Article
Medical Laboratory Technology
Hyunjung Kim, Maru Kim, Hae Kyung Lee, Dae Sang Lee, Dae Hyun Cho, Hangjoo Cho
Summary: The study aimed to investigate coagulation status in trauma patients using thromboelastography and its association with survival and blood transfusion. Results showed that TEG markers were more useful than routine coagulation tests for diagnosis and prediction of survival, with dysfunctional fibrinolysis showing higher mortality rates compared to the physiologic group.
CLINICAL LABORATORY
(2021)
Article
Critical Care Medicine
Christopher J. Dudek, Ian Little, Kyle Wiser, Joseph Ibrahim, Jose Ramirez, Linda Papa
Summary: This study retrospectively reviewed charts of trauma patients under 30 years old with active bleeding and found that TEG testing was associated with patients receiving TXA, MTP, and larger amounts of blood products, as well as significant correlations with PT and PIT levels. Patients who underwent TEG testing were more likely to undergo surgery within the first 24 hours of hospital arrival.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Review
Anesthesiology
J. D. Dias, A. J. Butwick, J. Hartmann, J. H. Waters
Summary: Viscoelastic haemostatic assays have potential clinical utility in obstetric patients by providing rapid and real-time assessment of coagulation function and identifying coagulation defects. The use of viscoelastic haemostatic assay-guided treatment algorithms can aid in diagnosing coagulopathy, predicting postpartum haemorrhage risk, reducing transfusion requirements, and monitoring fibrinolysis in obstetric patients.
Article
Surgery
John C. Cowling, Xu Zhang, Kulvinder S. Bajwa, Ekatarina G. Elliott, Melissa M. Felinski, Julie Holihan, Michelle Scerbo, Brad E. Snyder, Michael D. Trahan, Todd D. Wilson, Sharon L. Courtney, Connie L. Klein, Angielyn R. Rivera, Erik B. Wilson, Shinil K. Shah, Davide Cattano
Summary: The study evaluated pre-operative TEG(R) values in 422 morbidly obese patients undergoing bariatric surgery. It found that female patients had significantly different coagulation profiles compared to males, even in those not using medications that affect coagulation. The majority of patients with clot strength values above 15 dynes/cm(1) were female. Additionally, there was a significant difference in TEG(R) values between male patients with different BMIs.
Article
Emergency Medicine
Thomas E. Tanner, Zachary Drapkin, Nora Fino, Katie Russell, David Chaulk, Hilary A. Hewes
Summary: This retrospective study explored the use of thromboelastography (TEG) in pediatric trauma patients. The results showed that TEG values were associated with ICU length of stay, mortality, and the need for blood product transfusion. Patients with coagulopathy based on TEG had a higher mortality rate, and as TEG values approached transfusion-trigger cut points, the mortality rate increased.
PEDIATRIC EMERGENCY CARE
(2023)
Article
Critical Care Medicine
Pierre-Yves Cordier, Candice Pierrou, Alexandre Noel, Raphael Paris, Eliott Gaudray, Edouard Martin, Claire Contargyris, Frederik Belot-De Saint Leger, Arthur Lyochon, Helene Astier, Florian Desmots, Helene Savini, Corinne Surcouf
Summary: Thromboelastography (TEG) analysis revealed a complex and sustained hypercoagulable state in patients with COVID-19, including fast clot initiation and reinforcement, poor fibrinolysis, high thrombin generation potential, and elevated levels of fibrinogen and platelets. Further studies are needed to investigate antithrombotic strategies during and after ICU hospitalization for COVID-19 patients.
AUSTRALIAN CRITICAL CARE
(2021)
Article
Hematology
Ganesh Mohan, William Wilson, Bemma Paonam, Ashwinkumar Vaidya, Prithvishree Ravindra, Shamee Shastry, Jayaraj Mymbilly Balakrishnan, Shwethapriya Rao, Souvik Chaudhuri
Summary: This study verifies the usefulness of Thromboelastography (TEG) in diagnosing and differentiating coagulopathy associated with COVID-19. The results show that COVID-19 patients commonly exhibit a hypercoagulable state, and increased fibrinolysis activity is associated with thrombotic incidents.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Hematology
Rachel Collis, Sarah Bell
Summary: Postpartum hemorrhage (PPH) is a significant condition associated with coagulopathy. Point-of-care viscoelastic hemostatic assays (POC-VHA) have shown potential in diagnosing and treating PPH, but their universal adoption is limited due to cost and lack of definitive data on improving outcomes.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Critical Care Medicine
Matthew M. McDonough, John Keyloun, Thomas Orfeo, Kathleen Brummel-Zeidins, James A. Bynum, Xiaowu Wu, Daniel N. Darlington, Jeffrey W. Shupp, David M. Burmeister
Summary: By employing functional assessments, this study enhanced the understanding of burn-induced coagulation abnormalities in a pig model. Burn-induced coagulopathy presents as early hypercoagulability followed by hypocoagulability. Novel coagulation parameters may be more sensitive in characterizing coagulation function in burn patients.
Article
Surgery
Emily Breeding, Margaret Trainor, Ishraq Kabir, Michael Martyak
Summary: A retrospective chart review found that thromboelastography (TEG) is not reliable in assessing NOAC-related coagulopathy in traumatic brain injury (TBI) patients. Caution should be exercised when interpreting TEG data to determine reversal strategies in TBI patients on NOACs.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Lauren E. Favors, Kevin N. Harrell, M. Victoria P. Miles, Hayley Everett, Meredith Rippy, Robert Maxwell
Summary: Female trauma patients show a hypercoagulable state based on thromboelastrogram (TEG) compared to males during initial trauma evaluation. Female patients have shorter hospital lengths of stay, lower rates of surgical interventions, and lower rates of mechanical ventilation.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Mohammad Esmaeil Barbati, Frank Hildebrand, Hagen Andruszkow, Rolf Lefering, Michael J. Jacobs, Houman Jalaie, Alexander Gombert
Summary: This study examines the etiology, frequency, and impact of abdominal vascular injuries in polytrauma patients, highlighting the potentially underestimated significance of venous injuries. Venous trauma was associated with higher in-hospital mortality compared to arterial injuries, emphasizing the importance of further investigation and assessment in patients with suspected abdominal vascular injuries.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Thomas Clements, Cameron McCoy, Scott Assen, Jessica Cardenas, Charles Wade, David Meyer, Bryan A. Cotton
Summary: The study suggests that receiving younger whole blood in prehospital setting may improve coagulation, but did not lead to increased transfusion requirements. Further research is needed to determine the optimal storage duration for cold-stored whole blood for transfusion in trauma patients.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2021)
Article
Hematology
Taylor N. Anderson, David H. Farrell, Susan E. Rowell
Summary: Posttraumatic coagulopathy is caused by disruption of the coagulation and fibrinolytic pathways due to tissue damage, hypotension, and inflammatory upregulation. Early hyperfibrinolysis in TBI patients can lead to uncontrolled bleeding and higher mortality. Fibrinolytic assays are not routinely performed, while viscoelastic tests offer rapid evaluation of coagulation function and tranexamic acid may improve clinical outcomes.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Toxicology
Dong Lai, Yan Tian, Chang-Fu Ji, Yuan Zang, Yaw-Syan Fu, Ching-Feng Weng
Summary: A study using a massive wasp-stung animal model found that the blood coagulation function of the model was similar to that of patients who were stung by wasps, providing insights into the pathogenesis of the disease and offering clinical strategies for intervention.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)