Article
Fisheries
Sen Xu, Ming Jing, De-Min Kong, Ya-Ru Wang, Quan Zhou, Wen-Ying Liu, Fei Jiao, You-Jie Li, Shu-Yang Xie
Summary: The peritrophic membrane serves as a vital physical barrier allowing shrimp to resist pathogen invasion, primarily composed of chitin and proteins. The study identified a chitin-binding protein, MjCBP, in Marsupenaeus japonicus, which was effective in agglutinating bacteria and binding to lipopolysaccharides and peptidoglycans to combat both Gram-positive and Gram-negative bacteria. Dressing MjCBP and CBD1 led to enhanced clearance of V. anguillarum in vivo, demonstrating their role as opsonins or pattern recognition receptors in the shrimp's antibacterial immune response.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Cell Biology
Edna Ayerim Mandujano-Tinoco, Eliya Sultan, Aner Ottolenghi, Orly Gershoni-Yahalom, Benyamin Rosental
Summary: The evolution of the immune system is aimed at protecting organisms from infections and providing regenerative capacities and tissue maintenance. Despite the diverse range of effector cells, common features and interesting convergent mechanisms can be observed across different animals. The review explores the evolution of phagocytic and cytotoxic immune lineages, highlighting the diverse function plasticity within evolved immune effector cells.
Article
Endocrinology & Metabolism
Hans-Georg Sprenger, Thomas MacVicar, Amir Bahat, Kai Uwe Fiedler, Steffen Hermans, Denise Ehrentraut, Katharina Ried, Dusanka Milenkovic, Nina Bonekamp, Nils-Goeran Larsson, Hendrik Nolte, Patrick Giavalisco, Thomas Langer
Summary: The study reveals that cytosolic pyrimidine levels regulate the release of mitochondrial DNA and activation of cGAS-STING.
Article
Immunology
Shaoqing Zang, Li-Xia Lv, Chen-Fei Liu, Peng Zhang, Cang Li, Jin-Xing Wang
Summary: The mechanisms of trained immunity in shrimp, a phenomenon identified in invertebrates, were investigated in this study. Metabolomic analysis revealed significant changes in metabolism, including enrichment of glycolysis, pentose phosphate pathway, and AMPK signaling pathway, in shrimp trained with UV-inactivated white spot syndrome virus (UV-WSSV). Histone monomethylation and trimethylation were found to be involved in trained immunity. These findings provide insights for WSSV control in shrimp aquaculture.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Fisheries
Heqian Zhang, Jinbin Zheng, Wenzhi Cheng, Yong Mao, Xiangyong Yu
Summary: The anionic peptide MjALF-D displays modest antibacterial activity against certain bacteria and can bind to specific bacteria, providing insights into the function and role of ALF in shrimp immunity.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jinbin Zheng, Mengqi Ni, Yong Mao, Yongquan Su
Summary: The study produced and purified recombinant proteins of four CRDs from Marsupenaeus japonicus, demonstrating their varying bacterial binding and antibacterial activities. Additionally, the CRDs showed different capacities to regulate immune effector genes, with His-CRD2-3 displaying broader and stronger inductive effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Matthew R. Woeste, Rejeena Shrestha, Anne E. Geller, Shu Li, Diego Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Hong Li, Aaron Puckett, Robert A. Mitchell, Traci Hayat, Min Tan, Yan Li, Kelly M. McMasters, Robert C. G. Martin, Jun Yan
Summary: This study investigates the combination therapy of IRE and beta-glucan in the treatment of pancreatic cancer, and finds that this combination can enhance immune response, reduce tumor burden, and prolong survival in patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Fisheries
Jiaqian Zhu, Yina Shao, Kaiyu Chen, Weiwei Zhang, Chenghua Li
Summary: Transglutaminases (TGases) play critical roles in innate immunity, with TGase2 involved in autophagy to help degrade protein aggregates. A novel TGase2-like gene, AjTGase2-like, was cloned from the sea cucumber Apostichopus japonicus, showing high conservation with vertebrate TGase2. AjTGase2-like was widely expressed and played a key role in immune response, acting as a positive regulator in sea cucumber autophagy.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Cell Biology
Xuehua Xu, Miao Pan, Tian Jin
Summary: The discovery of how phagocytes effectively find and kill pathogens through chemotaxis and phagocytosis sheds light on the evolutionarily conserved mechanisms underlying these processes in mammals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Zihao He, Jichen Zhao, Xieyan Chen, Minze Liao, Yuan Xue, Jianing Zhou, Haozhen Chen, Guoliang Chen, Shuang Zhang, Chengbo Sun
Summary: The study revealed the toxicity of DIV1 to Marsupenaeus japonicus and its inhibition of enzyme activities. Transcriptomic analysis showed the genomic changes caused by DIV1 infection, as well as the significant impact on pathways and signaling pathways related to virus invasion, replication, and host antiviral infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Jomkuan Theprungsirikul, Sladjana Skopelja-Gardner, Ashley S. Burns, Rachel M. Wierzbicki, William F. C. Rigby
Summary: Chronic Pseudomonas aeruginosa infection is often associated with CF, BE, and COPD patients, and is linked to abnormalities in BPI immune function. Experimental findings show that BPI plays a crucial role in the in vivo immune response against P. aeruginosa.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Che-Feng Chang, Brittany A. Goods, Michael H. Askenase, Hannah E. Beatty, Artem Osherov, Jonathan H. DeLong, Matthew D. Hammond, Jordan Massey, Margaret Landreneau, J. Christopher Love, Lauren H. Sansing
Summary: Our study shows that microglia and MDMs have distinct functional properties in the brain after ICH, with MDMs exhibiting higher phagocytic activity, erythrophagocytosis, and antigen-presenting capabilities compared to microglia. This suggests that the different origins of microglia and MDMs lead to divergent responses and functions in the inflamed brain following ICH.
Review
Immunology
Jiaqi Li, Yanjin Wang, Hao Deng, Su Li, Hua-Ji Qiu
Summary: Cellular metabolism plays a crucial role in regulating immune responses, including both innate and adaptive immunity. Viral infections induce metabolic reprogramming, which affects immune cell function, immune molecule expression, and cell fate. It is vital to explore effector molecules involved in immunometabolism, such as metabolites, metabolic enzymes, and other related molecules, for the development of antiviral drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Fisheries
Yankai Wang, Jing Diao, Bei Wang, Xi Xu, Minjie Gui, Chenghua Li, Ming Guo
Summary: In this study, the second FADD gene in sea cucumber Apostichopus japonicus (AjFADD-2) was cloned and its potential function in innate responses was analyzed. It was found that AjFADD-2 was significantly induced in response to pathogen challenge and played a positive role in regulating apoptosis in coelomocytes.
FISH & SHELLFISH IMMUNOLOGY
(2022)