Prenatal Immune and Endocrine Modulators of Offspring's Brain Development and Cognitive Functions Later in Life

Maternal Systemic Interleukin-6 During Pregnancy Is Associated With Newborn Amygdala Phenotypes and Subsequent Behavior at 2 Years of Age

(2018) Alice M. Graham et al.   BIOLOGICAL PSYCHIATRY

Prenatal maternal stress is associated with toddler cognitive functioning: The Iowa Flood Study

(2018) David P. Laplante et al.   EARLY HUMAN DEVELOPMENT

Perinatal stress moderates the link between early and later emotional skills in very preterm-born children: An 11-year-long longitudinal study

(2018) Nevena Dimitrova et al.   EARLY HUMAN DEVELOPMENT

Maternal IL-17A in autism

(2018) Helen Wong et al.   EXPERIMENTAL NEUROLOGY

Prenatal maternal mood patterns predict child temperament and adolescent mental health

(2018) Laura M. Glynn et al.   JOURNAL OF AFFECTIVE DISORDERS

The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia

(2018) Jada Bittle et al.   Journal of Neuroinflammation

Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring

(2018) Marc D. Rudolph et al.   NATURE NEUROSCIENCE

Differential effects of childhood neglect and abuse during sensitive exposure periods on male and female hippocampus

(2018) Martin H. Teicher et al.   NEUROIMAGE

Maternal anxiety, depression and sleep disorders before and during pregnancy, and preschool ADHD symptoms in the NINFEA birth cohort study

(2018) L. Vizzini et al.   Epidemiology and Psychiatric Sciences

Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia

(2018) Chin W. Hui et al.   Frontiers in Molecular Neuroscience

Intergenerational Transmission of Maternal Childhood Maltreatment Exposure: Implications for Fetal Brain Development

(2017) Claudia Buss et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood

(2017) Wandert Schaafsma et al.   NEUROBIOLOGY OF DISEASE

Maternal exercise reverses morphologic changes in amygdala neurons produced by prenatal stress

(2017) Carlos Ancatén González et al.   NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH

Prenatal maternal cortisol concentrations predict neurodevelopment in middle childhood

(2017) Elysia Poggi Davis et al.   PSYCHONEUROENDOCRINOLOGY

The serological evidence for maternal influenza as risk factor for psychosis in offspring is insufficient: critical review and meta-analysis

(2017) Jean-Paul Selten et al.   SCHIZOPHRENIA RESEARCH

Modulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology

(2017) Sergei Kirischuk et al.   Frontiers in Cellular Neuroscience

Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role ofOXTRrs53576 genotype

(2016) Jolien Rijlaarsdam et al.   Autism Research

Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies

(2016) Sandra Giovanoli et al.   BRAIN BEHAVIOR AND IMMUNITY

Prenatal anxiety, maternal stroking in infancy, and symptoms of emotional and behavioral disorders at 3.5 years

(2016) Andrew Pickles et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Stressful Life Events During Pregnancy and Offspring Depression: Evidence From a Prospective Cohort Study

(2016) Mila Kingsbury et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Fetal exposure to maternal stress and risk for schizophrenia spectrum disorders among offspring: Differential influences of fetal sex

(2016) Anna M. Fineberg et al.   PSYCHIATRY RESEARCH

Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity

(2016) María Emilia Solano et al.   Seminars in Immunopathology

Implications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age

(2016) Alice M. Graham et al.   Developmental Cognitive Neuroscience

Prenatal maternal bereavement and risk of eating disorders in infants and toddlers: a population-based cohort study

(2015) Xiujuan Su et al.   BMC Psychiatry

Maternal depression during pregnancy and offspring depression in adulthood: Role of child maltreatment

(2015) Dominic T. Plant et al.   BRITISH JOURNAL OF PSYCHIATRY

Maternal prenatal depressive symptoms predict infantNR3C11F andBDNFIV DNA methylation

(2015) EC Braithwaite et al.   Epigenetics

Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex

(2015) Marie Anaïs Labouesse et al.   Epigenetics

Sex-specific and time-dependent effects of prenatal stress on the early behavioral symptoms of ADHD: a longitudinal study in China

(2015) Peng Zhu et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

A prospective study of effects of prenatal maternal stress on later eating-disorder manifestations in affected offspring: Preliminary indications based on the project ice storm cohort

(2015) Annie St-Hilaire et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

Associations of maternal and paternal antenatal mood with offspring anxiety disorder at age 18 years

(2015) Lauren E. Capron et al.   JOURNAL OF AFFECTIVE DISORDERS

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation

(2015) María Emilia Solano et al.   JOURNAL OF CLINICAL INVESTIGATION

High maternal cortisol levels during pregnancy are associated with more psychiatric symptoms in offspring at age of nine – A prospective study from Nicaragua

(2015) J. Isaksson et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Maternal microchimerism: lessons learned from murine models

(2015) Ina Annelies Stelzer et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Epigenetic and transgenerational reprogramming of brain development

(2015) Tracy L. Bale   NATURE REVIEWS NEUROSCIENCE

Stress Effects on Neuronal Structure: Hippocampus, Amygdala and Prefrontal Cortex

(2015) Bruce S McEwen et al.   NEUROPSYCHOPHARMACOLOGY

Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: A critical review

(2015) Helena Palma-Gudiel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

(2015) Ali B. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Associations Between Maternal Infection During Pregnancy, Childhood Infections and the Risk of Subsequent Psychotic Disorder—A Swedish Cohort Study of Nearly 2 Million Individuals

(2015) Åsa Blomström et al.   SCHIZOPHRENIA BULLETIN

Systematic Review of the Neurobiological Relevance of Chemokines to Psychiatric Disorders

(2015) Michael J. Stuart et al.   Frontiers in Cellular Neuroscience

Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells

(2015) Joanna Ślusarczyk et al.   Frontiers in Cellular Neuroscience

Oscillatory Activity in Developing Prefrontal Networks Results from Theta-Gamma-Modulated Synaptic Inputs

(2015) Sebastian H. Bitzenhofer et al.   Cell Reports

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

THE RELATIONSHIP BETWEEN MATERNAL DEPRESSIVE, ANXIOUS, AND STRESS SYMPTOMS DURING PREGNANCY AND ADULT OFFSPRING BEHAVIORAL AND EMOTIONAL PROBLEMS

(2014) Kim S. Betts et al.   DEPRESSION AND ANXIETY

The association between prenatal environment and children’s mental health trajectories from 2 to 14 years

(2014) Jessica E. Tearne et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes

(2014) A. L. Teh et al.   GENOME RESEARCH

Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells

(2014) Ana J. Chucair-Elliott et al.   GLIA

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Maternal immune activation and abnormal brain development across CNS disorders

(2014) Irene Knuesel et al.   Nature Reviews Neurology

Prenatal maternal stress predicts autism traits in 6½ year-old children: Project Ice Storm

(2014) Deborah J. Walder et al.   PSYCHIATRY RESEARCH

Prospective associations between prenatal adversities and borderline personality disorder at 11–12 years

(2014) C. Winsper et al.   PSYCHOLOGICAL MEDICINE

CXCL12 chemokine and its receptors as major players in the interactions between immune and nervous systems

(2014) Alice Guyon   Frontiers in Cellular Neuroscience

Interleukin-17 inhibits Adult Hippocampal Neurogenesis

(2014) Qiang Liu et al.   Scientific Reports

Severe bereavement stress during the prenatal and childhood periods and risk of psychosis in later life: population based cohort study

(2014) K. M. Abel et al.   BMJ-British Medical Journal

Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain

(2014) P Basil et al.   Translational Psychiatry

Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation

(2013) Zichen Li et al.   BMC IMMUNOLOGY

Epigenetic changes at gene promoters in response to immune activation in utero

(2013) Bin Tang et al.   BRAIN BEHAVIOR AND IMMUNITY

MATERNAL DEPRESSIVE, ANXIOUS, AND STRESS SYMPTOMS DURING PREGNANCY PREDICT INTERNALIZING PROBLEMS IN ADOLESCENCE

(2013) Kim S. Betts et al.   DEPRESSION AND ANXIETY

Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system

(2013) D.L.A. Van den Hove et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Elevated maternal C-reactive protein and autism in a national birth cohort

(2013) A S Brown et al.   MOLECULAR PSYCHIATRY

Maternal depressive symptoms: Associations with adolescents’ internalizing and externalizing problems and social competence

(2013) Marie Korhonen et al.   NORDIC JOURNAL OF PSYCHIATRY

Stress-Induced Inflammatory Responses in Women

(2013) Lisa M. Christian et al.   PSYCHOSOMATIC MEDICINE

Chronic stress disrupts neural coherence between cortico-limbic structures

(2013) João Filipe Oliveira et al.   Frontiers in Neural Circuits

Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization

(2013) Luis R. Jacinto et al.   Frontiers in Behavioral Neuroscience

Genetic Association, Mutation Screening, and Functional Analysis of a Kozak Sequence Variant in the Metabotropic Glutamate Receptor 3 Gene in Bipolar Disorder

(2013) Radhika Kandaswamy et al.   JAMA Psychiatry

Longevity and the long arm of epigenetics: Acquired parental marks influence lifespan across several generations

(2012) Shanshan Pang et al.   BIOESSAYS

Transgenerational Epigenetic Effects on Brain Functions

(2012) Johannes Bohacek et al.   BIOLOGICAL PSYCHIATRY

Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice

(2012) Yolanda Diz-Chaves et al.   BRAIN BEHAVIOR AND IMMUNITY

Prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review

(2012) Jane Fisher et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

IL-6 promotes regeneration and functional recovery after cortical spinal tract injury by reactivating intrinsic growth program of neurons and enhancing synapse formation

(2012) Ping Yang et al.   EXPERIMENTAL NEUROLOGY

Decreased thalamo-cortical connectivity by alteration of neural information flow in theta oscillation in depression-model rats

(2012) Chenguang Zheng et al.   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice

(2012) Yolanda Diz-Chaves et al.   Journal of Neuroinflammation

The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

(2012) Stefanie Seisenberger et al.   MOLECULAR CELL

Resetting for the Next Generation

(2012) Michael Cowley et al.   MOLECULAR CELL

A unique regulatory phase of DNA methylation in the early mammalian embryo

(2012) Zachary D. Smith et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems

(2012) C. Buss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress

(2012) Charlotte Laloux et al.   PSYCHONEUROENDOCRINOLOGY

Fetal Programming of Brain Development: Intrauterine Stress and Susceptibility to Psychopathology

(2012) C. Buss et al.   Science Signaling

Parallel mechanisms of epigenetic reprogramming in the germline

(2012) Jamie A. Hackett et al.   TRENDS IN GENETICS

The otherness of self: microchimerism in health and disease

(2012) J. Lee Nelson   TRENDS IN IMMUNOLOGY

Role of epigenetics in developmental biology and transgenerational inheritance

(2011) Michael K. Skinner   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression

(2011) Meina Quan et al.   BRAIN RESEARCH BULLETIN

Neutralization of LPS or blockage of TLR4 signaling prevents stress-triggered fetal loss in murine pregnancy

(2011) Astrid Friebe et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?

(2011) Sean J. Crampton et al.   JOURNAL OF NEUROCHEMISTRY

Dynamic CpG island methylation landscape in oocytes and preimplantation embryos

(2011) Sébastien A Smallwood et al.   NATURE GENETICS

Prenatal stress and neonatal handling induce sex-specific changes in dendritic complexity and dendritic spine density in hippocampal subregions of prepubertal rats

(2011) J. Bock et al.   NEUROSCIENCE

Association Between Parental Hospital-Treated Infection and the Risk of Schizophrenia in Adolescence and Early Adulthood

(2011) Philip R. Nielsen et al.   SCHIZOPHRENIA BULLETIN

Prenatal stress alters dendritic morphology and synaptic connectivity in the prefrontal cortex and hippocampus of developing offspring

(2011) Richelle Mychasiuk et al.   SYNAPSE

Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor

(2011) K M Radtke et al.   Translational Psychiatry

Epigenetic Transmission of the Impact of Early Stress Across Generations

(2010) Tamara B. Franklin et al.   BIOLOGICAL PSYCHIATRY

Early Life Programming and Neurodevelopmental Disorders

(2010) Tracy L. Bale et al.   BIOLOGICAL PSYCHIATRY

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

(2010) Tim F. Oberlander et al.   Epigenetics

Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress

(2010) Áine T. Behan et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Pro-gliogenic effect of IL-1α in the differentiation of embryonic neural precursor cellsin vitro

(2010) Maria Antonietta Ajmone-Cat et al.   JOURNAL OF NEUROCHEMISTRY

Abnormal Long-Range Neural Synchrony in a Maternal Immune Activation Animal Model of Schizophrenia

(2010) D. D. Dickerson et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus

(2010) Jisun Oh et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Danish National Birth Cohort study of maternal HSV-2 antibodies as a risk factor for schizophrenia in their offspring

(2010) Preben B. Mortensen et al.   SCHIZOPHRENIA RESEARCH

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Prenatal Exposure to Maternal Infection and Executive Dysfunction in Adult Schizophrenia

(2009) Alan S. Brown et al.   AMERICAN JOURNAL OF PSYCHIATRY

Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease

(2009) Andrea Danese et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Cognitive Functioning Prior to the Onset of Psychosis: The Role of Fetal Exposure to Serologically Determined Influenza Infection

(2009) Lauren M. Ellman et al.   BIOLOGICAL PSYCHIATRY

Prenatal stress causes dendritic atrophy of pyramidal neurons in hippocampal CA3 region by glutamate in offspring rats

(2009) Ning Jia et al.   Developmental Neurobiology

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

(2009) Jingxian Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Serological pattern consistent with infection with type I Toxoplasma gondii in mothers and risk of psychosis among adult offspring

(2009) Jianchun Xiao et al.   MICROBES AND INFECTION

Cytokines and CNS Development

(2009) Benjamin E. Deverman et al.   NEURON

Schizophrenia and 1957 Pandemic of Influenza: Meta-analysis

(2009) J.-P. Selten et al.   SCHIZOPHRENIA BULLETIN

Effects of prenatal immune activation on hippocampal neurogenesis in the rat

(2009) Ke Cui et al.   SCHIZOPHRENIA RESEARCH

Epigenetic biomarker development

(2009) Christoph Bock   Epigenomics

Early-life programming of later-life brain and behavior: a critical role for the immune system

(2009) Staci D. Bilbo   Frontiers in Behavioral Neuroscience

Upregulation of chemokine receptor expression by IL-10/IL-4 in adult neural stem cells

(2008) Yangtai Guan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Maternal immune activation in mice delays myelination and axonal development in the hippocampus of the offspring

(2008) Manabu Makinodan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats

(2008) Anna Rita Zuena et al.   PLoS One

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Listeria monocytogenes: Maternal-foetal infections in Denmark 1994–2005

(2008) Birgitte Smith et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Association Between Prenatal Exposure to Bacterial Infection and Risk of Schizophrenia

(2008) H. J. Sorensen et al.   SCHIZOPHRENIA BULLETIN

Prenatal immune challenge induces developmental changes in the morphology of pyramidal neurons of the prefrontal cortex and hippocampus in rats

(2008) Moogeh Baharnoori et al.   SCHIZOPHRENIA RESEARCH

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

Maternal Exposure to Herpes Simplex Virus and Risk of Psychosis Among Adult Offspring

(2007) Stephen L. Buka et al.   BIOLOGICAL PSYCHIATRY