Article
Multidisciplinary Sciences
Zhuofan Li, Xinliang Kang, Ki-Hye Kim, Yiwen Zhao, Yibo Li, Sang-Moo Kang, Xinyuan Chen
Summary: Physical radiofrequency adjuvant (RFA) can enhance immune responses and induce cross-protective immunity, making it a potential tool for boosting seasonal influenza vaccination and reducing vaccine doses.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Elvira Forte, Bryant Perkins, Amalia Sintou, Harkaran S. Kalkat, Angelos Papanikolaou, Catherine Jenkins, Mashael Alsubaie, Rasheda A. Chowdhury, Theodore M. Duffy, Daniel A. Skelly, Jane Branca, Mohamed Bellahcene, Michael D. Schneider, Sian E. Harding, Milena B. Furtado, Fu Siong Ng, Muneer G. Hasham, Nadia Rosenthal, Susanne Sattler
Summary: After ischemic injury to the heart, cross-priming dendritic cells play a role in activating cytotoxic CD8(+) T cells by presenting self-antigens from necrotic cardiac cells. Research suggests that activation of cytotoxic CD8(+) T cells by cross-priming DC may exacerbate inflammatory damage of the myocardium and corresponding decline in cardiac function.
Article
Immunology
Gaetan Barbet, Priyanka Nair-Gupta, Michael Schotsaert, Stephen T. Yeung, Julien Moretti, Fabian Seyffer, Giorgi Metreveli, Thomas Gardner, Angela Choi, Domenico Tortorella, Robert Tampe, Kamal M. Khanna, Adolfo Garcia-Sastre, J. Magarian Blander
Summary: The study explains how viruses target host cell antigen-processing pathways, focusing on MHC-I molecules and the re-routing of ERGIC-resident MHC molecules to phagosomal vesicles for cross-presentation. It suggests that even without TAP, protective CD8(+) T cells can still be mobilized during viral infection, highlighting a noncanonical cross-presentation pathway.
Article
Immunology
Jean-Pierre Bikorimana, Nehme El-Hachem, Abed El-Hakim El-Kadiry, Jamilah Abusarah, Natasha Salame, Riam Shammaa, Moutih Rafei
Summary: Proteasomes play a crucial role in regulating cellular processes and immune functions, with the TPr complex's contribution to peripheral T-cell immunity requiring further investigation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fangjie Chen, Zhongmin Geng, Lu Wang, Yan Zhou, Jinyao Liu
Summary: This study utilized cascade cell membrane coating to prepare biomimetic nanoparticles that can manipulate the cross-priming of T cells, leading to strong antitumor immune responses. Combination with clinical anti-programmed death-1 antibodies demonstrated the potential of this approach in enhancing tumor regression and survival rate.
Article
Chemistry, Multidisciplinary
Yu Zhao, Xiaoxue Hou, Jingshan Chai, Zhanzhan Zhang, Xue Xue, Fan Huang, Jianfeng Liu, Linqi Shi, Yang Liu
Summary: The development of an antigen-capturing stapled liposome (ACSL) enhances the cross-presentation of tumor-associated antigens in dendritic cells, leading to a strong anti-tumor immune response. In mouse models, ACSL encapsulating l-arginine significantly suppresses tumor growth and induces an abscopal effect. This suggests that ACSL could be a universal platform for the rapid development of various combinations of anticancer therapies using radiosensitizers, photosensitizers, and photothermal agents.
ADVANCED MATERIALS
(2022)
Article
Biology
Katherine A. Deets, Randilea Nichols Doyle, Isabella Rauch, Russell E. Vance
Summary: The study demonstrates that activation of inflammasomes in intestinal epithelial cells can initiate adaptive immune responses by activating CD8(+) T cells. However, cross-presentation of IEC-derived antigens to CD8(+) T cells is not solely dependent on IEC pyroptosis.
Article
Oncology
Federico Simonetta, Juliane K. Lohmeyer, Toshihito Hirai, Kristina Maas-Bauer, Maite Alvarez, Arielle S. Wenokur, Jeanette Baker, Amin Aalipour, Xuhuai Ji, Samuel Haile, Crystal L. Mackall, Robert S. Negrin
Summary: The study assessed the antitumor effects of allogeneic CAR iNKT cells, demonstrating their ability to induce tumor-specific immunity across major MHC barriers and elicit potent antitumor responses from host CD8 T cells. This suggests that the use of off-the-shelf allogeneic CAR iNKT cells could address significant unmet needs in the clinic.
CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Bahareh Vakili, Mahboubeh Karami-Darehnaranji, Esmaeil Mirzaei, Farnaz Hosseini, Navid Nezafat
Summary: Graphene, as a new type of vaccine adjuvant, has been found to enhance antigen immunogenicity and stimulate immune responses. However, its injection may lead to oxidative stress and inflammation, thereby requiring modifications to reduce adverse effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun, Jinping Dong, Guohua Yu, Zhiqin Gao, Bo Zhang, Guixiang Tian
Summary: In this study, glycyrrhetinic acid and hyaluronic acid-modified liposomes were prepared for co-delivery of curcumin and berberine for the treatment of hepatocellular carcinoma. The results showed that the liposomes could accumulate in tumor tissues and be taken up by relevant cells simultaneously. They exhibited stronger pro-apoptotic and anti-proliferation effect compared to free curcumin, and could inhibit the activation of hepatic stellate cells and restrain drug resistance of tumor cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Tsukasa Seya, Masashi Shingai, Tomomi Kawakita, Misako Matsumoto
Summary: Viral infections induce systemic cytokinemia. Vaccines can use virus-derived nucleic acids as adjuvants, activating dendritic cells (DCs) through Toll-like receptors (TLRs) in endosomes. Two subsets of DCs, CD141(+)DCs expressing TLR3 and plasmacytoid DCs (pDCs) expressing TLR7/9, play different roles in antiviral immunity. The mode of vaccine sought in infectious diseases and cancer differs based on prophylactic or therapeutic purposes and antigen delivery to cDCs. Adjuvants can be selected on a case-by-case basis.
Review
Chemistry, Multidisciplinary
Xuanbo Zhang, Bowei Yang, Qianqian Ni, Xiaoyuan Chen
Summary: Cancer vaccines have become an effective tool for cancer immunotherapy, and adjuvants play a crucial role in enhancing immune response. The success of adjuvants in developing stable and immunogenic cancer vaccines has sparked interest in adjuvant development. Advances in materials science offer insights into the rational design of vaccine adjuvants for topical cancer immunotherapy, including molecular adjuvants, polymers/lipids, inorganic nanoparticles, and bio-derived materials. Understanding the physicochemical features of these materials and their engineering strategies can help optimize the effects of adjuvants.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Plant Sciences
Lara Garcia-Campa, Sara Guerrero, Laura Lamelas, Monica Meijon, Rodrigo Hasbun, Maria Jesus Canal, Luis Valledor
Summary: Plants have stress memory, and chloroplast signaling is crucial for acquiring and extending this memory. This study examines the impact of the physiological status of Pinus radiata parents on the ability of their progeny to adapt to their first stress period. The results show that seedlings from stressed parents responded quicker and more efficiently, suggesting a potential biotechnological application in seed orchards.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Materials Science, Biomaterials
Ting Song, Yang Liao, Qinhua Zuo, Ning Liu, Zonghua Liu
Summary: Manganese dioxide nanoparticles act as a promising minimalist multi-mode vaccine adjuvant/delivery system for the development of practical tumor vaccines, as they can induce cellular immune response and enhance immune response through multiple modes.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Pharmacology & Pharmacy
Timothy W. Phares, Jing Huang, Vinayaka Kotraiah, Mary J. Hauser, Arban Domi, Sreenivasa Oruganti, Cecille D. Browne, Peter Buontempo, Marc Mansour, James Pannucci, Moriya Tsuji, Gabriel M. Gutierrez
Summary: The study identified a derivative LD10da that significantly improved T cell activation capability when combined with a malaria vaccine, enhancing antigen-specific CD8(+) T cell expansion. This new immunomodulator shows promise in improving the efficacy and delivery of vaccines.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anantharaman Ramasamy, Ameer Hamid A. Khan, Jackie Cooper, Judit Simon, Pal Maurovich-Horvat, Retesh Bajaj, Pieter Kitslaar, Rajiv Amersey, Ajay Jain, Andrew Deaner, Johan H. C. Reiber, James C. Moon, Jouke Dijkstra, Patrick W. Serruys, Anthony Mathur, Andreas Baumbach, Ryo Torii, Francesca Pugliese, Christos Bourantas
Summary: This study evaluated the application of different coronary computed tomography angiography (CCTA) reconstruction methods in coronary atherosclerosis using intravascular ultrasound as the reference standard. The results showed that CCTA reconstruction with thinner slice thickness, smooth kernel, and highest strength advanced IR enabled more accurate quantification of the lumen and plaque in coronary atherosclerosis. Rating: 8/10
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Instruments & Instrumentation
Emeka B. Okeke, Cameron Louttit, Caitlin M. Snyder, James J. Moon
Summary: Neutrophils and NETs play significant roles in cancer progression and metastasis and are associated with adverse patient outcomes. New drug delivery approaches targeting and modulating neutrophils and NETs have become a research focus in cancer therapeutics.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Computer Science, Interdisciplinary Applications
Daniele M. Papetti, Kirsten Van Abeelen, Rhodri Davies, Roberto Mene, Francesca Heilbron, Francesco P. Perelli, Jessica Artico, Andreas Seraphim, James C. Moon, Gianfranco Parati, Hui Xue, Peter Kellman, Luigi P. Badano, Daniela Besozzi, Marco S. Nobile, Camilla Torlasco
Summary: This study presents a deep-learning-based computational workflow for the segmentation of left ventricular myocardial infarction scar, and the computation of scar transmurality and extent. The system achieves high accuracy, time-effectiveness, and automatic generation of a clinical report.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
George Joy, James C. Moon, Luis R. Lopes
Summary: Hypertrophic cardiomyopathy (HCM) is characterized by ventricular hypertrophy, but it also involves other abnormalities such as cardiomyocyte disarray, myocardial ischemia, and electrical issues, which may appear before the onset of hypertrophy. With advancements in genetic testing and therapeutic agents, detecting subclinical HCM has become a growing priority. In this context, novel biomarkers like quantitative perfusion and diffusion tensor MRI play a significant role.
NATURE REVIEWS CARDIOLOGY
(2023)
Letter
Medicine, General & Internal
Marianna Fontana, Janet Gilbertson, Guglielmo Verona, Mattia Riefolo, Ivana Slamova, Ornella Leone, Dorota Rowczenio, Nicola Botcher, Adam Ioannou, Rishi K. Patel, Yousuf Razvi, Ana Martinez-Naharro, Carol J. Whelan, Lucia Venneri, Amanda Duhlin, Diana Canetti, Stephan Ellmerich, James C. Moon, Peter Kellman, Raya Al-Shawi, Laura Mccoy, J. Paul Simons, Philip N. Hawkins, Julian D. Gillmore
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Adam Ioannou, Rishi K. Patel, Ana Martinez-Naharro, Yousuf Razvi, Aldostefano Porcari, David F. Hutt, Francesco Bandera, Tushar Kotecha, Lucia Venneri, Liza Chacko, Paolo Massa, Melissa Hanger, Daniel Knight, Charlotte Manisty, James Moon, Cristina Quarta, Helen Lachmann, Carol Whelan, Peter Kellman, Philip N. Hawkins, Julian D. Gillmore, Ashutosh Wechelakar, Marianna Fontana
Summary: This study aims to assess multiorgan response to treatment using extracellular volume (ECV) mapping and examine the association between multiorgan treatment response and prognosis.
JACC-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Francesca Lo Iacono, Riccardo Maragna, Marco Guglielmo, Mattia Chiesa, Laura Fusini, Andrea Annoni, Mario Babbaro, Andrea Baggiano, Maria Ludovica Carerj, Francesco Cilia, Alberico Del Torto, Alberto Formenti, Maria Elisabetta Mancini, Francesca Marchetti, Manuela Muratori, Saima Mushtaq, Marco Penso, Sergio Pirola, Luigi Tassetti, Alessandra Volpe, Andrea Igoren Guaricci, Marianna Fontana, Gloria Tamborini, Thomas Treibel, James Moon, Valentina D. A. Corino, Gianluca Pontone
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
George Joy, Christopher I. Kelly, Matthew Webber, Iain Pierce, Irvin Teh, Louise Mcgrath, Paula Velazquez, Rebecca K. Hughes, Huafrin Kotwal, Arka Das, Fiona Chan, Athanasios Bakalakos, Massimiliano Lorenzini, Konstantinos Savvatis, Saidi A. Mohiddin, Peter W. Macfarlane, Michele Orini, Charlotte Manisty, Peter Kellman, Rhodri H. Davies, Pier D. Lambiase, Christopher Nguyen, Jurgen E. Schneider, Maite Tome, Gabriella Captur, Erica Dall'Armellina, James C. Moon, Luis R. Lopes
Summary: In patients with hypertrophic cardiomyopathy, alterations in myocardial microstructure and microvascular disease have been found to occur early in the disease process. These changes serve as potential early phenotype biomarkers for disease detection and management.
Article
Cardiac & Cardiovascular Systems
Adam Ioannou, Aldostefano Porcari, Rishi K. K. Patel, Yousuf Razvi, Giulio Sinigiani, Ana Martinez-Naharro, Lucia Venneri, James Moon, Muhammad U. U. Rauf, Helen Lachmann, Ashutosh Wechelakar, Philip N. N. Hawkins, Julian D. D. Gillmore, Marianna Fontana
Summary: AApoAI and AApoAIV are rare but increasingly recognized causes of cardiac amyloidosis (CA). This study aimed to define the cardiac phenotype in AApoAI and AApoAIV using multimodality imaging. The results showed that both AApoAI and AApoAIV were associated with a good prognosis and a lower risk of mortality.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Daniel M. Altmann, Catherine J. Reynolds, George Joy, Ashley D. Otter, Joseph M. Gibbons, Corinna Pade, Leo Swadling, Mala K. Maini, Tim Brooks, Amanda Semper, Aine Mcknight, Mahdad Noursadeghi, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Rosemary J. Boyton
Summary: This study analyzes the immune response in healthcare workers with mild or asymptomatic SARS-CoV-2 infection and compares it to those with Long Covid. The results show no significant differences in immune responses between the two groups up to 18 weeks post-infection and 1 year after vaccination, suggesting that immune response variations are unlikely to be a contributing factor to Long Covid development.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Francisco Gama, Pedro Custodio, Aliki Tsagkridi, James Moon, Guy Lloyd, Thomas A. Treibel, Sanjeev Bhattacharyya
Summary: High-definition blood flow imaging is a feasible technique that significantly improves the diagnostic accuracy and grading of left ventricular function compared to 2D echocardiography.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Oncology
Constantin-Cristian Topriceanu, Eesha Dev, Mahmood Ahmad, Rebecca Hughes, Hunain Shiwani, Matthew Webber, Kenan Direk, Andrew Wong, Martin Ugander, James C. Moon, Alun D. Hughes, Jane Maddock, Todd T. Schlegel, Gabriella Captur
Summary: This study investigates the relationship between DNAm age and A-ECG heart age, and finds that DNAm AgeAccel is associated with cardiovascular risk factors. The results suggest that participants with accelerated DNA methylation at the age of 60 may have older, weaker, and more electrically impaired hearts. Furthermore, the harmful effects of cardiovascular risk factors on cardiac age and health may be partially mediated by DNAm AgeAccel.
CLINICAL EPIGENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Rebecca K. Hughes, Joao B. Augusto, Kristopher Knott, Rhodri Davies, Hunain Shiwani, Andreas Seraphim, James W. Malcolmson, Shafik Khoury, George Joy, Saidi Mohiddin, Luis R. Lopes, William J. McKenna, Peter Kellman, Hui Xue, Maite Tome, Sanjay Sharma, Gabriella Captur, James C. Moon
Summary: This study found that apical perfusion defects are universally present in ApHCM patients, suggesting that ischemia may play a disease-defining role in ApHCM, which is supported by characteristic ECG results.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jessica Artico, Hunain Shiwani, James C. Moon, Miroslawa Gorecka, Gerry P. McCann, Giles Roditi, Andrew Morrow, Kenneth Mangion, Elena Lukaschuk, Mayooran Shanmuganathan, Christopher A. Miller, Amedeo Chiribiri, Sanjay K. Prasad, Robert D. Adam, Trisha Singh, Chiara Bucciarelli-Ducci, Dana Dawson, Daniel Knight, Marianna Fontana, Charlotte Manisty, Thomas A. Treibel, Eylem Levelt, Ranjit Arnold, Peter W. Macfarlane, Robin Young, Alex McConnachie, Stefan Neubauer, Stefan K. Piechnik, Rhodri H. Davies, Vanessa M. Ferreira, Marc R. Dweck, Colin Berry, John P. Greenwood
Summary: This study aimed to assess the presence, nature, and extent of myocardial damage in hospitalized patients with troponin elevation and COVID-19. The study found that patients with COVID-19 and elevated cardiac troponin levels had more ventricular impairment and myocardial scar compared to the control group. However, the proportion of myocarditis was low and scar pathogenesis was diverse.
Article
Cardiac & Cardiovascular Systems
Constantin-Cristian Topriceanu, Massimiliano Fornasiero, Han Seo, Matthew Webber, Kathryn E. E. Keenan, Karl F. F. Stupic, Ruediger Bruehl, Bernd Ittermann, Kirsty Price, Louise McGrath, Wenjie Pang, Alun D. D. Hughes, Reza Nezafat, Peter Kellman, Iain Pierce, James C. C. Moon, Gabriella Captur
Summary: A phantom dedicated to the quality assurance of T-2 mapping in CMR was fabricated and assessed. The phantom was able to mimic clinically relevant myocardial T-2 and demonstrated excellent structural integrity, magnetic field uniformity, and reproducibility. This device can now be mass-produced to support the quality assurance of T-2 mapping in CMR.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)