Article
Allergy
Alison M. Binder, Dena Cherry-Brown, Brad J. Biggerstaff, Emma S. Jones, Claire L. Amelio, Charles B. Beard, Lyle R. Petersen, Gilbert J. Kersh, Scott P. Commins, Paige A. Armstrong
Summary: This study reviewed the medical records of 100 AGS patients and found that most patients developed AGS after tick bites. Patients with reactions to dairy were more likely to experience gastrointestinal symptoms. Anaphylaxis was common among AGS patients, highlighting the need for increased awareness and attention among patients and healthcare providers.
Article
Allergy
Jeffrey M. Wilson, Behnam Keshavarz, Maya Retterer, Lisa J. Workman, Alexander J. Schuyler, Emily C. McGowan, Charles Lane, Alaaddin Kandeel, Jane Purser, Eva Ronmark, Joseph LaRussa, Scott P. Commins, Tina Merritt, Thomas A. E. Platts-Mills
Summary: The alpha-Gal syndrome is widely recognized across the Southeast, Midwest, and Atlantic Coast of North America, commonly acquired in adulthood as a consequence of tick bites. The distribution of cases generally conforms to the reported range of the lone star tick, with an inverse relationship between alpha-Gal cases and cases of imported fire ant anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Mauro Calvani
Summary: Idiopathic anaphylaxis refers to anaphylaxis without a known cause despite comprehensive allergic workup. The diagnostic approach involves ruling out common and uncommon allergens and other conditions that may mimic anaphylaxis. Idiopathic anaphylaxis is more prevalent in adults and the epidemiology has decreased in recent years due to increased knowledge and the discovery of new clinical entities. Activation of mast cells plays a pivotal role in anaphylaxis, therefore, disorders such as mastocytosis, mast cell activation syndrome, and alpha-tryptasemia should also be excluded as they may present with similar symptoms.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Jeanne E. Conner, Joshua A. Steinberg
Summary: Diagnosis of anaphylaxis should involve comprehensive consideration, including detailed history and objective findings. Using diagnostic criteria and considering rare triggers, as well as evaluating for mast cell disorders, can aid in the diagnosis. Referral to specialists may be necessary.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Immunology
Tiago Azenha Rama, Joana Miranda, Diana Silva, Luis Amaral, Eunice Castro, Alice Coimbra, Andre Moreira, Jose Luis Placido
Summary: This study aimed to assess the safety of COVID-19 vaccines in patients with clonal mast cell disorders. The results showed that COVID-19 vaccines seem to be safe in these patients, including those with prior anaphylaxis following vaccination.
Article
Oncology
Julien Serrier, Jean-Baptiste Davy, Benoit Dupont, Benedicte Clarisse, Jean-Jacques Parienti, Gautier Petit, Kathy Khoy, Yann Ollivier, Radj Gervais, Delphine Mariotte, Brigitte Le Mauff
Summary: This study compared the performances of an automated Fluoroenzyme-Immunoassay (FEIA) for screening anti-alpha-Gal IgE with a previously validated anti-cetuximab IgE ELISA. The results showed that FEIA had better discrimination of positive and negative patients, higher specificity, and a higher positive likelihood ratio compared to ELISA. The risk of severe HSR following a positive test was higher with FEIA, while the risk following a negative test was similar.
Review
Allergy
Theo Gulen, Cem Akin
Summary: The systematic review aims to present proposed theories of pathogenesis for idiopathic anaphylaxis (IA), discuss its classification, diagnostic approach, and management. Recent findings show that IA represents a major diagnostic challenge and certain conditions such as mastocytosis and red meat allergy may overlap with its symptomatology. Patients with IA should always carry an epinephrine autoinjector for prompt treatment and prophylaxis.
CURRENT ALLERGY AND ASTHMA REPORTS
(2021)
Article
Medicine, Research & Experimental
Hyun-Woo Kim, Ga-Hee Ryoo, Hyun-Young Jang, So-Young Rah, Dong Hyun Lee, Do-Kyun Kim, Eun Ju Bae, Byung-Hyun Park
Summary: Research reveals that restoring cellular NAD+ concentration by supplementing NAD+ precursors can suppress mast cell activity in allergic reactions, thus alleviating the allergic response. This therapeutic strategy may hold significant importance for limiting mast cell-mediated anaphylactic responses.
Article
Allergy
Julij Selb, Matija Rijavec, Renato Erzen, Mihaela Zidarn, Peter Kopac, Matevz Skerget, Nissera Bajrovic, Ajda Demsar Luzar, Young Hwan Park, Yihui Liu, Vladka Curin Serbec, Samo Zver, Mitja Kosnik, Jonathan J. Lyons, Peter Korosec
Summary: The study found that routine screening for KIT p.D816V can identify clonal diseases in high-risk patients with HVA who are often missed when only BST levels are used for diagnosis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Leander P. De Puysseleyr, Didier G. Ebo, Jessy Elst, Margaretha A. Faber, Marie-Line Van der Poorten, Athina L. Van Gasse, Chris H. Bridts, Christel Mertens, Michel Van Houdt, Margo M. Hagendorens, Anke Verlinden, Katrien Vermeulen, Marie-Berthe Maes, Zwi N. Berneman, Vito Sabato
Summary: In patients with severe anaphylaxis but no mastocytosis in the skin and baseline serum tryptase less than 30 ng/mL, detection of the KIT D816V mutation in peripheral blood may not be very helpful in diagnosing primary mast cell disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Food Science & Technology
Xiaohui Yang, Dohyeon Lee, Hyun-Woo Kim, Byung-Hyun Park, Changjin Lim, Eun Ju Bae
Summary: The study investigates the effects of cannabidiol (CBD) on mast cell degranulation and passive cutaneous anaphylaxis in mice. CBD suppresses antigen-stimulated mast cell degranulation by inhibiting downstream signaling molecules and calcium mobilization. In addition, CBD inhibits the development of mast cells and suppresses passive cutaneous anaphylaxis in mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jan Romantowski, Aleksandra Gorska, Marek Niedoszytko, Theo Gulen, Marta Gruchala-Niedoszytko, Boguslaw Nedoszytko, Magdalena Lange, Knut Brockow, Michel Arock, Cem Akin, Peter Valent
Summary: MCAS and mastocytosis are two disorders related to mast cell activation, with the former characterized by massive systemic activation of mast cells and the latter by clonal accumulation of mast cells in various organ systems. Mast cells are crucial effector cells in allergic diseases, and proper diagnosis and management are essential for patients with mastocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Health Care Sciences & Services
Dana Mihaela Mihele, Paul Andrei Nistor, Gabriela Bruma, Cristina Iulia Mitran, Madalina Irina Mitran, Carmen Elena Condrat, Mihaela Tovaru, Mircea Tampa, Simona Roxana Georgescu
Summary: Mast cells are not only IgE effectors of anaphylaxis, but also defenders against infections and toxins. They play a role in inflammation regulation and tissue repair but are also involved in allergies and various pathological conditions. Mast cell activation syndrome (MCAS) has been proposed to explain symptoms caused by mast cell activation, but there is still debate about the diagnostic criteria.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Hematology
Melody C. Carter, Dean D. Metcalfe
Summary: Historically, understanding of human mast cells has lagged behind other cell lineages, and there is currently no identified pharmacological agent that can completely and selectively inhibit human MC function. Mast cell diseases are categorized as intrinsic or extrinsic to the MC compartment, with mediators playing a key role in MC activation disorders.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Allergy
Allyson Mateja, Qinlu Wang, Jack Chovanec, Jiwon Kim, Kenneth J. Wilson, Lawrence B. Schwartz, Sarah C. Glover, Melody C. Carter, Dean D. Metcalfe, Erica Brittain, Jonathan J. Lyons
Summary: Based on the variability of BST, an acute tryptase/BST ratio exceeding 1.685 is the optimized diagnostic rule for distinguishing baseline variability from anaphylaxis, improving specificity among individuals with H alpha T and ISM while maintaining high sensitivity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
