Article
Clinical Neurology
Ajay Pal, HongGeun Park, Aditya Ramamurthy, Ahmet S. Asan, Thelma Bethea, Meenu Johnkutty, Jason B. Carmel
Summary: In this study, the researchers developed a plasticity protocol in rats that aims to activate both sensory and motor connections in the spinal cord. They found that repeated application of this protocol in rats with spinal cord injury improved their forelimb dexterity and reduced hyperreflexia. This study shows the importance of targeting the sensory and motor systems in the spinal cord for promoting recovery after spinal cord injury.
Article
Clinical Neurology
Tais Regina da Silva, Helio Rubens de Carvalho Nunes, Lais Geronutti Martins, Rafael Dalle Molle da Costa, Juli Thomaz de Souza, Fernanda Cristina Winckler, Lorena Cristina Alvarez Sartor, Gabriel Pinheiro Modolo, Natalia Cristina Ferreira, Josiela Cristina da Silva Rodrigues, Rafael Kanda, Marcelo Ortolani Fogarolli, Guilherme Ferreira Borges, Gabriela Rizzo Soares Rizzatti, Priscila Watson Ribeiro, Diandra B. Favoretto, Luan R. Aguiar dos Santos, Silmeia Garcia Zanati Bazan, Luiz Eduardo Betting, Leticia Claudia de Oliveira Antunes, Vitor Mendes Pereira, Taiza G. S. Edwards, Octavio Marques Pontes-Neto, Adriana Bastos Conforto, Rodrigo Bazan, Gustavo Jose Luvizutto
Summary: This study aimed to examine the effects of physical therapy after anodal and cathodal transcranial direct current stimulation (A-tDCS and C-tDCS, respectively) to improve visuospatial and functional impairments in individuals with USN after stroke. Results showed that A-tDCS led to greater improvement in BIT-C after intervention compared to sham, while no significant differences were observed in secondary outcomes between groups.
ANNALS OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhou Feng, Lingxia Min, Hui Chen, Weiwei Deng, Mingliang Tan, Hongliang Liu, Jingming Hou
Summary: The study demonstrated that activated microglia in the motor cortex induced iron overload after SCI, triggering motor neuronal ferroptosis and impeding motor functional recovery. Iron chelator and inhibitors could reduce iron overload-induced neuronal death, potentially offering novel therapeutic strategies for SCI.
Article
Neurosciences
Ali Khatibi, Shahabeddin Vahdat, Ovidiu Lungu, Jurgen Finsterbusch, Christian Buechel, Julien Cohen-Adad, Veronique Marchand-Pauvert, Julien Doyon
Summary: This study investigated the role of the spinal cord in human motor learning and found that there are changes in spinal cord activation and functional connectivity during the learning process. The subjects showed improved motor performance in the sequence task, which was associated with decreased co-contractions and increased reciprocal activations between wrist muscles. The early learning phase was characterized by activation in the C8 level, while a more rostral activation in the C6-C7 was found during the later learning phase. Increased spinal cord functional connectivity with brain networks, including the motor cortex, superior parietal lobule, and cerebellum, supported motor sequence learning at different stages.
Article
Neurosciences
Masahiro Sawada, Yukio Nishimura
Summary: Post-brain damage depression can hinder functional recovery, while higher motivation can facilitate recovery after damage to the central nervous system. The nucleus accumbens (NAcc), traditionally not considered directly linked to motor function, has been shown to contribute to motor performance after spinal cord injury by enhancing motor cortex activity. However, the exact neural mechanisms behind the psychological effects on functional recovery remain unclear.
NEUROSCIENCE RESEARCH
(2021)
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ciara M. Walsh, Khadija Gull, Dearbhaile Dooley
Summary: Traumatic spinal cord injury (SCI) has a significant impact on motor, sensory and autonomic function in patients. Despite the lack of a curative therapy, modulation of the inflammatory response through motor rehabilitation can improve recovery in SCI models. This review discusses the effect of motor rehabilitation on inflammatory mediators in both preclinical and human SCI studies and highlights the potential of using motor rehabilitation as an immunomodulatory therapy to improve patient outcome after SCI.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Review
Neurosciences
Mohammad Izadi, Sae Franklin, Marianna Bellafiore, David W. Franklin
Summary: Learning new movement patterns is important in both sport and rehabilitation, and there is evidence suggesting that pain can impact the learning process. However, there is currently no consensus on the effect of pain on motor learning. Further research is needed to investigate whether pain has different effects on different types of motor tasks.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Yuka Nakamura, Masaki Ueno, Jesse K. Niehaus, Richard A. Lang, Yi Zheng, Yutaka Yoshida
Summary: Deleting RhoA and RhoC genes to eliminate extrinsic inhibitory pathways, as well as deleting the PTEN gene to enhance intrinsic regenerative response, were found to promote neural circuit rewiring through a combinatorial approach. While this method increased the potential for rewiring, it did not significantly impact axon regrowth across the lesion and motor recovery.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Syed Faraz Kazim, Christian A. Bowers, Chad D. Cole, Samantha Varela, Zafar Karimov, Erick Martinez, Jonathan Ogulnick, Meic H. Schmidt
Summary: Spinal cord injury is a devastating condition affecting millions worldwide. While axonal regeneration in the adult CNS is limited, there is evidence of spontaneous neural reorganization and plasticity in the corticospinal motor circuitry, showing promise for functional recovery after SCI. Various therapeutic approaches, including neuromodulation and rehabilitative training, have been used to harness this neuroplasticity for improved outcomes in both animal models and clinical studies.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Wei-wei Deng, Guang-yan Wu, Ling-xia Min, Zhou Feng, Hui Chen, Ming-liang Tan, Jian-feng Sui, Hong-liang Liu, Jing-ming Hou
Summary: Activation of glutamate neurons in the primary motor cortex can significantly improve motor function scores in rats, shorten the incubation period of motor evoked potentials, and increase motor potentials' amplitude. Accurate activation of the primary motor cortex can effectively promote tissue recovery and neurofilament growth, while also increasing the content of some growth-related proteins at the injured site. These findings suggest that selective activation of glutamate neurons in the primary motor cortex may play a significant role in promoting functional recovery after SCI and understanding the neural cell mechanism involved in recovery induced by motor cortex stimulation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Xvlei Hu, Yifan Zhang, Lei Wang, Jiangwei Ding, Mei Li, Hailiang Li, Liang Wu, Zhong Zeng, Hechun Xia
Summary: This study found that microglia activation in the primary motor cortex (M1) after spinal cord injury (SCI) mediates chronic neuroinflammation and neuronal damage. The use of minocycline, a microglia inhibitor, can reduce inflammation-induced neuronal damage, protect the integrity of the motor conduction pathway, and promote motor function recovery.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Hang Jin Jo, Ethan Kizziar, Sina Sangari, David Chen, Allison Kessler, Ki Kim, Alan Anschel, Allen W. W. Heinemann, Brett D. D. Mensh, Saria Awadalla, Richard L. L. Lieber, Martin Oudega, Monica A. A. Perez
Summary: Strengthening corticospinal-motoneuronal synapses through Hebbian plasticity promotes functional recovery in chronic spinal cord injury patients, as shown in randomized and prospective studies.
ANNALS OF NEUROLOGY
(2023)
Article
Rehabilitation
Fareea Khaliq, Denesh Ratnasingam, Michael Bush-Arnold
Summary: Patients with spinal cord injuries who are infected with COVID-19 may present with mild symptoms, which can lead to delayed diagnosis and asymptomatic spread.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Review
Medicine, General & Internal
Trevor S. Barss, Behdad Parhizi, Jane Porter, Vivian K. Mushahwar
Summary: Transcutaneous spinal cord stimulation has the potential to improve sensorimotor rehabilitation by modulating spinal cord circuitry non-invasively. It can alter excitability across multiple segments of the spinal cord with single-site stimulation, and multiple sites of stimulation can converge to facilitate spinal reflex and corticospinal networks. Further mechanistic research is needed to optimize targeted rehabilitation strategies and improve clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Engineering, Biomedical
Reza Abiri, Soheil Borhani, Eric W. Sellers, Yang Jiang, Xiaopeng Zhao
JOURNAL OF NEURAL ENGINEERING
(2019)
Article
Clinical Neurology
Nick S. Ward, Fran Brander, Kate Kelly
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2019)
Article
Neurosciences
Andreas M. Ray, Thiago D. C. Figueiredo, Eduardo Lopez-Larraz, Niels Birbaumer, Ander Ramos-Murguialday
HUMAN BRAIN MAPPING
(2020)
Review
Neurosciences
Silvestro Micera, Matteo Caleo, Carmelo Chisari, Friedhelm C. Hummel, Alessandra Pedrocchi
Article
Clinical Neurology
Andrea Caria, Josue Luiz Dalboni da Rocha, Giuseppe Gallitto, Niels Birbaumer, Ranganatha Sitaram, Ander Ramos Murguialday
Article
Engineering, Biomedical
Nerea Irastorza-Landa, Eliana Garcia-Cossio, Andrea Sarasola-Sanz, Doris Broetz, Niels Birbaumer, Ander Ramos-Murguialday
Summary: This study proposed a novel method to measure the temporal correlation between recruitment profiles of healthy modules by paretic and healthy muscles following stroke, termed FSRI, which was shown to be a reliable physiological biomarker for motor function and recovery. Furthermore, BMI-based training with contingent positive proprioceptive feedback was found to improve FSRI values, enhancing effective rehabilitation in stroke patients.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Jingjing Luo, Junjie Zhen, Peng Zhou, Wei Chen, Yuzhu Guo
Summary: This study developed a video-based facial iPPG detecting equipment that provides multi-dimensional spatiotemporal hemodynamic pulsations for high portability and self-monitoring needs. A series of algorithms were also created for physiological indices extraction and visualization of hemodynamic pulsation distribution. The new device offers a reliable measurement of cardiovascular hemodynamics and, combined with advanced computing techniques, presents a promising solution for user-friendly pervasive healthcare.
Article
Neurosciences
Chenxi Chu, Jingjing Luo, Xiwei Tian, Xiangke Han, Shijie Guo
Summary: This study introduced a novel tactile-stimuli P300 paradigm for BCI targeting individuals with learning difficulties or attention deficits. The paradigm utilized a combination of spatial and frequency information to distinguish targets, achieving high classification accuracy.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Youhao Wang, Jingjing Luo, Yuzhu Guo, Qiang Du, Qiying Cheng, Hongbo Wang
Summary: The study demonstrated that for the neurofeedback group, ERP brain network parameters showed significant changes and trends, while for the non-feedback group, most network parameters did not change significantly. The short-term effects of MI-BCI training were not observed significantly in ERD analysis, but could be detected significantly by ERP-based network analysis.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
C. Vidaurre, T. Jorajuria, A. Ramos-Murguialday, K-R Mueller, M. Gomez, V. V. Nikulin
Summary: This study investigates the impact of perturbing motor imagery tasks through peripheral stimulation, showing that inducing movements in non-coincident limbs does not affect BCI performance, while inducing movements in limbs involved in the tasks can be alleviated through spatial filtering. The study also demonstrates the potential use of residual power of sensorimotor rhythm to predict BCI user performance under movement disturbances.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Engineering, Biomedical
Jingjing Luo, Zhengrong Yan, Shijie Guo, Wei Chen
Summary: Atherosclerosis screening plays an important role in the transformation of the medical model from therapeutic medicine to preventive medicine. This study introduces five cutting-edge pervasive technologies for atherosclerosis screening, including iPPG, laser Doppler, RF, TI, optical fiber sensing, and piezoelectric sensor. These noninvasive and mobile technologies can detect physiological parameters related to atherosclerosis.
IEEE REVIEWS IN BIOMEDICAL ENGINEERING
(2022)
Article
Robotics
Fuhao Wang, Hongbo Wang, Jingjing Luo, Xiaoyang Kang, Haoyang Yu, Hao Lu, Yu Dong, Xiaoxu Jia
Summary: This letter presents a flexible tendon-driven continuum surgical manipulator called FLORA, which aims to solve the problems of low flexibility, poor internal extension, and chopstick effect in most laparoscopic surgical robots. The manipulator is composed of three independent flexible segments in series, driven by twelve tendons, and has good flexibility and rigidity. It also features a compact actuation unit and a kinematic modeling method based on piecewise constant curvature model, which can accurately model and fast decouple the manipulator.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2022)
Article
Engineering, Electrical & Electronic
Qiliang Chen, Yulin Huang, Xing Zhu, Hong Lu, Zhongzhi Ji, Jiacheng Yang, Jingjing Luo
Summary: In this paper, a regression model using 3D convolution neural networks (CNN) for locating radial artery upon radius at the wrist using near-infrared picture sequences is proposed. Compared to previous 2D models, the 3D CNN model achieved superior performance accuracy and highlighted dynamic changes within image sequences.
EURASIP JOURNAL ON IMAGE AND VIDEO PROCESSING
(2022)
Article
Engineering, Electrical & Electronic
Yunjie Li, Min Wei, Qiliang Chen, Xing Zhu, Hui Li, Hongbo Wang, Jingjing Luo
Summary: Camera-based image sequences can be used to measure blood pressure continuously and noncontactly using a deep-learning approach called Hybrid D1DCnet. The model can predict systolic and diastolic blood pressure by analyzing forehead imaging photoplethysmography (iPPG) waveforms and personal information. The research demonstrates the feasibility and advantages of using this model to monitor circulatory health and contribute to the prevention and intervention of cardiovascular diseases.
IEEE SENSORS JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Jingjing Luo, Min Wei, Moyi Shi, Yunjie Li, Xing Zhu, Yang Zhou
Summary: This study proposes a novel cardiovascular health state detection procedure based on camera-based iPPG monitoring. The method achieves high accuracy in predicting whether subjects are CVDs relevant patients. The study emphasizes the advantages of using noncontact and high-dimensional features for cardiovascular health assessment.
IEEE SENSORS JOURNAL
(2023)
