Journal
CURRENT OSTEOPOROSIS REPORTS
Volume 10, Issue 3, Pages 228-235Publisher
SPRINGER
DOI: 10.1007/s11914-012-0112-5
Keywords
Systems genetics; Systems biology; Coexpression network; Causality modeling; Genetics of osteoporosis; Genome-wide association study
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Funding
- NIAMS/NIH (R01)
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From the early 1990s to the middle of the last decade, the search for genes influencing osteoporosis proved difficult with few successes. However, over the last 5 years this has begun to change with the introduction of genome-wide association (GWA) studies. In this short period of time, GWA studies have significantly accelerated the pace of gene discovery, leading to the identification of nearly 100 independent associations for osteoporosis-related traits. However, GWA does not specifically pinpoint causal genes or provide functional context for associations. Thus, there is a need for approaches that provide systemslevel insight on how associated variants influence cellular function, downstream gene networks, and ultimately disease. In this review we discuss the emerging field of systems genetics and how it is being used in combination with and independent of GWA to improve our understanding of the molecular mechanisms involved in bone fragility.
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