Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
Volume 2, Issue 1, Pages 13-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jaip.2013.11.007
Keywords
Allergy; Drug challenge; Drug desensitization; Skin testing; Monoclonal antibody; Chemotherapeutic agent; Adult; Pediatric; Hypersensitivity reactions
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Advances in the understanding of various malignancies and chronic inflammatory diseases has led to the development of better treatment options for prolonging patient survival and minimizing morbidity. The recognition of first-line chemotherapy and monoclonal agents for these conditions has given more urgency to the need to re-administer these drugs in cases of drug hypersensitivity reactions. Therefore, in these cases, not only is desensitization considered when there is no alternative therapy available but also when alternative treatments are considered therapeutically inferior and/or more toxic. In this article, we describe the steps involved in the evaluation of these patients, factors to consider before making a decision to desensitize, the implementation of desensitization protocols, and the outcomes of such procedures. (C) 2014 American Academy of Allergy, Asthma & Immunology
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