Article
Endocrinology & Metabolism
Arash Derakhshan, Tuija Mannisto, Liangmiao Chen, Joris A. J. Osinga, Ghalia Ashoor, Xuemian Lu, Sofie Bliddal, Fang-Biao Tao, Suzanne J. Brown, Bijay Vaidya, Andrew T. Hattersley, Sachiko Itoh, Polina Popova, Ashraf Aminorroaya, Reiko Kishi, Maryam Kianpour, Elena A. Vasukova, Abel Lopez-Bermejo, Emily Oken, Leda Chatzi, Marina Vafeiadi, Wichor M. Bramer, Judit Bassols, Aitana Lertxundi, Ana Fernandez-Somoano, Paula Carrasco, Juha Auvinen, Kun Huang, Ulla Feldt-Rasmussen, Elena N. Grineva, Erik K. Alexander, Elizabeth N. Pearce, Layal Chaker, John P. Walsh, Robin P. Peeters, Monica Guxens, Eila Suvanto, Kypros H. Nicolaides, Tim I. M. Korevaar
Summary: This study explores the association between gestational FT3 and TT3 levels and adverse obstetric outcomes. The findings suggest that FT3 and TT3 levels have different associations with various adverse obstetric outcomes, with high TT3 associated with an increased risk of gestational hypertension and low TT3 associated with a higher risk of very preterm birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Physiology
Francisco J. Valenzuela-Melgarejo, Constanza Lagunas, Fabiola Carmona-Pasten, Kevins Jara-Medina, Gustavo Delgado
Summary: Disruption of factors in blood pressure regulation can lead to hypertension, with melatonin playing a crucial role during pregnancy in modulating physiological functions. Supplementation of melatonin can reduce blood pressure, prevent oxidative stress, and repair endothelial damage at the placental level.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiujuan Su, Yang Liu, Guohua Li, Xiaosong Liu, Shijia Huang, Tao Duan, Qiaoling Du
Summary: This study found that hypothyroxinemia during pregnancy was associated with an increased risk of preeclampsia-eclampsia, especially in women with persistent hypothyroxinemia in early pregnancy. However, there was no significant association between hypothyroxinemia and gestational hypertension.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yi Zhang, Chen Sheng, Dingmei Wang, Xiaotian Chen, Yuan Jiang, Yalan Dou, Yin Wang, Mengru Li, Hongyan Chen, Wennan He, Weili Yan, Guoying Huang, SPCC Grp
Summary: Higher levels of ALT, ALP, and GGT within the normal range in early pregnancy are associated with an increased risk of gestational hypertension and preeclampsia, providing new insight into the role of hepatobiliary function in the pathogenesis of these conditions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Megan A. Opichka, Matthew W. Rappelt, David D. Gutterman, Justin L. Grobe, Jennifer J. McIntosh
Summary: Preeclampsia is a life-threatening cardiovascular disorder associated with pregnancy, potentially caused by dysfunction in maternal and placental blood vessels and other factors. Current gaps in knowledge include detailed understanding of its underlying causes and effective treatment options.
Article
Biochemistry & Molecular Biology
Marina M. Ziganshina, Kamilla T. Muminova, Nailia R. Khasbiullina, Zulfiya S. Khodzhaeva, Ekaterina L. Yarotskaya, Gennady T. Sukhikh
Summary: This paper assesses the changes in blood vessels during preeclampsia and describes the vascular patterns. The study found that in early-onset preeclampsia, there were changes in all structural components of endothelial glycocalyx, as well as severe disorders in central hemodynamics, arterial stiffness, and myocardial function. In late-onset preeclampsia, there were changes in hyaluronic acid levels, central hemodynamics, and myocardial function, which may indicate potential cardiovascular disorders.
Article
Cardiac & Cardiovascular Systems
Teodora R. Kolarova, Hilary S. Gammill, J. Lee Nelson, Christina M. Lockwood, Raj Shree
Summary: Total cfDNA levels are significantly higher in preeclampsia patients compared to normal pregnancies, while the placental-derived fraction of cfDNA remains similar. In preeclampsia, higher total cfDNA levels are associated with earlier delivery and higher systolic blood pressure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Jeanne A. Ishimwe, Adesanya Akinleye, Ashley C. Johnson, Michael R. Garrett, Jennifer M. Sasser
Summary: The study suggests that there may be an association between chronic hypertension and gut microbiome dysbiosis in pregnancy, which hinders gut microbial composition remodeling during superimposed preeclampsia.
PHYSIOLOGICAL GENOMICS
(2021)
Article
Environmental Sciences
Sumonthip Leelawai, Chitkasaem Suwanrath, Nannapat Pruphetkaew, Pensri Chongphattararot, Pornchai Sathirapanya
Summary: This study investigated the association between gestational Bell's palsy and late obstetric complications, revealing a potential relationship between gestational Bell's palsy and lower birth weight in newborns, although the association with other complications remains inconclusive.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Marija Majda Perisic, Klemo Vladimir, Sarah Karpov, Mario Storga, Ali Mostashari, Raya Khanin
Summary: Preeclampsia and gestational hypertensive disorders are common complications of pregnancy with long-term consequences. This study developed a risk score using machine learning to screen for GHD early. It confirmed that high BMI is a risk factor for GHD and explored the relationship between GHD and genetically constructed anthropometric measures and biomarkers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Adrianna Kondracka, Ilona Jaszczuk, Dorota Koczkodaj, Bartosz Kondracki, Karolina Fraszczak, Anna Oniszczuk, Magda Rybak-Krzyszkowska, Jakub Staniczek, Agata Filip, Anna Kwasniewska
Summary: This study found that circulating C19MC microRNA can serve as an early marker of hypertension and preeclampsia in pregnant patients, based on a systematic review of existing literature.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Chiara Giuliani, Laura Sciacca, Nicolina Di Biase, Andrea Tumminia, Agostino Milluzzo, Antongiulio Faggiano, Francesca Romana Amorosi, Alessio Convertino, Olimpia Bitterman, Camilla Festa, Angela Napoli
Summary: GDM has a high recurrence rate in pregnant women, with an increase in pregravid BMI for women with recurrent GDM between two pregnancies.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Review
Medicine, General & Internal
Elzbieta Poniedzialek-Czajkowska, Radzislaw Mierzynski, Dominik Dluski, Bozena Leszczynska-Gorzelak
Summary: Hypertensive disorders of pregnancy, such as preeclampsia, pose significant risks to both mother and fetus. Aspirin is currently the only recommended pharmacological agent for prevention in high-risk groups, while metformin shows potential as an interesting option for prophylaxis, although further research is needed to clarify its effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Luiz Gustavo N. de Almeida, Daniel Young, Lorraine Chow, Joshua Nicholas, Adrienne Lee, Man-Chiu Poon, Antoine Dufour, Ejaife O. Agbani
Summary: Platelets are important in linking inflammation and thrombosis with endothelial and vascular dysfunction in preeclampsia. This study aimed to identify biomarkers distinguishing preeclampsia from gestational hypertension and explore the contribution of platelets to the thrombo-inflammatory states in preeclampsia.
Article
Obstetrics & Gynecology
Edin Medjedovic, Milan Stanojevic, Asim Kurjak, Edin Begic, Amer Iglica, Sabaheta Jonuzovic-Prosic
Summary: The study explores the link between maternal thyroid function and incidence of gestational hypertension and preeclampsia. It found that impaired thyroid function was more common in pregnancies complicated with preeclampsia, leading to differences in gestational age at delivery, birth weight, blood pressure, and thyroid hormone levels between the two groups. It suggests that checking thyroid hormones in asymptomatic pregnancies with preeclampsia or gestational hypertension may be prudent.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Herbert Valensise, Daniele Farsetti, Ilaria Pisani, Grazia Maria Tiralongo, Giulia Gagliardi, Damiano Lo Presti, Gian Paolo Novelli, Barbara Vasapollo
Summary: The study aimed to evaluate the relationship between cardiovascular health and cardiac function during early pregnancy and the development of complications in chronic hypertensive patients. The results showed that patients with complications had abnormal cardiac indices in early pregnancy, including heart rate, cardiac output, vascular resistance, and left ventricular morphology. In addition, diastolic and systolic function were also affected. These findings suggest that early assessment of cardiovascular parameters during early pregnancy can help predict the development of complications in hypertensive patients.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Daniele Farsetti, Francesca Pometti, Grazia Maria Tiralongo, Damiano Lo Presti, Ilaria Pisani, Giulia Gagliardi, Barbara Vasapollo, Gian Paolo Novelli, Herbert Valensise
Summary: The study found that using QUV and maternal hemodynamics examination can accurately distinguish between SGA and FGR, with significant decrease in QUV and cQUV in early FGR, and lower maternal CO in both early and late FGR.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Biology
Francesco Campa, Diana Maria Thomas, Krista Watts, Nicholas Clark, Daniel Baller, Thomas Morin, Stefania Toselli, Josely Correa Koury, Giovanni Melchiorri, Angela Andreoli, Gabriele Mascherini, Cristian Petri, Luis Bettencourt Sardinha, Analiza Monica Silva
Summary: This study provides percentiles for phase angle in male and female athletes practicing different sports, which can track body composition and performance-related parameters in athletes.
Article
Endocrinology & Metabolism
Francesco Galanti, Ilaria Pisani, Serena Riccio, Daniele Farsetti, Barbara Vasapollo, Gian Paolo Novelli, Donatella Miriello, Rocco Rago, Herbert Valensise
Summary: This study evaluated the hemodynamic parameters in women undergoing in vitro fertilization (IVF) and found a possible correlation between hemodynamics and embryo implantation. Specifically, lower systemic vascular resistance (SVR) before the beginning of IVF techniques and during the window of implantation may positively influence embryo implantation.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Barbara Vasapollo, Gian Paolo Novelli, Daniele Farsetti, Herbert Valensise
Summary: This study found a strong relationship between maternal hemodynamics as expressed by PVR at mid gestation and fetal growth at delivery in chronic hypertension. PVR at mid gestation was strongly correlated with birthweight at delivery and the diagnosis of fetal growth restriction. This finding highlights the importance of maternal hemodynamics for identifying chronic hypertensive patients at risk for developing fetal growth restriction.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Herbert Valensise, Daniele Farsetti, Francesca Pometti, Barbara Vasapollo, Gian Paolo Novelli, Christoph Lees
Summary: This study investigated the relationships between maternal and fetal hemodynamics in a population with suspected fetal growth restriction. The results showed that maternal and fetal hemodynamic parameters were different in the three groups of fetuses: fetal growth restriction, small for gestational age, and adequate for gestational age. Maternal hemodynamic parameters were closely and continuously correlated with fetal hemodynamic features. Assessing maternal and fetal hemodynamic parameters is important for the diagnosis and monitoring of fetal growth restriction.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Herbert Valensise, Francesca Pometti, Daniele Farsetti, Gian Paolo Novelli, Barbara Vasapollo
Summary: This study aimed to assess the hemodynamic differences between women with pPROM and normal pregnancies. The results showed that pPROM patients had higher cardiac output, lower systemic vascular resistances, higher heart rate, and higher oxygen delivery compared to controls. The altered hemodynamics seemed to anticipate the changes in inflammatory markers and were more pronounced in pPROM patients with unfavorable outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Veronica Yacoub, Valerio Carletti, Debora Grilli, Claudia Morgani, Pierluigi Palazzetti, Marzio Angelo Zullo, Paolo Luffarelli, Herbert Carmelo Carlo Valensise, Michele Carlo Schiavi
Summary: This study aimed to evaluate the impact of SARS-CoV-2 vaccination on the quality of life, psychological aspects, and sexual life of postmenopausal women in Italy during the COVID-19 pandemic. The results showed that vaccination coverage positively influenced sexual function, quality of life, and psychological aspects in postmenopausal women.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Developmental Biology
Daniele Farsetti, Barbara Vasapollo, Francesca Pometti, Roberta Frantellizzi, Gian Paolo Novelli, Herbert Valensise
Summary: This study aimed to test the accuracy of systemic vascular resistance (SVR) in identifying early fetal growth restriction (FGR). The findings showed that SVR levels could correctly identify patients who later developed FGR, as well as those with subsequent umbilical artery Doppler alterations. These results highlight the potential importance of introducing USCOM for the identification and treatment of FGR in clinical practice.
Article
Urology & Nephrology
Federica Sala, Melania Loggia, Giorgia Cardella, Claudia Morgani, Giovanni Grossi, Marzio Angelo Zullo, Herbert Carmelo Carlo Valensise, Pier Luigi Palazzetti, Michele Carlo Schiavi
Summary: The objective of this study was to compare the efficacy of the transobturator tape (TOT) procedure combined with solifenacin (TOT-S) or prasterone (TOT-P) in postmenopausal women affected by mixed urinary incontinence (MUI). The study found that after 12 weeks of follow-up, TOT-P demonstrated the same effectiveness as TOT-S in reducing urinary symptoms, and TOT-P also improved vaginal health index (VHI) and sexual function scores compared with TOT-S.
LUTS-LOWER URINARY TRACT SYMPTOMS
(2023)
Article
Obstetrics & Gynecology
Barbara Vasapollo, Gian Paolo Novelli, Daniele Farsetti, Francesca Pometti, Roberta Frantellizzi, Filomena Maellaro, Marco Silvestrini, Marcello Pais, Herbert Valensise
Summary: Tailored treatment with NO donors and oral fluids for hypodynamic chronic hypertensive patients may reduce or mitigate adverse outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)