Article
Medicine, Research & Experimental
Tapani Salonen, Elina Jokinen, Reetta Satokari, Perttu Lahtinen
Summary: This study evaluated the effect of faecal microbiota transplantation (FMT) on fatigue severity and health-related quality of life (HRQOL) in patients with chronic fatigue syndrome (CFS). The results showed that FMT did not relieve symptoms or improve the HRQOL of patients with CFS. It is important to note that the small number of study subjects limits the generalizability of these results.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yihebali Chi, Yongqian Shu, Yi Ba, Yuxian Bai, Baoli Qin, Xiuwen Wang, Jianping Xiong, Nong Xu, Helong Zhang, Jianfeng Zhou, Jianming Xu, Ying Cheng, Jifeng Feng, Chunhong Hu, Yigui Chen, Zhendong Chen, Jufeng Wang, Chengxue Dang, Jianhong Wang, Yiye Wan, Yong Tang, Donglin Wang, Jiang Liu, Minhui Wu, Yanhong Deng, Xingwen Li, Yongqiang Li, Jian Dong, Da Jiang, Guisheng Li, Qiong Wu, Jin Li, Yujuan Qi, Yongkun Sun, Jianqiang Cai
Summary: In summary, the study showed that treatment with Anlotinib significantly prolonged progression-free survival in patients with refractory metastatic colorectal cancer, with improvements in objective response rate and disease control rate. However, overall survival was similar between the two groups.
Article
Multidisciplinary Sciences
Motlabur Rahman, Ponkaj K. Datta, Khairul Islam, Mahfuzul Haque, Reaz Mahmud, Uzzwal Mallik, Pratyay Hasan, Manjurul Haque, Imtiaz Faruq, Mohiuddin Sharif, Rifat H. Ratul, Khan Abul Kalam Azad, Titu Miah, Md Mujibur Rahman
Summary: Colchicine, as an anti-inflammatory drug, may have certain benefits in combating cytokine storms caused by COVID-19, but it does not significantly reduce mortality and the need for mechanical ventilation.
Article
Plant Sciences
Sungha Kim, Muhack Yang, Boncho Ku, Eunhye Cha, Wookcheol Seo, Ilhong Son, Hyungwon Kang, Dongwoung Kim, Bongkeun Song, Chang-Sop Yang, Sungchul Kim
Summary: This study aimed to evaluate the efficacy and safety of Mecasin in patients with ALS. Patients were randomized to receive daily doses of 1.6 g or 2.4 g Mecasin, or placebo for 12 weeks. The results showed that Mecasin can slow down the progression of symptoms in ALS patients without major adverse effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tine L. Dohlmann, Anja B. Kuhlman, Thomas Morville, Maria Dahl, Magnus Asping, Patrick Orlando, Sonia Silvestri, Luca Tiano, Jorn W. Helge, Flemming Dela, Steen Larsen
Summary: This study investigated whether concurrent administration of CoQ10 with statins increases muscle CoQ10 levels and improves mitochondrial function, as well as whether changes in muscle CoQ10 levels correlate with changes in the intensity of myalgia. The results showed that CoQ10 supplementation had no effect on muscle CoQ10 levels or mitochondrial function, and individual changes in muscle CoQ10 levels were not correlated with changes in intensity of myalgia.
Article
Pharmacology & Pharmacy
Jiansheng Li, Xue-qing Yu, Yang Xie, Shu-guang Yang, Limin Zhao, Miao Zhou, Yong Meng
Summary: The study aimed to evaluate the efficacy and safety of traditional Chinese medicine (TCM) treatment for idiopathic pulmonary fibrosis (IPF). The results showed that TCM treatment significantly reduced acute exacerbations, improved pulmonary function, health-related quality of life, exercise capacity, and symptoms, with acceptable side-effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Nasikarn Angkasekwinai, Pinyo Rattanaumpawan, Methee Chayakulkeeree, Pakpoom Phoompoung, Pornpan Koomanachai, Sorawit Chantarasut, Walaiporn Wangchinda, Varalak Srinonprasert, Visanu Thamlikitkul
Summary: A study conducted in Thailand showed that a 3-day once daily regimen of ivermectin is not effective for the prevention and treatment of COVID-19. This approach is unnecessary for populations with a high COVID-19 vaccination rate.
Article
Plant Sciences
Ju Hyun Lee, Eun Heui Jo, Jee Youn Jung, Su Jin Kang, Geum Jin Yang, Yu Hwa Shim, Min Cheol Park
Summary: This study evaluated the efficacy and safety of Soshiho-tang in atopic dermatitis patients with gastrointestinal disorders, showing that the administration of SSHT can reduce steroid ointment dependence and improve the quality of life by regulating the neutrophil-lymphocyte ratio.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Naoki Ozato, Tohru Yamaguchi, Tatsuya Kusaura, Hidefumi Kitazawa, Masanobu Hibi, Noriko Osaki, Takahiro Ono
Summary: This study aimed to evaluate the alleviating effect of consuming catechins through bottled beverages on the duration and severity of URTIs in winter. Results showed that daily consumption of catechins significantly reduced the duration and severity of URTIs in healthy individuals, particularly the symptoms of runny nose, nasal congestion, and headache.
Article
Psychology, Multidisciplinary
Jelena S. Rasic, Nevena D. J. Ivanovic, Marija S. Andjelkovic, Ivana P. Nedeljkovic, Ivan R. Nikolic, Sava D. Stojanovic, Danijela K. Ristic-Medic, Marija M. Takic, Brizita Djordjevic, Nenad Dikic
Summary: The study examined the ergogenic effects and safety profile of higenamine supplement in female recreational athletes. Results showed that supplementing with 75 mg of higenamine did not improve cardiopulmonary exercise fitness or weight loss in recreational female athletes, but it was found to be safe and well-tolerated in this population.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Ga Hyeon Jung, Chae Hyun Park, Hyun Lee, Jae Hui Kang
Summary: This study aims to evaluate the efficacy and safety of Liriope platyphylla (LP) extract in respiratory diseases. The study will be conducted using a randomized controlled trial, with participants assigned to receive either LP extract or placebo. The primary outcomes will include breathlessness, cough, and sputum scale score, while secondary outcomes will measure pulmonary function and changes in immune cells. The study will provide valuable insights into the potential anti-inflammatory effects and respiratory function improvement of LP extract.
Article
Oncology
Chung-Han Lee, Robert Motzer, Hamid Emamekhoo, Marc Matrana, Ivor Percent, James J. Hsieh, Arif Hussain, Ulka Vaishampayan, Sandy Liu, Steven McCune, Vijay Patel, Montaser Shaheen, Johanna Bendell, Alice C. Fan, Benjamin A. Gartrell, Oscar B. Goodman, Petros G. Nikolinakos, Arash Rezazadeh Kalebasty, Yousef Zakharia, Zhentao Zhang, Hema Parmar, Lalith Akella, Keith Orford, Nizar M. Tannir
Summary: The study results demonstrate that TelaE showed improved progression-free survival compared to PboE in patients with mRCC who had previously received treatment with VGEFR-targeted tyrosine kinase inhibitors and checkpoint inhibitors.
CLINICAL CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Rocco Mollace, Micaela Gliozzi, Roberta Macri, Annamaria Tavernese, Vincenzo Musolino, Cristina Carresi, Jessica Maiuolo, Carolina Muscoli, Carlo Tomino, Giuseppe Maria Rosano, Massimo Fini, Maurizio Volterrani, Bruno Silvestrini, Vincenzo Mollace
Summary: This study investigated the safety profile of a new sublingual aspirin formulation in healthy volunteers. The results showed that this formulation had a better safety profile compared to standard aspirin, especially in reducing gastric mucosal lesions.
Article
Immunology
Hirotsugu Oda, Hiroyuki Wakabayashi, Miyuki Tanaka, Koji Yamauchi, Chihiro Sugita, Hiroki Yoshida, Fumiaki Abe, Tohru Sonoda, Masahiko Kurokawa
Summary: The study found that lactoferrin has a certain alleviating effect on infectious diseases in Japanese summer, especially for summer colds. In both the 200 mg and 600 mg groups, the duration of total infectious diseases and summer colds was shorter compared to the placebo group.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Genetics & Heredity
Ophir Gilad, Guy Rosner, Dana Ivancovsky-Wajcman, Reut Zur, Rina Rosin-Arbesfeld, Nathan Gluck, Hana Strul, Dana Lehavi, Vivien Rolfe, Revital Kariv
Summary: Studies have shown that whole turmeric (WT) may contribute to the regression of polyps in familial adenomatous polyposis (FAP), particularly in the left colon. However, further larger prospective trials are needed to verify this effect.