Article
Biochemistry & Molecular Biology
Chao Ji, Yongming Pan, Songtao Xu, Chen Yu, Jian Ji, Minli Chen, Fuliang Hu
Summary: Propolis has a protective effect on carotid restenosis in hypercholesterolemia rabbits by inhibiting neointima hyperplasia, improving lipid profiles, enhancing anti-oxidative activities, and reducing inflammation. The anti-inflammatory activity of propolis may be related to the inhibition of the TLR4-mediated NF-kappa B signaling pathway, providing a potential mechanism for its therapeutic effects on vascular restenosis.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Takuto Nosaka, Yosuke Murata, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yoshiaki Imamura, Takanori Goi, Yasunari Nakamoto
Summary: This study identified the role of 5-LOX in hepatocellular carcinoma (HCC) progression and demonstrated that inhibition of 5-LOX activity can regulate HCC progression, suggesting it as a potential therapeutic target.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Jiaquan Chen, Weilun Wang, Qihong Ni, Lan Zhang, Xiangjiang Guo
Summary: This study identified differential genes between CD11c+ and CD11c- plaque macrophages, and found that expression of Il6 induced macrophage polarization. Furthermore, pharmaceutical suppression of Il6 attenuated the formation and progression of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tamara Melnik, Olivier Jordan, Jean-Marc Corpataux, Florence Delie, Francois Saucy
Summary: This article reviews the development pathways of intimal hyperplasia (IH) and discusses different drugs and drug combinations that interfere with these pathways. Local application of drugs and drug combinations may provide an effective and safe approach for preventing IH.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Utsab Subedi, Shrivats Manikandan, Susmita Bhattarai, Papori Sharma, Sudha Sharma, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam
Summary: Neointimal hyperplasia is characterized by a loss of the contractile phenotype of vascular smooth muscle cells (VSMCs). Our study found that autotaxin (ATX) and lysophosphatidic acid (LPA) play a role in VSMC proliferation and migration during restenosis. Inhibition of the ATX-LPA axis could potentially be used as a therapeutic target to minimize VSMC phenotypic modulation and inflammation after vascular injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Diane Macabrey, Alban Longchamp, Sebastien Deglise, Florent Allagnat
Summary: Arterial occlusive disease is a serious condition caused by narrowing of the arteries, primarily due to atherosclerosis. It is a leading cause of death in Western countries and can lead to peripheral arterial disease, stroke, and heart disease. Current treatment options are limited, but hydrogen sulfide shows potential in preventing arterial occlusive disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Physiology
Sebastien Deglise, Clemence Bechelli, Florent Allagnat
Summary: Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies suffer from high failure rates due to re-occlusive vascular wall adaptations and restenosis. Restenosis following vascular surgery is largely due to intimal hyperplasia.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Immunology
Seung Eun Baek, Eun Jeong Jang, Jong Min Choi, Young Whan Choi, Chi Dae Kim
Summary: This study investigates the effects of alpha-Iso-cubebene (ICB) on HMGB1-induced monocyte-macrophage differentiation (MMD) and suggests that ICB has therapeutic potential for vascular inflammation with subsequent intimal hyperplasia related to vascular injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biophysics
Andrea Corti, Annalisa De Paolis, John Tarbell, Luis Cardoso
Summary: This study evaluates the impact of stent overexpansion on Vasa Vasorum compression, particularly in the Intima and Media layers, which may result in a significant reduction in blood flow and oxygen delivery. The observed increase in flow resistance suggests a potential risk of intimal hyperplasia and restenosis as a consequence of stent-induced VV compression.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Surgery
Diane Macabrey, Celine Deslarzes-Dubuis, Alban Longchamp, Martine Lambelet, Charles K. Ozaki, Jean-Marc Corpataux, Florent Allagnat, Sebastien Deglise
Summary: This study investigates the role of zofenopril in reducing intimal hyperplasia and finds that zofenopril reduces intimal hyperplasia by releasing hydrogen sulphide and inhibits intimal hyperplasia in vitro. The results from experiments on hypertensive and normotensive mice both support this finding.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Teresa E. Fowler, Vivek Choudhary, Samuel Melnyk, Mishma Farsi, Luke Y. Y. Chang, Nyemkuna Fortingo, Xunsheng Chen, Mitchell A. Watsky, Wendy B. Bollag
Summary: Our previous work has shown that DOPG accelerates corneal epithelial healing, but the underlying mechanisms are unknown. In this study, we found that DOPG inhibits TLR activation induced by microbial components and endogenous molecules upregulated in psoriatic skin. Further experiments demonstrated that DOPG also inhibits TLR activation in response to DAMPs elevated in diabetes. Additionally, we discovered that the co-receptor CD14 is necessary for PAMP/DAMP-induced activation of TLR2 and TLR4. These findings suggest that DOPG has anti-inflammatory properties and could be a potential therapy for corneal injury, particularly in diabetic patients at risk of complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jong Min Choi, Seung Eun Baek, Ji On Kim, Eun Yeong Jeon, Eun Jeong Jang, Chi Dae Kim
Summary: In injured vasculatures, 5-LO-derived LTB4 plays a key role in MCP-1 expression in HMGB1-exposed VSMCs via BLTR1 signaling, suggesting the LTB4-BLTR1 signaling axis as a potential therapeutic target for vascular inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Mayuka Morimoto, Takafumi Nakano, Saki Egashira, Keiichi Irie, Kiyoshi Matsuyama, Momoka Wada, Yoshihiko Nakamura, Yutaka Shigemori, Hiroyasu Ishikura, Yuta Yamashita, Kazuhide Hayakawa, Kazunori Sano, Kenichi Mishima
Summary: Hp binds and sequesters HMGB1, rapidly clearing Hp-HMGB1 complexes and modulating macrophage/microglia polarization towards the M2 phenotype. This improves functional outcomes, including survival, motor function, and brain damage after cerebral ischemia.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Takahiro Kochi, Yoki Nakamura, Simeng Ma, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Masahiro Irifune, Norimitsu Morioka
Summary: The study found that blocking HMGB1 before nerve injury may prevent the onset of pain-related behaviors following orofacial surgery, possibly by inhibiting the activation of immune cells associated with nerve injury, both within the central nervous system and on peripheral nerves.
Article
Cell Biology
Maho Tsubota, Takaya Miyazaki, Yuya Ikeda, Yusuke Hayashi, Yui Aokiba, Shiori Tomita, Fumiko Sekiguchi, Dengli Wang, Masahiro Nishibori, Atsufumi Kawabata
Summary: Bortezomib-induced chemotherapy-induced peripheral neuropathy (CIPN) involves caspase-dependent release of HMGB1 from macrophages, leading to the activation of RAGE and CXCR4 receptors. Preventative measures for CIPN include the use of anti-HMGB1-neutralizing antibodies, thrombomodulin alfa, RAGE and CXCR4 antagonists, or macrophage depletion.