Review
Immunology
Zao Ji, Feifei Jiang
Summary: This study systematically evaluated the clinical efficacy and safety of sublingual immunotherapy for allergic rhinitis. The findings showed that sublingual immunotherapy has better efficacy and safety compared to traditional medicine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Shaobing Xie, Sijie Jiang, Hua Zhang, Fengjun Wang, Yongzhen Liu, Yongchuan She, Qiancheng Jing, Kelei Gao, Ruohao Fan, Shumin Xie, Zhihai Xie, Weihong Jiang
Summary: This study identified several serum biomarkers through metabolomics analysis that can reliably predict the efficacy of ASIT in AR patients, with these biomarkers mainly involving glycolysis, fatty acid metabolism, and other metabolic pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Otorhinolaryngology
Dijiang Ma, Qiling Zheng, Jianing Sun, Shenjun Tang, Wudan He
Summary: The findings of this meta-analysis indicate that sublingual immunotherapy (SLIT) may be a therapeutic approach to improve symptoms of allergic rhinitis and asthma in patients with asthma. However, further high-quality and well-designed studies are needed to clarify the efficacy of SLIT due to significant heterogeneity in the results.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2023)
Review
Allergy
Mariana Farraia, Ines Paciencia, Francisca Castro Mendes, Joao Cavaleiro Rufo, Mohamed Shamji, Ioana Agache, Andre Moreira
Summary: This study aimed to assess the preventive role of allergen immunotherapy (AIT) in asthma onset. The findings suggest a potential preventive effect of AIT in asthma onset, particularly in children completing 3 years of therapy and in mono-sensitized patients.
Article
Allergy
Gandhi F. Pavon-Romero, Desiree E. Larenas-Linnemann, Karen Eloisa Xochipa Ruiz, Fernando Ramirez-Jimenez, Luis M. Teran
Summary: SCIT is safe and effective for pediatric patients with allergic rhinitis, with low frequency of ADVrs, mainly grade 1 reactions. However, the risk of ADVrs involving 2 organs systems increases after 12 weeks of treatment.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Review
Otorhinolaryngology
Minh P. Hoang, Jompol Samuthpongtorn, Wirach Chitsuthipakorn, Kachorn Seresirikachorn, Kornkiat Snidvongs
Summary: Four double-blind randomized controlled trials and two observational studies indicate that allergen-specific immunotherapy (AIT) is beneficial and safe for patients with local allergic rhinitis (LAR), showing significant reductions in symptoms and improvement in quality of life.
Review
Health Care Sciences & Services
Kawita Atipas, Dichapong Kanjanawasee, Pongsakorn Tantilipikorn
Summary: This review examines the use of intradermal immunotherapy (IDIT) in the treatment of allergic rhinitis, including its advantages and effects. However, the current evidence on IDIT is conflicting, and further clinical trials are needed to determine its clinical utility and optimal treatment protocols.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Allergy
Wenlong Liu, Qingxiang Zeng, Chunhui He, Rongshan Chen, Yiquan Tang, Shengbao Yan, Xi Luo, Renzhong Luo
Summary: The study compared the efficacy, safety, and compliance of SCIT and SLIT in children with allergic rhinitis. Results indicated that SCIT was more effective than SLIT to a certain degree but had higher occurrence of adverse events. Individuals can choose the appropriate AIT route based on their specific conditions.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Mohamed H. Shamji, David Larson, Aarif Eifan, Guy W. Scadding, Tielin Qin, Kaitie Lawson, Michelle L. Sever, Ellen Macfarlane, Janice A. Layhadi, Peter A. Wurtzen, Rebecca Parkin, Srinath Sanda, Kristina M. Harris, Gerald T. Nepom, Alkis Togias, Stephen R. Durham
Summary: The study compared allergic responses in nasal and systemic fluids during sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) for grass pollen allergy, suggesting key differences in immunological mechanisms between the two treatments.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Otorhinolaryngology
Ying-Ying Zhang, Min Zhang, Jia-Qi Zhang, Qiu-Qi Li, Mei-Ping Lu, Lei Cheng
Summary: Combining AIT with omalizumab can significantly improve the efficacy and safety of AIT in treating allergic diseases, increasing tolerance to allergens and reducing severe systemic adverse events.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Allergy
Jin Youp Kim, Myoung-Jin Jang, Dong-Young Kim, Seok-Won Park, Doo Hee Han
Summary: This study compared the efficacy of SLIT drops, SLIT tablets, and SCIT in patients with perennial allergic rhinitis through network analysis. The results demonstrated that all immunotherapy modalities significantly reduced symptom and medication scores, with SCIT possibly being more effective in controlling symptoms compared to SLIT drops or tablets.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Allergy
Moises A. Calderon, Leonard B. Bacharier
Summary: Sublingual allergen immunotherapy (SLIT) is used in the treatment of respiratory allergies, including asthma, and multiple clinical trials have evaluated its efficacy and safety for asthma. Despite inconsistencies in the data, the house dust mite SLIT tablet has shown efficacy in the add-on management of house dust mite-associated allergic asthma in adults.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Martin Penagos, Stephen R. Durham
Summary: Allergen immunotherapy is highly effective in selected patients with allergic rhinitis, allergic asthma, and Hymenoptera venom allergy. Studies have shown that both subcutaneous and sublingual immunotherapies can modify the underlying cause of the disease and provide long-term clinical benefits and immunologic changes. Research suggests that at least 3 years of immunotherapy is needed to achieve long-term tolerance.
ALLERGY AND ASTHMA PROCEEDINGS
(2022)
Review
Allergy
David C. Wraith, Mamidipudi T. Krishna
Summary: Allergen-specific immunotherapy is the only way to change the natural immune response of allergic diseases, and using peptides based on CD4(+) T cell epitopes instead of whole allergens may overcome the challenges of current treatment methods.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Review
Medicine, Research & Experimental
Kevin Tie, Craig Miller, Adam M. Zanation, Charles S. Ebert
Summary: The study found that SCIT and SLIT are equally effective treatments for adults with AR/C, but more randomized controlled trials are needed to directly compare the two methods.