Journal
FRONTIERS IN IMMUNOLOGY
Volume 4, Issue -, Pages -Publisher
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fimmu.2013.00071
Keywords
allogeneic hematopoietic stem cell transplantation; immune reconstitution; biomarkers; opportunistic infections; graft-versus-host disease
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Funding
- Italian Ministry of Health (Eranet Transcan HAPLO-IMMUNE) [GR07-5 BO, RO10/07-B-1]
- Italian Ministry of Research and University (FIRB-IDEAS)
- Italian Association for Cancer Research
- EU-FP7 program (ATTACK, PERSIST)
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The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is strongly influenced from the potential complications arising during the delicate phase of post-transplant immune restoration. The quantitative aspects of immune-cell repopulation after HSCT and the qualitative features their functional restitution have been extensively reported. Nevertheless, measurable immune biomarkers predicting the clinical outcome of HSCT await formal validation. The aim of this review is an appraisal of most studies published so far on the predictive value of different T and NK-cell biomarkers after HSCT with emphasis on defined thresholds endorsed by multivariate analysis.
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