Journal
FRONTIERS IN IMMUNOLOGY
Volume 4, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2013.00420
Keywords
biomarkers; graft-versus-host disease; microRNAs; bioinformatics; allogeneic hematopoietic stem cell transplantation
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Funding
- European Commission Marie Curie Initial Training Network CELLEUROPE [315963]
- Newcastle University
- North East Promenaders Against Cancer
- Leukemia and Lymphoma Research
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Graft-versus-host disease (GVHD) is still the major complication of allogeneic hematopoietic stem cell transplantation. Despite extensive studies in understanding the pathophysiology of GVHD, its pathogenesis remains unclear. Recently, important functions of microRNAs have been demonstrated in various autoimmune diseases and cancers such as psoriasis and lymphoma. This review highlights the need to investigate the role of microRNAs in GVHD and hypothesizes that microRNAs may be one of the missing links in our understanding of GVHD, with the potential for novel therapeutics.
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