary: The study demonstrated that Gomisin A (GA) as an effective component of Schisandra can inhibit multidrug resistance in tumor cells and enhance the therapeutic effect of paclitaxel (PTX) in ovarian cancer. By reducing reactive oxygen species (ROS) levels, GA promotes PTX-induced cell cycle arrest in ovarian cancer cells both in vitro and in vivo. This novel combination therapy of PTX with the ROS inhibitor GA may offer a promising strategy for ovarian cancer chemotherapy.
Article
Pharmacology & Pharmacy
Yuwan Liu, Zhangjin Shen, Tingjia Zhu, Weiguo Lu, Yunfeng Fu
Summary: Curcumin has been found to enhance the anti-cancer efficacy of paclitaxel in ovarian cancer by regulating the miR-9-5p/BRCA1 axis. These findings provide strong evidence for the clinical investigation of curcumin and paclitaxel combination as a novel strategy for ovarian cancer patients, and also identify miR-9-5p and BRCA1 as key targets for regulating sensitivity to this therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Min Li, Xu Dong Dong, Qiu Bo Lyu, Wei Zhang, Shuai Huang, Chun Xue Yang, Di Cui, Hui Ying Lai
Summary: High levels of phosphorylated cofilin-1 (p-CFL-1) in epithelial ovarian cancer (EOC) cells are associated with paclitaxel resistance. This resistance is mediated by apoptosis inhibition and cytoplasmic accumulation of p-CFL-1, leading to suppressed mitochondrial apoptosis. Silencing of slingshot-1 (SSH-1) also plays a role in CFL-1 phosphorylation and chemotherapy resistance in EOC.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2021)
Article
Oncology
W. T. Kim, J. Kim, C. Yan, P. Jeong, S. Y. Choi, O. J. Lee, Y. B. Chae, S. J. Yun, S. C. Lee, W. J. Kim
ANNALS OF ONCOLOGY
(2014)
Article
Oncology
Geun Taek Lee, Yun-Sok Ha, Yeon Suk Jung, Sung-Kwon Moon, Ho Won Kang, Ok-Jun Lee, Jae Young Joung, Yung Hyun Choi, Seok-Joong Yun, Wun-Jae Kim, Isaac Yi Kim
ANNALS OF SURGICAL ONCOLOGY
(2014)
Article
Medicine, General & Internal
Ho Won Kang, Sung Phil Seo, Won Tae Kim, Yong-June Kim, Seok-Joong Yun, Sang-Cheol Lee, Wun-Jae Kim
JOURNAL OF KOREAN MEDICAL SCIENCE
(2014)
Article
Medicine, General & Internal
Ye-Hwan Kim, Won Tae Kim, Pildu Jeong, Yun-Sok Ha, Ho Won Kang, Seok Joong Yun, Sung-Kwon Moon, Yung Hyun Choi, Isaac Yi Kim, Wun-Jae Kim
JOURNAL OF KOREAN MEDICAL SCIENCE
(2014)
Article
Oncology
Hyun-Kyung Yu, Ho-Jeong Lee, Seok-Joong Yun, Sun-Joo Lee, Robert R. Langley, Yeup Yoon, Lee S. H. Yi, Duk-Soo Bae, Jang-Seong Kim, Sun Jin Kim
TRANSLATIONAL ONCOLOGY
(2014)
Article
Oncology
Ho Won Kang, Dong-Un Tchey, Chunri Yan, Won Tae Kim, Yong-June Kim, Seok-Joong Yun, Sang-Cheol Lee, Yung Hyun Choi, Isaac Yi Kim, Wun-Jae Kim
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2014)
Article
Urology & Nephrology
Ho Won Kang, Sung Pil Seo, Won Tae Kim, Yong-June Kim, Seok-Joong Yun, Sang-Cheol Lee, Wun-Jae Kim
Review
Biochemistry & Molecular Biology
Xuan-Mei Piao, Eun-Jong Cha, Seok Joong Yun, Wun-Jae Kim
Summary: Bladder cancer is the most common neoplasm of the urinary tract, and liquid biopsy has emerged as a promising field of cancer research. Liquid biopsy samples offer comprehensive information and enable tracking of genetic evolution of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
So Young Kim, Hyun Hwangbo, Min Yeong Kim, Seon Yeong Ji, Da Hye Kim, Hyesook Lee, Gi-Young Kim, Sung-Kwon Moon, Sun-Hee Leem, Seok Joong Yun, Wun-Jae Kim, JaeHun Cheong, Cheol Park, Yung Hyun Choi
Summary: The study demonstrates that betulinic acid induces apoptosis, necrosis, and cell cycle arrest in bladder cancer cells through modulation of cell cycle regulators and mitochondrial function, leading to decreased proliferation and migration.
Article
Biochemistry & Molecular Biology
Xuan-Mei Piao, Chaelin You, Young Joon Byun, Ho Won Kang, Junho Noh, Jaehyun Lee, Hee Youn Lee, Kyeong Kim, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Kyuho Kang, Yong-June Kim
Summary: NMIBC is a common disease with high recurrence rate, which may progress to the lethal form MIBC. BUB1, a mitotic checkpoint kinase, has been identified as a potential prognostic biomarker for NMIBC by promoting cell proliferation through regulating the G2/M transition of the cell cycle. Further validation in internal and external cohorts showed its correlation with NMIBC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Eun Hye Lee, Jae-Wook Chung, Eunji Sung, Bo Hyun Yoon, Minji Jeon, Song Park, So Young Chun, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Tae Hwan Kim, Seock Hwan Choi, Eun Sang Yoo, Tae Gyun Kwon, Ho Won Kang, Wun-Jae Kim, Seok Joong Yun, Sangkyu Lee, Yun-Sok Ha
Summary: This study evaluated the role of PDK4 in bladder cancer and its related protein changes. It was found that elevated expression of PDK4 was observed in high-grade bladder cancers. Knockdown of PDK4 in bladder cancer cells resulted in reduced cell migration and invasion. Additionally, a PDK4 knockdown xenograft model showed reduced bladder cancer growth. These findings suggest that PDK4 plays a critical role in the metastasis and growth of bladder cancer cells through changes in ERK, SRC, and JNK.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xuan-Mei Piao, Seon-Kyu Kim, Young Joon Byun, Chuang-Ming Zheng, Ho Won Kang, Won Tae Kim, Yong-June Kim, Sang-Cheol Lee, Wun-Jae Kim, Sung-Kwon Moon, Yung Hyun Choi, Seok Joong Yun
Summary: This study compared the utility of different risk assessments in NMIBC patients and found that the molecular signature-based subtype predictor (MSP888) had independent predictive value for NMIBC progression, especially in patients without intravesical BCG immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Min Yeong Kim, EunJin Bang, Sung-Kwon Moon, Seok Joong Yun, Wun-Jae Kim, Jeong Sook Noh, Gi-Young Kim, Suengmok Cho, Hyesook Lee, Yung Hyun Choi
Summary: The study found that phloroglucinol can protect human retinal pigment epithelium cells from oxidative damage, reduce apoptosis, and improve cell function by decreasing ROS production.
Meeting Abstract
Urology & Nephrology
S. J. Yun, H. W. Kang, W. T. Kim, Y-T. Kim, S-C. Lee, W-J. Kim
Article
Urology & Nephrology
Sang Keun Lee, Ho Won Kang, Won Tae Kim, Yong-June Kim, Seok Joong Yun, Sang-Cheol Lee, Wun-Jae Kim
KOREAN JOURNAL OF UROLOGY
(2014)