Article
Pharmacology & Pharmacy
Jiayun Xu, Shanshan Sun, Wei Zhang, Jianhong Dong, Changgang Huang, Xin Wang, Mengxian Jia, Hao Yang, Yongjie Wang, Yuanyuan Jiang, Liying Cao, Zhihui Huang
Summary: Irigenin inhibits the proliferation, induces apoptosis, and inhibits migration of GBM cells by suppressing YAP/β-catenin signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chien-Yu Huang, Po-Li Wei, Uyanga Batzorig, Precious Takondwa Makondi, Cheng-Chin Lee, Yu-Jia Chang
Summary: CRC is the second leading cause of cancer-related death, and identifying new therapeutic targets for CRC is essential. This study investigated the role of MSN in CRC progression and found that high MSN expression in CRC tissues was associated with poor patient outcomes. Further research revealed that MSN accelerated CRC progression via the beta-catenin-RUNX2 axis. These findings suggest that MSN holds potential as a new target for CRC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Yuanzhe Zhu, Huala Wu, Xi Yang, Zhijuan Xiong, Tiantian Zhao, Xin Gan
Summary: This study revealed that LINC00514 is upregulated in NSCLC and plays a role in the proliferation, migration, and invasion of NSCLC cells through activation of the Wnt/β-catenin pathway and EMT. Silencing LINC00514 restored the biological phenotypes of NSCLC cells by inhibiting the Wnt/β-catenin pathway. Additionally, silencing LINC00514 attenuated the growth of xenograft tumors in vivo.
Article
Biochemistry & Molecular Biology
Jing Cai, Song-Yun Shi, Fan Cheng, Min Wei, Kun Zou, Xiao-Qin Yu, Jian-Feng Chen
Summary: (E)-7-Phenyl-2-hepten-4,6-diyn-1-ol (1) and (Z)-7-Phenyl-2-hepten-4,6-diyn-1-ol (2) are isomeric natural polyacetylenes isolated from Bidens pilosa L., a Chinese medicinal plant. These polyacetylenes showed excellent anti-metastasis potential on HGC-27 cells, inhibiting their migration, invasion, and adhesion in a dose-dependent manner. The mechanism underlying the activities involved the reversal of the EMT process and the suppression of the Wnt/beta-catenin and Hippo/YAP signaling pathways.
Article
Pharmacology & Pharmacy
Hyeon Ji Kim, Tae-Jun Kim, Yu Gyung Kim, Chaeeun Seong, Jin-Hwa Cho, Wanil Kim, Kyung-Ha Lee, Do-Yeon Kim
Summary: Finasteride, known for treating benign prostate hyperplasia and androgenic alopecia, shows potential as an anti-glioblastoma drug by inhibiting glioma stem-like cells maintenance and glioblastoma proliferation, possibly through lowering intracellular ROS levels and reducing beta-catenin accumulation.
Article
Biotechnology & Applied Microbiology
Haitao Gu, Zhiquan Xu, Jianbo Zhang, Yanbing Wei, Ling Cheng, Jijian Wang
Summary: circ_0038718 is highly expressed in colon cancer and can sponge miR-195-5p in the cytoplasm, facilitating malignant progression of colon cancer cells through the miR-195-5p/Axin2 axis.
Article
Pharmacology & Pharmacy
Xueqin Jia, Shiying Yang, Xia Wang, Jianbing Ruan, Wenhua Huang
Summary: This study identified the impact of HOXB3 in preeclampsia and found that its overexpression can promote trophoblast cell proliferation and migration by regulating the Notch1 and β-catenin pathways. The study also showed that suppressing the Wnt/β-catenin pathway can alleviate the effects of HOXB3. These findings provide a novel approach for preeclampsia therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Xiaosong Wang, Xiaojun Yu, Haoran Xu, Kang Wei, Shanxi Wang, Yingguang Wang, Junfei Han
Summary: In this study, the researchers found that extracellular vesicles (EVs) transfer a long non-coding RNA (lncRNA) called HOTAIR, which regulates resistance to the chemotherapy drug temozolomide (TMZ) in glioblastoma (GBM). Through in vitro and in vivo experiments, it was demonstrated that HOTAIR promotes tumor growth, increases invasiveness, and enhances resistance to TMZ. In GBM cells, HOTAIR competitively binds to miR-526b-3p, weakening its ability to bind to EVA1 and consequently increasing EVA1 expression. Furthermore, HOTAIR carried by serum-EVs suppresses miR-526b-3p-mediated inhibition of EVA1, promoting tumor growth and TMZ resistance in vivo.
CELL DEATH & DISEASE
(2022)
Article
Pathology
Jie Zhang, Sujie Zhang, Xiaoyan Li, Fan Zhang, Lei Zhao
Summary: The study revealed that HOXB5 expression is increased in breast cancer and positively correlated with tumor size, TNM stage, and lymph node metastasis. The oncogenic function of HOXB5 in breast cancer is mediated through the activation of the wnt/beta-catenin pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Multidisciplinary Sciences
Jinshi Zhang, Wenjin Wei, Qinglin Zhong, Kaiming Feng, Ruijin Yang, Qiuhua Jiang
Summary: This study discovered a significant increase in BUB1 expression in glioma and its correlation with a high World Health Organization grade and poor prognosis in glioma patients. Additionally, BUB1 not only promotes glioma cell proliferation, migration, and infiltration but also triggers epithelial-mesenchymal transition through the activation of the Wnt/beta-catenin axis. Therefore, BUB1 may have the potential to serve as a target for GBM management.
Review
Biochemistry & Molecular Biology
Michael Latour, Nam-Gu Her, Santosh Kesari, Elmar Nurmemmedov
Summary: The WNT signaling pathway plays a crucial role in glioblastoma genesis and therapy resistance, presenting a therapeutic challenge. Current targeted therapies under clinical investigation may offer new treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Li Wang, Rujun Zhai, Hong Shen, Guodong Song, Fangxin Wan, Qiang Li
Summary: The study demonstrates that overexpression of VRK1 in gastric cancer cells promotes cell proliferation, migration, and invasion, and possibly regulates the transcriptional level of beta-catenin by phosphorylating c-Jun. Knockdown of VRK1 inhibits these processes, suggesting a potential role for VRK1 in tumor progression in gastric carcinoma.
Article
Medicine, Research & Experimental
Lu Wang, Xiao-Dan Hu, Shou-Ying Li, Xu-Yang Liang, Lin Ren, Sheng-Xiang Lv
Summary: Increased expression of abnormal spindle-like microcephaly (ASPM) has been associated with clinical stage and prognosis in cancers. This study found that ASPM plays a crucial role in promoting cell metastasis in colorectal cancer by upregulating beta-catenin expression and activating the Wnt/beta-catenin pathway.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Weida Chen, Chengli Miao
Summary: This study found that KRT15 is highly expressed in colorectal cancer cells and its overexpression significantly promotes the migration and invasion of these cells. It was also discovered that MMP-7 plays a crucial role in the KRT15-induced migration and invasion of colorectal cancer cells, and beta-catenin is responsible for the increased expression of MMP-7 induced by KRT15.
Article
Oncology
Er Nie, Xin Jin, Weining Wu, Tianfu Yu, Xu Zhou, Zhumei Shi, Junxia Zhang, Ning Liu, Yongping You
JOURNAL OF NEURO-ONCOLOGY
(2017)
Article
Oncology
Xuechao Wu, Yingyi Wang, Tianfu Yu, Er Nie, Qi Hu, Weining Wu, Tongle Zhi, Kuan Jiang, Xiefeng Wang, Xiaojie Lu, Hailin Li, Ning Liu, Junxia Zhang, Yongping You
Article
Multidisciplinary Sciences
Weining Wu, Qi Hu, Er Nie, Tianfu Yu, Youzhi Wu, Tongle Zhi, Kuan Jiang, Feng Shen, Yingyi Wang, Junxia Zhang, Yongping You
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Er Nie, Xin Jin, Weining Wu, Tianfu Yu, Xu Zhou, Tongle Zhi, Zhumei Shi, Junxia Zhang, Ning Liu, Yongping You
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Er Nie, Faan Miao, Xin Jin, Weining Wu, Xu Zhou, Ailiang Zeng, Tianfu Yu, Tongle Zhi, Zhumei Shi, Yingyi Wang, Junxia Zhang, Ning Liu, Yongping You
Article
Oncology
Er Nie, Xin Jin, Faan Miao, Tianfu Yu, Tongle Zhi, Zhumei Shi, Yingyi Wang, Junxia Zhang, Manyi Xie, Yongping You
Summary: The study revealed that TGF-beta 1 contributes to temozolomide resistance by reducing miR-198 expression and subsequently MGMT levels, while not affecting KSRP expression; TGF-beta 1 upregulates H19 and HOXD-AS2 lncRNAs, which competitively bind to KSRP and decrease miR-198 expression, promoting temozolomide resistance; Patients with low levels of TGF-beta 1 or lncRNA expression benefited from temozolomide therapy.
Article
Cell Biology
Yan Wang, Xiang Wang, Xu Wang, Di Wu, Ji Qi, Yu Zhang, Kai Wang, Ding Zhou, Qing-Ming Meng, Er Nie, Qiang Wang, Ru-Tong Yu, Xiu-Ping Zhou
Summary: The study demonstrates that imipramine inhibits the proliferation of malignant glioma by suppressing YAP, and concurrent use with temozolomide shows synergistic effects in inhibiting tumor growth.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Tian Gan, Yan Wang, Manyi Xie, Qiang Wang, Saisai Zhao, Peng Wang, Qinyu Shi, Xuanchen Qian, Faan Miao, Zhigang Shen, Er Nie
Summary: This study reveals that MEX3A is significantly upregulated in GBM tissues and cell lines following TMZ treatment. MEX3A binds to MSH2 mRNA and mediates its degradation, leading to reduced expression of MSH2. High expression of MEX3A is associated with poor prognosis in GBM patients.
Article
Medicine, General & Internal
Dong Liang, Yunnong Song, Guangwei Fan, Daofei Ji, Tong Zhang, Er Nie, Xuejiao Liu, Jun Liang, Rutong Yu, Shangfeng Gao
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
