Review
Environmental Sciences
Rekha Khandia, Shailja Singhal, Taha Alqahtani, Mohammad Amjad Kamal, Nahed A. El-Shall, Firzan Nainu, Perumal Arumugam Desingu, Kuldeep Dhama
Summary: Since December 2019, SARS-CoV-2 has been rapidly evolving and mutating, leading to various variants with different levels of infectivity and lethality. The most recent variant of concern is Omicron (B.1.1.529), which has raised concerns about its ability to evade pre-existing immunity and overcome antibody-based therapies. Several theories have been proposed to explain the high number of mutations in Omicron. To successfully handle the ongoing pandemic, a multifaceted approach including rapid diagnosis, genome analysis, vaccination, and updated medical facilities is needed.
ENVIRONMENTAL RESEARCH
(2022)
Review
Virology
Hai Xu, Shanyuan Zhu, Roshini Govinden, Hafizah Y. Chenia
Summary: "Progress in research on avian influenza vaccines" reviews the recent progress and delivery systems of avian influenza vaccines. It provides ideas for the design and development of new vaccines in the avian influenza research community.
Article
Public, Environmental & Occupational Health
Krish Seetah, Hannah Moots, David Pickel, Marit Van Cant, Alessandra Cianciosi, Erin Mordecai, Mark Cullen, Yvonne Maldonado
Summary: COVID-19 has had a significant impact on global public health and economy. Non-pharmaceutical interventions are crucial as pharmaceutical interventions take time. Anthropological and historical perspectives provide insights for future non-pharmaceutical interventions. Inadequate quarantine and containment infrastructure hinder effective pandemic response. Longitudinal assessment of past interventions and addressing historical legacies are essential for implementing effective quarantine policies and infrastructure. Social equity and compassion are emphasized in containment measures.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Holly Prudden, Roger Tatoud, Cathy Slack, Robin Shattock, Pervin Anklesaria, Linda-Gail Bekker, Susan Buchbinder
Summary: The development of safe and effective HIV vaccines has been a challenge for over 40 years. Despite disappointing clinical trial results, research has provided valuable insights. Swift evaluation and innovative clinical research methods are necessary in the evolving HIV prevention landscape. Experimental medicine studies can accelerate vaccine discovery and the Global HIV Vaccine Enterprise hosted online events to discuss their merits and challenges.
Review
Immunology
Jayanthi Wolf, Risat Jannat, Sheri Dubey, Sean Troth, Matthew T. Onorato, Beth-Ann Coller, Mary E. Hanson, Jakub K. Simon
Summary: Preventative vaccines are considered cost-effective and efficient in containing outbreaks and preventing pandemics, but the process of gaining licensure and manufacturing for human use is complex, costly, and time-consuming. In response to the largest Ebola outbreak to date, public and private partners collaborated to develop an investigational vaccine candidate, which was eventually approved after five years of development by the EMA and FDA.
Review
Immunology
Maria Monica Castellanos, Herve Gressard, Xiangming Li, Claudia Magagnoli, Alessio Moriconi, Daniela Stranges, Laurent Strodiot, Monica Tello Soto, Magdalena Zwierzyna, Cristiana Campa
Summary: This review provides an overview of key factors in accelerating vaccine development and pandemic preparedness, including CMC strategies and technical innovations. The article discusses implementation hurdles and opportunities for sustained acceleration, drawing on learnings from the COVID-19 pandemic and experience in addressing unmet medical needs. The reflections emphasize the importance of a cross-disciplinary technical framework, utilization of prior platform knowledge, and the implementation of innovation and digital tools for fast development and control strategies.
Review
Immunology
T. A. Jose Priya, Sudha Kappalli
Summary: This review discusses the prospects and challenges of utilizing genomics and genetic engineering technologies in the field of aquaculture vaccines, as well as the current limitations of biotechnology-based vaccines in commercial aquaculture. Although some efficient vaccines have been proven effective in field trials, challenges exist in commercialization, including immunological issues, vaccination constraints, and regulatory restrictions.
Review
Pharmacology & Pharmacy
Mikkel Bo Brent
Summary: Animal models are crucial for studying the pathophysiology of bone loss and testing pharmaceutical interventions. The review highlights the importance of studying bone loss from perspectives other than post-menopausal osteoporosis and discusses the current landscape of pharmaceutical countermeasures.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Medicine, Research & Experimental
Wen-Hung Wang, Aspiro Nayim Urbina, Chih-Yen Lin, Zih-Syuan Yang, Wanchai Assavalapsakul, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: The development of dengue vaccines is crucial in preventing and controlling the global health threat caused by Dengue virus. Current approved vaccines have demonstrated low efficacy in certain populations, leading to ongoing investigation and development of novel strategies for dengue vaccines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Pravas Kumar Baral, Jiang Yin, Michael N. G. James
Summary: Researchers worldwide are working on developing prophylactic and therapeutic interventions to combat the COVID-19 crisis, with a focus on antibody-based therapies targeting the viral spike protein, particularly monoclonal antibodies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Immunology
Steven Rockman, Beverly Taylor, John W. McCauley, Ian G. Barr, Ray Longstaff, Ranbir Bahra
Summary: The COVID-19 pandemic has led to rapid investigation and deployment of vaccine platforms never used before. Both new and existing vaccine platforms are likely to play a crucial role in combating future pandemics, especially influenza. The field of influenza vaccine manufacturing has a long history of successes and advancements in the past decade.
Article
Biotechnology & Applied Microbiology
Corey H. Basch, Zoe Meleo-Erwin, Joseph Fera, Christie Jaime, Charles E. Basch
Summary: Misinformation and disinformation surrounding COVID-19 and vaccination may affect vaccine hesitancy. Despite efforts by social media platforms to limit false information, misleading content related to COVID-19 still persists online. A study on TikTok revealed that videos discouraging vaccines outnumbered those encouraging them, but the latter garnered more views and likes. Parodies and false claims regarding vaccines in these videos could potentially hinder the widespread uptake of COVID-19 vaccines.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Michael Vallis, Simon Bacon, Kim Corace, Keven Joyal-Desmarais, Sherri Sheinfeld Gorin, Stefania Paduano, Justin Presseau, Joshua Rash, Abebaw Mengistu Yohannes, Kim Lavoie
Summary: This paper presents a behavioral sciences framework to promote vaccine acceptance in the complex and evolving landscape of COVID-19, by understanding context-specific barriers and taking appropriate actions to facilitate vaccination.
Editorial Material
Biotechnology & Applied Microbiology
Anna Larson, Ava Skolnik, Alexandra Bhatti, Rachel Mitrovich
Summary: The COVID-19 pandemic has greatly disrupted routine vaccination programs in numerous countries, leading to interruptions in vaccination services. Low vaccination coverage rates have impacts such as disease outbreaks, increased pressure on health systems, and heightened risks of disease-related deaths.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Immunology
Andrew Farlow, Els Torreele, Glenda Gray, Kiat Ruxrungtham, Helen Rees, Sai Prasad, Carolina Gomez, Amadou Sall, Jorge Magalhaes, Piero Olliaro, Petro Terblanche
Summary: This review discusses the core themes for investigation in papers submitted to the Vaccines Special Issue on the Future of Epidemic and Pandemic Vaccines. It highlights the limitations faced in the development and distribution of COVID-19 vaccines, and emphasizes the importance of sustainable and equitable vaccine development and manufacturing in low- and middle-income countries. The review also suggests various strategies and concepts, such as technology access pools and vaccine technology transfer hubs, to address the challenges and ensure global vaccine research and development. Overall, it calls for a reevaluation of existing assumptions and a focus on global public health needs. Rating: 8/10.