Article
Food Science & Technology
Yongxia Fu, Ruiyang Yin, Erhu Guo, Ruhong Cheng, Xianmin Diao, Yong Xue, Qun Shen
Summary: The study revealed that protein isolates from foxtail millet can effectively alleviate symptoms of diabetes in mice, with cooked foxtail millet protein isolates showing additional benefits in reversing weight loss trends and alleviating lipid disorders. Additionally, both raw and cooked foxtail millet protein isolates were found to influence gut dysbiosis caused by diabetes and affect the GLP-1R/PI3K/AKT pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jin Ook Chung, Seon-Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Summary: The study explores the relationship between plasma LRG1 level and urinary albumin excretion in patients with type 2 diabetes. The results show that there is a positive correlation between plasma LRG1 level and urinary albumin excretion, indicating that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Jianguo Wang, Yu Tina Zhao, Ling X. Zhang, Patrycja M. Dubielecka, Gangjian Qin, Y. Eugene Chin, Adam C. Gower, Shougang Zhuang, Paul Y. Liu, Ting C. Zhao
Summary: Irisin plays a critical role in regulating insulin resistance and cardiac function. Deletion of irisin does not affect cardiac function and insulin sensitivity under normal conditions. However, deletion of irisin exacerbates insulin resistance, metabolic disorders, and cardiac dysfunction in response to a high-fat diet.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cell Biology
Therese Martin Cheteu Wabo, Victorine Raissa Ngo Nkondjock, Justina Ucheojor Onwuka, Changhao Sun, Tianshu Han, Jackson Sira
Summary: The study found that long-term unhealthy diet is associated with an increased risk of type 2 diabetes, and gradually reducing the level of diet quality may not make a significant difference, highlighting the importance of promoting healthy eating habits in early adulthood.
Article
Medicine, Research & Experimental
Keon-Hee Lee, Jae Won Song, Chong -Su Kim, Hobin Seong, Dong-Mi Shin, Woo- Jeong Shon
Summary: This study investigates the role of TAS1R3 in regulating cognitive impairment induced by long-term consumption of a western diet (WD) in mice. The results show that only wild-type mice fed WD exhibit cognitive impairment, while mice lacking TAS1R3 are not affected even under long-term WD feeding.
Article
Toxicology
Shen Chen, Miao Li, Rui Zhang, Lizhu Ye, Yue Jiang, Xinhang Jiang, Hui Peng, Ziwei Wang, Zhanyu Guo, Liping Chen, Rong Zhang, Yujie Niu, Michael Aschner, Daochuan Li, Wen Chen
Summary: This study found that mice with type 1 diabetes (T1D) and diet-induced obesity (DIO) were more susceptible to PM-induced lung injury. The increased susceptibility may be associated with perturbations in glucose and lipid metabolism, inflammatory responses, oxidative stress, cellular senescence, and tissue remodeling.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Cell Biology
Haitao Yu, Yang Gao, Ting He, Mengzhu Li, Yao Zhang, Jie Zheng, Bijun Jiang, Chongyang Chen, Dan Ke, Yanchao Liu, Jian-Zhi Wang
Summary: This study identified differentially expressed proteins in T2DM-MCI patients compared to T2DM-nMCI patients using proteomics analysis. These proteins were enriched in several biological processes and showed strong correlation with high-risk genes for Alzheimer's disease. Furthermore, the levels of some proteins were correlated with cognitive impairment score and machine learning data showed that certain proteins had the greatest power to identify mild cognitive decline in T2DM patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kendra L. Francis, Kimberly M. Alonge, Maria Cristina Pacheco, Shannon J. Hu, Cody A. Krutzsch, Gregory J. Morton, Michael W. Schwartz, Jarrad M. Scarlett
Summary: This study found that diabetes worsened clinical and histopathologic outcomes of colitis in mice with diet-induced obesity, possibly due to hyperglycemia-induced intestinal barrier dysfunction. These findings suggest that effective diabetes management may decrease the clinical severity of inflammatory bowel disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Endocrinology & Metabolism
Eva Zatecka, Romana Bohuslavova, Eliska Valaskova, Hasmik Margaryan, Fatima Elzeinova, Alena Kubatova, Simona Hylmarova, Jana Peknicova, Gabriela Pavlinkova
Summary: This study demonstrates that paternal exposure to type 2 diabetes can have intergenerational and transgenerational effects on the reproductive health of offspring, especially on sperm quality and metabolic characteristics. These changes likely manifest as inherited epigenetic marks through the germline, leading to a lasting impact on subsequent generations. Therefore, improving metabolic health is crucial not only for women of reproductive age but also for potential fathers in order to mitigate the negative effects of diabetes on future generations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Park
Summary: The study indicates that deficiency of MsrB3 gene can inhibit high-fat diet-induced insulin resistance, possibly through increased mitochondrial biogenesis and antioxidant induction.
Article
Multidisciplinary Sciences
Pawel Gutaj, Jan Matysiak, Eliza Matuszewska, Katarzyna Jaskiewicz, Dorota Kaminska, Agata Swiatly-Blaszkiewicz, Tomasz Szczapa, Anastasia Kalantarova, Marzena Gajecka, Ewa Wender-Ozegowska
Summary: This study analyzed serum proteomic profiling in pregnant women with T1DM in the late third trimester and identified distinct protein differences in the coagulation and inflammatory pathways. However, further investigation is needed to determine the utility of these differential proteins as biomarkers for pregnancy complications in women with T1DM.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Marlon R. Schneider, Silja Zettler, Birgit Rathkolb, Maik Dahlhoff
Summary: TXNIP deficiency promotes beta cell survival, while overexpression of TXNIP can lead to increased blood glucose levels, impaired glucose tolerance, and worsen the severity of type 1 diabetes.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Huicui Liu, Tao Chen, Xiaoqing Xie, Xinlei Wang, Yiwen Luo, Nan Xu, Zhen Sa, Min Zhang, Zhifei Chen, Xinzhong Hu, Juxiu Li
Summary: The study demonstrates that BG from highland barley can significantly alleviate liver steatosis induced by NAFLD, by altering lipid metabolic patterns and regulating lipid metabolism-related genes. Additionally, the research also identified 13 differentially regulated lipid species that may serve as lipid biomarkers.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Nora A. Kalagi, Rohith N. Thota, Elizabeth Stojanovski, Khalid A. Alburikan, Manohar L. Garg
Summary: This study compared plasma TMAO levels in people with or without T2D and explored the association between TMAO and T2D. The results showed a significant association between higher plasma TMAO levels and T2D, with red meat consumption being a contributing factor. Further research is needed to assess the correlation between TMAO and T2D.
Article
Endocrinology & Metabolism
Xinyuan Zhang, Yao Nie, Zhizhong Gong, Meidong Zhu, Bingjie Qiu, Qiyun Wang
Summary: ApoE, apoC-II/apoC-III, apoE/apoC-II, and apoB/non-HDL-C could be novel biomarkers for the occurrence and severity of DR, while apoA-I and apoA-II are protective factors for DR.
FRONTIERS IN ENDOCRINOLOGY
(2022)
