Journal
JACC-HEART FAILURE
Volume 2, Issue 3, Pages 308-317Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jchf.2013.12.008
Keywords
heart failure; micronutrient; nutrition
Categories
Funding
- Northern Ireland Health & Social Care R&D Doctoral Fellowship Award
- Northern Ireland Chest Heart & Stroke Association
- Servier
- Medical Research Council [MR/K023241/1] Funding Source: researchfish
- MRC [MR/K023241/1] Funding Source: UKRI
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Objectives This study sought to investigate the effect of a multiple micronutrient supplement on left ventricular ejection fraction (LVEF) in patients with heart failure. Background Observational studies suggest that patients with heart failure have reduced intake and lower concentrations of a number of micronutrients. However, there have been very few intervention studies investigating the effect of micronutrient supplementation in patients with heart failure. Methods This was a randomized, double-blind, placebo-controlled, parallel-group study involving 74 patients with chronic stable heart failure that compared multiple micronutrient supplementation taken once daily versus placebo for 12 months. The primary endpoint was LVEF assessed by cardiovascular magnetic resonance imaging or 3-dimensional echocardiography. Secondary endpoints were Minnesota Living With Heart Failure Questionnaire score, 6-min walk test distance, blood concentrations of N-terminal prohormone of brain natriuretic peptide, C-reactive protein, tumor necrosis factor alpha, interleukin-6, interleukin-10, and urinary levels of 8-iso-prostaglandin F2 alpha. Results Blood concentrations of a number of micronutrients increased significantly in the micronutrient supplement group, indicating excellent compliance with the intervention. There was no significant difference in mean LVEF at 12 months between treatment groups after adjusting for baseline (mean difference: 1.6%, 95% confidence interval: -2.6 to 5.8, p = 0.441). There was also no significant difference in any of the secondary endpoints at 12 months between treatment groups. Conclusions This study provides no evidence to support the routine treatment of patients with chronic stable heart failure with a multiple micronutrient supplement. (C) 2014 by the American College of Cardiology Foundation
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