Article
Engineering, Biomedical
Cansel Ficici, Ziya Telatar, Osman Erogul
Summary: A method analyzing gray matter reduction in brain magnetic resonance images was proposed to identify epileptogenic focus of temporal lobe epilepsy (TLE) patients. Experimental results showed that the proposed algorithm can reveal subtle Gray matter reduction in the temporal lobe and limbic lobe areas, thus providing an automated medical support system for the expert in identifying the epileptic focus of TLE patients.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Kong, Nan Cheng, Feng-juan Qiu, Lei Yao, Ming Gao, An-qiang Chen, Qing-xia Kong, Gu-qing Zhang
Summary: This study demonstrates that multimodal MRI combined with PET metabolic parameters has high detection value in patients with TLE-DP and can provide independent prognostic information for those who undergo surgery.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Majdi Jber, Jafar Mehvari Habibabadi, Roya Sharifpour, Hengameh Marzbani, Masoud Hassanpour, Milad Seyfi, Neda Mohammadi Mobarakeh, Ahmedreza Keihani, Seyed Sohrab Hashemi-Fesharaki, Mohammadreza Ay, Mohammad-Reza Nazem-Zadeh
Summary: Patients with left TLE showed more prevalent and widespread changes in subcortical volumes and cortical thickness, mainly in the left hemisphere. Hippocampus, thalamus, and pallidum were vulnerable to TLE. Volume changes in hippocampus alone could lead to accurate lateralization of TLE.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Eva Nema, Adam Kalina, Tomas Nikolai, Martin Vyhnalek, Eva Meluzinova, Jan Laczo
Summary: Cognitive deficits are common in early multiple sclerosis (MS), with up to 41% of patients showing lower spatial navigation performance. Demyelinating lesions in early MS may disrupt neural networks associated with allocentric navigation.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Erik Kaestner, Jun Rao, Allen J. J. Chang, Zhong Irene Wang, Robyn M. M. Busch, Simon S. S. Keller, Theodor Ruber, Daniel L. L. Drane, Travis Stoub, Ezequiel Gleichgerrcht, Leonardo Bonilha, Kyle Hasenstab, Carrie McDonald
Summary: This study explores the use of a convolutional neural network (CNN) based on T1-weighted MRI images to determine seizure laterality in patients with epilepsy. The CNN model achieves an average concordance of 78% with clinician lateralization, with the best-performing model reaching 89% concordance. The CNN outperforms random and hippocampal volume models, and extratemporal lobe features contribute to the classification.
Article
Neurosciences
L. Gyger, C. Ramponi, J. F. Mall, K. Swierkosz-Lenart, D. Stoyanov, A. Lutti, A. von Gunten, F. Kherif, B. Draganski
Summary: Using quantitative MRI data, researchers found that ECT treatment can improve depression symptom severity, associated with changes in brain volume estimates and tissue properties. The results provide clues of ECT-induced brain tissue changes over time, and also highlight the preliminary nature of the study due to the small sample size.
Review
Clinical Neurology
Kamalesh Chakravarty, Sucharita Ray, Parampreet S. Kharbanda, Vivek Lal, Jitupam Baishya
Summary: Temporal lobe epilepsy with enlargement of the amygdala is a distinct clinical entity with contrasting clinical features compared to TLE with hippocampal sclerosis. Patients with AE tend to have an older age of onset, less febrile seizures, and similar aura and automatism types as TLE with HS but with lower prevalence.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Giorgi Kuchukhidze, Iris Unterberger, Elisabeth Schmid, Laura Zamarian, Christian Michael Siedentopf, Florian Koppelstaetter, Elke Gizewski, Martin Kronbichler, Gerhard Luef, Hennric Jokeit, Eugen Trinka
Summary: In this study, we found that unilateral mesial TLE and ipsilateral AE could lead to dysfunction in emotion recognition. Patients with right-side mTLE had more impaired perception and recognition of emotions compared to those with left-side mTLE. Patients also showed deficits in emotion recognition compared to healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Honghao Xu, Haitao Zhu, Lei Luo, Rui Zhan
Summary: This study investigated cortical changes in MRI-negative patients with FBTCS, revealing decreased GMV in regions such as the bilateral thalamus and orbitofrontal cortex, but increased GMV in bilateral para-hippocampal regions. GMV levels were significantly negatively correlated with disease duration, suggesting that seizures may lead to neuronal loss and a decrease in GMV. The increase in GMV in some regions may be due to inflammatory responses in the early stages of epileptic seizures.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Behavioral Sciences
Karoline Leiberg, Jane de Tisi, John S. Duncan, Bethany Little, Peter N. Taylor, Sjoerd B. Vos, Gavin P. Winston, Bruno Mota, Yujiang Wang
Summary: Neuroimaging captures brain restructuring after anterior temporal lobe resection (ATLR), a surgical procedure for drug-resistant temporal lobe epilepsy (TLE). This study examines the effects of ATLR on brain morphology, showing significant changes mainly in regions near the resection and structurally connected to the anterior temporal lobe.
Article
Biology
Iman Beheshti, Daichi Sone, Norihide Maikusa, Yukio Kimura, Yoko Shigemoto, Noriko Sato, Hiroshi Matsuda
Summary: This study demonstrates that combining DIR data with machine-learning algorithms can effectively distinguish normal individuals from epileptic subjects and accurately identify the laterality of the focus side in MRI-negative TLE patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Elisa Micalizzi, Anna Elisabetta Vaudano, Giada Giovannini, Giulia Turchi, Leandra Giunta, Stefano Meletti
Summary: Patients with temporal lobe epilepsy may present with central apnea as the first clinical manifestation of their seizures, which could be related to alterations in mesial temporal lobe structures, including the amygdala. Monitoring respiratory changes and oxygen saturation in focal seizures is important for identifying the epileptogenic zone and understanding risk factors for seizure-related autonomic changes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Karl-Heinz Nenning, Olivia Fosleitner, Ernst Schwartz, Michelle Schwarz, Victor Schmidbauer, Gudrun Geisl, Christian Widmann, Susanne Pirker, Christoph Baumgartner, Daniela Prayer, Ekaterina Pataraia, Lisa Bartha-Doering, Georg Langs, Gregor Kasprian, Silvia B. Bonelli
Summary: The study found significant differences in connectivity between left and right TLE patients compared to healthy controls. Left TLE showed widespread impairment of task-positive language networks, while right TLE showed less pronounced alterations. Particularly, right TLE exhibited altered connectivity for cortical regions associated with the default mode network (DMN).
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Mathematical & Computational Biology
Manju Jain, C. S. Rai, Jai Jain
Summary: The study proposes a novel computer-aided decision support system for radiologists to classify brain degeneration and aid in early prognosis of brain degenerative diseases. By utilizing Radiomics feature extraction and ensemble learning classification algorithms, the system achieved high accuracy in classifying brain MRI images. The introduction of a new texture analysis matrix, DGLM, also contributed to the improved performance of the decision support system.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Article
Psychology, Clinical
Mingming Zhang, Yufang Bian
Summary: This study found that the PIU tendency among adolescents is positively correlated with grey matter density in the right inferior parietal lobe, which plays a mediating role in the relationship between anxiety and PIU. The results support the mood enhancement theory and I-PACE model, indicating that individuals with higher anxiety levels are more likely to use the Internet.
ADDICTIVE BEHAVIORS
(2021)
Article
Neurosciences
Liara Rizzi, Thamires Naela Cardoso Magalhaes, Natalie Lecce, Adriel dos Santos Moraes, Raphael Fernandes Casseb, Camila Vieira Ligo Teixeira, Brunno Machado de Campos, Thiago Junqueira Ribeiro de Rezende, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthazar
Summary: This study aimed to evaluate the ability of cerebrospinal fluid (CSF) AD biomarkers, hippocampal volumes, and Default Mode Network functional connectivity to predict clinical response to ChEIs treatment in mild AD. The functional connectivity of the right hippocampus showed a direct relationship with the clinical response to cholinesterase inhibitors (ChEIs) treatment in patients with mild Alzheimer's disease. Transposing our findings to clinical settings could allow physicians to prescribe ChEIs for patients for whom treatment would be most beneficial.
BRAIN CONNECTIVITY
(2023)
Letter
Cardiac & Cardiovascular Systems
Lucas S. Silva, Vinicius O. Boldrini, Ana M. Marques, Clarissa L. Yasuda
CLINICAL CARDIOLOGY
(2023)
Review
Clinical Neurology
Lennart Walger, Sophie Adler, Konrad Wagstyl, Leonie Henschel, Bastian David, Valeri Borger, Elke Hattingen, Hartmut Vatter, Christian E. Elger, Torsten Baldeweg, Felix Rosenow, Horst Urbach, Albert Becker, Alexander Radbruch, Rainer Surges, Martin Reuter, Fernando Cendes, Zhong Irene Wang, Hans-Juergen Huppertz, Theodor Rueber
Summary: Focal cortical dysplasias (FCDs) are common pathologies causing treatment-resistant focal epilepsy. Resective neurosurgery can be successful, but the visual assessment of magnetic resonance imaging is not always accurate in locating FCDs. Computational approaches using artificial intelligence show promise in automatic FCD detection. However, challenges remain in organizing imaging data, evaluating algorithmic output, and making research accessible and reproducible.
Article
Behavioral Sciences
Thamires Naela Cardoso Magalhaes, Raphael Fernandes Casseb, Christian Luiz Baptista Gerbelli, Luciana Ramalho Pimentel-Siva, Mateus Henrique Nogueira, Camila Vieira Ligo Teixeira, Ana Flavia Mac Knight Carletti, Thiago Junqueira Ribeiro de Rezende, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthazar
Summary: The causes of neurodegenerative processes in Alzheimer's disease are not fully understood. Recent studies have shown that damage in white matter may be more severe and widespread than cortical atrophy in the brain, appearing even before gray matter damage. Amyloid-beta and tau proteins in AD can directly affect white matter and spread across brain networks. This study aimed to evaluate whole-brain white matter integrity using diffusion tensor imaging in mild AD and amnestic mild cognitive impairment (aMCI) due to AD. Widespread white matter alterations were found, with correlations between tau proteins and tracts linked to the mesial temporal lobe. However, hippocampal volume better explained the variation in diffusion tensor imaging measures compared to CSF proteins.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Alfredo Damasceno, Luciana Ramalho Pimentel-Silva, Benito Pereira Damasceno, Fernando Cendes
Summary: This study analyzed the cognitive performance of 42 RRMS patients and 30 controls over six years. Different cutoffs were used to evaluate the behavior of cognitive progression. The results showed that fixed cutoffs led to misclassification of many patients as having cognitive worsening, while the relative cutoff performed better.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Cell Biology
Paulo Rogerio Julio, Thais Caldeira, Gustavo Retuci Pinheiro, Carla Helena Capello, Renan Bazuco Fritolli, Roberto Marini, Fernando Cendes, Paula Teixeira Fernandes, Lilian T. L. Costallat, Leticia Rittner, Simone Appenzeller
Summary: Central nervous system (CNS) involvement is common in childhood-onset systemic lupus erythematosus (cSLE), with structural magnetic resonance imaging (MRI) showing global cerebral atrophy and specific involvement of the corpus callosum and hippocampus. A cross-sectional study compared 71 cSLE patients to two control groups, revealing reduced mid-sagittal area of the corpus callosum in both cSLE and adult-onset SLE (aSLE) patients, compared to healthy controls. Microstructural changes, including lower FA values and higher MD, RD, and AD values, were observed in cSLE patients, particularly in the posterior region of the corpus callosum. These changes were associated with low complement levels, presence of anticardiolipin antibodies, and cognitive impairment. Overall, adults with cSLE showed greater microstructural changes in the corpus callosum compared to aSLE, potentially explaining the more severe cognitive impairment and disability observed in cSLE.
Article
Neurosciences
Sophie L. L. Mason, Leandro Junges, Wessel Woldman, Elise R. R. Facer-Childs, Brunno M. de Campos, Andrew P. P. Bagshaw, John R. R. Terry
Summary: The article "The Impact of Chronotype on Cognition and Mental Health" suggests that individuals with a late chronotype have a higher likelihood of developing depression and exhibit poorer cognitive performance during the day. By analyzing rs-fMRI data from both early and late chronotypes, the study reveals that differential information about chronotype is embedded in functional brain networks and this embedding changes throughout the day. These findings provide insights into the relationship between internal physiology, external perturbations, brain networks, and disease.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Guilherme Rossi Assis-Mendonca, Maria Carolina Pedro Athie, Joao Vitor Gerdulli Tamanini, Arethusa de Souza, Gabriel Gerardini Zanetti, Patricia Aline Oliveira Ribeiro de Aguiar Araujo, Enrico Ghizoni, Helder Tedeschi, Marina Koutsodontis Machado Alvim, Vanessa Simao de Almeida, Welliton de Souza, Roland Coras, Clarissa Lin Yasuda, Ingmar Bluemcke, Andre Schwambach Vieira, Fernando Cendes, Iscia Lopes-Cendes, Fabio Rogerio
Summary: In this study, we analyzed the genetic material of FCD II patients and found that the cholesterol synthesis pathway was activated in the gray matter of the brain, which may be a neuroprotective response to seizures. Additionally, we identified upregulation of MTRNR2L12 and GPNMB expression, which may serve as potential neuropathological biomarkers for a cortex chronically exposed to seizures and balloon cells, respectively.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Clarissa Lin Yasuda, Luciana Ramalho Pimentel-Silva, Guilherme Coco Beltramini, Min Liu, Brunno Machado de Campos, Ana Carolina Coan, Christian Beaulieu, Fernando Cendes, Donald William Gross
Summary: Typical aging is associated with cognitive decline and changes in brain structure. In mesial temporal lobe epilepsy patients, cognitive decline starts early in life and runs parallel to controls, suggesting initial insult rather than accelerated decline due to seizures. Whether TLE patients show similar age-related gray and white matter changes as healthy controls is uncertain.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Tamires A. Zanao, Johanna Seitz-Holland, Lauren J. O'Donnell, Fan Zhang, Yogesh Rathi, Tatila M. Lopes, Luciana Ramalho Pimentel-Silva, Clarissa L. Yassuda, Nikos Makris, Martha E. Shenton, Sylvain Bouix, Amanda E. Lyall, Fernando Cendes
Summary: In this study, the relationship between hippocampal sclerosis (HS) and white matter structure in mesial temporal lobe epilepsy (MTLE) was investigated. The results showed that the presence and side of HS were associated with white matter abnormalities, with left-HS demonstrating widespread abnormalities and right-HS showing lower fractional anisotropy (FA). No differences in verbal/nonverbal memory performance were found between the groups, but there were associations between higher FA of visual and verbal memory and specific tracts.
Meeting Abstract
Clinical Neurology
Gabriel Salvador, Mateus Nogueira, Lucas Silva, Italo Aventurado, Fernando Cendes, Marcia Bandini, Antonio Del Nero, Clarissa Yasuda
Meeting Abstract
Clinical Neurology
Lucas Silva, Beatriz Amorim Da Costa, Vitor Guimaraes Correa, Rafael Batista Joao, Mateus Nogueira, Italo Karmann Aventurato, Marina Alvim, Mariana Brito, Fernando Cendes, Clarissa Yasuda
Meeting Abstract
Clinical Neurology
Lucas Silva, Italo Karmann Aventurato, Raphael Casseb, Brunno De Campos, Fernando Cendes, Clarissa Yasuda
Meeting Abstract
Clinical Neurology
Beatriz Amorim Da Costa, Lucas Silva, Maria Mendes, Italo Karmann, Brunno Campos, Mateus Nogueira, Rafael Batista, Fernando Cendes, Clarissa Yasuda
