Article
Cardiac & Cardiovascular Systems
Mona Al-Ahmad, David Webb
Summary: The study in a real-world population in Kuwait showed that switching asthma patients from ICS/LABA DPI to ICS/LABA pMDI can significantly improve lung function and increase asthma control within 12 months.
RESPIRATORY MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Ville A. Vartiainen, Federico Lavorini, Anna C. Murphy, Klaus F. Rabe
Summary: This review article discusses the sustainability of inhaler therapy in respiratory diseases, particularly the concern over the use of propellant-based inhalers with high global warming potential. It examines the airflow resistance of dry powder inhalers (DPIs) and their effectiveness in different respiratory conditions, including exacerbations.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Respiratory System
Ashley Woodcock, Christer Janson, Jamie Rees, Lucy Frith, Magnus Lofdahl, Alison Moore, Martin Hedberg, David Leather
Summary: The study compared the effects of switching from pMDI to DPI maintenance therapy on greenhouse gas emissions and asthma control. Results showed that patients who switched to DPI treatment more than halved their inhaler carbon footprint while maintaining good asthma control.
Article
Biochemistry & Molecular Biology
Azin Jahangiri, Ali Nokhodchi, Kofi Asare-Addo, Erfan Salehzadeh, Shahram Emami, Shadi Yaqoubi, Hamed Hamishehkar
Summary: The study aimed to develop carrier-free inhalable CLX microparticles for dry powder inhalation (DPI) using electrospraying. The results showed that electrosprayed particles prepared from the ethanol-acetone solvent mixture at a drug concentration of 3% exhibited the best in vitro aerosolization properties.
Article
Allergy
Thitima Sirimontakan, Wiparat Manuyakorn, Harutai Kamalaporn, Pornchai Wattanarungsun, Kuntalee Chonpaisan, Korakot Thongkum, Prapasiri Singvijarn, Sintra Phumethum
Summary: This study demonstrates that a 2-minute cartoon video instruction can effectively improve DPI technique in Thai children with asthma.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Toby G. D. Capstick, Nooria F. Azeez, Gary Deakin, Ashleigh Goddard, Dawn Goddard, Ian J. Clifton
Summary: By optimizing inhaler technique, this novel service significantly reduced the rate of moderate-to-severe exacerbations in asthma and COPD, leading to a decrease in hospital admissions, length of stay, and average cost of admission.
RESPIRATORY MEDICINE
(2021)
Article
Pediatrics
Petr Pohunek, Guido Varoli, Yuriy Reznichenko, Svetlana Mokia-Serbina, Jerzy Brzostek, Viktoriya Kostromina, Mykola Kaladze, Annamaria Muraro, Elena Carzana, Silvia Armani, Jadwiga Kaczmarek
Summary: The study demonstrated that CHF1535 pediatric fixed combination was non-inferior to the free combination in pulmonary function in asthmatic children, with a dose-related response trend, indicating high safety of the treatments.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Nursing
Ebru Yildiz, Sultan Cecen, Didem Lafci, Asli Eker
Summary: This study found that repeated video-training sessions significantly improved MDI skills among COPD patients, with the experimental group showing better adequacy and fewer mistakes in the 5th measurement. Supporting training on inhaler drug therapy with visual technological tools and regular checking of drug use will contribute to COPD management.
JOURNAL OF CLINICAL NURSING
(2022)
Review
Allergy
Sinthia Bosnic-Anticevich, Bruce G. Bender, Melinda T. Shuler, Mike Hess, Janwillem W. H. Kocks
Summary: Poor inhaler technique is a significant barrier to effective management of asthma and chronic obstructive pulmonary disease (COPD). It can lead to a perceived lack of treatment effectiveness, even when patients adhere to prescribed inhaled maintenance therapies. Training and ongoing assessment are often lacking in real-world practice. This review examines the evidence for deterioration of inhaler technique over time, identifies contributing factors, and explores innovative approaches to addressing the problem.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Pharmacology & Pharmacy
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Beatrice Ludovica Ritondo, Elena Pistocchini, Paola Rogliani, Alfredo Chetta
Summary: Sex may influence the proper use of inhaler devices in asthma and COPD, with females having a higher rate of critical errors when using DPI and SMI.
Article
Cardiac & Cardiovascular Systems
Job van der Palen, David Slade, Sunita Rehal, Manish Verma, Maximilian Plank
Summary: The study found that patients with asthma had fewer critical errors and overall errors with the ELLIPTA inhaler compared to the BREEZHALER inhaler after reading the patient information leaflet.
RESPIRATORY MEDICINE
(2022)
Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of mouthpiece designs in carrier-based dry powder inhalation on aerosol particle characteristics. It is found that a mouthpiece with a spiral channel and mixing chamber is effective in delivering drug particles uniformly to the peripheral target regions of the respiratory system under low flow velocities.
Article
Pharmacology & Pharmacy
Gajendra Singh, Albyn Lowe, Athiya Azeem, Shaokoon Cheng, Hak-Kim Chan, Ross Walenga, Agisilaos Kourmatzis
Summary: This study investigated the transport of pharmaceutical dry powder inside an inhaler-like device using high-speed imaging, focusing on the effect of inflow modifications on the dispersion characteristics of agglomerates inside the device. By strategically perturbing airflow conditions, the research observed complete fluidisation of the powder bed and various behaviors such as local turbulence, bimodal fragment size behavior, and flow separation induced by changes in flow behavior. The study's findings provide valuable data for understanding the impact of inflow conditions on a dry powder inhaler-like device and validating computational models.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of adding bypass holes in a dry powder inhaler on aerosol particle characteristics. The direction, size, and position of the bypass holes in the inhaler passage were found to significantly influence the spray output. Adding bypass holes decreased the mean penetration length of drug particles by 12%, but simultaneously increased the spray angle by 35%, resulting in a significant decrease in forward particle momentum.
Article
Respiratory System
Nethmi Kearns, Mathew Williams, Pepa Bruce, Melissa Black, Cilein Kearns, Jenny Sparks, Irene Braithwaite, Mark Weatherall, Richard Beasley
Summary: This study compared the bronchodilator response of salbutamol and budesonide/formoterol in adults with stable asthma. The results showed that after 2 minutes of treatment administration, both budesonide/formoterol and salbutamol had minimal changes in FEV1, but salbutamol had a stronger response in FEV1 over 30 minutes.
Article
Biology
Heledd H. Jarosz-Griffiths, Thomas Scambler, Chi H. Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F. McDermott, Daniel Peckham
Review
Cardiac & Cardiovascular Systems
Syed Shahzad Hasan, Toby Capstick, Syed Tabish Razi Zaidi, Chia Siang Kow, Hamid A. Merchant
RESPIRATORY MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Chia Siang Kow, Toby Capstick, Syed Tabish Razi Zaidi, Syed Shahzad Hasan
Summary: This study examined the consistency of recommendations on the management of critically ill COVID-19 patients between various clinical practice guidelines and those of the WHO. Inconsistencies were observed between some recommendations, highlighting the need for consensus among relevant bodies to address these discrepancies in clinical practice.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2021)
Letter
Allergy
Chia Siang Kow, Toby Capstick, Syed Shahzad Hasan
Article
Critical Care Medicine
Giulia Spoletini, Kim Pollard, Ruth Watson, Michael J. Darby, Annette Johnstone, Christine Etherington, Paul Whitaker, Ian J. Clifton, Daniel G. Peckham
Summary: NIV is commonly used to treat patients with cystic fibrosis, mainly for chronic and acute hypercapnic respiratory failure. Adherence to NIV treatment can stabilize lung function but does not reduce pulmonary exacerbations or intravenous antibiotic requirement.
Article
Allergy
Caroline Reilly, Antonis Stavropoulos-Kalinoglou, Ian Clifton, Jim McKenna, Daniel Peckham, Oliver J. Price
Summary: The findings suggest that the built-in iPhone (R) pedometer offers a practical approach for assessing physical activity in adults with and without asthma. During self-paced walking, all devices provided excellent step-count estimates. In free-living conditions, both Yamax Digiwalker (TM) SW800 and iPhone (R) pedometers showed similar accuracy, indicating the potential of smartphone pedometers in monitoring and promoting physical activity.
Article
Public, Environmental & Occupational Health
M. F. King, A. M. Wilson, M. Lopez-Garcia, J. Proctor, D. G. Peckham, I. J. Clifton, S. J. Dancer, C. J. Noakes
Summary: The study observed healthcare workers' behaviors during different types of care procedures, finding significant differences in surface contacts, contact time, and hand hygiene behaviors between actual and mock care settings. The study also highlighted variations in duration and hand hygiene practices among different healthcare professionals. Additionally, the study showed that mock care underestimated hand microbial contamination by approximately 30% compared to actual care.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Construction & Building Technology
Amanda M. Wilson, Marco-Felipe King, Martin Lopez-Garcia, Ian J. Clifton, Jessica Proctor, Kelly A. Reynolds, Catherine J. Noakes
Summary: Healthcare professionals are exposed to highly infectious viruses such as norovirus through multiple exposure routes. A study evaluated the influences of hospital patient room layout on differences in predicted hand contamination from deposited norovirus particles. Differences in viral accruement were influenced by bioaerosol deposition patterns and behavior sequences, with doctors' rounds resulting in the greatest predicted viral accruement on hands.
Article
Respiratory System
Giulia Spoletini, Ruth Watson, Wang Yng Lim, Kim Pollard, Christine Etherington, Ian J. Clifton, Daniel G. Peckham
Summary: The study explored the feasibility of using NHFT in patients with CF during exercise, showing that NHFT can improve exercise tolerance, dyspnoea, and comfort without significant adverse events.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Nutrition & Dietetics
Linsey King, Helen White, Ian Clifton, Giulia Spoletini, Theocharis Ispoglou, Daniel G. Peckham
Summary: This study aimed to investigate the nutritional status and intakes in patients with bronchiectasis, finding that most patients did not meet energy requirements but exceeded protein RNI, with inadequate intake of vitamin D. BMI masked functional, body composition, and nutritional deficits in patients, especially in the younger PCD subgroup.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Toby G. D. Capstick, Nooria F. Azeez, Gary Deakin, Ashleigh Goddard, Dawn Goddard, Ian J. Clifton
Summary: By optimizing inhaler technique, this novel service significantly reduced the rate of moderate-to-severe exacerbations in asthma and COPD, leading to a decrease in hospital admissions, length of stay, and average cost of admission.
RESPIRATORY MEDICINE
(2021)
Meeting Abstract
Allergy
C. Reilly, A. Stavropoulos-Kalinoglou, I. J. Clifton, O. J. Price
Article
Rehabilitation
Manoj Sivan, Stephen Halpin, Lisa Hollingworth, Niki Snook, Katherine Hickman, Ian J. Clifton
JOURNAL OF REHABILITATION MEDICINE
(2020)
Article
Respiratory System
Russell Frood, Shishir Karthik, Saeed Mirsadraee, Ian Clifton, Karen Flood, Simon J. McPherson