Review
Genetics & Heredity
Jingyao Cui, Haoran Chen, Kaiwen Zhang, Xin Li
Summary: Wnt pathway plays a crucial role in cancer bone metastasis and targeted therapeutic strategies have shown promise. Current progress includes research on pharmacological Wnt modulators against breast cancer bone metastasis and exploration of emerging therapeutic strategies based on Wnt pathway-related targets, providing new ideas for the development of Wnt-based intervention strategies in the future.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Biochemistry & Molecular Biology
Gaoyang Chen, Shang Wang, Canling Long, Zhenmin Wang, Xin Chen, Wanze Tang, Xiaoqin He, Zhiteng Bao, Baoyu Tan, William W. Lu, Zhizhong Li, Dazhi Yang, Guozhi Xiao, Songlin Peng
Summary: Bone remodeling is a dynamic process involving bone formation and resorption. PiRNA-63049, through the Wnt2b/13-β-catenin signaling pathway, has been shown to inhibit bone formation, making it a potential target for increasing bone formation in disorders such as postmenopausal osteoporosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Andrew Morris, Rosalie Hoyle, Piyusha P. Pagare, Shadid Uz Zaman, Zhikun Ma, Jiong Li, Yan Zhang
Summary: The Wnt/β-catenin signaling pathway plays important roles in cancer initiation, proliferation, and development, and has been implicated in the regulation of stem cells in the intestinal crypt. This study identified two naphthoquinone analogs that can inhibit the Wnt/β-catenin signaling pathway by inhibiting the TCF4/DNA interaction, a novel finding compared to previous studies. Computational studies suggested that these compounds bind to the DNA binding HMG-box domain of TCF4 to elicit their inhibitory action.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Manuela Johnson de Sousa Brito, Andrew Butcher, Addolorata Pisconti, Blandine Poulet, Amanda Prior, Gemma Charlesworth, Catherine Sperinck, Michele Scotto di Mase, Ke Liu, George Bou-Gharios, Robert Jurgen van 't Hof, Anna Daroszewska
Summary: Syndecan-3 promotes new bone formation in osteoblasts by enhancing WNT signaling, and its deficiency in mice results in an early osteoporosis-like phenotype due to delayed osteoblast maturation and impaired function. Overexpressing Sdc3 in osteoblasts rescues the low bone volume phenotype and increases bone mass, making SDC3 a potential target for novel bone anabolic drug development.
Article
Cell Biology
Changsheng Yang, Panpan Yang, Peilin Liu, Hong Wang, Ee Ke, Kai Li, Huibo Yan
Summary: This study revealed that FLNA plays a crucial role in osteoporosis by inhibiting osteogenesis and promoting osteoclastogenesis. Inhibiting FLNA and activating the WNT/β-catenin signaling pathway can protect against bone loss in postmenopausal osteoporosis.
CELLULAR SIGNALLING
(2022)
Review
Pharmacology & Pharmacy
Karmani Shah, Shivangi Panchal, Bhumika Patel
Summary: Porcupine, a member of the Wnt family, modulates cellular responses by palmitoylating Wnt proteins, showing potential in treating various cancers. While no Porcupine inhibitors have been commercialized yet, several molecules have progressed to Phase I clinical trials.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Orthopedics
Timur B. Kamalitdinov, Keitaro Fujino, Sinaia Keith Lang, Xi Jiang, Rashad Madi, Mary Kate Evans, Miltiadis H. Zgonis, Andrew F. Kuntz, Nathaniel A. Dyment
Summary: This study reveals a biphasic role for Hh signaling during the tendon-to-bone integration process after ACLR. In addition, the Hh pathway is a promising therapeutic target to improve tendon-to-bone repair outcomes.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Critical Care Medicine
Melanie Haffner-Luntzer
Summary: The article explains that fracture healing is a highly coordinated process involving tight interactions of multiple cell types and signaling molecules, with factors affecting fracture healing complexities and the need for improved treatment strategies.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Oncology
Yun Wang, Qian Liang, Kefeng Lei, Qingqing Zhu, Delong Zeng, Yuhong Liu, Yingsi Lu, Tingting Kang, Nannan Tang, Lifen Huang, Liping Ye, Di Tang, Chengming Zhu
Summary: MEX3A expression is significantly upregulated in breast cancer, related to tumor grade, and plays a critical role in promoting metastasis and maintaining stemness through the Wnt/beta-catenin pathway.
Review
Pharmacology & Pharmacy
Michal Caspi, Amnon Wittenstein, Michal Kazelnik, Yarden Shor-Nareznoy, Rina Rosin-Arbesfeld
Summary: The Wnt pathway plays a crucial role in regulating embryogenic developmental processes and tissue homeostasis via beta-catenin. Dysregulation of this pathway has been implicated in carcinogenesis, particularly in colorectal cancer. While the Wnt cascade is an attractive target for therapeutic intervention against CRC, its complexity and challenges need to be addressed for effective treatment.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Medicine, Research & Experimental
Se-Jin Lee
Summary: Since the discovery of myostatin as a critical regulator of skeletal muscle mass in 1997, efforts have been made to understand its activity mechanisms and develop drugs for treating muscle loss. Significant progress has been made in studying MSTN signaling, along with the development of various biologics tested in clinical trials.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Mohsen Hemmati-Dinarvand, Hassan Ahmadvand, Atefeh Seghatoleslam
Summary: The study aimed to investigate the molecular mechanism of multidrug resistance (MDR) in LS174T and LS174T/Oxaliplatin (OXP) cell lines during treatment with Nitazoxanide (NTZ) in combination with OXP. The results showed that NTZ could reverse MDR by downregulating the Wnt/β-catenin signaling pathway, leading to increased sensitivity of colorectal cancer (CRC) cells to OXP-induced apoptosis and inhibition of cell proliferation.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Dunja Mudri, Ines Bilic Curcic, Lucija Mestrovic, Ivica Mihaljevic, Tomislav Kizivat
Summary: Graves' disease is an autoimmune disease that leads to excessive production of thyroid hormones, affecting various organ systems. It can cause skeletal disorders and decrease bone density. The Wnt signaling pathway plays a role in maintaining bone mass, with inhibition causing bone loss and stimulation increasing it.
Article
Cell Biology
Xinwei Chen, Xuzhuo Chen, Rui Chao, Yexin Wang, Yi Mao, Baoting Fan, Yaosheng Zhang, Weifeng Xu, An Qin, Shanyong Zhang
Summary: This study demonstrates the important role of Dlk2 in osteoclast development and bone homeostasis, as well as the interaction between Dlk2 and the Syap1 signaling pathway. The results indicate that Dlk2 deletion inhibits osteoclast formation and leads to a high-bone-mass phenotype, with increased bone mass observed in ovariectomized mice.
CELL DEATH & DISEASE
(2023)
Article
Biology
Michala Steinerova, Cenek Horecky, Eliska Horecka, Ales Knoll, Sarka Nedomova, Petr Slama, Ales Pavlik
Summary: The Wnt signaling pathway plays a critical role in skeletal development, and targeting this pathway has implications for skeletal health. This study investigated single nucleotide polymorphisms in selected genes involved in this pathway and their associations with bone parameters in hens. Thirteen polymorphisms were found in the GPR177 gene, but only one was associated with bone length, and it was located in an intron. The ESR1 and RUNX2 genes were monomorphic in the tested regions.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
