Review
Anesthesiology
David Lagier, Congli Zeng, Ana Fernandez-Bustamante, Marcos F. Vidal Melo
Summary: The development of pulmonary atelectasis in surgical patients can impair gas exchange and respiratory mechanics. It can lead to respiratory insufficiency, pneumonia, and other complications. Risk assessment is important for selecting the optimal anesthetic technique and ensuring patient safety. Recent advancements in imaging and monitoring have improved bedside diagnosis and management.
Article
Nursing
Luciana Ramos Correa Pinto, Karina de Oliveira Azzolin, Amalia de Fatima Lucena, Miriane M. S. Moretti, Jaqueline S. Haas, Rafael B. Moraes, Gilberto Friedman
Summary: The study identified clinical indicators of septic shock in critical care patients, including hypotension, mechanical ventilation, lactate levels, hypothermia, radiotherapy-associated chemotherapy, Sequential Organ Failure Assessment score, and admittance through the emergency unit. Patients with septic shock presented hyperlactataemia and greater organic dysfunction compared to those with sepsis. Mechanical ventilation, chemotherapy, and radiotherapy were found to increase the risk of developing septic shock.
JOURNAL OF CLINICAL NURSING
(2021)
Review
Medicine, General & Internal
Ling-Xiao He, Jing-Ying Xie, Juan Lv, Huan Liu, Deng-Bin Liao, Guang-Lin Wang, Ning Ning, Zong-Ke Zhou
Summary: This review aims to critically appraise clinical practice guidelines for thromboprophylaxis in orthopaedic trauma patients, comparing the differences between these recommendations.
Review
Medicine, General & Internal
Lynne Moore, Gabrielle Freire, Anis Ben Abdeljelil, Melanie Berube, Pier-Alexandre Tardif, Eunice Gnanvi, Henry Thomas Stelfox, Marianne Beaudin, Sasha Carsen, Antonia Stang, Suzanne Beno, Matthew Weiss, Melanie Labrosse, Roger Zemek, Isabelle J. Gagnon, Emilie Beaulieu, Simon Berthelot, Terry Klassen, Alexis F. Turgeon, Francois Lauzier, Ian Pike, Alison Macpherson, Belinda J. Gabbe, Natalie Yanchar
Summary: This study aims to systematically review clinical practice guidelines (CPGs) for pediatric injury care and evaluate their quality. Through comprehensive search and evaluation, the study will synthesize and present recommendations in a matrix using the GRADE Evidence-to-Decision framework. The results of this study will provide valuable guidance for pediatric trauma care.
Article
Pediatrics
Asheley C. C. Skinner, Amanda E. E. Staiano, Sarah C. C. Armstrong, Shari L. L. Barkin, Sandra G. G. Hassink, Jennifer E. E. Moore, Jennifer S. S. Savage, Helene Vilme, Ashley E. E. Weedn, Janice Liebhart, Jeanne Lindros, Eileen M. M. Reilly
Summary: The aim of this technical report is to provide clinicians with evidence-based information and research outcomes for making treatment decisions regarding overweight and obesity in children and adolescents. It focuses on answering two overarching questions: (KQ1) What are the effective clinically based treatments for obesity? and (KQ2) What is the risk of comorbidities among children with obesity? The report also includes a conceptual framework and predefined key questions.
Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Petra de Sutter
Summary: Gender dysphoria affects approximately 0.5% of the population worldwide, with transgender men having access to gender affirming measures such as hormone therapy and surgical procedures.
FERTILITY AND STERILITY
(2021)
Review
Pediatrics
Mohamed El-Dib, Nicholas S. Abend, Topun Austin, Geraldine Boylan, Valerie Chock, M. Roberta Cilio, Gorm Greisen, Lena Hellstrom-Westas, Petra Lemmers, Adelina Pellicer, Ronit M. Pressler, Arnold Sansevere, Eniko Szakmar, Tammy Tsuchida, Sampsa Vanhatalo, Courtney J. Wusthoff
Summary: Neonatal intensive care has shifted focus from cardiorespiratory care to a holistic approach that emphasizes brain health. The most commonly used tools in the neonatal intensive care unit (NICU) to monitor brain function and physiology are amplitude-integrated EEG, full multichannel continuous EEG, and near-infrared spectroscopy. Each of these tools has unique characteristics and functions, but there is no consensus on the optimal approach to neuromonitoring in the NICU. This review examines current evidence to guide the use of these neuromonitoring tools for neuroprotective care in extremely premature infants and critically ill neonates.
PEDIATRIC RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Carl Otto Schell, Karima Khalid, Alexandra Wharton-Smith, Jacquie Oliwa, Hendry R. Sawe, Nobhojit Roy, Alex Sanga, John C. Marshall, Jamie Rylance, Claudia Hanson, Raphael K. Kayambankadzanja, Lee A. Wallis, Maria Jirwe, Tim Baker
Summary: The study has specified the content of care that should be provided to all critically ill patients, and proposed essential diagnosis-specific care for critically ill patients with COVID-19 in the ongoing pandemic, which could be an effective strategy for policy makers to reduce preventable deaths worldwide.
Article
Medicine, General & Internal
Nadja Weichselbaum, Daniel Oberladstaetter, Christoph J. Schlimp, Johannes Zipperle, Wolfgang Voelckel, Oliver Grottke, Georg Zimmermann, Marcin Osuchowski, Herbert Schochl
Summary: IL-6 plasma levels can effectively predict the need for massive transfusion in severely injured trauma patients, with high sensitivity and specificity. Patients with high IL-6 levels are more likely to develop coagulopathy and require MT.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Cardiac & Cardiovascular Systems
Kristen E. Rhodin, Vignesh Raman, Christopher W. Jensen, Lillian Kang, Daniel P. Nussbaum, Betty C. Tong, Dan G. Blazer III, Thomas A. D'Amico
Summary: This study aimed to determine the impact of multi-institutional care on survival in patients with clinical stage II or III esophageal cancer. The results showed that there was no significant difference in survival between patients who received multi-institutional care and those who received care at a single institution. Therefore, for complex cancer care, patients may consider receiving part of their care closer to home, but traveling to surgical centers of excellence should be encouraged.
ANNALS OF THORACIC SURGERY
(2023)
Article
Anesthesiology
Shahzad Shaefi, Ameeka Pannu, Ariel L. Mueller, Brigid Flynn, Adam Evans, Craig S. Jabaley, Domagoj Mladinov, Michael Wall, Shahla Siddiqui, David J. Douin, M. Dustin Boone, Erika Monteith, Vivian Abalama, Mark E. Nunnally, Miguel Cobas, Matthew A. Warner, Robert D. Stevens
Summary: This study surveyed critical care anesthesiologists in the United States to evaluate their clinical practice patterns, including compensation, types of ICUs covered, overnight ICU coverage models, and relationships between these factors. The study found significant variability in practice patterns, with female anesthesiologists reporting lower salaries but not statistically significant. These survey data can inform decision-making for the initiation and expansion of critical care services, staffing patterns, and further research on intensivist satisfaction and burnout.
ANESTHESIA AND ANALGESIA
(2023)
Article
Surgery
Adam Gyedu, Barclay T. Stewart, Emmanuel Nakua, Peter Donkor
Summary: This study demonstrates that the introduction of the Trauma Intake Form (TIF) in non-tertiary hospitals in low- and middle-income countries can improve key performance indicators in initial trauma care and reduce mortality among seriously injured patients.
BRITISH JOURNAL OF SURGERY
(2023)
Review
Pharmacology & Pharmacy
Johann Sellner, Harald H. Sitte, Paulus S. Rommer
Summary: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disease of the central nervous system (CNS) with poor outcomes, and recent clinical trials have shown therapeutic benefits of IL-6 blockade. Tocilizumab and satralizumab are widely used IL-6 receptor inhibitors, successful in extending the half-life of antibodies and highlighting the potential therapeutic benefits of the emerging technology.
DRUG DISCOVERY TODAY
(2021)
Review
Anesthesiology
Spencer P. Walsh, David Shaz, David Amar
Summary: Recent evidence indicates that there is no significant difference in outcomes between thoracic surgery patients who are ventilated with low or higher tidal volume. The effects of low versus higher positive end-expiratory pressure are also unclear.
