Article
Orthopedics
Gang Liu, Ming-hui Yang, Shi-wen Zhu, Ping Zhang, Geng Wang, Man-yi Wang, Xin-bao Wu
Summary: This study aimed to evaluate the effect of orthogeriatric co-management (OGC) in geriatric hip fracture patients in China. The results showed that OGC significantly shortened the time to surgery, but had no significant effect on mortality rate within 1 year and functional status at 1 year of follow-up compared to traditional orthopaedic care (TOC).
ORTHOPAEDIC SURGERY
(2022)
Article
Endocrinology & Metabolism
Wei Huang, Yingqi Xiao, Hongwei Wang, Kaixiang Li
Summary: This study found that GNRI is an independent risk factor for osteoporosis in the elderly population, with a positive linear correlation with bone mineral density in older adults and a significant negative correlation with femoral neck BMD T-scores, but not with lumbar BMD T-score. Additionally, there is a non-linear negative correlation between GNRI and the risk of osteoporosis in the elderly, with a more significant decrease in risk when GNRI is above 100.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jeannette M. Beasley, Emily A. Johnston, Mary Ann Sevick, Melanie Jay, Erin S. Rogers, Hua Zhong, Sondra Zabar, Eric Goldberg, Joshua Chodosh
Summary: In the DPP trial, older adults who received intensive lifestyle intervention had a 71% reduction in incident diabetes. However, a small number of older adults with prediabetes are participating in the National DPP. The BRIDGE trial aims to compare the effectiveness of in-person and virtual DPP programs in older adults and provide insights into the delivery of evidence-based interventions.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Johannes Gleich, Evi Fleischhacker, Katherine Rascher, Thomas Friess, Christian Kammerlander, Wolfgang Boecker, Benjamin Buecking, Ulrich Liener, Michael Drey, Christine Hoefer, Carl Neuerburg
Summary: Interdisciplinary orthogeriatric care for older adult hip fracture patients is crucial, and increased involvement of geriatricians has a significant impact on outcomes, including early mobilization, mobility, and initiation of osteoporosis treatment. Standardized treatment pathways and structured data collection in specific registries improve outcome monitoring and interpretation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Amil R. Agarwal, Jordan S. Cohen, Alexis Jorgensen, Savyasachi C. Thakkar, Umasuthan Srikumaran, Gregory J. Golladay
Summary: The utilization rate of osteoporosis treatment following fragility fractures remains low, with no significant change in the past decade. Bisphosphonates and denosumab are the most frequently prescribed medications, while calcitonin utilization has decreased. More resources and interventions are needed to address the osteoporosis epidemic.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Georgina L. K. McDonald, Mengdi Wang, Chrissy L. Hammond, Dylan J. M. Bergen
Summary: Osteoporosis and other conditions related to low bone density are becoming more prevalent as the population ages and glucocorticoid use increases. Research suggests that targeting genes associated with high bone mass, such as SMAD9, could offer potential for future osteoanabolic therapies.
Review
Orthopedics
L. Henry Goodnough, Harsh Wadhwa, Seth S. Tigchelaar, Malcolm R. DeBaun, Michael J. Chen, Matt L. Graves, Michael J. Gardner
Summary: Cement augmentation in geriatric intertrochanteric fractures improves construct stability and outcomes based on biomechanical and early clinical studies. These findings suggest a significant role for cement augmentation in preventing mechanical failure in high-risk patient populations.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Review
Medicine, General & Internal
Chunzhi Zhang, Congling Xiang, Xin Tian, Jun Xue, Gengxu He, Xueliang Wu, Zubing Mei, Tian Li
Summary: This paper reviews the role of nursing in the management of geriatric cardiovascular disease, emphasizing its importance in improving outcomes of myocardial ischemia and heart failure. Nursing plays a crucial role in the recovery, rehabilitation, and overall outcomes of geriatric CVD, particularly for chronic heart diseases. By focusing on the current status of cardiovascular nursing, this review may help facilitate future treatment and rehabilitation in geriatric CVD.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Angela Frances Yap Hui Wen, Bernard Yap Kok Chong, Lissa Vazhayil Joseph, Joyce Koh Suang Bee, Howe Tet Sen, Kaysar Mamun
Summary: This study found a low prescribing rate of osteoporosis treatment medication of 22.4% in older people admitted under the hip-fracture pathway. Factors associated with greater odds of being prescribed osteoporosis medications are categorized into patient-related, physician-related and system-related factors.
ARCHIVES OF OSTEOPOROSIS
(2022)
Review
Endocrinology & Metabolism
G. Hampson, M. Stone, J. R. Lindsay, R. K. Crowley, S. H. Ralston
Summary: The COVID-19 pandemic has disrupted the diagnosis and management of osteoporosis, but clinical recommendations and innovative care pathways can ensure continued treatment for patients and reduce fracture risks.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Review
Geriatrics & Gerontology
Jean-Marc Kaufman
Summary: Osteoporosis in older men is a significant threat to individual patients' quality of life and a burden for society, but only a small minority of high-risk older men receive treatment. Despite the availability of tools and drugs for treatment, evidence for the management of osteoporosis in older men remains limited.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Ping Wang, Yuanfeng Zhang, Ruiqi Shan, Jing Wu, Sailimai Man, Yuhan Deng, Jun Lv, Xiaona Wang, Jianchun Yin, Yi Ning, Bo Wang, Liming Li
Summary: This study investigates the association between the trajectories of fasting plasma glucose (FPG) and osteoporosis risk for non-diabetic and diabetic populations. The findings indicate that distinct FPG trajectories are associated with differential risk of osteoporosis in these populations. Controlling a proper FPG level is necessary for osteoporosis prevention.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Orthopedics
S. G. Kinney, J. D. Kiesel
Summary: This case study examined the incorporation of Safe Fall Landing Strategies (SFLS) into a physical therapy program for a geriatric patient, showing significant improvements in static balance and functional scores through a combination of various SFLS and physical therapy interventions. Further research is needed to evaluate the effectiveness and safety of SFLS in physical therapy practice.
Article
Chemistry, Multidisciplinary
Minh T. H. Nguyen, Quang Ngo, Huyen T. T. Nguyen, Quan M. Pham, Trang H. Dinh, Huong T. T. Nguyen, Nguyen Tinh, Phuong T. M. Nguyen
Summary: This study found that lupeol derived from Clinacanthus nutans Lindau exhibits osteogenic activity by enhancing alkaline phosphatase and mineralization activity of osteoblast cells, as well as upregulating the expression of marker genes related to osteoblast differentiation. Additionally, lupeol affects the MAPK signaling pathway involved in osteoblast differentiation.
JOURNAL OF CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Xiawen Yu, Yue Xia, Jue Jia, Guoyue Yuan
Summary: The FGF19 subfamily plays a significant role in maintaining bone metabolism balance and provides new possibilities for the treatment of bone diseases such as osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
