Article
Biochemistry & Molecular Biology
Lucas Henrique Rodrigues da Silva, Luana Correia Croda Catharino, Viviane Jennifer da Silva, Gabriela Coeli Menezes Evangelista, Jose Alexandre Marzagao Barbuto
Summary: Natural killer (NK) cells are innate lymphocytes that play a vital role in immune surveillance against tumors. Various NK-based therapies, including transfer of expanded and activated cells, genetic engineering, cytokine therapy, and tumor-specific antibody-guided cells, are being used in cancer treatment. This article also discusses the potential approaches to control glioblastoma.
Review
Microbiology
Julia Schwarz, Kilian Schumacher, Sophie Brameyer, Kirsten Jung
Summary: This review discusses how acid-resistant Gram-negative bacteria, such as Escherichia, Salmonella, Helicobacter, and Brucella, adapt to acidic environments and the defense mechanisms they employ, including proton consumption, ammonia production, cellular remodeling, and chemotaxis. It also explores how these bacteria sense environmental acidity and provides a detailed examination of the powerful proton-consuming decarboxylase systems.
FEMS MICROBIOLOGY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Weichen Duan, Miao Yu, Jiajia Chen
Summary: The BET family proteins, including BRD2, BRD3 and BRD4, are epigenetic readers that play multiple roles in the tumorigenesis and growth of various human malignancies. This review focuses on summarizing the roles and mechanisms of BRD4 in the initiation and development of glioblastoma, and evaluates the use of various BRD4 inhibitors and degraders as novel treatment strategies against glioblastoma.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Bingqing Yang, Dan Fang, Qingyan Lv, Zhiqiang Wang, Yuan Liu
Summary: The emergence and rapid spread of antibiotic resistance pose a global public health threat. Innovations in targeted therapy strategies are urgently needed to combat this crisis, with abuse of broad-spectrum antibiotics exacerbating resistance and burdening intestinal microbiota.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Plant Sciences
Ping Wang, Brendan Mormile, Ping He
Summary: Glutamate receptor-like (GLR) proteins are ligand-gated ion channels that play important roles in plant immunity by regulating calcium channels and mediating long-distance defense against herbivores. A recent study identified a cotton GLR as a noncanonical resistance protein to Fusarium wilt, expanding the paradigm of GLR functions in plant immunity.
TRENDS IN PLANT SCIENCE
(2021)
Editorial Material
Parasitology
Ilinca I. Ciubotariu, April Monroe, Nana Aba Williams, Sheila B. Ogoma, Fredros Okumu
Summary: The Ifakara MasterClasses are expert training courses that focus on specific topics related to malaria control. By bringing together the global community, they provide a platform for sharing best practices in fighting malaria.
TRENDS IN PARASITOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wanda Maczka, Anna Duda-Madej, Malgorzata Grabarczyk, Katarzyna Winska
Summary: The purpose of this article is to present recent studies on the antimicrobial properties of linalool, the mechanism of action on cells, and detoxification processes. Linalool, commonly found in many herbs and black tea, has been shown to have a broad spectrum of biological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, and antimicrobial effects. It is particularly effective against Gram-negative bacteria, and further research is being conducted to understand its mechanism of action and biotransformation processes.
Article
Multidisciplinary Sciences
Ekta Chaudhary, Franciosalgeo George, Aswathi Saji, Sagnik Dey, Santu Ghosh, Tinku Thomas, Anura. V. Kurpad, Sumit Sharma, Nimish Singh, Shivang Agarwal, Unnati Mehta
Summary: This study showed that increased exposure to PM2.5 is associated with higher prevalence of anemia, acute respiratory infection, and low birth weight among children in India. Nitrate, elemental carbon, and ammonium were found to be more correlated with these health outcomes compared to other PM2.5 species. The study also suggests that using total PM2.5 mass as an indicator of air pollution exposure may underestimate the composite impact of different components of PM2.5.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Carson J. Miller, Karen Usdin
Summary: Approximately 3% of the human genome consists of microsatellites or short tandem repeats (STRs), which are often unstable and undergo expansions or contractions. Microsatellite instability (MSI) can be seen in certain types of cancer, and expansions of specific STRs are responsible for genetic disorders known as repeat expansion diseases (REDs). The mismatch repair (MMR) pathway suppresses some forms of expansion but promotes others. This review discusses the paradoxical effect of MMR on microsatellite expansion in mammalian cells.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Silvia Mara Baez Rodriguez, Georgiana-Adeline Staicu, Ani-Simona Sevastre, Carina Baloi, Vasile Ciubotaru, Anica Dricu, Ligia Gabriela Tataranu
Summary: Glioblastoma stem cells (GSCs) are self-renewing cells that can initiate tumors and are linked to tumor heterogeneity. Standard treatments fail to eradicate GSCs, leading to disease recurrence. Understanding the biology and survival mechanisms of GSCs is crucial for targeting them effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zhirui Yang, Feng Qin
Summary: With global climate change, water scarcity-induced drought stress poses a significant threat to agricultural productivity. Plants adapt to drought stress through physiological and morphological changes, such as stomatal closure and altered root architecture. Recent studies have identified drought-related genetic resources in various crop species, and the molecular analysis of these genes has enhanced our understanding of drought responses in crops and provided targets for improving drought resistance. This review summarizes recent advances in cloning and functional analysis of drought resistance genes, as well as the development of technologies to mitigate the impacts of drought on crop production.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Subramaniyan Divya, Palaniyandi Ravanan
Summary: The endoplasmic reticulum (ER) is a dynamic organelle responsible for correctly folding proteins. Various internal and external factors can disrupt its function and trigger ER stress responses. The unfolded protein response (UPR) mechanism and ER-associated degradation systems help to reduce misfolded proteins and maintain cell survival, while communication with other organelles and stress signaling pathways regulate cell survival or cell death. The UPR can be targeted for therapeutic purposes and used as a biomarker for diseases.
Review
Biochemistry & Molecular Biology
Claudia Rebeca Rivera-Yanez, Porfirio Alonso Ruiz-Hurtado, Maria Isabel Mendoza-Ramos, Julia Reyes-Reali, Gina Stella Garcia-Romo, Glustein Pozo-Molina, Aldo Arturo Resendiz-Albor, Oscar Nieto-Yanez, Adolfo Rene Mendez-Cruz, Claudia Fabiola Mendez-Catala, Nelly Rivera-Yanez
Summary: Skin is the main external organ that needs protection from various harmful agents. There are skin disorders that lack effective and accessible treatment. Flavonoids from propolis have beneficial effects on skin diseases, with antioxidant and anti-inflammatory properties that help control and regulate cellular and biochemical changes caused by these diseases.
Article
Microbiology
Minghua Li
Summary: Interferons and interferon-stimulated genes play a crucial role in the host's innate immunity against viral infection. A recent study identified phospholipid scramblase 1 as a novel interferon-stimulated gene that restricts SARS-CoV-2 infection by blocking virus-cell fusion.
CELL HOST & MICROBE
(2023)
Review
Public, Environmental & Occupational Health
Nurul Aqilah Mohd Zaini, Nur Asyiqin Zahia Azizan, Muhamad Hafiz Abd Rahim, Adi Ainurzaman Jamaludin, Antonio Raposo, Siva Raseetha, Renata Puppin Zandonadi, Mona N. BinMowyna, Dele Raheem, Linda Heejung Lho, Heesup Han, Wan Abd Al Qadr Imad Wan-Mohtar
Summary: Hunger continues to affect generations and hundreds of millions of people worldwide, despite efforts to minimize it. Food waste poses a critical problem in many countries, disrupting the food chain system and negatively impacting the environment.
FRONTIERS IN PUBLIC HEALTH
(2023)