Article
Biochemistry & Molecular Biology
Nurul Aida Ngah, George J. Dias, Darryl C. Tong, Siti Noor Fazliah Mohd Noor, Jithendra Ratnayake, Paul R. Cooper, Haizal Mohd Hussaini
Summary: This study successfully prepared lyophilised PRF with a dense and homogeneous 3D fibrin network structure, and demonstrated the release of PDGF-AB. The findings provide a foundation for the potential widespread clinical application of Ly-PRF in craniofacial tissue engineering.
Review
Medicine, General & Internal
Djandan Tadum Arthur Vithran, Miao He, Wenqing Xie, Anko Elijah Essien, Michael Opoku, Yusheng Li
Summary: Autologous and recombinant biologic substances have been generated from cellular research on the healing process. Orthobiologics are becoming more commonly used in sports medicine and musculoskeletal surgery. However, more studies are needed, particularly in foot and ankle pathologies, to provide further clinical data and determine the effectiveness of platelet-rich plasma (PRP) in treating these conditions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Liam D. A. Paget, Gustaaf H. Reurink, Robert-Jan de Vos, Adam Weir, Maarten H. Moen, Sita M. A. Bierma-Zeinstra, Sjoerd A. S. Stufkens, Rover E. Krips, Mario A. Maas, Duncan E. Meuffels, Gino M. M. J. Kerkhoffs, Johannes L. L. Tol
Summary: This study found that PRP injections did not improve symptoms and function in patients with ankle osteoarthritis over 52 weeks compared with placebo injections.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Balaji Mahendiran, Shalini Muthusamy, Sowndarya Sampath, S. N. Jaisankar, R. Selvakumar, Gopal Shankar Krishnakumar
Summary: This study describes the fabrication of cellulose scaffold loaded with platelet rich plasma (PRP) and evaluates its physicochemical properties, growth factor release, and biological performance. The results demonstrate that the scaffold can sustainably release growth factors and improve cellular proliferation and differentiation of osteoblasts. In vivo studies show that the PRP enriched scaffold promotes angiogenesis and tissue remodeling.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Jeffrey L. Van Eps, Joseph S. Fernandez-Moure, Fernando J. Cabrera, Francesca Taraballi, Francesca Paradiso, Silvia Minardi, Xin Wang, Bayan Aghdasi, Ennio Tasciotti, Bradley K. Weiner
Summary: The human bony skeleton undergoes constant remodeling with a turnover of up to 10% bone volume annually. The study evaluated the regenerative ability of a nanostructured MHA/Coll scaffold augmented by autologous PRP in a model of spinal fusion. Both groups showed significantly more new bone formation compared to controls, with Group 2 exhibiting enhanced bone production and successful fusion rates. This study demonstrates the potential of using nanostructured MHA/Coll scaffold and autologous PRP in achieving successful clinical fusion.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Jie Zhou, Yufei Liu, Xiangsheng Liu, Jinpeng Wan, Shuyu Zuo, Tengwu Pan, Yanyu Liu, Feifan Sun, Minli Gao, Xinyi Yu, Weihong Zhou, Jun Xu, Zhenyu Zhou, Shufang Wang
Summary: In recent years, there has been an increase in the incidence of diabetic skin ulcers, which poses a significant burden to patients and society due to its high disability and fatality rate. Platelet-rich plasma (PRP) is clinically valuable for wound treatment, but its weak mechanical properties and abrupt release of active substances limit its efficacy. In this study, a hydrogel was prepared using hyaluronic acid (HA) and e-polylysine (e-PLL) to prevent infections and promote tissue regeneration. The hydrogel, combined with the macropore barrier effect of a lyophilized scaffold, created a double network hydrogel that slowly released growth factors, resulting in superior therapeutic effects in diabetic rats with full skin defects.
CARBOHYDRATE POLYMERS
(2023)
Article
Veterinary Sciences
Alessio Franini, Maria Grazia Entani, Elisa Colosio, Luca Melotti, Marco Patruno
Summary: In this case report, a 7-year-old male Whippet competing in lure-coursing exhibited third-degree recurrent lameness in the right forelimb, with pain and swelling in the caudal aspect of the carpus. Conservative treatments such as NSAIDs administration, palmar splint application, and rest were ineffective. The dog received autologous PRP injections followed by PL injections at three-week intervals. Clinical and ultrasonographic assessments showed improvements in lameness and healing of the tendinopathy. The combination treatment of autologous PRP and PL for FCU tendinopathy in lure-coursing dogs was found to be feasible with no adverse reactions.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Jianying Zhang, Feng Li, Tyler Augi, Kelly M. Williamson, Kentaro Onishi, MaCalus Hogan, Matthew D. Neal, James H-C Wang
Summary: Platelet-rich plasma (PRP) containing PLT HMGB1 plays a crucial role in tendon wound healing by reducing inflammation, increasing local HMGB1 levels, and recruiting stem cells to the injured area. The efficacy of PRP treatment for tendon injuries in clinics may be dependent on the presence of PLT HMGB1 in PRP preparations.
Review
Biotechnology & Applied Microbiology
Shuang Liang, Zhiqiang Zheng, Yaxin Li, Yuanming Yang, Lifeng Qin, Zhen Zhao, Licun Wang, Haiyan Wang
Summary: This review summarizes the clinical approaches and advantages of autologous platelet-rich plasma (PRP) in the management of enteric fistula (EF). The mechanism of action of PRP in EF treatment remains unclear, but it may promote healing through the involvement of cytokines.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yanling Wang, Bang Liu, Yinzhen Pi, Li Hu, Yeling Yuan, Jiao Luo, Yixiao Tao, Ping Li, Shan Lu, Wei Song
Summary: The purpose of this study was to assess the risk factors for morbidity and mortality of diabetic foot ulcers (DFUs). The study also investigated the effectiveness of negative pressure wound therapy (NPWT) combined with platelet-rich plasma-fibrin glue (PRP) in the treatment of diabetic foot ulcers. They found new risk factors for DFUs and concluded that the combination therapy could accelerate wound healing and reduce mortality rate.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell & Tissue Engineering
Lindsey G. Johnson, Erin H. Buck, Albert T. Anastasio, Bijan Abar, Amanda N. Fletcher, Samuel B. Adams
Summary: The purpose of this review is to develop evidence-based practices for the use of platelet-rich plasma (PRP) to treat bony pathologies of the lower extremity. Moderate high-quality evidence supports the use of PRP in surgery to treat damage of both cartilage and bone in the foot. PRP may augment bone stimulation surgery in cases of cartilage and bone defects with promise for increasing bone to bone healing following surgical operations. Further high-quality, comparative studies with longer clinical follow-up are required.
REGENERATIVE MEDICINE
(2023)
Article
Medicine, General & Internal
Shaolong Zhou, Li Li, Chen Chen, Yi Chen, Linhua Zhou, Fiona H. Zhou, Jianghui Dong, Liping Wang
Summary: By immobilizing platelets from platelet-rich plasma onto gelatin microspheres, a biomimetic bioreactor GM+PRP was formed which accelerated wound healing in rats by increasing vessel density and reducing inflammation. Compared with PRP alone, GM+PRP significantly increased the expression of angiogenic factors and promoted inflammatory and angiogenic responses.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Dentistry, Oral Surgery & Medicine
Richard J. Miron, Masako Fujioka-Kobayashi, Anton Sculean, Yufeng Zhang
Summary: This article summarizes the methods to optimize platelet-rich fibrin (PRF) technology for faster wound healing postsurgery. It explains the differences between RPM and RCF (g-force) and discusses methods to maximize platelet concentrations using optimized protocols. The article also emphasizes the importance of chemically modified PRF tubes without chemical additives and the regulation of temperature for clotting induction/delay. It is the first article to summarize recent literature on PRF for optimizing PRF production for clinical treatment.
PERIODONTOLOGY 2000
(2023)
Article
Biochemistry & Molecular Biology
Lin Zhang, Yunsheng Dong, Yufei Liu, Xiangsheng Liu, Zhitao Wang, Jinpeng Wan, Xinyi Yu, Shufang Wang
Summary: Multifunctional composite scaffolds have potential applications in the treatment of periodontal diseases, promoting bone regeneration and preventing fibrous tissue infiltration into bone defects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biotechnology & Applied Microbiology
Maddalena Mastrogiacomo, Marta Nardini, Maria Chiara Collina, Cristiana Di Campli, Gilberto Filaci, Ranieri Cancedda, Teresa Odorisio
Summary: Cutaneous chronic wounds are a major health burden globally, and various treatments have been proposed. Stem cells and platelet-rich plasma (PRP) are considered promising tools for promoting ulcer healing. However, their use may be limited in certain conditions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Giuseppe Filardo, Matilde Tschon, Francesco Perdisa, Silvia Brogini, Carola Cavallo, Giovanna Desando, Gianluca Giavaresi, Brunella Grigolo, Lucia Martini, Nicolo Nicoli Aldini, Alice Roffi, Milena Fini, Elizaveta Kon
Summary: The study compared three procedures for treating osteoarthritis using adipose-derived cells. Mechanical micro-fragmentation (MF) showed the most promising results in protecting the articular surface from OA processes.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Alberto Poggi, Alessandro Di Martino, Luca Andriolo, Davide Reale, Giuseppe Filardo, Elizaveta Kon, Stefano Zaffagnini
Summary: The study aimed to evaluate the efficacy of a chitosan bioscaffold in treating patellar cartilage lesions. The results showed significant clinical improvement at 24 months after surgery, indicating that this treatment method is safe and effective.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Review
Clinical Neurology
Alessandro Sangiorgio, Lorenzo Massimo Oldrini, Christian Candrian, Costantino Errani, Giuseppe Filardo
Summary: This systematic review and meta-analysis compared the safety and efficacy of radiofrequency ablation (RFA) and surgical excision for the treatment of spinal osteoid osteoma (OO). The results showed that both RFA and surgical excision were effective in pain relief with low recurrence and complication rates. RFA, being a less invasive procedure, proved to be a safe and effective alternative to surgical excision.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
Elizaveta Kon, Angelo Boffa, Luca Andriolo, Alessandro Di Martino, Berardo Di Matteo, Nicola Magarelli, Nicoletta Trenti, Stefano Zaffagnini, Giuseppe Filardo
Summary: The combination of subchondral and intra-articular BMAC injections showed positive clinical and imaging outcomes for the treatment of knee osteoarthritis. The treatment resulted in stable subjective scores and improvements in KOOS subscales, while VAS pain worsened over time. The MRI findings showed a reduction in bone marrow edema.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Carola Cavallo, Angelo Boffa, Laura de Girolamo, Giulia Merli, Elizaveta Kon, Luca Cattini, Emma Santo, Brunella Grigolo, Giuseppe Filardo
Summary: This study compared the number and properties of bone marrow stromal cells (BMSCs) collected from different harvest sites and from patients of different ages. The results showed that younger patients and BMAC obtained from the iliac crest had a higher number of mononuclear cells and clonogenic capacity.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Review
Biochemistry & Molecular Biology
Cristiano Sconza, Giulia Leonardi, Carla Carfi, Elizaveta Kon, Stefano Respizzi, Dalila Scaturro, Giulia Letizia Mauro, Giuseppe Massazza, Berardo Di Matteo
Summary: The purpose of this study was to review the evidence on intra-articular botulinum toxin (BTX) injection for knee osteoarthritis (OA) and compare it with other treatment options. A systematic review was conducted on randomized controlled trials (RCTs) published in the past 20 years. Nine studies involving 811 patients were included. The quality of the included studies varied, but overall, BTX injection showed positive effects on pain relief and improved function and quality of life. However, compared to other established treatments for knee OA, no clear indication emerged. The methodological quality of the available RCTs on BTX intra-articular injection for knee OA was modest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Orthopedics
Alexander Korneev, Marina Lipina, Alexey Lychagin, Peter Timashev, Elizaveta Kon, Dmitry Telyshev, Yuliya Goncharuk, Ivan Vyazankin, Mikhail Elizarov, Emirkhan Murdalov, David Pogosyan, Sergei Zhidkov, Anastasia Bindeeva, Xing-Jie Liang, Vladimir Lasovskiy, Victor Grinin, Alexey Anosov, Eugene Kalinsky
Summary: This study describes and assesses the integration of artificial intelligence (AI) technology in preventive orthopaedics of the knee and hip joints. The study found that there are insufficient, varied, and low-quality data for training and validating AI models, as well as a lack of rational evaluation of the models. However, the study suggests that optimizing and confirming the models' quality on different datasets are the final technical barriers for creating usable software and integrating them into the routine of an orthopaedic physician.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Biochemistry & Molecular Biology
Cristiano Sconza, Berardo Di Matteo, Paolo Queirazza, Arianna Dina, Roberta Amenta, Stefano Respizzi, Giuseppe Massazza, Antonio Ammendolia, Elizaveta Kon, Alessandro de Sire
Summary: Ozone therapy (OT) and hyaluronic acid (HA) injections have similar short-term pain relief effects for knee osteoarthritis (OA) patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Stefano Zaffagnini, Iacopo Romandini, Giuseppe Filardo, Giacomo Dal Fabbro, Alberto Grassi
Summary: This study aimed to evaluate the clinical and functional outcomes of a salvage surgical approach combining meniscal allograft transplantation (MAT), anterior cruciate ligament reconstruction (ACLR), and high tibial osteotomy (HTO) in patients with complex knee lesions. The patients were evaluated using various scores and tests at short and mid-term follow-ups. The combined procedure showed good and stable results, reducing pain, improving knee function, and slowing down the progression of osteoarthritis, making it a valid treatment option for complex patients.
INTERNATIONAL ORTHOPAEDICS
(2023)
Review
Chemistry, Medicinal
Anna Tampieri, Elizaveta Kon, Monica Sandri, Elisabetta Campodoni, Massimiliano Dapporto, Simone Sprio
Summary: The degeneration of osteochondral tissue is a major cause of disability in modern society and there is a growing demand for solutions to repair and regenerate damaged articular joints. Osteoarthritis is the most common complication in articular diseases and a leading cause of chronic disability. Regenerating osteochondral defects is a challenging task in orthopedics, but marine-derived ingredients hold promise for their unique properties and potential biomedical applications.
Article
Orthopedics
Lorenzo Massimo Oldrini, Alessandro Sangiorgio, Pietro Feltri, Francesco Marbach, Giuseppe Filardo, Christian Candrian
Summary: This study compared the two main surgical approaches for proximal humerus fractures (PHFs) and demonstrated that the MIPO with DS approach showed similar functional outcomes to the ORIF with DP approach, especially for Neer II and III fracture types.
EFORT OPEN REVIEWS
(2023)
Review
Pharmacology & Pharmacy
G. Anzillotti, P. Conte, B. DI Matteo, E. M. Bertolino, M. Marcacci, E. Kon
Summary: This study analyzed the use of injectable orthobiological treatments in patients with severe knee osteoarthritis and found no consistent beneficial effects. Therefore, further clinical trials are needed to validate the use of injectable biologic agents in the treatment of grade IV knee osteoarthritis in everyday practice.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
F. TASSO, V. SIMILI, B. DI MATTEO, G. MONTELEONE, F. MARTORELLI, A. DE ANGELIS, T. D'AMATO, M. BOVIO, D. ALTOMARE, G. CAMPOFREDA, M. MARCACCI, M. SCARDINO
Summary: This study describes the outcomes of implementing a rapid recovery protocol in a referral center for hip and knee replacement surgery. The protocol was able to reduce the length of stay, increase the number of joint replacement procedures, and optimize the use of blood products without increasing complications.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
C. Sconza, M. Anza, B. Di Matteo, M. Lipina, E. Kon, S. Respizzi, E. Tibalt, M. C. D'Agostino
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
