4.8 Editorial Material

Ca2+ influx in T cells: how many Ca2+ channels?

Journal

FRONTIERS IN IMMUNOLOGY
Volume 4, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2013.00099

Keywords

-

Categories

Funding

  1. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI097302] Funding Source: NIH RePORTER
  2. NIAID NIH HHS [R01 AI097302] Funding Source: Medline

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Multidisciplinary Sciences

Store-operated Ca2+ entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration

Larissa Bendiks, Fabienne Geiger, Thomas Gudermann, Stefan Feske, Alexander Dietrich

SCIENTIFIC REPORTS (2020)

Article Medicine, Research & Experimental

STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells

Sascha Kahlfuss, Ulrike Kaufmann, Axel R. Concepcion, Lucile Noyer, Dimitrius Raphael, Martin Vaeth, Jun Yang, Priya Pancholi, Mate Maus, James Muller, Lina Kozhaya, Alireza Khodadadi-Jamayran, Zhengxi Sun, Patrick Shaw, Derya Unutmaz, Peter B. Stathopulos, Cori Feist, Scott B. Cameron, Stuart E. Turvey, Stefan Feske

EMBO MOLECULAR MEDICINE (2020)

Article Multidisciplinary Sciences

STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca2+ entry with NFAT1 activation

Ga-Yeon Son, Krishna Prasad Subedi, Hwei Ling Ong, Lucile Noyer, Hassan Saadi, Changyu Zheng, Rajesh Bhardwaj, Stefan Feske, Indu Suresh Ambudkar

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Editorial Material Cell Biology

Straight from the channel's mouth: AKAP79 links Ca2+ influx through ORAI1 to NFAT activation

Lucile Noyer, Stefan Feske

CELL CALCIUM (2021)

Article Immunology

The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling

Axel R. Concepcion, Larry E. Wagner, Jingjie Zhu, Anthony Y. Tao, Jun Yang, Alireza Khodadadi-Jamayran, Yin-Hu Wang, Menghan Liu, Rebecca E. Rose, Drew R. Jones, William A. Coetzee, David Yule, Stefan Feske

Summary: LRRC8C is a critical component of VRAC in T cells, mediating the transport of 2'3' cGAMP and activating the STING-p53 signaling pathway. Its deletion enhances T cell function and increases T cell-dependent immune responses.

NATURE IMMUNOLOGY (2022)

Article Immunology

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses

Gesine Behrens, Stephanie L. Edelmann, Timsse Raj, Nina Kronbeck, Thomas Monecke, Elena Davydova, Elaine H. Wong, Lisa Kifinger, Florian Giesert, Martin E. Kirmaier, Christine Hohn, Laura S. de Jonge, Mariano Gonzalez Pisfil, Mingui Fu, Sebastian Theurich, Stefan Feske, Naoto Kawakami, Wolfgang Wurst, Dierk Niessing, Vigo Heissmeyer

Summary: The proteins Roquin-1 and Regnase-1 play crucial roles in maintaining immune homeostasis, with mutations leading to systemic lupus erythematosus-like phenotypes and autoimmunity. Additionally, these mutations affect T cell activation, metabolic reprogramming, and autoimmunity processes.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function

Serap Erdogmus, Axel R. Concepcion, Megumi Yamashita, Ikjot Sidhu, Anthony Y. Tao, Wenyi Li, Pedro P. Rocha, Bonnie Huang, Ralph Garippa, Boram Lee, Amy Lee, Johannes W. Hell, Richard S. Lewis, Murali Prakriya, Stefan Feske

Summary: The regulatory beta subunit of voltage-gated calcium channels regulates T cell function despite no evidence that these channels were functional within T cells during activation.

NATURE COMMUNICATIONS (2022)

Article Medicine, Research & Experimental

Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease

Marilena Letizia, Yin-Hu Wang, Ulrike Kaufmann, Lorenz Gerbeth, Annegret Sand, Max Brunkhorst, Patrick Weidner, Joern Felix Ziegler, Chotima Boettcher, Stephan Schlickeiser, Camila Fernandez, Megumi Yamashita, Kenneth Stauderman, Katherine Sun, Desiree Kunkel, Murali Prakriya, Ashley D. Sanders, Britta Siegmund, Stefan Feske, Carl Weidinger

Summary: Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. This study found that store-operated Ca2+ entry (SOCE) regulates the function of immune cells in the lamina propria of IBD patients. Inhibiting SOCE reduced the production of proinflammatory cytokines, suggesting that targeting SOCE may be a potential treatment for IBD.

EMBO MOLECULAR MEDICINE (2022)

Article Physiology

ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages

Liwei Wang, Lucile Noyer, Yin-Hu Wang, Anthony Y. Tao, Wenyi Li, Jingjie Zhu, Pedro Saavedra, Syed T. Hoda, Jun Yang, Stefan Feske

Summary: Despite its expression in immune cells, ORAI3 appears to be dispensable or redundant for physiological and pathological immune responses mediated by these cells.

JOURNAL OF GENERAL PHYSIOLOGY (2022)

Article Immunology

The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells

Taku Ito-Kureha, Cristina Leoni, Kayla Borland, Giulia Cantini, Marian Bataclan, Rebecca N. Metzger, Gregor Ammann, Anne B. Krug, Annalisa Marsico, Stefanie Kaiser, Stefan Canzar, Stefan Feske, Silvia Monticelli, Julian Koenig, Vigo Heissmeyer

Summary: The m(6)A modification plays a crucial role in the development, activation and survival of T cells. The Wtap protein is essential for m(6)A methyltransferase complex function and is crucial in TCR signaling. m(6)A modification destabilizes Orai1 and Ripk1 mRNAs, impacting the survival of T cells.

NATURE IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

Distinct roles of ORAI1 in T cell-mediated allergic airway inflammation and immunity to influenza A virus infection

Yin -Hu Wang, Lucile Noyer, Sascha Kahlfuss, Dimitrius Raphael, Anthony Y. Tao, Ulrike Kaufmann, Jingjie Zhu, Marisa Mitchell-Flack, Ikjot Sidhu, Fang Zhou, Martin Vaeth, Paul G. Thomas, Sean P. Saunders, Kenneth Stauderman, Maria A. Curotto de Lafaille, Stefan Feske

Summary: The study reveals that SOCE through CRAC channels plays a crucial role in regulating T cell function, particularly in TH2 cells, by controlling the expression of transcription factors and cytokines. Inhibition of SOCE shows potential as a treatment for allergic airway disease.

SCIENCE ADVANCES (2022)

Article Biology

Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells

Scott M. Emrich, Ryan E. Yoast, Xuexin Zhang, Adam J. Fike, Yin-Hu Wang, Kristen N. Bricker, Anthony Y. Tao, Ping Xin, Vonn Walter, Martin T. Johnson, Trayambak Pathak, Adam C. Straub, Stefan Feske, Ziaur S. M. Rahman, Mohamed Trebak

Summary: This study reveals that Orai3 and Orai1 mediate native CRAC channels in B cells during activation, and the combined loss of both isoforms impairs various functions in B cells, including SOCE, proliferation, survival, NFAT activation, mitochondrial respiration, glycolysis, and metabolic reprogramming. However, the deletion of Orai1 and Orai3 does not affect humoral immunity to influenza A virus infection in mice, suggesting the presence of other co-stimulatory signals that compensate for the requirement of BCR-mediated CRAC channel function in B cells. These findings provide important insights into the physiological roles of Orai1 and Orai3 proteins in SOCE and effector functions of B lymphocytes.

ELIFE (2023)

Meeting Abstract Immunology

Store-operated calcium entry controls immune cell function and activation in inflammatory bowel disease

Marilena Letizia, Ulirike Kaufmann, Lorenz Gerbeth, Annegret Sand, Max Brunkhorst, Yinhu Wang, Chotima Boettcher, Stephan Schlickeiser, Camila Fernandez Zapata, Desiree Kunkel, Britta Siegmund, Stefan Feske, Carl Weidinger

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Review Physiology

Calcium regulation of T cell metabolism

Yin-Hu Wang, Anthony Y. Tao, Martin Vaeth, Stefan Feske

CURRENT OPINION IN PHYSIOLOGY (2020)

Meeting Abstract Immunology

The Other Side Of STIM1: Chronic Myopathy And Platelet Dysfunction In A Patient With A Gain Of Function Mutation In STIM1

Christian Wysocki, Gulbu Uzel, Hye Sun Kuehn, Stefan Feske

JOURNAL OF CLINICAL IMMUNOLOGY (2020)

No Data Available