Article
Immunology
Xinxia Lu, Liangao Wang, Meng Wang, Yuejin Li, Qinqin Zhao, Yanjun Shi, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li
Summary: This study evaluated the performance of IgG N-glycosylation in diagnosing lupus nephritis (LN) in female systemic lupus erythematosus (SLE) patients. The results showed that specific glycans and anemia were associated with LN. These IgG N-glycans can serve as potential biomarkers to differentiate LN among SLE patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
John Tchen, Quentin Simon, Lea Chapart, Christophe Pellefigues, Hajime Karasuyama, Kensuke Miyake, Ulrich Blank, Marc Benhamou, Eric Daugas, Nicolas Charles
Summary: Tissue-specific mouse models are important tools for studying the role of different cell compartments and genes in diseases. A new knock-in mouse model is described here, allowing selective expression of fluorescent protein tdTomato and CRE recombinase in the basophil compartment. This model enabled the identification and study of basophils, and breeding with another mouse model resulted in basophil-deficient mice with no abnormalities in other cell compartments. The study showed that basophils play a nonredundant role in pristane-induced lupus-like disease, both in its induction and amplification.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Gaelle Tilman, Emilie Dupre, Laura Watteyne, Charlotte Anne Baert, Delphine Nolf, Fatima Benhaddi, Fanny Lambert, Aurelie Daumerie, Caroline Bouzin, Sophie Lucas, Nisha Limaye
Summary: The presence of p16(INK4a)-positive cells, a marker of cellular senescence, is associated with renal disease severity in both human and mouse models of lupus nephritis.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Multidisciplinary Sciences
Tatsuma Ban, Masako Kikuchi, Go R. Sato, Akio Manabe, Noriko Tagata, Kayo Harita, Akira Nishiyama, Kenichi Nishimura, Ryusuke Yoshimi, Yohei Kirino, Hideyuki Yanai, Yoshiko Matsumoto, Shuichi Suzuki, Hiroe Hihara, Masashi Ito, Kappei Tsukahara, Kentaro Yoshimatsu, Tadashi Yamamoto, Tadatsugu Taniguchi, Hideaki Nakajima, Shuichi Ito, Tomohiko Tamura
Summary: IRF5 is a potential therapeutic target for systemic lupus erythematosus (SLE). Studies show that inhibition of IRF5 after disease onset can suppress disease progression and maintain remission effectively. Inhibiting IRF5 may overcome the limitations of current SLE therapies.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Peter Korsten, Bjoern Tampe
Summary: Recent research has shown that in systemic lupus erythematosus (SLE), the tubulointerstitial expression of type I interferon IFNA5 is associated with proteinuria in lupus nephritis, while other type I interferons expressed in the glomerular compartment are not correlated. This finding is important for understanding the mechanism and treatment of lupus nephritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
F. Szymczak, M. L. Colli, M. J. Mamula, C. Evans-Molina, D. L. Eizirik
Summary: Research has shown that autoimmune diseases exhibit similar molecular signatures in target tissues, with many related to interferon signaling, which could be targeted for therapy. This suggests that future studies should focus on both the immune system and target tissues, and their interactions.
Article
Rheumatology
Xin-yu Zhao, Shuang-shuang Li, Ying-xin He, Li-jie Yan, Fu Lv, Qi-meng Liang, Yu-hui Gan, Li-pei Han, Hong-de Xu, Yong-chun Li, Yuan-yuan Qi
Summary: The study reveals that SGLT2 inhibitors provide renal protection in patients with lupus nephritis. The use of SGLT2 inhibitors decreases anti-dsDNA IgG-specific antibody levels, serum creatinine, and proteinuria. Furthermore, SGLT2 inhibitors alleviate glomerular and tubulointerstitial damages. This study provides more evidence for non-immunosuppressive therapies to improve renal function in classic autoimmune kidney diseases such as lupus nephritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Jiaxuan Chen, Shuzhen Liao, Huimin Zhou, Lawei Yang, Fengbiao Guo, Shuxian Chen, Aifen Li, Quanren Pan, Chen Yang, Hua-feng Liu, Qingjun Pan
Summary: Animal models play a crucial role in understanding human diseases, but they cannot fully simulate the occurrence and progression of diseases due to genetic and disease-specific differences. Humanized immune system mice, developed from immunodeficient mice, provide a partial reconstruction of the human immune system and mimic the in vivo microenvironment. However, there are challenges in developing humanized mice models for systemic lupus erythematosus (SLE), including improving immune response reconstruction efficiency, extending observation period, and improving model development and utilization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shannon N. Loftus, Jianhua Liu, Celine C. Berthier, Johann E. Gudjonsson, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, J. Michelle Kahlenberg
Summary: Abnormal activation of the immune system is a known cause of lupus. Inhibiting the inflammasome and its downstream components has been shown to reduce disease severity in lupus mouse models. This study examines the effects of IL-1 beta loss on disease severity in a lupus-prone mouse model and identifies potential clinical relevance of TNF and IL-17 signaling pathways. Caution may be needed when inhibiting inflammasome or IL-1 beta signaling in SLE, especially in patients with renal involvement.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Kuan-Ju Chen, Jimin Zhang, Daniel LaSala, Jessica Basso, Donald Chun, Yuchen Zhou, Patrick P. McDonald, Walter R. Perkins, David C. Cipolla
Summary: Neutrophil serine proteases (NSPs) released by neutrophils have been implicated in systemic lupus erythematosus and lupus nephritis. In this study, a DPP1 inhibitor called brensocatib was found to reduce kidney damage and improve renal function in a mouse model, suggesting the potential for DPP1 inhibition in the treatment of lupus nephritis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Bing Wu, Yanwei Wu, Chen Fan, Chunlan Feng, Haoyu Wang, Fang Bai, Jianping Zuo, Wei Tang
Summary: Heme plays an important role in the pathogenesis of systemic lupus erythematosus (SLE), and supplementation of heme can significantly improve lupus symptoms, reduce proteinuria levels, and alleviate organ enlargement.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Shogo Matsuda, Takuya Kotani, Takashi Saito, Takayasu Suzuka, Tatsuhiko Mori, Tohru Takeuchi
Summary: This study investigated the therapeutic effects of LMWH-activated human ASCs in an SLE mouse model. The results showed that hep-hASC exhibited higher anti-inflammatory and anti-fibrotic effects compared to hASCs, suggesting it as a potential candidate for future SLE treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Li-ying He, Shu-qi Niu, Cai-xia Yang, Pan Tang, Jiao-jiao Fu, Li Tan, Yong Li, Ya-nan Hua, Si-jing Liu, Jin-lin Guo
Summary: This study aimed to examine the therapeutic potential of Cordyceps proteins (CP) in lupus nephritis (LN) and uncover the underlying molecular mechanism. The results showed that CP had a favorable bidirectional immunomodulatory effect, reducing proteinuria, renal inflammation, and fibrosis in LN mice. CP's regulatory effects surpassed artificial Cordyceps fungus powder (BC) and prednisolone acetate (PA), modulating the STAT3/mTOR/NF-kB signaling pathway and lowering the levels of IL-6 and IL-1 beta.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Urology & Nephrology
Yutian Lei, Bettina Sehnert, Reinhard E. Voll, Conxita Jacobs-Cacha, Maria Jose Soler, Maria D. Sanchez-Nino, Alberto Ortiz, Roman D. Buelow, Peter Boor, Hans-Joachim Anders
Summary: The study conducted a multicenter preclinical randomized controlled trial in the kidney domain to evaluate the effect of Jak1/2 inhibition in lupus nephritis. The results showed that while multicenter trials can reduce single-center bias, they may also increase data heterogeneity and reduce effect size. Phenotype differences among mice bred at different sites were noted, mirroring patient phenotype diversity seen in lupus trials.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Yiyao Deng, Ying Zheng, Delun Li, Quan Hong, Min Zhang, Qinggang Li, Bo Fu, Lingling Wu, Xu Wang, Wanjun Shen, Yingjie Zhang, Jiakai Chang, Kangkang Song, Xiaomin Liu, Shunlai Shang, Guangyan Cai, Xiangmei Chen
Summary: Through single-cell RNA sequencing analysis, it was found that monocytes, B cells, dendritic cells, and granulocytes were significantly increased in SLE patients, while subsets of T cells were significantly decreased. Neutrophils and low-density granulocytes exhibited the highest ISG activity. 31 common ISGs were found expressed in both PBMCs and kidneys, and these ISGs were also most active in neutrophils and LDGs.
Article
Immunology
Anne Davidson, Ramalingam Bethunaickan, Celine Berthier, Ranjit Sahu, Weijia Zhang, Matthias Kretzler
IMMUNOLOGIC RESEARCH
(2015)
Review
Rheumatology
Anne Davidson
NATURE REVIEWS RHEUMATOLOGY
(2016)
Editorial Material
Rheumatology
Anne Davidson, David Polsky
ARTHRITIS CARE & RESEARCH
(2015)
Review
Immunology
Megan Woods, Yong-Rui Zou, Anne Davidson
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Alexis Boneparth, Megan Woods, Weiqing Huang, Meredith Akerman, Martin Lesser, Anne Davidson
MOLECULAR MEDICINE
(2016)
Article
Immunology
K. Worthmann, F. Gueler, S. von Vietinghoff, A. Davalos-Militz, F. Wiehler, A. Davidson, T. Witte, H. Haller, M. Schiffer, C. S. Falk, L. Schiffer
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2014)
Article
Immunology
Chao Dai, Hongyang Wang, Sun-Sang J. Sung, Rahul Sharma, Carol Kannapell, Wei Han, Qian Wang, Anne Davidson, Felicia Gaskin, Shu Man Fu
CLINICAL IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Ramalingam Bethunaickan, Celine C. Berthier, Weijia Zhang, Matthias Kretzler, Anne Davidson
Article
Multidisciplinary Sciences
Alexis Boneparth, Weiqing Huang, Ramalingam Bethunaickan, Megan Woods, Ranjit Sahu, Shitij Arora, Meredith Akerman, Martin Lesser, Anne Davidson
Meeting Abstract
Rheumatology
Ramalingam Bethunaickan, Celine C. Berthier, Weijia Zhang, Ridvan Eksi, Hong-Dong Li, Yuanfang Guan, Matthias Kretzler, Anne Davidson
ARTHRITIS RESEARCH & THERAPY
(2014)
Article
Rheumatology
Ramalingam Bethunaickan, Celine C. Berthier, Weijia Zhang, Ridvan Eksi, Hong-Dong Li, Yuanfang Guan, Matthias Kretzler, Anne Davidson
ARTHRITIS & RHEUMATOLOGY
(2014)
Editorial Material
Rheumatology
Anne Davidson
ARTHRITIS & RHEUMATOLOGY
(2014)
Article
Rheumatology
Ranjit Sahu, Ramalingam Bethunaickan, Satwinder Singh, Anne Davidson
ARTHRITIS & RHEUMATOLOGY
(2014)
Article
Immunology
Celine C. Berthier, Matthias Kretzler, Anne Davidson
CLINICAL IMMUNOLOGY
(2017)
Article
Urology & Nephrology
Hans-Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, Juergen Floege, Steffen Frese, Loic Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa Lapteva, Adeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Stephen McAdoo, Eoin McKinney, Ulf Panzer, Samir Parikh, Charles Pusey, Chaim Putterman, Ton Rabelink, Andreas Radbruch, Andrew Rees, Mary Reilly, Marlies Reinders, Giuseppe Remuzzi, Piero Ruggenenti, Steven Sacks, Thomas J. Schall, Catherine Meyer-Schwesinger, Kumar Sharma, Yusuke Suzuki, Nicola M. Tomas, Ming-Hui Zhao
KIDNEY INTERNATIONAL REPORTS
(2016)
