Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein

Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase

(2014) C. M. Casadei et al.   SCIENCE

L-Arabinose Binding, Isomerization, and Epimerization by D-Xylose Isomerase: X-Ray/Neutron Crystallographic and Molecular Simulation Study

(2014) Paul Langan et al.   STRUCTURE

Joint X-ray/Neutron Crystallographic Study of HIV-1 Protease with Clinical Inhibitor Amprenavir: Insights for Drug Design

(2013) Irene T. Weber et al.   JOURNAL OF MEDICINAL CHEMISTRY

Near-Atomic Resolution Neutron Crystallography on PerdeuteratedPyrococcus furiosusRubredoxin: Implication of Hydronium Ions and Protonation State Equilibria in Redox Changes

(2012) M. G. Cuypers et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nearly 200 X-Ray Crystal Structures of Transthyretin: What Do They Tell Us About This Protein and the Design of Drugs for TTR Amyloidoses?

(2012) S. K. Palaninathan   CURRENT MEDICINAL CHEMISTRY

Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin

(2012) Takeshi Yokoyama et al.   JOURNAL OF STRUCTURAL BIOLOGY

Solution conformations of early intermediates in Mos1 transposition

(2012) Maxime G. Cuypers et al.   NUCLEIC ACIDS RESEARCH

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Preliminary neutron crystallographic study of human transthyretin

(2011) Melina Haupt et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Identification of the Elusive Hydronium Ion Exchanging Roles with a Proton in an Enzyme at Lower pH Values

(2011) Andrey Y. Kovalevsky et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bilayer-Mediated Clustering and Functional Interaction of MscL Channels

(2011) Stephan L. Grage et al.   BIOPHYSICAL JOURNAL

Neutron structure of type-III antifreeze protein allows the reconstruction of AFP-ice interface

(2011) Eduardo I. Howard et al.   JOURNAL OF MOLECULAR RECOGNITION

Familial amyloid polyneuropathy

(2011) Violaine Planté-Bordeneuve et al.   LANCET NEUROLOGY

Neutron macromolecular crystallography with LADI-III

(2010) Matthew P. Blakeley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Looking at hydrogen bonds in cellulose

(2010) Yoshiharu Nishiyama et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Neutron structure analysis using the IBARAKI biological crystal diffractometer (iBIX) at J-PARC

(2010) Ichiro Tanaka et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Joint X-ray and neutron refinement withphenix.refine

(2010) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

(2010) Stephen Connelly et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The active site protonation states of perdeuterated Toho-1 β-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylation

(2010) Stephen J. Tomanicek et al.   FEBS LETTERS

Wild-type transthyretin significantly contributes to the formation of amyloid fibrils in familial amyloid polyneuropathy patients with amyloidogenic transthyretin Val30Met

(2010) Ayako Tsuchiya-Suzuki et al.   HUMAN PATHOLOGY

Variation in amount of wild-type transthyretin in different fibril and tissue types in ATTR amyloidosis

(2010) Elisabet Ihse et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and Cytotoxicity

(2010) Sungwook Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trapping of palindromic ligands within native transthyretin prevents amyloid formation

(2010) S. E. Kolstoe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metal Ion Roles and the Movement of Hydrogen during Reaction Catalyzed by D-Xylose Isomerase: A Joint X-Ray and Neutron Diffraction Study

(2010) Andrey Y. Kovalevsky et al.   STRUCTURE

Perdeuteration, purification, crystallization and preliminary neutron diffraction of an ocean pout type III antifreeze protein

(2009) Isabelle Petit-Haertlein et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Hormone delivery systems to the brain - transthyretin

(2009) G. Schreiber et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein

(2009) Erik Lundberg et al.   FEBS Journal

Evolutionary changes to transthyretin: structure-function relationships

(2009) P. Prapunpoj et al.   FEBS Journal

Neutron Diffraction Studies of a Class A β-Lactamase Toho-1 E166A/R274N/R276N Triple Mutant

(2009) Stephen J. Tomanicek et al.   JOURNAL OF MOLECULAR BIOLOGY

The ID23-2 structural biology microfocus beamline at the ESRF

(2009) David Flot et al.   JOURNAL OF SYNCHROTRON RADIATION

Neutron macromolecular crystallography

(2009) M.P. Blakeley   Crystallography Reviews

Pathogenesis of and Therapeutic Strategies to Ameliorate the Transthyretin Amyloidoses

(2008) Yoshiki Sekijima et al.   CURRENT PHARMACEUTICAL DESIGN

Amyloid fibril composition is related to the phenotype of hereditary transthyretin V30M amyloidosis

(2008) E Ihse et al.   JOURNAL OF PATHOLOGY

A molecular correlate of clinicopathology in transthyretin amyloidosis

(2008) Mark B Pepys   JOURNAL OF PATHOLOGY