Article
Engineering, Biomedical
Shuangpeng Jiang, Guangzhao Tian, Zhen Yang, Xiang Gao, Fuxin Wang, Juntan Li, Zhuang Tian, Bo Huang, Fu Wei, Xinyu Sang, Liuqi Shao, Jian Zhou, Zhenyong Wang, Shuyun Liu, Xiang Sui, Quanyi Guo, Weimin Guo, Xu Li
Summary: This study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. The promoting effect may be related to the polarization of macrophages and inhibition of inflammatory response by hWJMSC-Exos. Additionally, hWJMSC-Exos contain miRNAs that can promote hyaline cartilage regeneration.
BIOACTIVE MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Zeqing Zhao, Jin Liu, Michael D. Weir, Abraham Schneider, Tao Ma, Thomas W. Oates, Hockin H. K. Xu, Ke Zhang, Yuxing Bai
Summary: This review article presents the recent advances in PDLSC-based bone regeneration and periodontal tissue regeneration. By combining PDLSCs with various materials and scaffolds, as well as applying different osteoinductive agents and strategies, PDLSCs demonstrate the potential for bone and periodontal tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jun Kim, Hoon-Seong Choi, Young-Min Kim, Soo-Chang Song
Summary: In this study, a bioink system with tunable mechanical properties and biological activities for 3D bioprinting is developed. The bioink system allows easy control of mechanical properties by varying temperature. The printed scaffold using this bioink system shows significantly improved bone regenerative effects when implanted in vivo.
Article
Health Care Sciences & Services
Xiaodi Sun, Yupu Mao, Beibei Liu, Ke Gu, Han Liu, Wei Du, Ruixin Li, Jian Zhang
Summary: Researchers combined human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) with 3D-printed silk fibroin/collagen I/nano-hydroxyapatite (SF/COL-I/nHA) scaffolds and implanted them into alveolar bone defects, promoting angiogenesis and osteogenesis and providing new ideas for treating alveolar bone defects.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell Biology
Sandra Stamnitz, Agnieszka Krawczenko, Urszula Szalaj, Zaneta Gorecka, Agnieszka Antonczyk, Zdzislaw Kielbowicz, Wojciech Swieszkowski, Witold Lojkowski, Aleksandra Klimczak
Summary: FGF-2 and BMP-2 enhance the osteogenic differentiation potential of MSCs grown on a scaffold, making them promising tools for bone regeneration. This was confirmed through in vitro and in vivo experiments.
Article
Chemistry, Medicinal
Farah Alwani Azaman, Margaret E. Brennan E. Fournet, Suzina Sheikh Ab Hamid, Muhamad Syahrul Fitri Zawawi, Valdemiro Amaro da Silva Junior, Declan M. M. Devine
Summary: The field of bone tissue engineering is developing various bone graft substitute materials to reconstruct new bone tissue while maintaining native bone characteristics. Insufficient scaffold degradation is currently the critical limitation for tailoring bone formation turnover rate. This study examines novel scaffold formulations, and results show that the CS/HAp/FAp 1:1 formulation can improve scaffold degradation and bone regeneration, providing a cost-effective alternative to traditional methods (BMP-2).
Article
Engineering, Biomedical
Liaobing Xin, Xiaowen Zheng, Jianmin Chen, Sentao Hu, Yilun Luo, Qunzi Ge, Xiaoying Jin, Lie Ma, Songying Zhang
Summary: This study explores an acellular biomaterial called SDF-1 alpha/E7-modified collagen scaffold (CES), which enables near-complete endometrium regeneration and fertility restoration by mobilizing endogenous MSCs. The results demonstrate that CES can overcome the traditional limitations of cell-based therapies and serve as a clinically feasible and cell-free strategy with high therapeutic efficiency for IUA treatment.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Mehdi Azizi, Amin Shavandi, Masoud Hamidi, Shayan Gholizadeh, Mahnaz Mohammadpour, Mohammad Saeid Salami, Hadi Samadian
Summary: Tissue engineering is an innovative approach that combines engineering, biomaterials, and biomedicine to improve conventional bone defect treatment. This study developed bioengineered electroactive and bioactive mineralized carbon nanofibers as a scaffold for bone tissue engineering. The fabricated scaffold showed osteoactivity, electrical conductivity, and biocompatibility, making it an effective solution for bone tissue engineering.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Linqi Guo, Zhihui Liang, Liang Yang, Wenyan Du, Tao Yu, Huayu Tang, Changde Li, Hongbin Qiu
Summary: Bone is a dynamic self-healing organ with continuous remodeling, but surgical interventions and bone substitutes are needed for repairing large traumatic injuries. Bone tissue engineering aims to repair and regenerate tissues, with natural polymers like collagen and chitosan widely used in the field.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Cam-Hoa Mac, Hao-Yu Chan, Yi-Hsuan Lin, Amit Kumar Sharma, Hsiang-Lin Song, Yi-Sheng Chan, Kun-Ju Lin, Yu-Jung Lin, Hsing-Wen Sung
Summary: This study proposes a biomaterial-based scaffold consisting of radially aligned mineralized collagen fibers and nanosilicon. The scaffold guides the directional infiltration and migration of reparative cells and releases hydrogen gas and silicic acid, promoting bone regeneration.
Review
Engineering, Biomedical
Xiurui Zhang, Yuwei Liu, Karen L. Clark, Anne-Marie Padget, Peter G. Alexander, Jianwu Dai, Weimin Zhu, Hang Lin
Summary: Mesenchymal stem cell-derived extracellular matrix (mECM) is gaining attention in tissue engineering due to its bioactivity, biocompatibility, and potential for autologous tissue engineering. However, current mECM methods have limitations such as low mechanical properties and lack of internal architecture. This review summarizes the development of mECM, recent methods to improve its properties, and proposes future studies for its application in regenerating tissues in humans.
BIOMEDICAL MATERIALS
(2021)
Review
Cell Biology
Venkata Suresh Venkataiah, Yoshio Yahata, Akira Kitagawa, Masahiko Inagaki, Yusuke Kakiuchi, Masato Nakano, Shigeto Suzuki, Keisuke Handa, Masahiro Saito
Summary: Bone tissue engineering involves combining MSCs with a biocompatible scaffold to aid in bone regeneration and recovery. While promising results have been seen in clinical trials, regenerating large bone defects remains a challenge.
Article
Engineering, Multidisciplinary
Lin Zou, Le Hu, Panpan Pan, Solaiman Tarafder, Mingzu Du, Yusheng Geng, Gan Xu, Li Chen, Jingdi Chen, Chang H. Lee
Summary: The polycaprolactone and nano-hydroxyapatite composite is a promising material for bone scaffolds with excellent mechanical properties. In this study, a 3D printed scaffold embedded with poly (lactic-co-glycolic acid) microspheres was developed for controlled delivery of Icariin to promote bone regeneration.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Shengqi Zang, Can Xiao, Maodian He, Bo Chen, Bingyao Liu, Shuai Yi, Lei Wang, Junxia Li, Xiaolei Shi, Shoushan Bu, Lei Jin
Summary: Biomimetic surface modification using ZrO2 scaffold with rhBMP-7 and RGD has shown promising results in improving bioactivity and stimulating stem cell signals in bone tissue engineering. The combination of rhBMP-7 and RGD enhanced osteogenic differentiation and in vivo bone formation in critical-sized calvarial bone defects implanted with hDPSCs-seeded ZrO2-RGD-BMP-7 scaffold. These findings support the application of this surface-modifying biomolecule and stem cell-based approach for bone regeneration.
MATERIALS & DESIGN
(2023)
