Review
Neurosciences
Adnan Hassan Tahir, Jia-Jia Li, Yong Tang
Summary: Visceral hypersensitivity (VH) is a significant characteristic feature of gastrointestinal disorders, and treatment efficacy is limited. Electro-acupuncture (EA) is a popular secondary therapy with fewer side effects for managing VH, but the underlying mechanisms still require further exploration.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Yuanzhen Yang, Jiaqi Wang, Chaoyang Zhang, Yi Guo, Meidan Zhao, Man Zhang, Zhongzheng Li, Feifei Gao, Yu Luo, Yiru Wang, Junyi Cao, Mingfang Du, Yuzhe Wang, Xiaowei Lin, Zhifang Xu
Summary: This review explores the central and peripheral analgesic mechanisms of acupuncture in the treatment of Irritable Bowel Syndrome (IBS). Acupuncture can alleviate inflammation and pain, regulate emotional components, and improve pain caused by IBS.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Veterinary Sciences
Jingwen Cui, Wanrong Song, Yipeng Jin, Huihao Xu, Kai Fan, Degui Lin, Zhihui Hao, Jiahao Lin
Summary: Acupuncture, a conventional treatment method, is an essential part of Traditional Chinese Medicine. Recent studies have shown that acupuncture can activate local cell functions and regulate the release of biomolecules, ultimately affecting the neuroendocrine-immune network for holistic regulation. Efforts are ongoing to further understand the mechanisms of acupuncture through systems approaches like metabolomics and genomics.
VETERINARY SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura
Summary: In this study, it was found that Imeglimin can improve visceral hypersensitivity and colonic hyperpermeability in the IBS rat model by acting on AMPK and opioid receptors, suggesting its potential effectiveness in the treatment of IBS.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Oncology
He-Yong Tang, Xi-Qiuyu Chen, Hao Wang, Hao-Ran Chu, Cai-Feng Zhu, Shun Huang, Meng-Ting Zhang, Guo-Ming Shen
Summary: This study found that acupuncture treatment can effectively alleviate diarrhea symptoms in IBS-D rats. It achieves this by regulating the expression of certain genes and proteins, reducing the release of inflammatory factors, chemokines, and neurotransmitters, thus lowering visceral hypersensitivity.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Yuqin He, Yan Tan, Jianru Zhu, Xiaofeng Wu, Zhiyong Huang, Hengsheng Chen, Min Yang, Dongfeng Chen
Summary: The study found a clear positive correlation between the level of IRAK1 and visceral hypersensitivity in IBS models, and treatment with sodium butyrate could alleviate visceral hypersensitivity by inhibiting the expression of IRAK1.
Article
Medicine, Research & Experimental
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura
Summary: Phlorizin was found to improve visceral hypersensitivity and colonic hyperpermeability in IBS models by inhibiting SGLT2, and these effects were mediated via the AMPK, NO, and opioid pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ting-Hao Wang, Ming-Hui Wang, Chih-Cheng Shih, Ying-Hsin Lu, Hao-Xuan Zheng, Yi-Ting Tseng, Wen-Long Hu, Ting-Chang Chang, Yu-Chiang Hung
Summary: The study investigated a new acupuncture needle material treated with nitrogen, showing significantly improved needling sensations and therapeutic effects compared to conventional stainless steel needles. Results indicated that the SCF-N surface treatment enhanced electrical conductivity and de-qi sensations, suggesting potential for future use as a new acupuncture needle material.
BIOMEDICAL JOURNAL
(2021)
Review
Neurosciences
Zhiqiang Dou, Na Su, Ziyang Zhou, Aoyue Mi, Luyao Xu, Jiazheng Zhou, Sizhe Sun, Yanyi Liu, Mingyao Hao, Zhaofeng Li
Summary: Visceral pain is a complex condition that can be alleviated by acupuncture. Acupuncture modulates multiple brain regions and neural circuits, as well as neurotransmitters and receptors. However, there are limitations in understanding the specific brain mechanisms associated with the effects of acupuncture on visceral pain.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Integrative & Complementary Medicine
Won-Suk Sung, Jeong-Hyun Moon, Seong-Kyeong Choi, Hyo-Rim Jo, Hye-Ryeon Kim, Chi-Yeon Lim, Byung-Kwan Seo, Seung-Deok Lee, Eun-Jung Kim
Summary: This study investigated the analgesic effects of electroacupuncture (EA) using the quantitative sensory test (QST). The results showed significant changes in thermal pain thresholds in the EA group, supporting the analgesic effect of EA.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Toshikatsu Okumura, Tsukasa Nozu, Masatomo Ishioh, Sho Igarashi, Shima Kumei, Masumi Ohhira
Summary: The study found that butyrate can improve gut permeability and visceral nociception through central nervous system, possibly through cannabinoid signaling. Endogenous orexin in the brain may mediate the reduction of intestinal hyperpermeability by butyrate. Central butyrate may induce visceral antinociception and protection from septic lethality.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Urban Studies
Rano Turaeva
Summary: This paper explores the composition of the propiska regime in post-Soviet urban space and its implications for state and society relations, finding that both internal and international migrants are restricted by this system in their movements and welfare entitlements, leading to legal and illegal situations.
Article
Multidisciplinary Sciences
Cheng Zhao, Yuan Xie, Lizhen Xu, Fan Ye, Ximing Xu, Wei Yang, Fan Yang, Jiangtao Guo
Summary: The TRPM8 channel acts as the primary cold sensor in humans and can be activated by ligands such as menthol, icilin, and PIP2. This study determined the structures of mouse TRPM8 in different states, revealing its overall architecture and the basis for ligand recognition.
NATURE COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Li Wang, Chao-Chao Yu, Jia Li, Qing Tian, Yan-Jun Du
Summary: This review mainly discusses the relationship between the hypothalamic nuclei, related neuropeptides, brainstem, peripheral signals, and obesity, as well as mechanisms of acupuncture on obesity, exploring the current evidence and therapeutic targets for mechanism of action of acupuncture in obesity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura
Summary: The study demonstrated that EMA401 may improve gut function in IBS through opioid signaling, blocking visceral hypersensitivity and colonic hypermeability. These findings provide a new potential treatment for IBS.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
