Review
Clinical Neurology
Konark Malhotra, Christina Zompola, Aikaterini Theodorou, Aristeidis H. Katsanos, Ashkan Shoamanesh, Himanshu Gupta, Simon Beshara, Nitin Goyal, Jason Chang, Ashis H. Tayal, Efstathios Boviatsis, Konstantinos Voumvourakis, Charlotte Cordonnier, David J. Werring, Andrei V. Alexandrov, Georgios Tsivgoulis
Summary: Among patients with spontaneous intracerebral hemorrhage, approximately 1 in 4 cases have undetermined etiology, leading to a relatively high short-term mortality rate. Cerebral amyloid angiopathy accounts for the largest hemorrhage volume, while hypertensive arteriopathy and undetermined ICH have smaller volumes.
Article
Neurosciences
Mengke Zhang, Ruiwen Che, Wenbo Zhao, Hailiang Sun, Changhong Ren, Jin Ma, Wenbo Hu, Milan Jia, Chuanjie Wu, Xin Liu, Xunming Ji
Summary: This study aimed to explore the relationship between computed tomography (CT)-based cerebral small vessel disease (SVD) markers and the clinical outcomes in patients with cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH). The results showed that the SVD markers based on CT could predict the short-term outcome more effectively in patients with CAA-ICH. Further studies are needed to validate these findings and identify modifiable factors for preventing CAA-ICH development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Mingxu Xia, Ya Su, Jiayu Fu, Jiajie Xu, Qiong Wang, Feng Gao, Yong Shen, Qiang Dong, Xin Cheng
Summary: This study found that serum MMP-2 levels in the acute phase may serve as a promising biomarker to predict CAA-ICH recurrence and evaluate the risk of cognitive impairment. Additionally, higher levels of MMP-2 were associated with cerebral microbleeds count and MRI burden score.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Sabine Voigt, Siham Amlal, Emma A. Koemans, Ingeborg Rasing, Ellis S. van Etten, Erik W. van Zwet, Mark A. van Buchem, Gisela M. Terwindt, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: The study investigated the topographical and temporal patterns of index and recurrent intracerebral hemorrhages in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA). Results showed a preference for occipital lobe in both index and recurrent ICHs, with no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Aayushi Garg, Santiago Ortega-Gutierrez, Mudassir Farooqui, Nandakumar Nagaraja
Summary: This study found that patients with intracerebral hemorrhage (ICH) and concomitant cerebral amyloid angiopathy (CAA) are three times more likely to have readmissions for recurrent ICH compared to patients without CAA.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Howard Kirshner, Matthew Schrag
Summary: Intracerebral hemorrhage (ICH) accounts for 15% of all strokes in the US, yet almost 50% of fatal strokes. The most common causes are hypertension and cerebral amyloid angiopathy. Treatment focuses on managing edema, reducing blood pressure, and correcting coagulopathy. Current standard of care includes supportive therapies, but there is no definitive curative therapy like mechanical thrombectomy for ischemic stroke. New medical and surgical approaches show promise in improving ICH management.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Clinical Neurology
Yuyi Zhu, Lu Liu, Luyao Zhong, Yajun Cheng, Shihong Zhang, Bo Wu, Deren Wang, Mangmang Xu
Summary: The study aims to investigate the association between burden of cerebral small vessel disease (CSVD) caused by hypertensive angiopathy (HA) and cerebral amyloid angiopathy (CAA) on MRI in patients with primary intracerebral hemorrhage (ICH). The results showed a significant association between HA-CSVD and CAA-CSVD, which needs to be confirmed in future studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Simon Fandler-Hoefler, Thomas Gattringer, Christian Enzinger, David J. Werring
Summary: This study found that patients with probable CAA who were diagnosed using the Boston v2.0 criteria had a lower risk of ICH recurrence compared to those diagnosed using the v1.5 criteria.
Article
Clinical Neurology
Evangelos Pavlos Myserlis, Christopher D. Anderson, Marios K. Georgakis
Summary: Recent evidence suggests that higher CRP levels are associated with lower risk of Alzheimer disease, and this study explores whether genetically proxied CRP levels are also associated with lobar intracerebral hemorrhage (ICH) caused by cerebral amyloid angiopathy. The results show that higher genetically proxied CRP levels are associated with lower odds of lobar ICH, supporting the hypothesis that high CRP levels may have a protective role in amyloid-related pathology.
Article
Medicine, General & Internal
Russell P. Sawyer, Stacie L. Demel, Mary E. Comeau, Miranda Marion, Jonathan Rosand, Carl D. Langefeld, Daniel Woo
Summary: Apolipoprotein E alleles are associated with both Alzheimer's disease and intracerebral hemorrhage; intracerebral hemorrhage has a high risk of subsequent dementia; variations in CR1 and CLU genes are associated with an increased risk of lobar ICH.
Article
Clinical Neurology
Joan Marti-Fabregas, Pol G. Camps-Renom, Jonathan G. Best, Anna Ramos-Pachon, Marina Guasch-Jimenez, Alejandro Martinez-Domeno, Daniel M. Guisado-Alonso, Beatriz M. Gomez-Anson, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Hee-Joon Bae, Masayuki Shiozawa, Masatoshi Koga, Kazunori G. Toyoda, Michael G. Hennerici, Hugues Chabriat, Eric Jouvent, Debbie Yuen Kwun Wong, Henry Mak, Kui Kai Lau, Young Dae Kim, Tae-Jin Song, Ji-Hoe Heo, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Derya Selcuk Demirelli, Natan Bornstein, Einor Ben Assayag, Hen A. Hallevi, Jeremy A. Molad, Masashi Nishihara, Jun Tanaka, Hideo Hara, Yusuke B. Yakushiji, Shelagh B. Coutts, Eric A. Smith, Alexandros A. Polymeris, Benjamin Wagner, David A. Seiffge, Philippe A. Lyrer, Nils T. Peters, Stefan T. Engelter, Rustam Al-Shahi Salman, Hans Rudolf Jager, Gregory Y. H. Lip, Martina Goeldlin, Leonidas Panos, Christopher Charles G. Karayiannis, Thanh G. K. Phan, Velandai K. Srikanth, Nicolas Christ, Sarah Gunkel, Felix W. Fluri, Thomas W. Leung, Yannie O. Y. Soo, Winnie Chu, Jill Abrigo, Carmen Barbato, Simone Browning, Robert Simister, Anne-Marie Mendyk, Regis Bordet, Saima Hilal, Bibek Gyanwali, Christopher Chen, Simon Jung, Dilek Necioglu Orken, David Werring, Luis Prats-Sanchez
Summary: This study aimed to investigate the risk of future cerebrovascular events in patients with ischemic stroke (IS) or transient ischemic attack (TIA) and cortical superficial siderosis (cSS), as well as the benefits and safety of antithrombotic drugs for secondary prevention. The study found that cSS was associated with an increased risk of stroke, and the risk of IS was higher than that of intracranial hemorrhage (ICrH) in patients receiving antiplatelet or anticoagulant treatment alone, while the risk of ICrH was higher than that of IS in patients receiving both treatments. Therefore, the study suggests that using antiplatelet or anticoagulant drugs alone is safe in patients with cSS, but combined antithrombotic therapy might be hazardous.
Article
Clinical Neurology
Suzanne E. van Dijk, Jeroen van der Grond, Jessie Lak, Annette van den Berg-Huysmans, Gerda Labadie, Gisela M. Terwindt, Marieke J. H. Wermer, M. Edip Gurol, Mark A. van Buchem, Steven M. Greenberg, Sanneke van Rooden
Summary: This study found that cerebrovascular reactivity worsens progressively in the presymptomatic phase of Dutch-type hereditary cerebral amyloid angiopathy (D-CAA). Recurrent intracerebral hemorrhage appears to be the most salient marker of progression in the symptomatic phase of the disease.
Article
Clinical Neurology
Giuseppe Scopelliti, Barbara Casolla, Gregoire Boulouis, Gregory Kuchcinski, Solene Moulin, Didier Leys, Hilde Henon, Charlotte Cordonnier, Marco Pasi
Summary: Anxiety is common among survivors of spontaneous intracerebral hemorrhage (ICH), often occurring together with depressive symptoms even years after the initial event. Lobar ICH location is significantly associated with anxiety 1-2 years after ICH.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Review
Clinical Neurology
Mangmang Xu, Yuyi Zhu, Xindi Song, Xuelian Zhong, Xinxin Yu, Deren Wang, Yajun Cheng, Wendan Tao, Bo Wu, Ming Liu
Summary: In this systematic review and meta-analysis, we investigated the relationship between cerebral amyloid angiopathy (CAA) and arteriolosclerosis in intracerebral hemorrhage (ICH) patients. We also compared the MRI and pathological changes of markers of cerebral small vessel disease (CSVD). The results indicated that severe CAA was potentially associated with arteriolosclerosis. Patients with evidence of CAA had a higher number of microbleeds compared to those without CAA. However, further research is needed to explore the pathological changes of CSVD markers according to the etiology of ICH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Medicine, General & Internal
Carmen Barbato, Piergiuseppe Liuzzi, Anna Maria Romoli, Francesca Draghi, Daniela Maccanti, Andrea Mannini, Claudio Macchi, Francesca Cecchi, Bahia Hakiki
Summary: This study found that sporadic CAA associated with cerebral hemorrhage is independently associated with poorer rehabilitation outcomes, regardless of age. This suggests the importance of improving knowledge about CAA to better predict rehabilitation outcomes.
Article
Neurosciences
Ping Sun, Fan Bu, Jia-Wei Min, Yashasvee Munshi, Matthew D. Howe, Lin Liu, Edward C. Koellhoffer, Li Qi, Louise D. McCullough, Jun Li
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Matthew D. Howe, J. Weldon Furr, Liang Zhu, Nancy J. Edwards, Louise D. McCullough, Nicole R. Gonzales
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2019)
Article
Medicine, General & Internal
Daniel F. Hanley, Richard E. Thompson, Michael Rosenblum, Gayane Yenokyan, Karen Lane, Nichol McBee, Steven W. Mayo, Amanda J. Bistran-Hall, Dheeraj Gandhi, W. Andrew Mould, Natalie Ullman, Hasan Ali, J. Ricardo Carhuapoma, Carlos S. Kase, Kennedy R. Lees, Jesse Dawson, Alastair Wilson, Joshua F. Betz, Elizabeth A. Sugar, Yi Hao, Radhika Avadhani, Jean-Louis Caron, Mark R. Harrigan, Andrew P. Carlson, Diederik Bulters, David LeDoux, Judy Huang, Cully Cobb, Gaurav Gupta, Ryan Kitagawa, Michael R. Chicoine, Hiren Patel, Robert Dodd, Paul J. Camarata, Stacey Wolfe, Agnieszka Stadnik, P. Lynn Money, Patrick Mitchell, Rosario Sarabia, Sagi Harnof, Pal Barzo, Andreas Unterberg, Jeanne S. Teitelbaum, Weimin Wang, Craig S. Anderson, A. David Mendelow, Barbara Gregson, Scott Janis, Paul Vespa, Wendy Ziai, Mario Zuccarello, Issam A. Awad
Article
Clinical Neurology
Issam A. Awad, Sean P. Polster, Julian Carrion-Penagos, Richard E. Thompson, Ying Cao, Agnieszka Stadnik, Patricia Lynn Money, Maged D. Fam, Janne Koskimaeki, Romuald Girard, Karen Lane, Nichol McBee, Wendy Ziai, Yi Hao, Robert Dodd, Andrew P. Carlson, Paul J. Camarata, Jean-Louis Caron, Mark R. Harrigan, Barbara A. Gregson, A. David Mendelow, Mario Zuccarello, Daniel F. Hanley, Azmil Abdul-Rahim, Amal Abou-Hamden, Michael Abraham, Azam Ahmed, Carlos Alarcon Alba, E. Francois Aldrich, Hasan Ali, David Altschul, Sepideh Amin-Hanjani, Craig S. Anderson, Doug Anderson, Safdar Ansari, David Antezana, Agnieszka Ardelt, Fuat Arikan, Radhika Avadhani, Marcelino Baguena, Alexandra Baker, Steven J. Barrer, Pal Barzo, Kyra J. Becker, Thomas Bergman, Joshua F. Betz, Amanda J. Bistran-Hall, Azize Bostrom, Jamie Braun, Peter Brindley, William C. Broaddus, Robert Brown, Andras Buki, Diederik Bulters, Bing Cao, J. Ricardo Carhuapoma, Julio Chalela, Tiffany Chang, Michael R. Chicoine, Indalecio Moran Chorro, Shakeel Chowdhry, Cully Cobb, Luisa Corral, Laszlo Csiba, Jason Davies, Jesse Dawson, Alberto Torres Diaz, Colin P. Dierdeyn, Michael Diringer, Rachel Dlugash, Robert Ecker, Tracey Economas, Pedro Enriquez, Erzsebet Ezer, Yuhua Fan, Hua Feng, Douglas Franz, W. David Freeman, Matthew Fusco, Walter Galicich, Dheeraj Gandhi, Mary Leigh Gelea, Joshua Goldstein, Alejandro Carrasco Gonzalez, Christina Grabarits, Steven Greenberg, Barbara Gregson, Daryl Gress, Eugene Gu, Gaurav Gupta, Christiana Hall, Sagi Harnof, Fernando Munoz Hernandez, Robert Hoesch, Brian L. Hoh, Jennifer Houser, Rong Hu, Judy Huang, Yi Huang, Mohammed Akbar Hussain, Salvatore Insinga, Ashutosh Jadhav, Jennifer Jaffe, Babak S. Jahromi, Jack Jallo, Michael James, Robert F. James, Scott Janis, Brian Jankowitz, Esther Jeon, Draga Jichici, Karin Jonczak, Ben Jonker, Nicki Karlen, Carlos S. Kase, Naureen Keric, Thomas Kerz, Ryan Kitagawa, Jared Knopman, Carolyn Koenig, Satish Krishnamurthy, Avinash Kumar, Inam Kureshi, John Laidlaw, Arun Lakhanpal, Julius Gene Latorre, David LeDoux, Kennedy R. Lees, Dana Leifer, James Leiphart, Sarah Lenington, Yunke Li, George Lopez, Darren Lovick, Christianto Lumenta, Jinbiao Luo, Matthew B. Maas, Joel MacDonald, Larami MacKenzie, Vikram Madan, Ryan Majkowski, Otto Major, Rishi Malhorta, Marc Malkoff, Halinder Mangat, Ahmed Maswadeh, Charles Matouk, Steven W. Mayo, Kate McArthur, Scott McCaul, Joshua Medow, Geza Mezey, Janet Mighty, David Miller, Patrick Mitchell, Krishna K. Mohan, W. Andrew Mould, Keith Muir, Lorenzo Munoz, Peter Nakaji, Alex Nee, Saman Nekoovaght-Tak, Paul Nyquist, Roddy O'Kane, Mohamed Okasha, Cian O'Kelly, Noeleen Ostapkovich, Aditya Pandey, Adrian Parry-Jones, Hiren Patel, Krissia Rivera Perla, Ania Pollack, Nader Pouratian, Terry Quinn, Ventatakrishna Rajajee, Kesava Reddy, Mohammed Rehman, Ronald Reimer, Fred Rincon, Michael Rosenblum, Igor Rybinnik, Baltasar Sanchez, Lauren Sansing, Rosario Sarabia, Michael Schneck, Ludwig Schuerer, David Schul, Jeffrey Schweitzer, David B. Seder, Donald Seyfried, Kevin Sheth, Alejandro Spiotta, Michael Stechison, Elizabeth A. Sugar, Katalin Szabo, Gonzalo Tamayo, Krisztian Tanczos, Philipp Taussky, Jeanne S. Teitelbaum, John Terry, Fernando Testai, Kathrine Thomas, Carol B. Thompson, Gregory Thompson, James C. Torner, Huy Tran, Kristi Tucker, Natalie Ullman, Lior Ungar, Andreas Unterberg, Panos Varelas, Nataly Montano Vargas, Hartmut Vatter, Chitra Venkatasubramanian, Krista Vermillion, Paul Vespa, Dennis Vollmer, Weimin Wang, Yan Wang, Ying Wang, Jiajun Wen, Louis Tony Whitworth, Byron Willis, Alastair Wilson, Stacey Wolfe, Myriha Wrencher, Shawn E. Wright, Yongge Xu, Lisa Yanase, Gayane Yenokyan, Xuxia Yi, Zhiyuan Yu, Ali Zomorodi
Article
Biochemistry & Molecular Biology
Ishraq Alim, Joseph T. Caulfield, Yingxin Chen, Vivek Swarup, Daniel H. Geschwind, Elena Ivanova, Javier Seravalli, Youxi Ai, Lauren H. Sensing, Emma J. Ste Marie, Robert J. Hondal, Sushmita Mukherjee, John W. Cave, Botir T. Sagdullaev, Saravanan S. Karuppagounder, Rajiv R. Ratan
Article
Clinical Neurology
Santosh B. Murthy, Alessandro Biffi, Guido J. Falcone, Lauren H. Sansing, Victor Torres Lopez, Babak B. Navi, David J. Roh, Pitchaiah Mandava, Daniel F. Hanley, Wendy C. Ziai, Hooman Kamel, Jonathan Rosand, Kevin N. Sheth, D. F. Hanley, K. Butcher, S. Davis, B. Gregson, K. R. Lees, P. Lyden, S. Mayer, K. Muir, T. Steiner
Article
Clinical Neurology
Audrey C. Leasure, Adnan Qureshi, Santosh B. Murthy, Hooman Kamel, Joshua N. Goldstein, Kyle B. Walsh, Daniel Woo, Fu-Dong Shi, Hagen B. Huttner, Wendy C. Ziai, Daniel F. Hanley, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Article
Medicine, General & Internal
Joji B. Kuramatsu, Alessandro Biffi, Stefan T. Gerner, Jochen A. Sembill, Maximilian I. Spruegel, Audrey Leasure, Lauren Sansing, Charles Matouk, Guido J. Falcone, Matthias Endres, Karl Georg Haeusler, Jan Sobesky, Johannes Schurig, Sarah Zweynert, Miriam Bauer, Peter Vajkoczy, Peter A. Ringleb, Jan Purrucker, Timolaos Rizos, Jens Volkmann, Wolfgang Muellges, Peter Kraft, Anna-Lena Schubert, Frank Erbguth, Martin Nueckel, Peter D. Schellinger, Joerg Glahn, Ulrich J. Knappe, Gereon R. Fink, Christian Dohmen, Henning Stetefeld, Anna Lena Fisse, Jens Minnerup, Georg Hagemann, Florian Rakers, Heinz Reichmann, Hauke Schneider, Jan Rahmig, Albert Christian Ludolph, Sebastian Stoesser, Hermann Neugebauer, Joachim Roether, Peter Michels, Michael Schwarz, Gernot Reimann, Hansjoerg Baezner, Henning Schwert, Joseph Classen, Dominik Michalski, Armin Grau, Frederick Palm, Christian Urbanek, Johannes C. Woehrle, Fahid Alshammari, Markus Horn, Dirk Bahner, Otto W. Witte, Albrecht Guenther, Gerhard F. Hamann, Manuel Hagen, Sebastian S. Roeder, Hannes Luecking, Arnd Doerfler, Fernando D. Testai, Daniel Woo, Stefan Schwab, Kevin N. Sheth, Hagen B. Huttner
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2019)
Article
Cell Biology
Meaghan A. Roy-O'Reilly, Hilda Ahnstedt, Monica S. Spychala, Yashasvee Munshi, Jaroslaw Aronowski, Lauren H. Sansing, Louise D. McCullough
Article
Clinical Neurology
Audrey C. Leasure, Zachary A. King, Victor Torres-Lopez, Santosh B. Murthy, Hooman Kamel, Ashkan Shoamanesh, Rustam Al-Shahi Salman, Jonathan Rosand, Wendy C. Ziai, Daniel F. Hanley, Daniel Woo, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Article
Clinical Neurology
Aaron M. Gusdon, Paul A. Nyquist, Victor M. Torres-Lopez, Audrey C. Leasure, Guido J. Falcone, Kevin N. Sheth, Lauren H. Sansing, Daniel F. Hanley, Rachna Malani
Article
Clinical Neurology
Che-Feng Chang, Jordan Massey, Artem Osherov, Luis Henrique Angenendt da Costa, Lauren H. Sansing
Article
Neurosciences
Nia M. Harris, Meaghan Roy-O'Reilly, Rodney M. Ritzel, Aleah Holmes, Lauren H. Sansing, Lena M. O'Keefe, Louise D. McCullough, Anjali Chauhan
EXPERIMENTAL NEUROLOGY
(2020)
Review
Physiology
Matthew D. Howe, Louise D. McCullough, Akihiko Urayama
FRONTIERS IN PHYSIOLOGY
(2020)
Editorial Material
Clinical Neurology
Matthew D. Howe, Gil D. Rabinovici, Stephen P. Salloway
Summary: The treatment landscape for Alzheimer's disease is evolving rapidly with the approval of amyloid-lowering monoclonal antibodies for early AD. The full FDA approval of lecanemab and subsequent coverage by the Center for Medicare Services have opened a new era in the diagnosis and treatment of AD, posing challenges for providers, payers, and healthcare systems.