Article
Medicine, General & Internal
Nathalie Noirclerc, Olivier Huttin, Christian de Chillou, Christine Selton-Suty, Laura Fillipetti, Jean Marc Sellal, Erwan Bozec, Erwan Donal, Zohra Lamiral, Masatake Kobayashi, Joao Pedro Ferreira, Patrick Rossignol, Nicolas Girerd
Summary: The study found that patients with paroxysmal atrial fibrillation exhibit early cardiac remodeling, characterized by increased left ventricular mass and left atrial enlargement. Although less than 10% of patients show diastolic dysfunction, there is a significant association with atrial fibrillation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
C. H. Lee, M. Z. Wu, D. T. W. Lui, C. H. Y. Fong, Q. W. Ren, S. Y. Yu, M. M. A. Yuen, W. S. Chow, J. Y. Huang, A. Xu, K. H. Yiu, K. S. L. Lam
Summary: This study found that serum TSP2 levels were independently associated with incident heart failure and deterioration in diastolic function in patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander C. Egbe, William R. Miranda, Heidi M. Connolly
Summary: This study aimed to evaluate the role of echocardiography in the comprehensive assessment of cardiac remodeling and the relationship between indices of cardiac remodeling and cardiovascular events in adults with cc-TGA. The results showed that biatrial dysfunction was common in cc-TGA patients and correlated with clinical outcomes.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel Soetkamp, Romain Gallet, Sarah J. Parker, Ronald Holewinski, Vidya Venkatraman, Kiel Peck, Joshua Goldhaber, Eduardo Marban, Jennifer E. Van Eyk
Summary: The study suggests that the phosphorylation of sarcomeric proteins is associated with heart failure with preserved ejection fraction, and treatment with cardiosphere-derived cells can partially reverse this process, with PKC beta identified as a potential therapeutic target in HFpEF.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ambarish Pandey, Nobuyuki Kagiyama, Naveena Yanamala, Matthew W. Segar, Jung S. Cho, Marton Tokodi, Partho P. Sengupta
Summary: The study developed a DeepNN model to predict high- and low-risk phenogroups in a derivation cohort, with validation in external cohorts to assess its accuracy in predicting left ventricular filling pressure. Results showed that the model outperformed current guidelines in predicting elevated filling pressure and identified specific patient subgroups with adverse outcomes and potential spironolactone response.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
T. Jake Samuel, Dalane W. Kitzman, Mark J. Haykowsky, Bharathi Upadhya, Peter Brubaker, M. Benjamin Nelson, W. Gregory Hundley, Michael D. Nelson
Summary: The study revealed that LV circumferential early diastolic strain rate was impaired in older obese patients with HFpEF compared to controls, and there was only modest correlation between LV relaxation and reduced peak (V)over dotO(2). On the other hand, it showed a stronger relationship between elevated LV filling pressures and exercise intolerance in determining future therapeutic priorities.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
Andreas B. Gevaert, Stephan Mueller, Ephraim B. Winzer, Andre Duvinage, Caroline M. Van de Heyning, Elisabeth Pieske-Kraigher, Paul J. Beckers, Frank Edelmann, Ulrik Wisloff, Burkert Pieske, Volker Adams, Martin Halle, Emeline M. Van Craenenbroeck
Summary: Iron deficiency is associated with impaired diastolic function and reduced aerobic exercise capacity in patients with heart failure with preserved ejection fraction. Including iron status in patient phenotyping improves classification accuracy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Darwin F. Yeung, River Jiang, Delaram Behnami, John Jue, Rajat Sharma, Mansi Turaga, Christina L. Luong, Michael Y. C. Tsang, Kenneth G. Gin, Hany Girgis, Pui-Kee Lee, Parvathy Nair, Purang Abolmaesumi, Teresa S. M. Tsang
Summary: The study assessed the impact of the 2016 ASE/EACVI updated algorithm on the assessment of diastolic function in real-world clinical practice. Significant differences were found in the evaluation results based on different guidelines, especially in reclassifying mild diastolic dysfunction to normal diastolic function.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zheina Cherneva, Dinko Valev, Vania Youroukova, Radostina Cherneva
Summary: This study aimed to evaluate the predictive value of inflammatory, oxidative stress, cardio-pulmonary, and echocardiographic parameters at rest for the diagnosis of stress LVDD in non-severe COPD patients. Results showed a high prevalence of masked HFpEF in COPD patients, with parameters like RV E/A >0.75 being the best independent predictors for stress LVDD.
Article
Cardiac & Cardiovascular Systems
Thomas Lindow, Aristomenis Manouras, Per Lindqvist, Daniel Manna, Bjorn Wieslander, Rebecca Kozor, Geoff Strange, David Playford, Martin Ugander
Summary: The estimation of pulmonary artery wedge pressure (PAWP) using echocardiography (ePAWP) has prognostic value beyond diastolic dysfunction grading.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Medicine, General & Internal
Bledar Daka, Louise Bennet, Lennart Rastam, Margareta Hellgren, Ying Li, Martin Magnusson, Ulf Lindblad
Summary: This study aimed to investigate the independent impact of low levels of alcohol consumption on diastolic dysfunction in a community setting. The results showed a significant association between low levels of alcohol consumption and diastolic dysfunction.
Article
Cardiac & Cardiovascular Systems
Won-Jung Shin, Hye-Mee Kwon, Sung-Hoon Kim, Hwa-Young Jang, Yong-Seok Park, Jae-Hwan Kim, Kyoung-Sun Kim, Young-Jin Moon, In-Gu Jun, Jun -Gol Song, Gyu-Sam Hwang
Summary: This study investigated the influence of liver disease severity on left ventricular diastolic properties in patients with end-stage liver disease. The results showed that as liver disease severity increased, there was a gradual change in left ventricular diastolic properties, indicating larger capacitance and higher diastolic stiffness. Among patients who underwent liver transplantation, leftward-shifted diastolic properties were associated with lower survival rates.
AMERICAN HEART JOURNAL
(2023)
Article
Rheumatology
Laura Ross, Shreeya Patel, Wendy Stevens, Andrew Burns, David Prior, Andre La Gerche, Mandana Nikpour
Summary: This study aimed to quantify the prevalence and progression of left ventricular diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction (HFpEF) in patients with systemic sclerosis (SSc). The study found that LVDD was a common finding in SSc and showed a tendency to worsen over time. LVDD was associated with more severe dyspnoea but not with clinical signs of heart failure.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rehabilitation
Ali Ashraf, Siamak Rimaz, Abbas Seddighinejad, Amin Karimi, Afagh Hassanzadeh-Rad, Mahboobeh Gholipour, Mahsa Motiei, Mohammad Ali Yazdanipour, Sheida Rimaz
Summary: This study investigated the effect of physical activity level on diastolic function of the left ventricle. The results showed an inverse relationship between physical activity level and diastolic dysfunction, suggesting that maintaining an appropriate level of physical activity can reduce the risk of cardiovascular events in patients undergoing non-cardiac surgeries.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2023)
Article
Multidisciplinary Sciences
Daniel Dalos, Theresa Dachs, Constantin Gatterer, Matthias Schneider, Thomas Binder, Diana Bonderman, Christian Hengstenberg, Simon Panzer, Stefan Aschauer
Summary: Conflicting data on cardiac remodeling in veteran athletes suggest that endurance training in individuals over 50 years old is not associated with chamber dilatation or left ventricular hypertrophy. A weekly training duration of at least 6 hours seems beneficial in preserving diastolic function and enhancing left atrial reservoir function.
Article
Cardiac & Cardiovascular Systems
Alice Y. Chang, Shannon J. FitzGerald, John Cannaday, Song Zhang, Amit Patel, M. Dean Palmer, Gautham P. Reddy, Karen G. Ordovas, Arthur E. Stillman, Warren Janowitz, Nina B. Radford, Arthur J. Roberts, Benjamin D. Levine
AMERICAN JOURNAL OF CARDIOLOGY
(2009)
Review
Medicine, General & Internal
Laura F. DeFina, Benjamin L. Willis, Nina B. Radford, Ang Gao, David Leonard, William L. Haskell, Myron F. Weiner, Jarett D. Berry
ANNALS OF INTERNAL MEDICINE
(2013)
Article
Cardiac & Cardiovascular Systems
Laura DeFina, Nina Radford, David Leonard, Larry Gibbons, Amit Khera
Article
Oncology
Susan G. Lakoski, Carolyn E. Barlow, Graeme J. Koelwyn, Whitney E. Hornsby, Jesse Hernandez, Laura F. DeFina, Nina B. Radford, Samantha M. Thomas, James E. Herndon, Jeffrey Peppercorn, Pamela S. Douglas, Lee W. Jones
BREAST CANCER RESEARCH AND TREATMENT
(2013)
Article
Cardiac & Cardiovascular Systems
Stephen W. Farrell, Carrie E. Finley, Nina B. Radford, William L. Haskell
CIRCULATION-HEART FAILURE
(2013)
Article
Cardiac & Cardiovascular Systems
John Ho, Shannon FitzGerald, John Cannaday, Lisa Stolfus, Dana Weilbacher, Yvette Henderson, Tiffany Newman, Robin Whitehead, Nina Radford
AMERICAN JOURNAL OF CARDIOLOGY
(2007)
Article
Cardiac & Cardiovascular Systems
John Ho, Shannon FitzGerald, Lisa Stolfus, John Cannaday, Nina Radford
JOURNAL OF NUCLEAR CARDIOLOGY
(2007)
Article
Public, Environmental & Occupational Health
MJ LaMonte, SJ FitzGerald, TS Church, CE Barlow, NB Radford, BD Levine, JJ Pippin, LW Gibbons, SN Blair, MZ Nichaman
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2005)
Article
Medicine, General & Internal
CB Spranger, AJ Ries, CA Berge, NB Radford, RG Victor
AMERICAN JOURNAL OF MEDICINE
(2004)
Letter
Medicine, General & Internal
N Radford, T Church
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2002)
Article
Cardiac & Cardiovascular Systems
NB Radford, B Wan, A Richman, LS Szczepaniak, JL Li, K Li, K Pfeiffer, H Schägger, DJ Garry, RW Moreadith
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2002)
Article
Cardiac & Cardiovascular Systems
AP Meeson, N Radford, JM Shelton, PPA Mammen, JM DiMaio, K Hutcheson, YF Kong, J Elterman, RS Williams, DJ Garry
CIRCULATION RESEARCH
(2001)