Article
Ophthalmology
Peizeng Yang, Chaokui Wang, Guannan Su, Su Pan, Yang Qin, Jun Zhang, Qingfeng Cao, Zhenyu Zhong, Chunjiang Zhou, Yao Wang, Aize Kijlstra
Summary: This study examined the prevalence, risk factors, and treatment outcomes of OHT/glaucoma in Chinese patients with VKH. Risk factors included poorer visual acuity, longer intervals between uveitis attacks and referral, more recurrent episodes, and posterior synechiae. Medical treatment and surgical interventions were effective in achieving normalized intraocular pressure in affected eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Yangfan Yang, Xinyi Zhang, Zidong Chen, Yifan Wei, Qiaona Ye, Yanmei Fan, Neil Nathwani, Gus Gazzard, Minbin Yu
Summary: This study aimed to report the baseline characteristics and diurnal fluctuation of intraocular pressure (IOP) in a Chinese cohort of patients with glaucoma and ocular hypertension. The results showed that younger age, male gender, and thicker central corneal thickness were correlated with higher IOP in patients with primary open-angle glaucoma, while only thicker central corneal thickness was related to higher IOP in patients with ocular hypertension. Peak IOP occurred mostly in the early morning or late afternoon, and trough IOP occurred mostly in the early afternoon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Colleen M. McDowell, Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph Van Batenburg-Sherwood, J. Cameron Millar, Markus H. Kuehn, Gulab Zode, Ted S. Acott, Michael G. Anderson, Sanjoy K. Bhattacharya, Jacques A. Bertrand, Terete Borras, Diane E. Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A. Faralli, Rudolf Fuchshofer, Preethi S. Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W. M. John, Paul L. Kaufman, Kate E. Keller, Mary J. Kelley, Ruth A. Kelly, David Krizaj, Ajay Kumar, Brian C. Leonard, Raquel L. Lieberman, Paloma Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J. McLellan, Philip Mzyk, Andrews Nartey, Louis R. Pasquale, Gaurang C. Patel, Padmanabhan P. Pattabiraman, Donna M. Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R. Samples, E. Griffen Samples, Najam Sharif, Joel S. Schuman, Val C. Sheffield, Cooper H. Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B. Toris, Karen Y. Torrejon, Amir Vahabikashi, Janice A. Vranka, Ting Wang, Colin E. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, Michael P. Fautsch, Ernst R. Tamm, Abbot F. Clark, C. Ross Ethier, W. Daniel Stamer
Summary: This article highlights the importance of using mice as a valuable model system for studying conventional outflow resistance and intraocular pressure. It also outlines the minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. These standards are expected to enhance scientific rigor and replicability of research findings.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Wungrak Choi, Hyoung Won Bae, Hye Jung Shin, Eun Woo Kim, Chan Yun Kim, Min Kim, Gong Je Seong
Summary: This study developed two nomograms to predict a safety zone for intravitreal DEX implantation. These can be used to identify individuals who may be safely prescribed steroid treatments and for whom extra caution should be exercised.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Kelsey Stuart, Anthony P. Khawaja
Summary: Glaucoma is a major cause of visual impairment and a significant public health concern. Genomics holds potential for cost-effective screening, risk prediction, treatment response, and lifestyle advice in managing glaucoma.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Sean Mullany, Lewis Xiao, Ayub Qassim, Henry Marshall, Puya Gharahkhani, Stuart MacGregor, Mark M. Hassall, Owen M. Siggs, Emmanuelle Souzeau, Jamie E. Craig
Summary: This study investigated the association between normal-tension glaucoma (NTG) and cognitive impairment, finding that cognitive impairment was more prevalent in the NTG group compared to the high-tension glaucoma (HTG) group. While a linear trend was observed in lower T-MoCA scores in the NTG group compared to the HTG group, the association was not statistically significant.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Adi Mohammed Al Owaifeer, Sarah Al-Omair, Shaimaa Alrefaie, Saad H. Alenezi, Sami Al-Shahwan
Summary: The incidence of ocular hypertension and glaucoma is high in patients with acanthamoeba keratitis, with the use of corticosteroids in the treatment regimen significantly increasing the risk of glaucoma development. Close monitoring of intraocular pressure is recommended for these patients.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Ophthalmology
Chenna Kesavulu Sugali, Naga Pradeep Rayana, Jiannong Dai, Michael Peng, Weiming Mao
Summary: Glaucoma is a leading cause of blindness worldwide, mainly due to optic nerve damage. Elevated intraocular pressure is the most important risk factor for glaucoma. Animal models are crucial for studying glaucoma. In this study, adenoviral vector mediated TGF82 was found to increase intraocular pressure in C57BL/6J mice, with age and sex playing a role.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Ellen E. Freeman, Joseph Bastasic, Alyssa Grant, Gareth Leung, Gisele Li, Ralf Buhrmann, Marie-Helene Roy-Gagnon
Summary: This study found an association between the APOE e4 allele and glaucoma, suggesting a possible protective effect of this allele against glaucoma. However, this association was only observed in individuals without systemic hypertension.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Medicine, General & Internal
Michal Krzysztofik, Dorota Zygadlo, Paulina Trybek, Jakub Jarosz, Adam Zajac, Nicholas Rolnick, Michal Wilk
Summary: Resistance training may be harmful to patients with or at risk of glaucoma, thus combining it with blood flow restriction may be a solution. While BFR holds potential for improving fitness, there is limited research on its safety regarding ocular health.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Aleksandra Zgryzniak, Joanna Przezdziecka-Dolyk, Marek Szalinski, Anna Turno-Krecicka
Summary: Selective laser trabeculoplasty (SLT) is an effective treatment for reducing intraocular pressure in open-angle glaucoma and ocular hypertension. It can be used as a primary or adjunct therapy, helping to reduce medication use and achieve target IOP with low complication rates and the potential for repeat procedures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Cynthia L. Pervan-Steel, Uttio Roy Chowdhury, Hemchand K. Sookdeo, Ralph A. Casale, Peter I. Dosa, Thurein M. Htoo, Michael P. Fautsch, Barbara M. Wirostko
Summary: The study characterized the ocular hypotensive and pharmacological properties of QLS-101, a novel ATP-sensitive potassium channel opening prodrug. Results showed that QLS-101 lowered intraocular pressure (IOP) in mice, with a sustained effect when administered topically. The conversion of QLS-101 to levcromakalim, its active form, was also confirmed.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Joelle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Gregoire, Cecile Delcourt, Cedric Schweitzer, Patricia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja
Summary: This study investigated the association between commonly used systemic medications and glaucoma and intraocular pressure (IOP) in the European population. The use of calcium channel blockers (CCBs) was found to be associated with a higher prevalence of glaucoma, while the use of β-blockers was associated with lower IOP.
Article
Medicine, General & Internal
Silvia Mendez-Martinez, Teresa Martinez-Rincon, Manuel Subias, Luis E. Pablo, David Garcia-Herranz, Julian Garcia Feijoo, Irene Bravo-Osuna, Rocio Herrero-Vanrell, Elena Garcia-Martin, Maria J. Rodrigo
Summary: The study demonstrates that chronic ocular hypertension can accelerate the development of slowly progressive myopia in Long-Evans rat eyes, accompanied by an initial increase in eye structure and function that later reverses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Binze Han, Maomao Song, Liping Li, Xinghuai Sun, Yuan Lei
Summary: Despite various therapeutic methods for ocular hypertension and glaucoma, lowering intraocular pressure remains the most effective way to slow disease progression and prevent blindness. Only a couple of ocular hypotensive drugs act on the conventional outflow system, which is the main pathway for aqueous humor outflow and the major lesion site causing ocular hypertension.