Article
Clinical Neurology
Vera Bril, Andrzej Szczudlik, Antanas Vaitkus, Csilla Rozsa, Anna Kostera-Pruszczyk, Petr Hon, Josef Bednarik, Michaela Tyblova, Wolfgang Koehler, Toomas Toomsoo, Richard J. Nowak, Tahseen Mozaffar, Miriam L. Freimer, Michael W. Nicolle, Tim Magnus, Michael T. Pulley, Michael Rivner, Mazen M. Dimachkie, B. Jane Distad, Robert M. Pascuzzi, Donna Babiar, Jiang Lin, Montse Querolt Coll, Rhonda Griffin, Elsa Mondou
Summary: This study aimed to determine whether immune globulin (human), 10% caprylate/chromatography purified (IGIV-C) could facilitate corticosteroid (CS) dose reduction in CS dependent patients with myasthenia gravis (MG). The results showed that IGIV-C was not more effective than placebo in reducing daily CS dose.
Article
Immunology
Hirotsugu Oda, Hiroyuki Wakabayashi, Miyuki Tanaka, Koji Yamauchi, Chihiro Sugita, Hiroki Yoshida, Fumiaki Abe, Tohru Sonoda, Masahiko Kurokawa
Summary: The study found that lactoferrin has a certain alleviating effect on infectious diseases in Japanese summer, especially for summer colds. In both the 200 mg and 600 mg groups, the duration of total infectious diseases and summer colds was shorter compared to the placebo group.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Allergy
Freda Yang, John Busby, Liam G. Heaney, Ian D. Pavord, Chris E. Brightling, Katie Borg, Jane P. McDowell, Sarah E. Diver, Rahul Shrimanker, Peter Bradding, Malcolm Shepherd, Rekha Chaudhuri
Summary: In patients with severe eosinophilic asthma (SEA) receiving treatment with mepolizumab, the use of oral cortico-steroids (OCS) did not significantly improve symptoms or quality of life. However, it did improve small-airway obstruction and reduce biomarkers of type 2 inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Gastroenterology & Hepatology
Miriam B. Vos, Mark L. Van Natta, Niviann M. Blondet, Srinivasan Dasarathy, Mark Fishbein, Paula Hertel, Ajay K. Jain, Saul J. Karpen, Joel E. Lavine, Saeed Mohammad, Laura A. Miriel, Jean P. Molleston, Marialena Mouzaki, Arun Sanyal, Emily P. Sharkey, Jeffrey B. Schwimmer, James Tonascia, Laura A. Wilson, Stavra A. Xanthakos
Summary: This study aimed to evaluate the effect of losartan on ALT levels in children with NAFLD. The results showed that losartan did not significantly reduce ALT levels, but it did significantly decrease alkaline phosphatase and systolic blood pressure.
Article
Medicine, General & Internal
Yuan Ma, Feng J. He, Qi Sun, Changzheng Yuan, Lyanne M. Kieneker, Gary C. Curhan, Graham A. MacGregor, Stephan J. L. Bakker, Norm R. C. Campbell, Molin Wang, Eric B. Rimm, JoAnn E. Manson, Walter C. Willett, Albert Hofman, Ron T. Gansevoort, Nancy R. Cook, Frank B. Hu
Summary: This study analyzed data from six prospective cohorts of healthy adults and found that higher sodium and lower potassium intakes, estimated from multiple 24-hour urine samples, were associated in a dose-dependent manner with a higher cardiovascular risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Neurosciences
Katharina Schultebraucks, Tolou Maslahati, Katja Wingenfeld, Julian Hellmann-Regen, Julia Kraft, Maureen Kownatzki, Behnoush Behnia, Stephan Ripke, Christian Otte, Stefan Roepke
Summary: This study found that intranasal oxytocin significantly increased intrusive memories, and this effect was influenced by several biological and genetic factors, including salivary cortisol, heart rate variability, and polygenic risk for PTSD.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Kokila Thiagarajah, Huei Phing Chee, Nam Weng Sit
Summary: This study investigated the effects of RLX2 (TM) on working adults with poor sleep quality. The results showed that RLX2 (TM) improved sleep quality, prolonged total sleeping time, and increased alpha power in the brain. These beneficial effects can help promote better sleep quality.
Article
Nutrition & Dietetics
Verena Theiler-Schwetz, Christian Trummer, Martin R. Grubler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Spyridon N. Karras, Winfried Marz, Stefan Pilz, Stephanie Gangler
Summary: This post hoc analysis investigated the effects of vitamin D on blood pressure and found that vitamin D supplementation did not have an antihypertensive effect in individuals with vitamin D deficiency. However, there was a significant association between achieved 25(OH)D concentrations and blood pressure.
Article
Chemistry, Medicinal
Mahbubeh Karbalaiee, Azar Daneshpajooh, Narges Khanjani, Samira Sohbati, Mehrnaz Mehrabani, Mehrzad Mehrbani, Mitra Mehrabani
Summary: This study evaluated the efficacy of a frankincense-based herbal product (FHP) in the treatment of urinary incontinence. The results showed that the FHP group and the solifenacin group had significantly reduced frequency and amount of leakage compared to the placebo group. Two weeks after treatment completion, the effects of the FHP were still significant.
PHYTOTHERAPY RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Dawson Church, Amy Yang, Jeffrey Fannin, Katharina Blickheuser
Summary: This study evaluated the biological dimension of meditation and self-transcendent states, and found that autonomic self-regulation and transcendent states can be measured in both biological and psychological dimensions and are associated with pervasive health benefits.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Genetics & Heredity
Nicky Daniels, Matthijs Moerkerke, Jean Steyaert, Annelies Bamps, Edward Debbaut, Jellina Prinsen, Tiffany Tang, Stephanie Van der Donck, Bart Boets, Kaat Alaerts
Summary: This study examined the efficacy of multiple-dose oxytocin administration in children with autism spectrum disorder (ASD). The results showed that both the oxytocin and placebo groups experienced improvements in social responsiveness, but these improvements were not specifically related to oxytocin administration. Interestingly, participants who initially received placebo and later switched to oxytocin showed significant improvement in social responsiveness. Furthermore, children who received psychosocial trainings along with oxytocin administration demonstrated a more pronounced improvement.
Article
Endocrinology & Metabolism
Jingyi Qian, Christopher J. J. Morris, Rosanna Caputo, Frank A. J. L. Scheer
Summary: This study examined the impact of circadian misalignment in chronic shift workers and found that it increased ghrelin levels and hunger. However, it did not significantly affect energy expenditure or respiratory exchange ratio.
Article
Obstetrics & Gynecology
Graham C. Chapman, David Sheyn, Emily A. Slopnick, Kasey Roberts, Sherif A. El-Nashar, Joseph W. Henderson, Jeffrey Mangel, Adonis K. Hijaz, Robert R. Pollard, Sangeeta T. Mahajan
Summary: The study found that tamsulosin reduced the risk of postoperative urinary retention in women undergoing surgery for pelvic organ prolapse without an increased rate of urinary tract infection. Additionally, it improved urinary symptoms compared to placebo.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Psychiatry
Eric Hollander, Kayla G. Levine, Casara J. Ferretti, Katherine Freeman, Ellen Doernberg, Nilifa Desilva, Bonnie P. Taylor
Summary: In children and adolescents with Prader Willi Syndrome, placebo showed modest improvement in hyperphagia and repetitive behaviors, while intranasal oxytocin did not show improvement in these areas. Further research is needed to understand the implications and mechanisms of these findings.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Urology & Nephrology
Gopal Narang, Jonathan Moore, Kevin Wymer, Yu-Hui Chang, Elisabeth Lim, Olufunmilola Adeleye, Mitchell R. Humphreys, Karen L. Stern
Summary: This study evaluated the effects of cannabidiol oil on pain control and opioid usage in post-ureteroscopy setting. The results showed that cannabidiol oil was safe but ineffective compared to placebo in reducing post-ureteroscopic stent discomfort or opioid usage. Additional research focusing on novel interventions and pain control is needed to address post-stent symptoms dissatisfaction among patients.
JOURNAL OF UROLOGY
(2023)