Article
Nutrition & Dietetics
Betsy Szeto, Chris Valentini, Anil K. Lalwani
Summary: This study found that low vitamin D status was associated with low-frequency and speech-frequency HL in the elderly, while serum PTH and total calcium were not associated with HL.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Matteo Franchi, Joel Gunnarsson, Emilio Gonzales-Parra, Anibal Ferreira, Oskar Stroem, Giovanni Corrao
Summary: This study compared the efficacy of ERC and PCT in treating non-dialysis CKD patients and found no significant differences in reducing PTH levels. PCT was associated with a significant increase in serum calcium compared to ERC. Therefore, ERC is an effective and well-tolerated treatment option for managing SHPT in patients with ND-CKD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Wei Zhang, Wei Zhao, Wei Li, Qi Geng, Rui Zhao, Yungui Yang, Luyan Lv, Weiwen Chen
Summary: Osteoporosis is a debilitating disease that is often overlooked and poorly studied in elderly male patients. This study aims to investigate molecular alterations in immune cells in men with osteoporosis and identify potential immunomodulatory strategies for treatment. The results show that there are molecular changes in immune cells of male osteoporotic patients and suggest potential therapeutic value of immunomodulation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Alicia R. Jones, Koen Simons, Susan Harvey, Vivian Grill
Summary: Individuals with primary hyperparathyroidism have reduced cortical bone mineral density, but relatively preserved trabecular bone density. However, their fracture risk is still increased. Trabecular bone score may provide a more accurate assessment of bone quality and fracture risk. This study compared the effectiveness of bone mineral density and trabecular bone score in describing bone quality in patients with primary hyperparathyroidism, and also evaluated changes in trabecular bone score following parathyroidectomy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Vincent Brandenburg, Markus Ketteler
Summary: This review examines the developments of vitamin D therapies in CKD patients and discusses the association between vitamin D deficiency and sHPT as well as its impact on important clinical outcomes in CKD patients. However, vitamin D therapy also comes with the risk of side effects, so it is necessary to address core issues regarding PTH target levels, optimal vitamin D levels, and the effectiveness of sHPT treatment in CKD patients.
Article
Surgery
Laura E. Fischer, Fernando Moreno-Garcia, Rachel Tran, Allison Harmon, Cooper Little, Grayson Domingue, Kenneth Stewart, Fernando Mier Giraud, Rishi Thakral
Summary: The prevalence of secondary hyperparathyroidism (SHPT) is high in patients undergoing bariatric surgery, with a significant number of patients experiencing persistent SHPT for more than 1 year. The current vitamin D3 and calcium supplementation protocols may not effectively prevent SHPT in post-bariatric patients. Further studies are needed to develop effective treatment strategies to mitigate the adverse effects of bariatric surgery on bone metabolism.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Nutrition & Dietetics
Masaki Nakano, Yukio Nakamura, Akiko Miyazaki, Jun Takahashi
Summary: This study investigated the efficacy and safety of zinc pharmacotherapy in Japanese elderly patients with osteoporosis. The results showed that zinc treatment successfully elevated serum zinc levels, significantly increased bone mineral density, and had a positive association with BMD changes. Zinc supplementation also significantly raised bone formation markers, potentially contributing to fracture prevention in elderly osteoporotic patients.
Article
Nutrition & Dietetics
Pavel Marozik, Alena Rudenka, Katsiaryna Kobets, Ema Rudenka
Summary: This study demonstrated significant effects of VDR gene variants ApaI rs7975232, BsmI rs1544410, TaqI rs731236, and Cdx2 rs11568820 on bone mineral density, 25-hydroxyvitamin D level, and osteoporosis risk in Belarusian women. The findings suggest the importance of genetic markers for personalized medicine strategies.
Article
Endocrinology & Metabolism
Michael Thompson, Dawn Aitken, Saliu Balogun, Flavia Cicuttini, Graeme Jones
Summary: The longitudinal increase in population 25(OH)D concentration is attributed to increased sun exposure and supplement use. Maintaining or achieving vitamin D sufficiency is associated with less bone mineral density loss over 10 years.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Immunology
Indu Grover, Namrata Singh, Deepak Gunjan, Jaya Benjamin, Lakshmy Ramakrishnan, R. M. Pandey, Hem Chandra Sati, Anoop Saraya
Summary: This study aimed to investigate the prevalence of vitamin D deficiency and bone health in patients with cirrhosis. The results showed that both vitamin D deficiency and low bone mineral density were common in Indian patients with cirrhosis, especially in those with decompensated cirrhosis.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Peter R. Ebeling, Hanh H. Nguyen, Jasna Aleksova, Amanda J. Vincent, Phillip Wong, Frances Milat
Summary: Osteoporosis is a global public health problem with high prevalence rates among postmenopausal women, premenopausal women, and men. Identifying secondary causes of osteoporosis is crucial as treatment often involves addressing the underlying condition. Screening is recommended for all osteoporosis patients, with advanced investigations necessary for certain groups. The response to conventional therapy may be insufficient if the underlying condition is not recognized and treated. Bone densitometry can underestimate or overestimate fracture risk in certain chronic diseases. Tools such as FRAX and trabecular bone score provide additional information on fracture risk in secondary osteoporosis.
Review
Oncology
Nasser M. Al-Daghri, Sobhy Yakout, Afnan Ghaleb, Syed Danish Hussain, Shaun Sabico
Summary: Iron and vitamin D deficiencies are common health problems that can affect bone health, but their impact on bone metabolism is not fully understood. Further investigation is needed to explore the relationship between iron and vitamin D deficiencies and the development of osteoporosis, a prevalent chronic disease. Promoting complete recovery from anemia and preventing nutrient deficiencies is crucial for improving quality of life and bone health.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Orthopedics
Fei Feng, Guan Shi, Hao Chen, Pu Jia, Li Bao, Feng Xu, Qin-chao Sun, Hai Tang
Summary: The study results suggest that active vitamin D is more effective than non-active vitamin D in improving physical ability and lumbar vertebral bone mineral density in elderly patients, reducing the risk of falls.
ORTHOPAEDIC SURGERY
(2021)
Article
Geriatrics & Gerontology
Nekoo Panahi, Afshin Ostovar, Noushin Fahimfar, Hamid Reza Aghaei Meybodi, Safoora Gharibzadeh, Babak Arjmand, Mahnaz Sanjari, Kazem Khalagi, Ramin Heshmat, Iraj Nabipour, Akbar Soltani, Bagher Larijani
Summary: This study aimed to identify factors associated with worse TBS than BMD in non-osteoporotic elderly individuals. The results showed that higher waist circumference was significantly associated with more degraded TBS in both men and women. Years since menopause and current smoking were also associated with worse TBS, indicating the importance of considering these factors in assessing bone health.
Article
Public, Environmental & Occupational Health
Yichen Liu, Yue Zeng, Jun Lu, Xiaoya Zhang, Zikai Zhang, Huijuan Li, Peipei Liu, Bin Ma, Yiqun Gu, Lige Song
Summary: This study aimed to evaluate the correlation between hemoglobin (Hb) and osteoporosis (OP) in the Chinese elderly population. The results showed that Hb level was positively correlated with bone mineral density (BMD) at the lumbar spine, femur neck, and total hip. After adjusting for confounding variables, the relationship remained significant. Additionally, lower Hb levels were associated with a higher risk of OP.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Dermatology
Kanhaiya Singh, Neeraj K. Agrawal, Sanjeev K. Gupta, Gyanendra Mohan, Sunanda Chaturvedi, Kiran Singh
INTERNATIONAL WOUND JOURNAL
(2016)
Article
Geriatrics & Gerontology
Geeta Rao, Rakesh Verma, Arun Mukherjee, Chandana Haldar, Neeraj Kumar Agrawal
EXPERIMENTAL GERONTOLOGY
(2016)
Article
Endocrinology & Metabolism
Kanhaiya Singh, Prabhjot Goyal, Manju Singh, Sujit Deshmukh, Divyesh Upadhyay, Sri Kant, Neeraj K. Agrawal, Sanjeev K. Gupta, Kiran Singh
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2017)
Article
Infectious Diseases
Dinesh Prasad Gond, Shivendra Singh, N. K. Agrawal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2018)
Article
Genetics & Heredity
Dinesh Prasad Gond, Shivendra Singh, N. K. Agrawal
Article
Obstetrics & Gynecology
Kumar Mohanty Sujit, Saumya Sarkar, Vertika Singh, Rajesh Pandey, Neeraj Kumar Agrawal, Sameer Trivedi, Kiran Singh, Gopal Gupta, Singh Rajender
HUMAN REPRODUCTION
(2018)
Article
Genetics & Heredity
Vertika Singh, Deepika Jaiswal, Kanhaiya Singh, Sameer Trivedi, Neeraj K. Agrawal, Gopal Gupta, Singh Rajender, Kiran Singh
Article
Endocrinology & Metabolism
Rujul Jain, S. K. Singh, N. K. Agrawal
HORMONE AND METABOLIC RESEARCH
(2020)
Article
Surgery
Neeraj Kant Agrawal, Visweswar Bhattacharya, Rahul Dubepuria
Summary: Mapping of vascular perforators is crucial for planning flaps in lower limbs. This study assessed changes in posterior tibial perforators post fasciocutaneous flap transfer. Results showed morphological changes in perforators explained the success of these flaps.
INDIAN JOURNAL OF PLASTIC SURGERY
(2021)
Article
Endocrinology & Metabolism
Saurabh Arora, Neeraj Kumar Agrawal, Dhananjaya Melkunte Shanthaiah, Ashish Verma, Sanjay Singh, Shashikant C. U. Patne, Sanjay Kalra, Parminder Singh, Saloni Goyal
Summary: This study aimed to assess the prevalence and risk factors of cutaneous complications in Indian diabetes patients injecting insulin, with results showing that improper rotation of sites and needle reuse are leading causes of lipohypertrophy, and ultrasonography is a more reliable method of detection. Insulin-derived amyloidosis may also be a more common complication than previously thought.
PRIMARY CARE DIABETES
(2021)
Article
Endocrinology & Metabolism
Jaya Chakravarty, Munesh Kumar Gupta, Ragini Tilak, Rajesh Kumar, Rajendra Prakash Maurya, Nilesh Kumar, Susheel Kumar Aggarwal, S. Shiva, Naresh Kumar Sharma, Neeraj Kumar Dhiman, Manaswi Chaubey, Vishambhar Singh, Ashish Verma, Tuhina Banerjee, Neeraj Kumar Agrawal, Ravi Shankar Prasad
Summary: There was a significant increase in COVID-19-associated mucormycosis (CAM) cases during the second wave of the pandemic in India. Uncontrolled hyperglycemia, SARS-CoV-2 infection, widespread use of antibiotics, zinc supplementation, and steroids were identified as risk factors for mucormycosis. Despite the large number of patients, the six-month mortality rate was lower than expected.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Medicine, Research & Experimental
Shriti Singh, Neeraj Kumar Agrawal, Girish Singh, Sangeeta Gehlot, Santosh Kumar Singh, Rajesh Singh
Summary: This study explores the relationship between type 2 diabetes and an individual's constitution based on anthropometric and biochemical characteristics. Significant differences in constitution were found between diabetes patients and non-diabetic individuals. The study also identified a positive relationship between diabetes-related secondary problems and constitution types. Additionally, a discriminant function was created using waist-hip ratio, postprandial blood sugar, and serum creatinine to predict diabetes susceptibility.
Article
Endocrinology & Metabolism
Parminder Singh, Saurabh Arora, Naveen Mittal, Amroz Singh, Rohit Verma, Sarit Sharma, Neeraj Kumar Agrawal, Saloni Goyal
Summary: Rhino-orbito-cerebral mucormycosis (ROCM) in patients with diabetes mellitus is a rapidly progressive disease with a high fatality rate. Ophthalmoplegia and proptosis are common clinical features, with male patients being more predominant. Factors such as intracranial involvement and loss of vision at presentation adversely affect the outcome. Aggressive surgical management through multiple debridements has been shown to be superior in improving survival rates.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2021)
Article
Dermatology
Sanjay Singh, Bandana Jha, Narendra Kumar Tiwary, Neeraj Kumar Agrawal
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2019)
Article
Dermatology
Satyendra K. Singh, Neeraj K. Agrawal, Ajay K. Vishwakarma
INDIAN JOURNAL OF DERMATOLOGY
(2020)