Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 5, Issue 3, Pages 201-207Publisher
SPRINGER
DOI: 10.1007/s12079-011-0144-0
Keywords
CCN1; Age-associated secretory phenotype; Skin connective tissue aging
Categories
Funding
- National Institute of Health [ES014697, ES014697 30S1, AG019364, AG025186]
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Dermal connective tissue collagen is the major structural protein in skin. Fibroblasts within the dermis are largely responsible for collagen production and turnover. We have previously reported that dermal fibroblasts, in aged human skin in vivo, express elevated levels of CCN1, and that CCN1 negatively regulates collagen homeostasis by suppressing collagen synthesis and increasing collagen degradation (Quan et al. Am J Pathol 169: 482-90, 2006, J Invest Dermatol 130: 1697-706, 2010). In further investigations of CCN1 actions, we find that CCN1 alters collagen homeostasis by promoting expression of specific secreted proteins, which include matrix metalloproteinases and proinflammatory cytokines. We also find that CCN1-induced secretory proteins are elevated in aged human skin in vivo. We propose that CCN1 induces an Age-Associated Secretory Phenotype, in dermal fibroblasts, which mediates collagen reduction and fragmentation in aged human skin.
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