Article
Clinical Neurology
Lukas Sveikata, Andreas Charidimou, Anand Viswanathan
Summary: This article reviews the implications of aducanumab amyloid-beta immunotherapy for treating Alzheimer's disease with comorbid cerebral amyloid angiopathy. It discusses the potential impact of cerebral amyloid angiopathy on the effectiveness of immunotherapy and proposes strategies to identify it in patients considered for this treatment.
Review
Clinical Neurology
Konark Malhotra, Christina Zompola, Aikaterini Theodorou, Aristeidis H. Katsanos, Ashkan Shoamanesh, Himanshu Gupta, Simon Beshara, Nitin Goyal, Jason Chang, Ashis H. Tayal, Efstathios Boviatsis, Konstantinos Voumvourakis, Charlotte Cordonnier, David J. Werring, Andrei V. Alexandrov, Georgios Tsivgoulis
Summary: Among patients with spontaneous intracerebral hemorrhage, approximately 1 in 4 cases have undetermined etiology, leading to a relatively high short-term mortality rate. Cerebral amyloid angiopathy accounts for the largest hemorrhage volume, while hypertensive arteriopathy and undetermined ICH have smaller volumes.
Article
Neurosciences
Mengke Zhang, Ruiwen Che, Wenbo Zhao, Hailiang Sun, Changhong Ren, Jin Ma, Wenbo Hu, Milan Jia, Chuanjie Wu, Xin Liu, Xunming Ji
Summary: This study aimed to explore the relationship between computed tomography (CT)-based cerebral small vessel disease (SVD) markers and the clinical outcomes in patients with cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH). The results showed that the SVD markers based on CT could predict the short-term outcome more effectively in patients with CAA-ICH. Further studies are needed to validate these findings and identify modifiable factors for preventing CAA-ICH development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Edgar Chan, Guendalina B. Bonifacio, Corin Harrison, Gargi Banerjee, Jonathan G. Best, Benjamin Sacks, Nicola Harding, Maria del Rocio Hidalgo Mas, H. Rolf Jager, Lisa Cipolotti, David J. Werring
Summary: This study investigated the cognitive function of patients with cerebral amyloid angiopathy (CAA) with and without intracerebral hemorrhage (ICH) and found that cognitive impairment is common in CAA, indicating the potential role of underlying neurodegeneration, possibly related to co-existing Alzheimer's disease pathology.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
S. Voigt, P. C. de Kruijff, E. A. Koemans, I Rasing, E. S. van Etten, G. M. Terwindt, M. J. P. van Osch, M. A. van Buchem, M. A. A. van Walderveen, M. J. H. Wermer
Summary: Superficially located asymptomatic cerebellar macrobleeds and microbleeds are common in Dutch-type hereditary CAA. Cerebellar microbleeds are already present in the presymptomatic stage and are predominantly superficially located. Despite the high frequency of cerebellar micro and macrobleeds, CAA pathology did not result in symptomatic cerebellar ICH in patients with D-CAA.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Nicolas Raposo, Maria Clara Zanon Zotin, David J. Seiffge, Qi Li, Martina B. Goeldlin, Andreas Charidimou, Ashkan Shoamanesh, Hans Rolf Jager, Charlotte Cordonnier, Catharina Jm Klijn, Eric E. Smith, Steven M. Greenberg, David J. Werring, Anand Viswanathan
Summary: The study developed a new classification system called CLAS-ICH for subtyping intracerebral hemorrhage (ICH) based on recent advances in neuroimaging. The system assigns scores to each category to determine the underlying causes of ICH. The system was validated in two cohorts and demonstrated reliability and consistency.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yuyi Zhu, Lu Liu, Luyao Zhong, Yajun Cheng, Shihong Zhang, Bo Wu, Deren Wang, Mangmang Xu
Summary: The study aims to investigate the association between burden of cerebral small vessel disease (CSVD) caused by hypertensive angiopathy (HA) and cerebral amyloid angiopathy (CAA) on MRI in patients with primary intracerebral hemorrhage (ICH). The results showed a significant association between HA-CSVD and CAA-CSVD, which needs to be confirmed in future studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Simon Fandler-Hoefler, Thomas Gattringer, Christian Enzinger, David J. Werring
Summary: This study found that patients with probable CAA who were diagnosed using the Boston v2.0 criteria had a lower risk of ICH recurrence compared to those diagnosed using the v1.5 criteria.
Article
Clinical Neurology
Evangelos Pavlos Myserlis, Christopher D. Anderson, Marios K. Georgakis
Summary: Recent evidence suggests that higher CRP levels are associated with lower risk of Alzheimer disease, and this study explores whether genetically proxied CRP levels are also associated with lobar intracerebral hemorrhage (ICH) caused by cerebral amyloid angiopathy. The results show that higher genetically proxied CRP levels are associated with lower odds of lobar ICH, supporting the hypothesis that high CRP levels may have a protective role in amyloid-related pathology.
Article
Clinical Neurology
Sandro Marini, Jaeyoon Chung, Xudong Han, Xinyu Sun, Livia Parodi, Lindsay A. Farrer, Jonathan Rosand, Jose Rafael Romero, Christopher D. Anderson
Summary: This study identified a potential association between the CDH9 gene and lobar intracerebral hemorrhage (ICH), which is related to cerebral amyloid angiopathy (CAA) and cerebrospinal fluid amyloid-beta 42 (CSF-A beta 42) levels. Further research is needed to understand the effects of this gene variant on the pathogenesis of ICH and its clinical significance.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Ulf Jensen-Kondering, Nils G. Margraf, Caroline Weiler, Walter Maetzler, Justina Dargvainiene, Kim Falk, Sarah Philippen, Thorsten Bartsch, Charlotte Flueh, Christoph Roecken, Bettina Moeller, Georg Royl, Alexander Neumann, Norbert Brueggemann, Benjamin Roeben, Claudia Schulte, Benjamin Bender, Daniela Berg, Gregor Kuhlenbaeumer
Summary: This study compared the clinical, radiological, and cerebrospinal fluid marker data of patients with CAA, MLH, AD, and healthy controls. The results showed that cSS was more common in CAA, and MLH with cSS was associated with ICH. The concentrations of cerebrospinal fluid markers differed among the groups.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Endocrinology & Metabolism
Jenny Szu, Andre Obenaus
Summary: Alzheimer's disease is a devastating neurological disorder characterized by memory and cognitive decline, with two main hypotheses proposed regarding its underlying mechanisms. The amyloid hypothesis suggests A beta accumulation as the basis of AD, while the vascular hypothesis links early vascular damage to increased A beta deposits in the brain. Studies have shown significant morphological changes in the cerebrovasculature associated with AD progression, highlighting the need for further research in this area.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Hsin-Hsi Tsai, Szu-Ju Chen, Li-Kai Tsai, Marco Pasi, Yen-Ling Lo, Ya-Fang Chen, Sung-Chun Tang, Jiann-Shing Jeng
Summary: This study compared clinical data and follow-up outcomes of patients with mixed ICH, CAA-ICH, and HTN-ICH, and found that mixed ICH has a higher risk of unfavorable vascular outcome compared to HTN-ICH. The presence of cortical superficial siderosis (cSS) in mixed ICH independently predicts vascular events, suggesting a detrimental effect due to coexisting CAA.
Article
Medicine, General & Internal
Russell P. Sawyer, Stacie L. Demel, Mary E. Comeau, Miranda Marion, Jonathan Rosand, Carl D. Langefeld, Daniel Woo
Summary: Apolipoprotein E alleles are associated with both Alzheimer's disease and intracerebral hemorrhage; intracerebral hemorrhage has a high risk of subsequent dementia; variations in CR1 and CLU genes are associated with an increased risk of lobar ICH.
Article
Neurosciences
Riccardo Milani, Lucio Aniello Mazzeo, Daniela Vismara, Ilaria Salemi, Emanuele Dainese, Emanuela Maderna, Elisa Pellencin, Marcella Catania, Nicole Campanella, Giuseppe Di Fede, Giorgio Giaccone, Andrea Salmaggi
Summary: Cerebral amyloid angiopathy (CAA) is a small vessel disease that leads to spontaneous intracerebral hemorrhage (ICH) in the elderly and is strongly associated with Alzheimer's disease (AD). Recently, iatrogenic early-onset CAA has been identified in patients who had a history of traumatic brain injury or other cerebral and extra-cerebral lesions that required neurosurgery or other medical procedures. The transmission of A beta seeds from neurosurgical instruments or exposure to cadaveric dura mater is suspected to be involved.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
