Review
Biochemistry & Molecular Biology
Marcelle Mehu, Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Summary: Atherosclerosis is a chronic disease characterized by damage to the intima, inflammatory cell recruitment, and lipid accumulation followed by calcification and plaque rupture. Inflammation is believed to play a crucial role in the development and progression of the disease. This paper discusses the various types of inflammatory cells involved in atherosclerosis and their significance in the disease's development and progression. Understanding the role of these cells at different stages of the disease provides valuable insights for targeted therapy.
Article
Immunology
Hideaki Fujiwara, Keisuke Seike, Michael D. Brooks, Anna Mathew, Ilya Kovalenko, Anupama Pal, Ho-Joon Lee, Daniel Peltier, Stephanie Kim, Chen Liu, Katherine Oravecz-Wilson, Lu Li, Yaping Sun, Jaeman Byun, Yoshinobu Maeda, Max S. Wicha, Tom Saunders, Alnawaz Rehemtulla, Costas A. Lyssiotis, Subramanian Pennarthur, Pavan Reddy
Summary: The alteration of IEC-specific mitochondrial complex II component SDHA plays a critical role in regulating the severity of T cell-mediated intestinal diseases, including graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis.
Review
Cell Biology
Luise Mueller, Antje Tunger, Manja Wobus, Malte von Bonin, Russell Towers, Martin Bornhaeuser, Francesco Dazzi, Rebekka Wehner, Marc Schmitz
Summary: Mesenchymal stromal cells (MSCs) have the ability to regulate and inhibit the function of immune cells, playing a crucial role in the pathogenesis of inflammatory disorders and showing promise in the treatment of conditions such as acute graft-versus-host disease, graft rejection, and autoimmune diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Inaya Hayek, Valentin Schatz, Christian Bogdan, Jonathan Jantsch, Anja Luehrmann
Summary: The tissue microenvironment, including factors like oxygen concentration, plays a crucial role in host-pathogen interactions. Hypoxia and hypoxia-inducible factors (HIF) have been identified as important factors affecting both pathogens and hosts, influencing inflammatory and antimicrobial activities in myeloid cells, bacterial responses to low oxygen conditions, and the metabolism of immune cells. Additionally, the consequences of hypoxia and HIF alpha activation on various invading pathogens like Pseudomonas aeruginosa, Mycobacterium tuberculosis, Coxiella burnetii, Salmonella enterica, and Staphylococcus aureus, including how these pathogens sense and respond to hypoxic environments, are discussed.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Rajan Singh, Anshul Anand, Arun K. Rawat, Shashi Saini, Baishakhi Mahapatra, Naveen K. Singh, Alok K. Mishra, Samer Singh, Nisha Singh, Dhiraj Kishore, Vinod Kumar, Pradeep Das, Rakesh K. Singh
Summary: Leishmania parasites upregulate the expression of immune inhibitory receptor CD300a on host antigen presenting and phagocytic cells to dampen their effector functions. Blocking CD300a signals enhances the immune response, reduces parasitic uptake, and promotes the conversion of CD4(+) T cells to memory cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Lilian van Vlerken-Ysla, Yulia Y. Tyurina, Valerian E. Kagan, Dmitry I. Gabrilovich
Summary: This review discusses the classification of myeloid cells using single-cell omics technologies in the tumor microenvironment (TME). It suggests that the biology of myeloid cells is primarily determined by a limited number of functional states, including classical and pathological activation states. The article also explores the relationship between lipid peroxidation of myeloid cells and their activation state in the TME, highlighting its potential as a therapeutic target.
Article
Biochemistry & Molecular Biology
Maura B. Bendix, Aileen Houston, Patrick F. Forde, Elizabeth Brint
Summary: Electrochemotherapy (ECT) is a potential treatment for lung cancer, which has traditionally been difficult to treat. This study found that cisplatin at 11 μM is the suggested drug of choice for ECT in lung cancer. Additionally, high electric field strengths used in current ECT protocols negatively impact the survival of immune cells, suggesting a need for modifications to improve therapy outcomes.
BIOELECTROCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Guoshuai Feng, Geetika Bajpai, Pan Ma, Andrew Koenig, Andrea Bredemeyer, Inessa Lokshina, Lulu Lai, Irmgard Foerster, Florian Leuschner, Daniel Kreisel, Kory J. Lavine
Summary: This study identified CCL17 as a proinflammatory mediator in CCR2(+) macrophages and dendritic cells, and suggested that inhibiting CCL17 could promote Treg recruitment and suppress myocardial inflammation.
Article
Chemistry, Analytical
Mahmoud Al Ahmad, Rasha A. Nasser, Lillian J. A. Olule, Bassam R. Ali
Summary: Accurate classification of innate immune players is crucial for evaluating immune system interactions, where electrical characterization serves as a novel immunophenotyping technique to differentiate between different cell types.
Article
Medicine, Research & Experimental
Paul R. Hartmeier, Jessica L. Kosanovich, Ketki Y. Velankar, Jennifer Armen-Luke, Madeline A. Lipp, Ellen S. Gawalt, Nick Giannoukakis, Kerry M. Empey, Wilson S. Meng
Summary: This study used biotin-modified PLGA nanoparticles to deliver proteins and stimulate professional antigen-presenting cells. The results showed that these nanoparticles were capable of retaining proteins and had self-adjuvant properties, inducing specific antigen-presenting cell responses. In addition, bNPs demonstrated feasibility and effectiveness in vivo.
MOLECULAR PHARMACEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaoqiong Wei, Song Zou, Zhonghui Xie, Zhen Wang, Nongyu Huang, Zhifu Cen, Yan Hao, Chengxin Zhang, Zhenyu Chen, Fulei Zhao, Zhonglan Hu, Xiu Teng, Yiyue Gui, Xiao Liu, Huaping Zheng, Hong Zhou, Shuwen Chen, Juan Cheng, Fanlian Zeng, Yifan Zhou, Wenling Wu, Jing Hu, Yuquan Wei, Kaijun Cui, Jiong Li
Summary: The study demonstrates the important role of EDIL3 in cardiac remodeling after myocardial infarction. EDIL3 deficiency improves adverse cardiac healing mainly through the mechanism of neutrophil extracellular trap-mediated pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ferran Soldevila, Jane C. Edwards, Simon P. Graham, Helen R. Crooke, Dirk Werling, Falko Steinbach
Summary: The study found that the C-strain vaccine caused changes in the myeloid cell compartment of the tonsil, leading to an increase and activation of specific immune cells. Additionally, the C-strain vaccine also promoted the activation of conventional dendritic cells 1 (cDC1) in the tonsil, which coincided with the induction of CSFV-specific CD8 T cell responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Dong Yang, Hin Chu, Gang Lu, Huiping Shuai, Yixin Wang, Yuxin Hou, Xi Zhang, Xiner Huang, Bingjie Hu, Yue Chai, Terrence Tsz-Tai Yuen, Xiaoyu Zhao, Andrew Chak-Yiu Lee, Ziwei Ye, Cun Li, Kenn Ka-Heng Chik, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Jasper Fuk-Woo Chan
Summary: Macrophages and dendritic cells play different roles in Zika virus infection, with macrophages restricting viral replication while dendritic cells may be exploited to facilitate virus replication.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Immunology
Ella Bhagyaraj, Hongbin Wang, Xinghong Yang, Carol Hoffman, Ali Akgul, Zakia Goodwin, David W. Pascual
Summary: znBAZ infection induces an increase and activation of lung NK cells in mice, which play a crucial role in promoting lung DC activation, migration, and the development of protective CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Stefan Schuelke, Stefanie Gilles, Adan C. Jirmo, Johannes U. Mayer
Summary: Antigen-presenting cells (APCs) play a critical role in bridging innate and adaptive immune responses by presenting antigens to T cells. In allergies, APCs drive immune responses against harmless antigens. Different types of APCs contribute differently to tissue-specific immune tolerance, allergen sensitization, and allergic inflammation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Editorial Material
Immunology
Rommel Chacon-Salinas, Anna Di Nardo, Soman N. Abraham
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Gerardo Manuel Corral-Ruiz, Luvia Enid Sanchez-Torres
Summary: The complex relationship between helminths, microbiota, and humans plays a crucial role in human evolution and immune system development. Understanding this relationship is vital for maintaining health and finding new therapeutic approaches.
CELLULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Itzia S. Gomez-Alonso, Sergio Martinez-Garcia, Gabriel Betanzos-Cabrera, Esmeralda Juarez, Maria C. Sarabia-Leon, Maria Teresa Herrera, Fernando Gomez-Chavez, Luvia Sanchez-Torres, Sandra Rodriguez-Martinez, Mario E. Cancino-Diaz, Jorge Cancino, Juan C. Cancino-Diaz
Summary: Protease-3 released by neutrophils in the presence of commensal non-biofilm-forming S. epidermidis plays a key role in promoting biofilm formation by facilitating cell aggregation through the release of bacterial DNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence S. C. Lok, Jeremy A. Pike, Jennifer Mueller-Winkler, Thomas W. Dennison, John R. Ferdinand, Cameron J. M. Burnett, Juan C. Yam-Puc, Lingling Zhang, Raul Maqueda Alfaro, Yousuke Takahama, Izumi Ohigashi, Geoffrey Brown, Tomohiro Kurosaki, Victor L. J. Tybulewicz, Antal Rot, Anja E. Hauser, Menna R. Clatworthy, Kai-Michael Toellner
Summary: This study demonstrates that memory B cells can recycle back to germinal centers via CCL-21 mediated chemotaxis to transport antigens, potentially contributing to affinity maturation and antigenic drift.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Bibiana Patricia Ruiz-Sanchez, Jessica Castaneda-Casimiro, Graciela L. Cabrera-Rivera, Owen Marlon Brito-Arriola, David Cruz-Zarate, Victor Gabriel Garcia-Paredes, Catalina Casillas-Suarez, Jeanet Serafin-Lopez, Rommel Chacon-Salinas, Sergio Estrada-Parra, Alejandro Escobar-Gutierrez, Iris Estrada-Garcia, Alejandro Hernandez-Solis, Isabel Wong-Baeza
Summary: This study compared the response of different human cell populations to Mycobacterium tuberculosis antigens or pathogen-associated molecular patterns in different infection states, and identified the characteristics of innate and adaptive lymphocyte subsets that produce specific cytokines in active tuberculosis patients.
MICROBIOLOGY AND IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rosario Garcia-Rocha, Alberto Monroy-Garcia, Monserrat Carrera-Martinez, Jorge Hernandez-Montes, Christian Azucena Don-Lopez, Benny Weiss-Steider, Katia Alheli Monroy-Mora, Maria de los Angeles Ponce-Chavero, Juan Jose Montesinos-Montesinos, Maria Luisa Escobar-Sanchez, Gabriela Molina Castillo, Rommel Chacon-Salinas, Luis Vallejo-Castillo, Sonia Mayra Perez-Tapia, Maria de Lourdes Mora-Garcia
Summary: The study reveals a feedback loop involving TGF-β1, CD73, and Ado in cervical cancer cells, promoting tumorigenic characteristics and enrichment of cancer stem cell-like phenotype in tumorspheres. Inhibition of TGF-β1 reverses the protumor phenotype in these cells.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Article
Immunology
Alejandro Hernandez-Solis, Azmavet M. Guemes-Gonzalez, Ximena Ruiz-Gomez, Pablo Alvarez-Maldonado, Jessica Castaneda-Casimiro, Argelia Flores-Lopez, Martha Alicia Ramirez-Guerra, Omar Munoz-Miranda, Ruth L. Madera-Sandoval, Lourdes A. Arriaga-Pizano, Alejandro Nieto-Patlan, Sergio Estrada-Parra, Sonia Mayra Perez-Tapia, Jeanet Serafin-Lopez, Rommel Chacon-Salinas, Alejandro Escobar-Gutierrez, Rodolfo Soria-Castro, Bibiana Patricia Ruiz-Sanchez, Isabel Wong-Baeza
Summary: The clinical presentation of COVID-19 can range from mild respiratory symptoms to severe sepsis-like disease. This study found that non-surviving COVID-19 patients had higher levels of low-affinity anti-RBD IgA antibodies and identified potential early biomarkers, such as sFas and granulysin, that could differentiate between surviving and non-surviving patients. Increased intestinal permeability markers, such as D-lactate and zonulin, were associated with severe COVID-19 and secondary infections.
Article
Biochemistry & Molecular Biology
Jessica Lizbeth Hernandez-Rivera, Jose C. Espinoza-Hicks, Karla F. Chacon-Vargas, Javier Carrillo-Campos, Luvia Enid Sanchez-Torres, Alejandro A. Camacho-Davila
Summary: Drug therapy for leishmaniasis is challenging due to limited efficacy and serious side effects of currently available drugs. Affordable drugs are urgently needed. Chalcones have shown potential as bioactive agents due to their simple structure and functionalization capacity. In this study, twenty-five novel prenylated chalcones were synthesized and tested for their antiparasitic activity in Leishmania mexicana. Several compounds exhibited strong inhibitory effects, with three compounds (49, 30 and 55) showing the highest activity and selectivity. Docking studies also suggested that these chalcones could modulate the activity of fumarate reductase, an important target, by binding to critical binding sites. Overall, these novel prenylated chalcones hold promise as antileishmanial agents.
MOLECULAR DIVERSITY
(2023)
Article
Multidisciplinary Sciences
Rodolfo Soria-Castro, Yatsiri G. Meneses-Preza, Gloria M. Rodriguez-Lopez, Alfredo Ibarra-Sanchez, Claudia Gonzalez-Espinosa, Sonia M. Perez-Tapia, Fabian Flores-Borja, Sergio Estrada-Parra, Alma D. Chavez-Blanco, Rommel Chacon-Salinas
Summary: The study found that valproic acid (VPA) inhibits the activation of mast cells (MC) during Listeria monocytogenes (L.m) infection, reducing degranulation and cytokine release. VPA also reduces intracellular calcium increase and phosphorylation of key signaling molecules in MC. These findings suggest that VPA can modulate the functional activity of immune cells involved in controlling L.m infection.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Adriana Dominguez-Flores, Gloria M. Rodriguez Lopez, Rodolfo Soria-Castro, Ruben Lopez-Santiago, Octavio Rodriguez-Cortes, Sonia M. Perez-Tapia, Alma D. Chavez-Blanco, Sergio Estrada-Parra, Raul Flores-Mejia, Rommel Chacon-Salinas
Summary: Brucella abortus, a Gram-negative bacteria, is a major cause of brucellosis in animals and humans. This study analyzed the role of innate immune receptors TLR2 and TLR4 in mast cell activation during B. abortus infection. The results showed that B. abortus induced the synthesis of several cytokines and activated key cell signaling molecules in mast cells. Blockade of TLR2 and TLR4 receptors decreased the release of TNF-alpha and IL-6 by mast cells in response to B. abortus. Overall, mast cells are activated by B. abortus and may contribute to the inflammatory response during the initial phase of the infection.
MICROBIAL PATHOGENESIS
(2023)
Article
Veterinary Sciences
Anabelle Manzo-Sandoval, Laura Jaramillo-Meza, Roxana Olguin-Alor, Luvia Enid Sanchez-Torres, Fernando Diaz-Otero
Summary: Flow cytometry is a technique used to identify different cell populations based on their morphological characteristics and protein presence. Despite its wide use in biomedical research and clinical diagnosis, its application in the veterinary field is limited due to the lack of specific antibodies for bovine proteins. In this study, two panels were designed and tested to identify T cell populations in heifers positive and negative for tuberculin. The panels successfully identified the cells of interest, with a higher number of activated and memory cells in tuberculin-positive heifers. These panels can be used in immunopathogenesis studies and vaccine evaluation in cattle.
VETERINARY SCIENCES
(2023)
Article
Immunology
G. M. Corral-Ruiz, M. J. Perez-Vega, A. Galan-Salinas, I. Mancilla-Herrera, J. Barrios-Payan, L. Fabila-Castillo, R. Hernandez-Pando, L. E. Sanchez-Torres
Summary: This study investigated the impact of malaria parasites on the thymus and found that infection resulted in reduced thymic weight and cellularity, primarily affecting T cell differentiation and development. Thymic atrophy was not associated with elevated serum cytokines levels but with increased glucocorticoid levels. Both malaria infection models caused the same extent of thymic damage, regardless of parasitemia level but dependent on the specific host-parasite interaction.
IMMUNOLOGY LETTERS
(2023)
Article
Multidisciplinary Sciences
Juan Carlos Yam-Puc, Zhaleh C. Hosseini, Emily Horner, Pehuen Pereyra Gerber, Nonantzin Beristain-Covarrubias, Robert Hughes, Aleksei Lulla, Maria Rust, Rebecca Boston, Magda Ali, Katrin Fischer, Edward Simmons-Rosello, Martin O'Reilly, Harry H. Robson, Lucy Booth, Lakmini Kahanawita, Andrea Correa-Noguera, David Favara, Lourdes Ceron-Gutierrez, Baerbel Keller, Andrew Craxton, Georgina S. F. Anderson, Xiao-Ming Sun, Anne Elmer, Caroline Saunders, Areti Bermperi, Sherly Jose, Nathalie E. Kingston, Thomas Mulroney, Lucia P. G. A. Pinon, Michael Chapman, Sofia E. Grigoriadou, Marion R. MacFarlane, Anne Willis, Kiran Patil, Sarah Spencer, Emily S. Staples, Klaus Warnatz, Matthew Buckland, Florian Hollfelder, Marko Hyvonen, Rainer Doffinger, Christine J. Parkinson, Sara Lear, Nicholas Matheson, James E. D. Thaventhiran
Summary: The research shows that age-associated B cells (ABC) remain transcriptionally similar in individuals with reduced immune cell function. Higher pre-vaccine levels of ABC are associated with poor vaccine response. ABCs from different conditions have common transcriptional profiles and can be categorized based on their expression of immune genes.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Jose Luis Maldonado-Garcia, Gilberto Perez-Sanchez, Enrique Becerril-Villanueva, Samantha Alvarez-Herrera, Lenin Pavon, Luvia Sanchez-Torres, Gabriel Gutierrez-Ospina, Manuel Ivan Giron-Perez, Gabriela Damian-Morales, Jesus Octavio Maldonado-Tapia, Ruben Lopez-Santiago, Martha C. Moreno-Lafont
Summary: This study evaluated the effects of Imipramine on mice infected with Brucella abortus. The results showed that Imipramine treatment improved mood, equilibrium, muscle strength, and reduced inflammation and bacterial load. These findings suggest the potential of Imipramine as an adjuvant treatment for brucellosis symptoms.
Review
Hematology
R. Arreola-Diaz, A. Majluf-Cruz, L. E. Sanchez-Torres, J. Hernandez-Juarez
Summary: Antiphospholipid syndrome is a systemic autoimmune disease characterized by hypercoagulability and obstetric complications. Antiphospholipid antibodies induce various physiological responses, leading to thrombosis and obstetric morbidity.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2022)