Carbon nanotubes as delivery systems for respiratory disease: do the dangers outweigh the potential benefits?

Carbon Nanotubes – Curse or Blessing

(2012) J.-P. Kaiser et al.   CURRENT MEDICINAL CHEMISTRY

Mechanistic Toxicity Evaluation of Uncoated and PEGylated Single-Walled Carbon Nanotubes in Neuronal PC12 Cells

(2011) Yongbin Zhang et al.   ACS Nano

Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure

(2011) Alexey V. Tkach et al.   ACS Nano

Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura

(2011) Fiona A. Murphy et al.   AMERICAN JOURNAL OF PATHOLOGY

A Brief Summary of Carbon Nanotubes Science and Technology: A Health and Safety Perspective

(2011) Peter Wick et al.   ChemSusChem

Nanomaterial cell interactions: are currentin vitrotests reliable?

(2011) Cordula Hirsch et al.   Nanomedicine

Multi-Walled Carbon Nanotube Instillation Impairs Pulmonary Function in C57BL/6 Mice

(2011) Xiaojia Wang et al.   Particle and Fibre Toxicology

Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping

(2010) Saji George et al.   ACS Nano

Quantitative Techniques for Assessing and Controlling the Dispersion and Biological Effects of Multiwalled Carbon Nanotubes in Mammalian Tissue Culture Cells

(2010) Xiang Wang et al.   ACS Nano

Toxicology of engineered nanomaterials: Focus on biocompatibility, biodistribution and biodegradation

(2010) Andrea Kunzmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss-Webster mice

(2010) Anita K. Patlolla et al.   ENVIRONMENTAL TOXICOLOGY

Lung exposure to nanoparticles modulates an asthmatic response in a mouse model

(2010) S. Hussain et al.   EUROPEAN RESPIRATORY JOURNAL

Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stress

(2010) Ken-ichiro Inoue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape

(2010) Kohei Yamashita et al.   INFLAMMATION

Drug delivery and nanoparticles: Applications and hazards

(2010) de Jong   International Journal of Nanomedicine

Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safety-by-design

(2010) Ken Donaldson et al.   Nanomedicine

A critical review of the biological mechanisms underlying thein vivoandin vitrotoxicity of carbon nanotubes: The contribution of physico-chemical characteristics

(2010) Helinor J. Johnston et al.   Nanotoxicology

Nanoparticles in the lung

(2010) Wolfgang G Kreyling et al.   NATURE BIOTECHNOLOGY

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

(2010) Valerian E. Kagan et al.   Nature Nanotechnology

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes

(2010) Robert R Mercer et al.   Particle and Fibre Toxicology

Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies

(2010) Liying Wang et al.   Particle and Fibre Toxicology

A comparison of acute and long-term effects of industrial multiwalled carbon nanotubes on human lung and immune cells in vitro

(2010) Tina Thurnherr et al.   TOXICOLOGY LETTERS

Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes

(2009) Mark F. Cesta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Induction of aneuploidy by single-walled carbon nanotubes

(2009) L.M. Sargent et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Nanoparticle-Mediated Drug Delivery and Pulmonary Hypertension

(2009) James C. Bonner et al.   HYPERTENSION

Mechanistic Investigations of Horseradish Peroxidase-Catalyzed Degradation of Single-Walled Carbon Nanotubes

(2009) Brett L. Allen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Inhaled carbon nanotubes reach the subpleural tissue in mice

(2009) Jessica P. Ryman-Rasmussen et al.   Nature Nanotechnology

Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice

(2009) L. A. Mitchell et al.   Nature Nanotechnology

Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection

(2009) Ilona Jaspers et al.   Particle and Fibre Toxicology

Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo

(2009) Nagarjun V. Konduru et al.   PLoS One

Single-Walled and Multi-Walled Carbon Nanotubes Promote Allergic Immune Responses in Mice

(2009) Unni C. Nygaard et al.   TOXICOLOGICAL SCIENCES

Subchronic 13-Week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects Are Determined by Density of Agglomerate Structures, Not Fibrillar Structures

(2009) Jürgen Pauluhn   TOXICOLOGICAL SCIENCES

Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation

(2009) Eun-Jung Park et al.   TOXICOLOGY

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

(2009) Dale W. Porter et al.   TOXICOLOGY

Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model

(2009) Ken-ichiro Inoue et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhaled Multiwalled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma

(2008) Jessica P. Ryman-Rasmussen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Effects of Pulmonary Exposure to Carbon Nanotubes on Lung and Systemic Inflammation with Coagulatory Disturbance Induced by Lipopolysaccharide in Mice

(2008) Ken-ichiro Inoue et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers

(2008) Aaron Erdely et al.   NANO LETTERS

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus?

(2008) A.A. Shvedova et al.   PHARMACOLOGY & THERAPEUTICS

Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes

(2008) P. Chakravarty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionalized Carbon Nanotubes in Drug Design and Discovery

(2007) Maurizio Prato et al.   ACCOUNTS OF CHEMICAL RESEARCH

Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model

(2007) R. R. Mercer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity

(2007) Anna A. Shvedova et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY