Article
Allergy
Riccardo Asero, Renato Ariano, Arianna Aruanno, Claudio Barzaghi, Paolo Borrelli, Moira Busa, Giorgio Celi, Massimo Cinquini, Gabriele Cortellini, Francesca D'Auria, Marco De Carli, Camilla Di Paolo, Giulia Garzi, Fabio Lodi Rizzini, Monica Magnani, Giuseppina Manzotti, Alessandro Marra, Stefano Miceli Sopo, Francesco Murzilli, Eleonora Nucera, Elena Pinter, Valerio Pravettoni, Federica Rivolta, Angela Rizzi, Nicoletta Saporiti, Enrico Scala, Danilo Villalta, Mona-Rita Yacoub, Giuliana Zisa
Summary: The study found that systemic reactions induced by PR-10 and profilin are facilitated by PPI, ingestion of large amounts of unprocessed foods, and fasting. Soybean beverages represent a risk for PR-10 hypersensitive patients.
Article
Allergy
Adam Aue, Joella Ho, Rongbo Zhu, Harold Kim, Samira Jeimy
Summary: In a 12-month period, 4242 injections of SCIT were performed, with 10 resulting in systemic reactions requiring epinephrine administration (incidence of 0.24%). Major risk factors included seasonal exacerbation of allergic rhinitis, uncontrolled asthma, and errors in route of administration. Improved patient and health care practitioner education, along with pre-administration screening, are recommended.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Daichi Utsumi, Takeru Sugawara, Kosumo Hashida, Yuki Yasuhara, Koji Fujinami, Kaare Lund, Katsuyo Ohashi-Doi
Summary: A new allergen derivative Dn p-Cry j 1 was developed in this study to reduce IgE-binding and anaphylactic potential in patients with Japanese Cedar pollinosis, showing promising results for the next generation of treatment options.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Allergy
Oliver Pfaar, Angelika Sager, Ralph Moesges, Margitta Worm
Summary: This study aimed to evaluate the efficacy of different doses of depigmented, polymerized birch pollen extract in treating patients with birch-pollen-induced allergic rhinitis or rhinoconjunctivitis. The results showed that higher doses had better treatment outcomes, with mild or moderate adverse events.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Review
Pharmacology & Pharmacy
Juan L. Paris, Lalitkumar K. Vora, Maria Jose Torres, Cristobalina Mayorga, Ryan F. Donnelly
Summary: The incidence of allergies has been increasing recently. Allergen-specific immunotherapy (AIT) is the only approach that can induce long-term immune tolerance towards allergens. However, its clinical success is limited by efficacy and safety concerns related to the administration route. Microneedles have been proposed to improve therapeutic delivery into the skin, but the stratum corneum poses a challenge. This review discusses recent developments in the use of microneedles for AIT and suggests future research directions.
DRUG DISCOVERY TODAY
(2023)
Review
Immunology
Nishelle D'souza, Milena Weber, Eszter Sarzsinszky, Susanne Vrtala, Mirela Curin, Mirjam Schaar, Victoria Garib, Margarete Focke-Tejkl, Yanqiu Li, Richard Jones, Hao Chen, Rudolf Valenta, Baoqing Sun
Summary: Approximately 30% of the global population suffers from IgE-mediated allergy, with China having the largest population and over 400 million allergic patients. Allergy prevention and treatment strategies include allergen avoidance, vaccination, and tolerance induction, requiring a detailed understanding of relevant allergen molecules affecting specific populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Torsten Zuberbier, Tamara Doerr, Werner Aberer, Montserrat Alvaro, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Barbara Ballmer-Weber, Joan Bartra, Lisa Beck, Philippe Begin, Carsten Bindslev-Jensen, Jovanka Bislimovska, Jean Bousquet, Knut Brockow, Andrew Bush, Antonella Cianferoni, Michael J. Cork, Adnan Custovic, Ulf Darsow, Nicolette Jong, Diana Deleanu, Stefano Del Giacco, Antoine Deschildre, Audrey Dunn Galvin, Motohiro Ebisawa, Montserrat Fernandez-Rivas, Marta Ferrer, Alessandro Fiocchi, Roy Gerth van Wijk, Maia Gotua, Kate Grimshaw, Josefine Gruenhagen, Enrico Heffler, Michihiro Hide, Karin Hoffmann-Sommergruber, Cristoforo Incorvaia, Christer Janson, Swen Malte John, Carla Jones, Marek Jutel, Norito Katoh, Benjamin Kendziora, Tamar Kinaciyan, Edward Knol, Oksana Kurbacheva, Susanne Lau, Richard Loh, Carlo Lombardi, Mika Makela, Mary Jane Marchisotto, Michael Makris, Marcus Maurer, Rosan Meyer, Dragan Mijakoski, Jordan Minov, Joaquim Mullol, Caroline Nilsson, Anna Nowak-Wegrzyn, Bright Nwaru, Mikela Odemyr, Giovanni Battista Pajno, Sushil Paudel, Nikolaos G. Papadopoulos, Harald Renz, Giampaolo Ricci, Johannes Ring, Barbara Rogala, Hugh Sampson, Gianenrico Senna, Brigita Sitkauskiene, Peter Kenneth Smith, Katarina Stevanovic, Sasho Stoleski, Hania Szajewska, Akio Tanaka, Ana Todo-Bom, Fatih Alexander Topal, Erkka Valovirta, Ronald Van Ree, Carina Venter, Stefan Woehrl, Gary W. K. Wong, Zuotao Zhao, Margitta Worm
Summary: Based on a systematic review, it is unlikely that cross-contamination of major food allergens below 0.5 mg/100 g will endanger most food allergic patients when consuming a standard portion of food. The suggestion is to use a voluntary declaration on processed food packages stating that the product contains named allergens and may contain traces of other contaminations at concentrations less than 0.5 mg per 100 g of the product, which can be technically achieved in most processed foods. Further research on threshold levels is encouraged for a legally binding solution in the future.
Article
Allergy
P. J. de Kam, S. Zielen, J. A. Bernstein, U. Berger, M. Berger, M. Cuevas, D. Cypcar, A. Fuhr-Horst, W. A. Greisner, M. Jandl, S. Lassmann, M. Worm, J. Matz, E. Sher, C. Smith, G. C. Steven, R. Moesges, M. H. Shamji, L. DuBuske, F. Borghese, K. Oluwayi, T. Zwingers, M. Seybold, O. Armfield, M. D. Heath, S. J. Hewings, M. F. Kramer, M. A. Skinner
Summary: The study evaluated the efficacy and safety of a modified grass allergen subcutaneous immunotherapy for grass-pollen allergic rhinitis/rhinoconjunctivitis. The results showed clinically relevant and statistically significant improvements in symptom and medication scores, as well as a good safety profile.
Article
Cell Biology
Constantinos Pitsios, Konstantinos Petalas, Anastasia Dimitriou, Konstantinos Parperis, Kyriaki Gerasimidou, Caterina Chliva
Summary: Allergen Immunotherapy (AIT) is an effective and safe treatment for respiratory and insect-venom allergies. However, not all patients are eligible for this treatment. Allergists often face clinical, ethical, and legal issues when deciding whether to order extensive workup for apparently healthy AIT candidates. This article suggests an approach to evaluate the presence of any underlying diseases/conditions in patients with no case history before starting AIT.
Review
Veterinary Sciences
Ina Herrmann, Adrianna Jordan Sanchez
Summary: This study systematically evaluated the efficacy and safety of subcutaneous allergen-specific immunotherapy (AIT) in horses with allergic diseases. The results showed that multi-allergen AIT had beneficial effects in respiratory diseases, urticaria, and pruritic dermatitis. However, the response rate was lower when insect AIT was used solely for pruritic dermatitis. Overall, AIT was generally safe, with mostly self-limiting adverse events. The study highlighted the presence of biases and confounding factors in the included studies, calling for further research.
VETERINARY SCIENCES
(2023)
Review
Otorhinolaryngology
Michelle J. Park, Shrey Kapoor, Julie Yi, Nanki Hura, Sandra Y. Lin
Summary: This review assessed the adherence of subcutaneous immunotherapy (SCIT) in real-world settings and found that the rates of SCIT persistence and adherence were generally poor. The included studies reported persistence rates ranging from 16.0% to 93.7% and adherence rates ranging from 15.1% to 99%. The wide range of rates can be attributed to the differences in measuring and reporting adherence-related findings among studies.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Review
Medicine, General & Internal
Riccardo Castagnoli, Mattia Giovannini, Francesca Mori, Simona Barni, Luca Pecoraro, Stefania Arasi, Francesca Saretta, Carla Mastrorilli, Lucia Liotti, Lucia Caminiti, Gunter Johannes Sturm, Gian Luigi Marseglia, Elio Novembre
Summary: Hymenoptera stings typically result in local reactions, with potential for immediate, delayed, or unusual hypersensitivity responses. While uncommon, it is important for clinicians to be aware of the possible clinical manifestations of unusual reactions to Hymenoptera stings. Further research is needed to improve diagnostic and therapeutic approaches for these conditions.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Litty Johnson, Lorenz Aglas, Benjamin Punz, Hieu-Hoa Dang, Constantin Christ, Lisa Pointner, Mario Wenger, Norbert Hofstaetter, Sabine Hofer, Mark Geppert, Ancuela Andosch, Fatima Ferreira, Jutta Horejs-Hoeck, Albert Duschl, Martin Himly
Summary: The incorporation of nanomaterials into consumer products has raised safety concerns due to their ability to cross epithelial barriers and interact with allergens, potentially affecting immune responses. This study investigates the impact of silica nanoparticle-allergen interactions on allergic sensitization by studying molecular mechanisms affecting allergic responses. The results suggest that the interaction of birch pollen allergen with silica nanoparticles skews the immune response towards a Th1-dominated profile, indicating a potential decrease in allergic sensitization.
Review
Allergy
Yulia Dorofeeva, Igor Shilovskiy, Inna Tulaeva, Margarete Focke-Tejkl, Sabine Flicker, Dmitriy Kudlay, Musa Khaitov, Antonina Karsonova, Ksenja Riabova, Alexander Karaulov, Roman Khanferyan, Winfried F. Pickl, Thomas Wekerle, Rudolf Valenta
Summary: Allergen-specific immunotherapy (AIT) is a specialized treatment for allergic patients, aiming to induce immune protection against allergens. While AIT offers long-lasting and cost-effective benefits, its broad application is hindered by technical challenges such as allergen preparation quality and the risk of side effects.
Article
Allergy
R. Sharon Chinthrajah, Stacie M. Jones, Edwin H. Kim, Scott H. Sicherer, Wayne Shreffler, Bruce J. Lanser, Negin Atri, Denise C. Babineau, Daniel C. Adelman, Ahmar Iqbal, Susan L. Limb, Amanda K. Rudman Spergel, Alkis Togias, Robert A. Wood
Summary: Immunotherapy for food allergy is promising, but adverse events and their severity during treatment are not standardized. This study developed a revised grading scale to categorize and assess adverse allergic reactions in food allergy clinical trials. The use of this revised scale would allow for better data aggregation and safety comparisons.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
