Type I Interferons in Bacterial Infections: Taming of Myeloid Cells and Possible Implications for Autoimmunity

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Listeria monocytogenes induces IFN  expression through an IFI16-, cGAS- and STING-dependent pathway

(2014) K. Hansen et al.   EMBO JOURNAL

Type I interferons have opposing effects during the emergence and recovery phases of colitis

(2014) Isabella Rauch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I Interferons Promote Severe Disease in a Mouse Model of Lethal Ehrlichiosis

(2014) Yubin Zhang et al.   INFECTION AND IMMUNITY

Type I IFNs Enhance Susceptibility to Chlamydia muridarum Lung Infection by Enhancing Apoptosis of Local Macrophages

(2014) H. Qiu et al.   JOURNAL OF IMMUNOLOGY

A comparative study of matrix metalloproteinase and aggrecanase mediated release of latent cytokines at arthritic joints

(2013) Lisa Mullen et al.   ANNALS OF THE RHEUMATIC DISEASES

The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

(2013) Yaya Wang et al.   IMMUNITY

Type I IFNs Downregulate Myeloid Cell IFN-  Receptor by Inducing Recruitment of an Early Growth Response 3/NGFI-A Binding Protein 1 Complex That Silences ifngr1 Transcription

(2013) S. J. Kearney et al.   JOURNAL OF IMMUNOLOGY

Identifying the Initiating Events of Anti-Listeria Responses Using Mice with Conditional Loss of IFN-  Receptor Subunit 1 (IFNGR1)

(2013) S. H. Lee et al.   JOURNAL OF IMMUNOLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells

(2013) Cristina Amparo Hagmann et al.   PLoS One

Route of Infection Determines the Impact of Type I Interferons on Innate Immunity to Listeria monocytogenes

(2013) Elisabeth Kernbauer et al.   PLoS One

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Interferon-  Protects the Female Reproductive Tract from Viral and Bacterial Infection

(2013) K. Y. Fung et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Type I Interferon Suppresses Type II Interferon-Triggered Human Anti-Mycobacterial Responses

(2013) R. M. B. Teles et al.   SCIENCE

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection

(2013) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Sensing Microbial RNA in the Cytosol

(2013) Nicolas Vabret et al.   Frontiers in Immunology

IFN-Inducible GTPases in Host Cell Defense

(2012) Bae-Hoon Kim et al.   Cell Host & Microbe

RIG-I detects infection with liveListeriaby sensing secreted bacterial nucleic acids

(2012) Zeinab Abdullah et al.   EMBO JOURNAL

Inflammatory Monocytes Activate Memory CD8+ T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion

(2012) Saïdi M'Homa Soudja et al.   IMMUNITY

Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections

(2012) Staci Kearney et al.   IMMUNOLOGIC RESEARCH

Dynamic Roles of Type I and Type II IFNs in Early Infection with Mycobacterium tuberculosis

(2012) L. Desvignes et al.   JOURNAL OF IMMUNOLOGY

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

(2012) Inmoo Rhee et al.   NATURE IMMUNOLOGY

Both TLR2 and TRIF Contribute to Interferon-β Production during Listeria Infection

(2012) Camille Aubry et al.   PLoS One

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

(2011) Christoph Thomas et al.   CELL

Type I interferon signaling regulates the composition of inflammatory infiltrates upon infection with Listeria monocytogenes

(2011) Kristina L. Brzoza-Lewis et al.   CELLULAR IMMUNOLOGY

Type I IFN protects against antigen-induced arthritis

(2011) Fei Ying et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Specific depletion reveals a novel role for neutrophil-mediated protection in the liver during Listeria monocytogenes infection

(2011) Karen D. Carr et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection

(2011) Katrin D. Mayer-Barber et al.   IMMUNITY

Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1  Production in Human Macrophages

(2011) A. Novikov et al.   JOURNAL OF IMMUNOLOGY

Ly6G + Neutrophils Are Dispensable for Defense against Systemic Listeria monocytogenes Infection

(2011) Chao Shi et al.   JOURNAL OF IMMUNOLOGY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Suppression of inflammation in ulcerative colitis by interferon- -1a is accompanied by inhibition of IL-13 production

(2010) P. J. Mannon et al.   GUT

Risk factors for infection during treatment with peginterferon alfa and ribavirin for chronic hepatitis C

(2010) Robert Roomer et al.   HEPATOLOGY

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Induction of IFN-αβ enablesListeria monocytogenesto suppress macrophage activation by IFN-γ

(2010) Manira Rayamajhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of Naive NK Cells in Response to Listeria monocytogenes Requires IL-18 and Contact with Infected Dendritic Cells

(2010) J. Humann et al.   JOURNAL OF IMMUNOLOGY

N-Ethyl-N-Nitrosourea-Induced Mutation in Ubiquitin-Specific Peptidase 18 Causes Hyperactivation of IFN-   Signaling and Suppresses STAT4-Induced IFN-  Production, Resulting in Increased Susceptibility to Salmonella Typhimurium

(2010) E. Richer et al.   JOURNAL OF IMMUNOLOGY

Infection-Induced Myelopoiesis during Intracellular Bacterial Infection Is Critically Dependent upon IFN-  Signaling

(2010) K. C. MacNamara et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Caspase-1 Independent IL-1  Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

(2010) K. D. Mayer-Barber et al.   JOURNAL OF IMMUNOLOGY

Type I IFN Signaling Constrains IL-17A/F Secretion by    T Cells during Bacterial Infections

(2010) T. Henry et al.   JOURNAL OF IMMUNOLOGY

The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens

(2010) Julia P. Hunn et al.   MAMMALIAN GENOME

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

(2010) Pengyuan Yang et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Type I interferons: crucial participants in disease amplification in autoimmunity

(2010) John C. Hall et al.   Nature Reviews Rheumatology

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Bacterial infection and neutropenia during peginterferon plus ribavirin combination therapy in patients with chronic hepatitis C with and without baseline neutropenia in clinical practice

(2009) J.-F. YANG et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Redefining the role of interferon in the treatment of malignant diseases

(2009) Sergio Bracarda et al.   EUROPEAN JOURNAL OF CANCER

Interferons Direct an Effective Innate Response toLegionella pneumophilaInfection

(2009) Courtney R. Plumlee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice with a Selective Impairment of IFN-  Signaling in Macrophage Lineage Cells Demonstrate the Critical Role of IFN- -Activated Macrophages for the Control of Protozoan Parasitic Infections In Vivo

(2009) J. E. Lykens et al.   JOURNAL OF IMMUNOLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation

(2009) K M Shah et al.   ONCOGENE

Cytoskeleton rearrangements duringListeriainfection: Clathrin and septins as new players in the game

(2009) Serge Mostowy et al.   CELL MOTILITY AND THE CYTOSKELETON

Identification of Host Cytosolic Sensors and Bacterial Factors Regulating the Type I Interferon Response to Legionella pneumophila

(2009) Kathryn M. Monroe et al.   PLoS Pathogens

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

IFNβ responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI)

(2008) Juliane Lippmann et al.   CELLULAR MICROBIOLOGY

Type I IFN are host modulators of strain-specific Listeria monocytogenes virulence

(2008) Benjamin Reutterer et al.   CELLULAR MICROBIOLOGY

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

(2008) Marco Prinz et al.   IMMUNITY

Type I Interferon Signaling Exacerbates Chlamydia muridarum Genital Infection in a Murine Model

(2008) U. M. Nagarajan et al.   INFECTION AND IMMUNITY

Francisella inhibits STAT1-mediated signaling in macrophages and prevents activation of antigen-specific T cells

(2008) K. M. Roth et al.   INTERNATIONAL IMMUNOLOGY

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen

(2008) Jess H. Leber et al.   PLoS Pathogens