Article
Clinical Neurology
Luc Masset, Milan Nigam, Anne Ladarre, Marie Vidailhet, Smaranda Leu-Semenescu, Philippe Fossati, Isabelle Arnulf, Jean-Baptiste Maranci
Summary: Dreams during REM sleep can help reduce negative emotions, as shown by the study on emotional dynamics. Previous studies were limited to dream reports, but by studying individuals with REM sleep behavior disorder (RBD), researchers gained direct access to observe emotional dream behaviors. Analysis of 17 participants with RBD and 39.7 hours of REM sleep video revealed that emotional behaviors follow a biphasic temporal course, with an initial increase in frequency followed by a progressive decrease. Negative emotional behaviors occurred earlier than positive and neutral behaviors, and rapid succession of emotions of opposite valence was observed to prevent prolonged periods of negative emotions.
Article
Peripheral Vascular Disease
Rong Ren, Ye Zhang, Linghui Yang, Yuan Shi, Naima Covassin, Xiangdong Tang
Summary: This study aimed to quantify the independent association between arousals during REM/NREM sleep and prevalent hypertension. The results showed a significant dose-response relationship between arousal index during REM sleep and hypertension, while arousal index during NREM sleep was not a significant predictor of hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Pao-Huan Chen, Cheng-Chih Chung, Shuen-Hsin Liu, Yu-Hsun Kao, Yi-Jen Chen
Summary: Lithium treatment can improve cardiac dysfunction caused by REM sleep deprivation and alleviate fibrosis. The potential mechanisms may involve the regulation of TGF-β, angiotensin II, and Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Cole D. Stang, Aidan F. Mullan, Mania Hajeb, Emanuele Camerucci, Pierpaolo Turcano, Peter Martin, Michelle M. Mielke, Keith A. Josephs, James H. Bower, Erik K. St Louis, Bradley F. Boeve, Rodolfo Savica
Summary: The study revealed that the prevalence of rapid eye movement (REM) sleep behavior disorder (RBD) increased over time in patients with alpha-synucleinopathies, with higher likelihood of developing RBD in male patients. However, RBD did not increase mortality risk within the cohort.
ANNALS OF NEUROLOGY
(2021)
Article
Clinical Neurology
Marcus O. Harrington, Jennifer E. Ashton, Hong-Viet V. Ngo, Scott A. Cairney
Summary: This study manipulated theta activity during sleep using auditory closed-loop stimulation, showing that stimulation led to a short-term increase in theta power followed by a prolonged suppression, as well as an increase in beta power. These results highlight the potential of auditory stimulation in investigating REM sleep electrophysiology and its impact on behavior.
Article
Biology
Brittany J. Bush, Caroline Donnay, Eva-Jenee A. Andrews, Darielle Lewis-Sanders, Cloe L. Gray, Zhimei Qiao, Allison J. Brager, Hadiya Johnson, Hamadi C. S. Brewer, Sahil Sood, Talib Saafir, Morris Benveniste, Ketema N. Paul, J. Christopher Ehlen
Summary: Resilience, the ability to overcome stressful conditions, varies significantly among individuals and is influenced by sleep amount and sleep regulation in the prefrontal cortex.
Article
Clinical Neurology
Carlos M. O. de Almeida, Manuelina M. C. Brito, Nayanne B. Bosaipo, Angela V. Pimentel, Vitor Tumas, Antonio W. Zuardi, Jose A. S. Crippa, Jaime E. C. Hallak, Alan L. Eckeli
Summary: This study evaluated the efficacy and safety of CBD as an alternative therapy for RBD in patients with Parkinson's disease. While CBD did not show significant differences compared to placebo for primary outcomes, there was a transient improvement in sleep satisfaction observed with a 300mg dose.
MOVEMENT DISORDERS
(2021)
Article
Physiology
Evgeny Yu Bersenev, Yulia Ukraintseva, Gennadiy Kovrov, Yusef D. Yakhya, Galina Yu Vassilieva, Elena S. Tomilovskaya, Ilya Rukavishnikov, Sergey Posokhov, Artemiy Orlov, Nikolay Yu Osetsky, Oleg Orlov
Summary: During the 21-day Dry Immersion (DI), sleep architecture was significantly disturbed on the 3rd day, but returned to baseline values after the 10th day. An increase in REM duration on the 19th day and in recovery was accompanied by changes in nighttime heart rate and blood pressure parameters, suggesting regulatory changes in the cardiovascular system in response to environmental changes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Geriatrics & Gerontology
Chao Han, Jing An, Piu Chan
Summary: The study found that both pRBD and sleep insufficiency were independently associated with an increased risk of falls among the elderly population in China. When these two factors coexisted, the risk of falls increased less than expected, indicating a negative interaction between them.
Article
Clinical Neurology
Julia E. Perkins, Annette Janzen, Felix P. Bernhard, Karen Wilhelm, Donald C. Brien, Jeff Huang, Brian C. Coe, David Vadasz, Geert Mayer, Douglas P. Munoz, Wolfgang H. Oertel
Summary: Patients with isolated REM Sleep Behavior Disorder (RBD) and Parkinson's disease (PD) show altered pupil and blink behavior compared to healthy controls. While RBD saccade parameters were similar to controls, suggesting that pupil and blink brain areas may be impacted before saccadic control areas, making them potential prodromal PD biomarkers.
MOVEMENT DISORDERS
(2021)
Review
Multidisciplinary Sciences
Zhiqiang Que, Cuifeng Zheng, Zhenhua Zhao, Yanhong Weng, Zhibao Zhu, Yuqi Zeng, Qinyong Ye, Fabin Lin, Guoen Cai
Summary: Clonazepam and melatonin are effective medications for RBD, with clonazepam improving sleep stage and melatonin improving sleep efficiency and quality. Ramelteon can reduce RWA, and pramipexole can increase total sleep time and reduce PLMS index. Pramipexole also has different effects on different types of RBD.
Review
Pediatrics
Marit S. Knoop, Eline R. de Groot, Jeroen Dudink
Summary: Understanding the relationship between sleep and brain development is crucial, as REM sleep and NREM sleep play different roles in various aspects of brain maturation. Research suggests that sleep problems can have different consequences on the developing brain, depending on the age of the individual. A hypothetical model has been proposed to illustrate the dynamic relationship between REM sleep, NREM sleep, and brain maturation processes, providing implications for neonatal care practices and future research directions.
Article
Food Science & Technology
Min Young Um, Minseok Yoon, Jaekwang Lee, Jonghoon Jung, Suengmok Cho
Summary: The study found that turmeric has a sleep-promoting effect by reducing sleep latency and enhancing non-rapid eye movement sleep through H1R blockade. This mechanism was validated in experiments and may have potential clinical value for treating insomnia.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Neurosciences
Qin Chen, Xiang Fu, Xian-Hui Wang, Jing Chen, Jun-Ying Huang, Cheng-Jie Mao, Wan-Qing Zhai, Jie Li, Chun-Feng Liu
Summary: Sleep-disordered breathing is an independent risk factor for short-term outcomes of acute ischemic stroke, while the influence during rapid eye movement sleep and non-rapid eye movement sleep does not significantly differ in affecting stroke outcomes.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Jing Chen, Liche Zhou, Chao Jiang, Zhichun Chen, Lina Zhang, Haiyan Zhou, Wenyan Kang, Xufeng Jiang, Yuanyuan Li, Ningdi Luo, Mengsha Yao, Mengyue Niu, Shengdi Chen, Xi-Nian Zuo, Li Li, Jun Liu
Summary: This study identified ocular-tracking abnormalities in patients with iRBD even in early disease progression, coupled with atrophy of brain areas involved in the perception of object motion, indicating potential phenoconversion to synucleinopathies in iRBD.
MOVEMENT DISORDERS
(2022)